YPL165C / SET6

SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL165C / SET6

Click on Significant Values for Screen Details ID:SGTC_106|Compound:0092-0003|FD-Score:3.10|P-value:3.73E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:4.05|P-value:5.08E-6 ID:SGTC_205|Compound:1486-1330|FD-Score:3.71|P-value:2.66E-5 ID:SGTC_300|Compound:r073-0011|FD-Score:-3.19|P-value:2.52E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.32|P-value:1.51E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.31|P-value:1.55E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-2.99|P-value:5.53E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.18|P-value:2.65E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.18|P-value:2.66E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.24|P-value:2.11E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.13|P-value:3.22E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.20|P-value:2.42E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-6.20|P-value:7.19E-12 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.32|P-value:1.45E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:3.15|P-value:2.97E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.86|P-value:1.26E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:-2.98|P-value:5.88E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.18|P-value:2.69E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:2.95|P-value:6.59E-4 ID:SGTC_1605|Compound:st000082|FD-Score:2.93|P-value:6.97E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.20|P-value:2.43E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.12|P-value:3.39E-4 ID:SGTC_1635|Compound:st007035|FD-Score:7.20|P-value:2.09E-15 ID:SGTC_1732|Compound:st034308|FD-Score:5.56|P-value:7.07E-10 ID:SGTC_1794|Compound:st048918|FD-Score:2.90|P-value:7.98E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.62|P-value:3.94E-5 ID:SGTC_1911|Compound:st060208|FD-Score:-2.86|P-value:9.00E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.51|P-value:9.64E-10 ID:SGTC_2049|Compound:5262831|FD-Score:3.07|P-value:4.16E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.07|P-value:4.18E-4 ID:SGTC_2089|Compound:5281248|FD-Score:2.99|P-value:5.73E-4 ID:SGTC_2287|Compound:7945887|FD-Score:3.02|P-value:5.01E-4 ID:SGTC_2299|Compound:7976368|FD-Score:3.15|P-value:3.01E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.42|P-value:9.65E-5 ID:SGTC_2321|Compound:7390090|FD-Score:-2.95|P-value:6.38E-4 ID:SGTC_2360|Compound:9040895|FD-Score:-2.89|P-value:8.09E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.36|P-value:1.24E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.03|P-value:4.85E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.25|P-value:2.00E-4 ID:SGTC_2451|Compound:5856223|FD-Score:2.89|P-value:8.37E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-2.97|P-value:6.10E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.35|P-value:1.27E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.03|P-value:4.80E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-2.83|P-value:9.98E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.10|P-value:3.67E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-5.39|P-value:2.08E-9 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.03|P-value:4.82E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:-3.45|P-value:8.26E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.38|P-value:1.12E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.93|P-value:9.26E-6 ID:SGTC_2976|Compound:9009005|FD-Score:3.09|P-value:3.88E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.32|P-value:1.49E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.12|P-value:3.43E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-2.87|P-value:8.86E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.76|P-value:2.14E-5 ID:SGTC_3317|Compound:9138495|FD-Score:3.17|P-value:2.73E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:3.10|P-value:3.73E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:4.05|P-value:5.08E-6 ID:SGTC_205|Compound:1486-1330|FD-Score:3.71|P-value:2.66E-5 ID:SGTC_300|Compound:r073-0011|FD-Score:-3.19|P-value:2.52E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.32|P-value:1.51E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.31|P-value:1.55E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-2.99|P-value:5.53E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:3.18|P-value:2.65E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:-3.18|P-value:2.66E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.24|P-value:2.11E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.13|P-value:3.22E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.20|P-value:2.42E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-6.20|P-value:7.19E-12 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.32|P-value:1.45E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:3.15|P-value:2.97E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.86|P-value:1.26E-5 ID:SGTC_1269|Compound:0831-0796|FD-Score:-2.98|P-value:5.88E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.18|P-value:2.69E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:2.95|P-value:6.59E-4 ID:SGTC_1605|Compound:st000082|FD-Score:2.93|P-value:6.97E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.20|P-value:2.43E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.12|P-value:3.39E-4 ID:SGTC_1635|Compound:st007035|FD-Score:7.20|P-value:2.09E-15 ID:SGTC_1732|Compound:st034308|FD-Score:5.56|P-value:7.07E-10 ID:SGTC_1794|Compound:st048918|FD-Score:2.90|P-value:7.98E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.62|P-value:3.94E-5 ID:SGTC_1911|Compound:st060208|FD-Score:-2.86|P-value:9.00E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.51|P-value:9.64E-10 ID:SGTC_2049|Compound:5262831|FD-Score:3.07|P-value:4.16E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.07|P-value:4.18E-4 ID:SGTC_2089|Compound:5281248|FD-Score:2.99|P-value:5.73E-4 ID:SGTC_2287|Compound:7945887|FD-Score:3.02|P-value:5.01E-4 ID:SGTC_2299|Compound:7976368|FD-Score:3.15|P-value:3.01E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.42|P-value:9.65E-5 ID:SGTC_2321|Compound:7390090|FD-Score:-2.95|P-value:6.38E-4 ID:SGTC_2360|Compound:9040895|FD-Score:-2.89|P-value:8.09E-4 ID:SGTC_2363|Compound:9053361|FD-Score:3.36|P-value:1.24E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.03|P-value:4.85E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.25|P-value:2.00E-4 ID:SGTC_2451|Compound:5856223|FD-Score:2.89|P-value:8.37E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-2.97|P-value:6.10E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.35|P-value:1.27E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.03|P-value:4.80E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-2.83|P-value:9.98E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.10|P-value:3.67E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-5.39|P-value:2.08E-9 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.03|P-value:4.82E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:-3.45|P-value:8.26E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.38|P-value:1.12E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.93|P-value:9.26E-6 ID:SGTC_2976|Compound:9009005|FD-Score:3.09|P-value:3.88E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.32|P-value:1.49E-4 ID:SGTC_3303|Compound:9125618|FD-Score:3.12|P-value:3.43E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-2.87|P-value:8.86E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.76|P-value:2.14E-5 ID:SGTC_3317|Compound:9138495|FD-Score:3.17|P-value:2.73E-4

Top fitness defect scores for YPL165C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1635 st007035 7.20 42.4 µM 2.09E-15 110 2.93E-13
2 SGTC_1732 st034308 5.56 51.8 µM 7.07E-10 5 1.38E-8
3 SGTC_1926 methyl fluorone black 5.51 53.6 µM 9.64E-10 DNA intercalators 26 1.79E-8
4 SGTC_131 0141-0277 4.05 33.9 µM 5.08E-6 35 2.54E-5
5 SGTC_2877 9040724 3.93 71.4 µM 9.26E-6 9 4.24E-5
6 SGTC_3310 9130229 3.76 44.1 µM 2.14E-5 Golgi 33 8.64E-5
7 SGTC_205 1486-1330 3.71 71.9 µM 2.66E-5 21 1.04E-4
8 SGTC_1909 st060837 3.62 51.5 µM 3.94E-5 67 1.45E-4
9 SGTC_2316 5844804 3.42 197.4 µM 9.65E-5 60 3.10E-4
10 SGTC_2363 9053361 3.36 176.0 µM 1.24E-4 Golgi 54 3.85E-4
11 SGTC_3300 9124615 3.32 50.5 µM 1.49E-4 39 4.50E-4
12 SGTC_367 0335-0881 3.32 7.1 µM 1.51E-4 ubiquinone biosynthesis & proteasome 119 4.55E-4
13 SGTC_426 0988-0037 3.31 14.6 µM 1.55E-4 ERAD & cell cycle 65 4.64E-4
14 SGTC_512 prima-1 3.24 270.0 µM 2.11E-4 DNA intercalators 47 6.04E-4
15 SGTC_612 0302-0167 3.20 22.4 µM 2.42E-4 copper-dependent oxidative stress 68 6.79E-4
16 SGTC_1606 st000094 3.20 49.2 µM 2.43E-4 60S ribosome export 41 6.81E-4
17 SGTC_431 k089-0097 3.18 107.0 µM 2.65E-4 iron homeostasis 81 7.34E-4
18 SGTC_1280 0880-0253 3.18 10.1 µM 2.69E-4 42 7.43E-4
19 SGTC_3317 9138495 3.17 8.8 µM 2.73E-4 48 7.54E-4
20 SGTC_818 4072-2707 3.15 53.5 µM 2.97E-4 35 8.08E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.254 1.11E-50 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.221 2.20E-38 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.217 5.91E-37 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.211 5.49E-35 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.205 4.75E-33 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.196 2.84E-30 YPL175W SPT14 het UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins
0.193 1.89E-29 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.170 3.92E-23 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
0.166 3.75E-22 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.159 1.91E-20 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.156 1.07E-19 YLR038C COX12 hom Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV
0.155 1.51E-19 YEL006W YEA6 hom Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog
0.152 6.53E-19 YOR093C_p YOR093C_p hom Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
0.152 1.04E-18 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.146 1.52E-17 YIR021W MRS1 hom Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA