YPL168W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL168W / YPL168W

Click on Significant Values for Screen Details ID:SGTC_162|Compound:k030-0015|FD-Score:3.34|P-value:5.99E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:3.71|P-value:1.56E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:5.10|P-value:3.78E-7 ID:SGTC_426|Compound:0988-0037|FD-Score:3.55|P-value:2.89E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:5.51|P-value:4.55E-8 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.58|P-value:2.56E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:-4.18|P-value:2.48E-5 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.34|P-value:5.95E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.02|P-value:4.73E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.56|P-value:2.78E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.51|P-value:3.30E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.30|P-value:6.73E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:4.69|P-value:2.59E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.30|P-value:6.91E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.54|P-value:2.95E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.61|P-value:2.31E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:4.67|P-value:2.87E-6 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.38|P-value:5.22E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.30|P-value:6.74E-4 ID:SGTC_1822|Compound:st052468|FD-Score:3.67|P-value:1.82E-4 ID:SGTC_1907|Compound:st060210|FD-Score:-3.44|P-value:4.16E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.79|P-value:1.18E-4 ID:SGTC_2177|Compound:5811945|FD-Score:-3.56|P-value:2.79E-4 ID:SGTC_2240|Compound:6690706|FD-Score:3.63|P-value:2.16E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-4.52|P-value:5.66E-6 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.43|P-value:8.45E-6 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:4.49|P-value:6.48E-6 ID:SGTC_3002|Compound:9075603|FD-Score:3.19|P-value:9.67E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:3.34|P-value:5.99E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:3.71|P-value:1.56E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:5.10|P-value:3.78E-7 ID:SGTC_426|Compound:0988-0037|FD-Score:3.55|P-value:2.89E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:5.51|P-value:4.55E-8 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.58|P-value:2.56E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:-4.18|P-value:2.48E-5 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.34|P-value:5.95E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.02|P-value:4.73E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.56|P-value:2.78E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.51|P-value:3.30E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.30|P-value:6.73E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:4.69|P-value:2.59E-6 ID:SGTC_1230|Compound:0170-0365|FD-Score:-3.30|P-value:6.91E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.54|P-value:2.95E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.61|P-value:2.31E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:4.67|P-value:2.87E-6 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.38|P-value:5.22E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.30|P-value:6.74E-4 ID:SGTC_1822|Compound:st052468|FD-Score:3.67|P-value:1.82E-4 ID:SGTC_1907|Compound:st060210|FD-Score:-3.44|P-value:4.16E-4 ID:SGTC_1968|Compound:st069590|FD-Score:3.79|P-value:1.18E-4 ID:SGTC_2177|Compound:5811945|FD-Score:-3.56|P-value:2.79E-4 ID:SGTC_2240|Compound:6690706|FD-Score:3.63|P-value:2.16E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-4.52|P-value:5.66E-6 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.43|P-value:8.45E-6 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:4.49|P-value:6.48E-6 ID:SGTC_3002|Compound:9075603|FD-Score:3.19|P-value:9.67E-4

Top fitness defect scores for YPL168W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_632 0781-2353 5.51 4.7 µM 4.55E-8 Golgi 12 1.84E-8
2 SGTC_390 dec-rvkr-cmk 5.10 16.7 µM 3.78E-7 calcium & mitochondrial duress 9 1.74E-7
3 SGTC_1221 2958-7315 4.69 257.0 µM 2.59E-6 12 1.34E-6
4 SGTC_1249 0481-0015 4.67 10.2 µM 2.87E-6 14 1.49E-6
5 SGTC_2627 acetyl isogambogic acid 4.49 100.0 µM 6.48E-6 TSC3-RPN4 30 3.52E-6
6 SGTC_2562 3',7'-dimethoxyflavone 4.43 64.9 µM 8.45E-6 19 4.67E-6
7 SGTC_1047 2043-3044 4.02 82.0 µM 4.73E-5 30 2.89E-5
8 SGTC_1968 st069590 3.79 43.6 µM 1.18E-4 18 7.64E-5
9 SGTC_322 k048-0136 3.71 19.3 µM 1.56E-4 RSC & ERG11 17 1.02E-4
10 SGTC_1822 st052468 3.67 42.0 µM 1.82E-4 16 1.20E-4
11 SGTC_2240 6690706 3.63 185.9 µM 2.16E-4 23 1.44E-4
12 SGTC_1195 1502-0147 3.56 41.1 µM 2.78E-4 39 1.88E-4
13 SGTC_426 0988-0037 3.55 14.6 µM 2.89E-4 ERAD & cell cycle 51 1.96E-4
14 SGTC_1243 0416-0003 3.54 5.7 µM 2.95E-4 PDR1 42 2.00E-4
15 SGTC_1197 1601-0112 3.51 267.0 µM 3.30E-4 30 2.26E-4
16 SGTC_1046 2001-0062 3.34 216.0 µM 5.95E-4 35 4.21E-4
17 SGTC_162 k030-0015 3.34 37.8 µM 5.99E-4 iron homeostasis 34 4.24E-4
18 SGTC_1713 st033146 3.30 12.8 µM 6.74E-4 51 4.80E-4
19 SGTC_3002 9075603 3.19 71.4 µM 9.67E-4 54 7.03E-4
20 SGTC_1539 benzyladenosine 3.13 56.0 µM 0.00120 39 8.85E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.094 5.53E-8 YOR353C SOG2 het Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis
0.091 1.39E-7 YLR354C TAL1 hom Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate
0.088 2.95E-7 YJL211C_d YJL211C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2
0.087 4.61E-7 YEL023C_p YEL023C_p hom Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene
0.087 4.88E-7 YPL240C HSP82 hom Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication
0.086 6.47E-7 YPR032W SRO7 hom Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication
0.083 1.63E-6 YER024W YAT2 hom Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane
0.083 1.70E-6 YFR043C IRC6 hom Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci
0.078 6.00E-6 YGL028C SCW11 hom Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p
0.078 6.80E-6 YCL034W LSB5 hom Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat
0.075 1.21E-5 YLR088W GAA1 het Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER
0.075 1.77E-5 YKR099W BAS1 hom Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
0.075 1.47E-5 YPL001W HAT1 hom Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair
0.074 1.63E-5 YDR420W HKR1 hom Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection
0.074 1.85E-5 YMR315W YMR315W hom Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress