Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated
Zygosity: Homozygous strain
fixedexpanded
![]() ![]() Click on Significant Values for Screen Details |
Top fitness defect scores for YPL168W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.094 | 5.53E-8 | YOR353C | SOG2 | het | Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis |
0.091 | 1.39E-7 | YLR354C | TAL1 | hom | Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate |
0.088 | 2.95E-7 | YJL211C_d | YJL211C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2 |
0.087 | 4.61E-7 | YEL023C_p | YEL023C_p | hom | Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene |
0.087 | 4.88E-7 | YPL240C | HSP82 | hom | Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication |
0.086 | 6.47E-7 | YPR032W | SRO7 | hom | Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication |
0.083 | 1.63E-6 | YER024W | YAT2 | hom | Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane |
0.083 | 1.70E-6 | YFR043C | IRC6 | hom | Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci |
0.078 | 6.00E-6 | YGL028C | SCW11 | hom | Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p |
0.078 | 6.80E-6 | YCL034W | LSB5 | hom | Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat |
0.075 | 1.21E-5 | YLR088W | GAA1 | het | Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER |
0.075 | 1.77E-5 | YKR099W | BAS1 | hom | Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes |
0.075 | 1.47E-5 | YPL001W | HAT1 | hom | Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair |
0.074 | 1.63E-5 | YDR420W | HKR1 | hom | Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection |
0.074 | 1.85E-5 | YMR315W | YMR315W | hom | Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress |