YPL169C / MEX67

Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL169C / MEX67

Click on Significant Values for Screen Details ID:SGTC_81|Compound:0411-0046|FD-Score:5.40|P-value:6.97E-6 ID:SGTC_97|Compound:0535-0701|FD-Score:5.19|P-value:1.50E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:5.39|P-value:7.26E-6 ID:SGTC_140|Compound:0062-0056|FD-Score:4.03|P-value:6.12E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:4.18|P-value:3.98E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.96|P-value:7.59E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.32|P-value:2.59E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.86|P-value:9.91E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:7.93|P-value:7.40E-11 ID:SGTC_309|Compound:k408-0051|FD-Score:5.17|P-value:1.58E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.97|P-value:2.01E-5 ID:SGTC_393|Compound:acivicin|FD-Score:-3.75|P-value:9.30E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:7.23|P-value:2.65E-9 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.92|P-value:8.35E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:6.71|P-value:3.03E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:11.60|P-value:2.31E-21 ID:SGTC_562|Compound:3772-2733|FD-Score:4.03|P-value:6.21E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-5.96|P-value:4.41E-7 ID:SGTC_578|Compound:3460-0051|FD-Score:4.72|P-value:7.55E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:4.92|P-value:3.83E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:5.41|P-value:6.68E-6 ID:SGTC_664|Compound:1222-0054|FD-Score:3.88|P-value:9.43E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.87|P-value:9.65E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:5.19|P-value:1.47E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:5.79|P-value:1.55E-6 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.64|P-value:9.63E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:5.37|P-value:7.61E-6 ID:SGTC_1527|Compound:coumarin|FD-Score:8.25|P-value:1.26E-11 ID:SGTC_1553|Compound:gossypol|FD-Score:-4.25|P-value:2.17E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:5.80|P-value:1.47E-6 ID:SGTC_1637|Compound:st007924|FD-Score:3.94|P-value:7.93E-4 ID:SGTC_1638|Compound:st008370|FD-Score:5.35|P-value:8.19E-6 ID:SGTC_1681|Compound:tripelennamine|FD-Score:4.35|P-value:2.39E-4 ID:SGTC_1687|Compound:st020778|FD-Score:6.96|P-value:9.55E-9 ID:SGTC_1689|Compound:st020265|FD-Score:-3.97|P-value:4.96E-4 ID:SGTC_1694|Compound:st024011|FD-Score:5.34|P-value:8.52E-6 ID:SGTC_1712|Compound:st032288|FD-Score:7.18|P-value:3.38E-9 ID:SGTC_1724|Compound:st037281|FD-Score:4.27|P-value:3.05E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.19|P-value:3.92E-4 ID:SGTC_1896|Compound:st058441|FD-Score:9.90|P-value:5.53E-16 ID:SGTC_1974|Compound:st069448|FD-Score:4.94|P-value:3.52E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.87|P-value:9.78E-4 ID:SGTC_2021|Compound:4019055|FD-Score:5.10|P-value:2.01E-5 ID:SGTC_2095|Compound:5432005|FD-Score:4.08|P-value:5.36E-4 ID:SGTC_2140|Compound:5586273|FD-Score:5.96|P-value:7.73E-7 ID:SGTC_2344|Compound:7990960|FD-Score:-11.90|P-value:9.65E-23 ID:SGTC_2347|Compound:9049783|FD-Score:10.90|P-value:4.61E-19 ID:SGTC_2348|Compound:9022543|FD-Score:13.00|P-value:2.41E-26 ID:SGTC_2350|Compound:9023895|FD-Score:-5.67|P-value:1.43E-6 ID:SGTC_2352|Compound:9027995|FD-Score:-5.34|P-value:5.22E-6 ID:SGTC_2354|Compound:9060492|FD-Score:-10.00|P-value:1.04E-16 ID:SGTC_2356|Compound:9061756|FD-Score:-7.50|P-value:3.44E-10 ID:SGTC_2361|Compound:9034121|FD-Score:10.80|P-value:9.65E-19 ID:SGTC_2364|Compound:9055074|FD-Score:-4.50|P-value:9.70E-5 ID:SGTC_2368|Compound:9071271|FD-Score:5.87|P-value:1.10E-6 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.17|P-value:4.13E-4 ID:SGTC_2426|Compound:5582046|FD-Score:4.27|P-value:3.06E-4 ID:SGTC_2431|Compound:5490079|FD-Score:4.53|P-value:1.37E-4 ID:SGTC_2438|Compound:5259590|FD-Score:4.61|P-value:1.06E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:-5.51|P-value:2.70E-6 ID:SGTC_2505|Compound:galangin|FD-Score:4.03|P-value:6.19E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-6.32|P-value:9.66E-8 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:5.53|P-value:4.28E-6 ID:SGTC_2606|Compound:farnesol|FD-Score:6.96|P-value:9.61E-9 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-4.04|P-value:4.04E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.12|P-value:3.19E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.87|P-value:9.63E-4 ID:SGTC_2873|Compound:9040596|FD-Score:5.76|P-value:1.71E-6 ID:SGTC_2989|Compound:9073649|FD-Score:6.03|P-value:5.93E-7 ID:SGTC_3006|Compound:9075424|FD-Score:4.97|P-value:3.25E-5 ID:SGTC_3007|Compound:9078383|FD-Score:4.64|P-value:9.71E-5 ID:SGTC_3148|Compound:9097893|FD-Score:4.39|P-value:2.14E-4 ID:SGTC_3292|Compound:9120825|FD-Score:4.99|P-value:2.95E-5 ID:SGTC_3296|Compound:9122258|FD-Score:-3.78|P-value:8.60E-4 ID:SGTC_3324|Compound:9138759|FD-Score:7.22|P-value:2.80E-9 ID:SGTC_3337|Compound:9144342|FD-Score:5.66|P-value:2.58E-6 ID:SGTC_3346|Compound:9158254|FD-Score:4.03|P-value:6.10E-4 ID:SGTC_3350|Compound:9150499|FD-Score:4.95|P-value:3.46E-5 ID:SGTC_81|Compound:0411-0046|FD-Score:5.40|P-value:6.97E-6 ID:SGTC_97|Compound:0535-0701|FD-Score:5.19|P-value:1.50E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:5.39|P-value:7.26E-6 ID:SGTC_140|Compound:0062-0056|FD-Score:4.03|P-value:6.12E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:4.18|P-value:3.98E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.96|P-value:7.59E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:4.32|P-value:2.59E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.86|P-value:9.91E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:7.93|P-value:7.40E-11 ID:SGTC_309|Compound:k408-0051|FD-Score:5.17|P-value:1.58E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.97|P-value:2.01E-5 ID:SGTC_393|Compound:acivicin|FD-Score:-3.75|P-value:9.30E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:7.23|P-value:2.65E-9 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.92|P-value:8.35E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:6.71|P-value:3.03E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:11.60|P-value:2.31E-21 ID:SGTC_562|Compound:3772-2733|FD-Score:4.03|P-value:6.21E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-5.96|P-value:4.41E-7 ID:SGTC_578|Compound:3460-0051|FD-Score:4.72|P-value:7.55E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:4.92|P-value:3.83E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:5.41|P-value:6.68E-6 ID:SGTC_664|Compound:1222-0054|FD-Score:3.88|P-value:9.43E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.87|P-value:9.65E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:5.19|P-value:1.47E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:5.79|P-value:1.55E-6 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.64|P-value:9.63E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:5.37|P-value:7.61E-6 ID:SGTC_1527|Compound:coumarin|FD-Score:8.25|P-value:1.26E-11 ID:SGTC_1553|Compound:gossypol|FD-Score:-4.25|P-value:2.17E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:5.80|P-value:1.47E-6 ID:SGTC_1637|Compound:st007924|FD-Score:3.94|P-value:7.93E-4 ID:SGTC_1638|Compound:st008370|FD-Score:5.35|P-value:8.19E-6 ID:SGTC_1681|Compound:tripelennamine|FD-Score:4.35|P-value:2.39E-4 ID:SGTC_1687|Compound:st020778|FD-Score:6.96|P-value:9.55E-9 ID:SGTC_1689|Compound:st020265|FD-Score:-3.97|P-value:4.96E-4 ID:SGTC_1694|Compound:st024011|FD-Score:5.34|P-value:8.52E-6 ID:SGTC_1712|Compound:st032288|FD-Score:7.18|P-value:3.38E-9 ID:SGTC_1724|Compound:st037281|FD-Score:4.27|P-value:3.05E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.19|P-value:3.92E-4 ID:SGTC_1896|Compound:st058441|FD-Score:9.90|P-value:5.53E-16 ID:SGTC_1974|Compound:st069448|FD-Score:4.94|P-value:3.52E-5 ID:SGTC_2015|Compound:5119600|FD-Score:3.87|P-value:9.78E-4 ID:SGTC_2021|Compound:4019055|FD-Score:5.10|P-value:2.01E-5 ID:SGTC_2095|Compound:5432005|FD-Score:4.08|P-value:5.36E-4 ID:SGTC_2140|Compound:5586273|FD-Score:5.96|P-value:7.73E-7 ID:SGTC_2344|Compound:7990960|FD-Score:-11.90|P-value:9.65E-23 ID:SGTC_2347|Compound:9049783|FD-Score:10.90|P-value:4.61E-19 ID:SGTC_2348|Compound:9022543|FD-Score:13.00|P-value:2.41E-26 ID:SGTC_2350|Compound:9023895|FD-Score:-5.67|P-value:1.43E-6 ID:SGTC_2352|Compound:9027995|FD-Score:-5.34|P-value:5.22E-6 ID:SGTC_2354|Compound:9060492|FD-Score:-10.00|P-value:1.04E-16 ID:SGTC_2356|Compound:9061756|FD-Score:-7.50|P-value:3.44E-10 ID:SGTC_2361|Compound:9034121|FD-Score:10.80|P-value:9.65E-19 ID:SGTC_2364|Compound:9055074|FD-Score:-4.50|P-value:9.70E-5 ID:SGTC_2368|Compound:9071271|FD-Score:5.87|P-value:1.10E-6 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.17|P-value:4.13E-4 ID:SGTC_2426|Compound:5582046|FD-Score:4.27|P-value:3.06E-4 ID:SGTC_2431|Compound:5490079|FD-Score:4.53|P-value:1.37E-4 ID:SGTC_2438|Compound:5259590|FD-Score:4.61|P-value:1.06E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:-5.51|P-value:2.70E-6 ID:SGTC_2505|Compound:galangin|FD-Score:4.03|P-value:6.19E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-6.32|P-value:9.66E-8 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:5.53|P-value:4.28E-6 ID:SGTC_2606|Compound:farnesol|FD-Score:6.96|P-value:9.61E-9 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-4.04|P-value:4.04E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.12|P-value:3.19E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.87|P-value:9.63E-4 ID:SGTC_2873|Compound:9040596|FD-Score:5.76|P-value:1.71E-6 ID:SGTC_2989|Compound:9073649|FD-Score:6.03|P-value:5.93E-7 ID:SGTC_3006|Compound:9075424|FD-Score:4.97|P-value:3.25E-5 ID:SGTC_3007|Compound:9078383|FD-Score:4.64|P-value:9.71E-5 ID:SGTC_3148|Compound:9097893|FD-Score:4.39|P-value:2.14E-4 ID:SGTC_3292|Compound:9120825|FD-Score:4.99|P-value:2.95E-5 ID:SGTC_3296|Compound:9122258|FD-Score:-3.78|P-value:8.60E-4 ID:SGTC_3324|Compound:9138759|FD-Score:7.22|P-value:2.80E-9 ID:SGTC_3337|Compound:9144342|FD-Score:5.66|P-value:2.58E-6 ID:SGTC_3346|Compound:9158254|FD-Score:4.03|P-value:6.10E-4 ID:SGTC_3350|Compound:9150499|FD-Score:4.95|P-value:3.46E-5

Top fitness defect scores for YPL169C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2348 9022543 13.00 33.4 µM 2.41E-26 mitochondrial processes 5 5.16E-39 1.93
2 SGTC_528 3492-0019 11.60 172.0 µM 2.31E-21 calcium & mitochondrial duress 1 1.66E-31 2.01
3 SGTC_2347 9049783 10.90 174.8 µM 4.61E-19 1 4.89E-28 7.37
4 SGTC_2361 9034121 10.80 116.0 µM 9.65E-19 RSC complex & mRNA processing 3 1.49E-27 1.48
5 SGTC_1896 st058441 9.90 89.0 µM 5.53E-16 1 2.13E-23 4.64
6 SGTC_1527 coumarin 8.25 137.0 µM 1.26E-11 1 7.84E-17 1.38
7 SGTC_302 1094-0063 7.93 18.9 µM 7.40E-11 1 1.13E-15 1.27
8 SGTC_445 e6 berbamine 7.23 66.0 µM 2.65E-9 NEO1-PIK1 8 2.47E-13 0.14
9 SGTC_3324 9138759 7.22 60.8 µM 2.80E-9 1 2.68E-13 1.42
10 SGTC_1712 st032288 7.18 53.4 µM 3.38E-9 calcium & mitochondrial duress 10 3.56E-13 0.82
11 SGTC_1687 st020778 6.96 55.4 µM 9.55E-9 2 1.70E-12 0.98
12 SGTC_2606 farnesol 6.96 9.8 µM 9.61E-9 1 1.71E-12 1.09
13 SGTC_505 gw-5074 6.71 63.9 µM 3.03E-8 1 9.61E-12 1.34
14 SGTC_2989 9073649 6.03 71.4 µM 5.93E-7 2 8.42E-10 0.66
15 SGTC_2140 5586273 5.96 200.0 µM 7.73E-7 RSC complex & mRNA processing 6 1.25E-9 0.51
16 SGTC_2368 9071271 5.87 200.0 µM 1.10E-6 1 2.13E-9 1.32
17 SGTC_1564 D-Arginine 5.80 115.0 µM 1.47E-6 1 3.27E-9 0.69
18 SGTC_1141 3253-0389 5.79 52.6 µM 1.55E-6 1 3.56E-9 1.43
19 SGTC_2873 9040596 5.76 71.4 µM 1.71E-6 3 4.11E-9 1.35
20 SGTC_3337 9144342 5.66 33.5 µM 2.58E-6 9 7.66E-9 1.40

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.215 1.94E-36 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.203 1.65E-32 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.185 3.99E-27 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.169 7.95E-23 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.163 2.19E-21 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.146 1.97E-17 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.141 2.13E-16 YFR002W NIC96 het Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)
0.134 6.62E-15 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.128 1.06E-13 YIL041W GVP36 hom BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis
0.127 1.84E-13 YLR204W QRI5 hom Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.127 1.92E-13 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.126 2.51E-13 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.124 4.88E-13 YOL072W THP1 hom Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding
0.123 7.59E-13 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.121 1.92E-12 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family