YPL170W / DAP1

Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL170W / DAP1

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:3.64|P-value:3.10E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.57|P-value:4.01E-4 ID:SGTC_57|Compound:miconazole|FD-Score:5.49|P-value:1.06E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:3.93|P-value:1.10E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:13.90|P-value:5.08E-40 ID:SGTC_141|Compound:0443-0274|FD-Score:9.15|P-value:1.76E-18 ID:SGTC_165|Compound:k038-0023|FD-Score:3.72|P-value:2.32E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:3.57|P-value:4.01E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:7.63|P-value:2.20E-13 ID:SGTC_227|Compound:fluconazole|FD-Score:9.75|P-value:9.44E-21 ID:SGTC_256|Compound:clotrimazole|FD-Score:5.34|P-value:2.23E-7 ID:SGTC_273|Compound:hydroxyurea|FD-Score:8.70|P-value:7.19E-17 ID:SGTC_294|Compound:k038-0071|FD-Score:3.43|P-value:6.36E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:7.16|P-value:5.63E-12 ID:SGTC_383|Compound:2324-0395|FD-Score:8.10|P-value:7.59E-15 ID:SGTC_525|Compound:k781-2675|FD-Score:6.28|P-value:1.36E-9 ID:SGTC_526|Compound:4469-0568|FD-Score:14.10|P-value:2.19E-41 ID:SGTC_547|Compound:1120-0019|FD-Score:6.96|P-value:2.07E-11 ID:SGTC_550|Compound:4123-0385|FD-Score:3.29|P-value:9.97E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.79|P-value:1.84E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.73|P-value:2.24E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:-3.47|P-value:3.68E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:3.87|P-value:1.37E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.68|P-value:4.96E-6 ID:SGTC_689|Compound:0833-0039|FD-Score:5.74|P-value:2.81E-8 ID:SGTC_733|Compound:4069-0007|FD-Score:4.05|P-value:6.95E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:7.75|P-value:9.73E-14 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.29|P-value:6.77E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.77|P-value:1.97E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:6.81|P-value:5.56E-11 ID:SGTC_1027|Compound:k015-0025|FD-Score:-4.67|P-value:3.00E-6 ID:SGTC_1036|Compound:k216-0215|FD-Score:8.30|P-value:1.61E-15 ID:SGTC_1044|Compound:1222-0021|FD-Score:6.99|P-value:1.74E-11 ID:SGTC_1055|Compound:3448-0672|FD-Score:8.76|P-value:4.37E-17 ID:SGTC_1067|Compound:clotrimazole|FD-Score:6.33|P-value:1.02E-9 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.05|P-value:6.92E-5 ID:SGTC_1088|Compound:bifonazole|FD-Score:4.85|P-value:2.36E-6 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.99|P-value:8.55E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:6.71|P-value:1.03E-10 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:6.91|P-value:2.89E-11 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.94|P-value:1.05E-4 ID:SGTC_1115|Compound:galangin|FD-Score:4.12|P-value:5.28E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:5.56|P-value:7.38E-8 ID:SGTC_1310|Compound:1188-0297|FD-Score:6.40|P-value:6.62E-10 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.65|P-value:3.00E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:6.19|P-value:2.36E-9 ID:SGTC_1754|Compound:st042065|FD-Score:-3.46|P-value:3.72E-4 ID:SGTC_1772|Compound:st048439|FD-Score:3.34|P-value:8.47E-4 ID:SGTC_1773|Compound:st048542|FD-Score:4.25|P-value:3.06E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:8.96|P-value:8.59E-18 ID:SGTC_1799|Compound:st045822|FD-Score:3.30|P-value:9.68E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.82|P-value:1.60E-4 ID:SGTC_1907|Compound:st060210|FD-Score:-4.46|P-value:7.59E-6 ID:SGTC_2070|Compound:5230947|FD-Score:3.56|P-value:4.15E-4 ID:SGTC_2389|Compound:9091542|FD-Score:4.63|P-value:6.15E-6 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.60|P-value:2.27E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.36|P-value:8.03E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.57|P-value:4.03E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:6.27|P-value:1.43E-9 ID:SGTC_2816|Compound:7982706|FD-Score:7.76|P-value:9.21E-14 ID:SGTC_2858|Compound:9025781|FD-Score:3.77|P-value:1.92E-4 ID:SGTC_2892|Compound:9047358|FD-Score:3.45|P-value:6.04E-4 ID:SGTC_2925|Compound:9010536|FD-Score:5.03|P-value:1.03E-6 ID:SGTC_2928|Compound:9011484|FD-Score:5.24|P-value:3.75E-7 ID:SGTC_2930|Compound:9013230|FD-Score:3.94|P-value:1.05E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.68|P-value:2.66E-4 ID:SGTC_2965|Compound:9082772|FD-Score:4.26|P-value:2.95E-5 ID:SGTC_2991|Compound:9074669|FD-Score:7.22|P-value:3.73E-12 ID:SGTC_3018|Compound:9082602|FD-Score:6.31|P-value:1.17E-9 ID:SGTC_3062|Compound:9077494|FD-Score:5.90|P-value:1.15E-8 ID:SGTC_3227|Compound:9130768|FD-Score:5.81|P-value:1.96E-8 ID:SGTC_3245|Compound:9134821|FD-Score:3.76|P-value:2.04E-4 ID:SGTC_3314|Compound:9135860|FD-Score:-3.27|P-value:7.06E-4 ID:SGTC_3317|Compound:9138495|FD-Score:4.57|P-value:8.13E-6 ID:SGTC_1|Compound:0258-0098|FD-Score:3.64|P-value:3.10E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.57|P-value:4.01E-4 ID:SGTC_57|Compound:miconazole|FD-Score:5.49|P-value:1.06E-7 ID:SGTC_103|Compound:0844-0104|FD-Score:3.93|P-value:1.10E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:13.90|P-value:5.08E-40 ID:SGTC_141|Compound:0443-0274|FD-Score:9.15|P-value:1.76E-18 ID:SGTC_165|Compound:k038-0023|FD-Score:3.72|P-value:2.32E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:3.57|P-value:4.01E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:7.63|P-value:2.20E-13 ID:SGTC_227|Compound:fluconazole|FD-Score:9.75|P-value:9.44E-21 ID:SGTC_256|Compound:clotrimazole|FD-Score:5.34|P-value:2.23E-7 ID:SGTC_273|Compound:hydroxyurea|FD-Score:8.70|P-value:7.19E-17 ID:SGTC_294|Compound:k038-0071|FD-Score:3.43|P-value:6.36E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:7.16|P-value:5.63E-12 ID:SGTC_383|Compound:2324-0395|FD-Score:8.10|P-value:7.59E-15 ID:SGTC_525|Compound:k781-2675|FD-Score:6.28|P-value:1.36E-9 ID:SGTC_526|Compound:4469-0568|FD-Score:14.10|P-value:2.19E-41 ID:SGTC_547|Compound:1120-0019|FD-Score:6.96|P-value:2.07E-11 ID:SGTC_550|Compound:4123-0385|FD-Score:3.29|P-value:9.97E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.79|P-value:1.84E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.73|P-value:2.24E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:-3.47|P-value:3.68E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:3.87|P-value:1.37E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.68|P-value:4.96E-6 ID:SGTC_689|Compound:0833-0039|FD-Score:5.74|P-value:2.81E-8 ID:SGTC_733|Compound:4069-0007|FD-Score:4.05|P-value:6.95E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:7.75|P-value:9.73E-14 ID:SGTC_806|Compound:3966-4455|FD-Score:-3.29|P-value:6.77E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.77|P-value:1.97E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:6.81|P-value:5.56E-11 ID:SGTC_1027|Compound:k015-0025|FD-Score:-4.67|P-value:3.00E-6 ID:SGTC_1036|Compound:k216-0215|FD-Score:8.30|P-value:1.61E-15 ID:SGTC_1044|Compound:1222-0021|FD-Score:6.99|P-value:1.74E-11 ID:SGTC_1055|Compound:3448-0672|FD-Score:8.76|P-value:4.37E-17 ID:SGTC_1067|Compound:clotrimazole|FD-Score:6.33|P-value:1.02E-9 ID:SGTC_1084|Compound:voriconazole|FD-Score:4.05|P-value:6.92E-5 ID:SGTC_1088|Compound:bifonazole|FD-Score:4.85|P-value:2.36E-6 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.99|P-value:8.55E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:6.71|P-value:1.03E-10 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:6.91|P-value:2.89E-11 ID:SGTC_1113|Compound:artemisinin|FD-Score:3.94|P-value:1.05E-4 ID:SGTC_1115|Compound:galangin|FD-Score:4.12|P-value:5.28E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:5.56|P-value:7.38E-8 ID:SGTC_1310|Compound:1188-0297|FD-Score:6.40|P-value:6.62E-10 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.65|P-value:3.00E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:6.19|P-value:2.36E-9 ID:SGTC_1754|Compound:st042065|FD-Score:-3.46|P-value:3.72E-4 ID:SGTC_1772|Compound:st048439|FD-Score:3.34|P-value:8.47E-4 ID:SGTC_1773|Compound:st048542|FD-Score:4.25|P-value:3.06E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:8.96|P-value:8.59E-18 ID:SGTC_1799|Compound:st045822|FD-Score:3.30|P-value:9.68E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.82|P-value:1.60E-4 ID:SGTC_1907|Compound:st060210|FD-Score:-4.46|P-value:7.59E-6 ID:SGTC_2070|Compound:5230947|FD-Score:3.56|P-value:4.15E-4 ID:SGTC_2389|Compound:9091542|FD-Score:4.63|P-value:6.15E-6 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.60|P-value:2.27E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.36|P-value:8.03E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.57|P-value:4.03E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:6.27|P-value:1.43E-9 ID:SGTC_2816|Compound:7982706|FD-Score:7.76|P-value:9.21E-14 ID:SGTC_2858|Compound:9025781|FD-Score:3.77|P-value:1.92E-4 ID:SGTC_2892|Compound:9047358|FD-Score:3.45|P-value:6.04E-4 ID:SGTC_2925|Compound:9010536|FD-Score:5.03|P-value:1.03E-6 ID:SGTC_2928|Compound:9011484|FD-Score:5.24|P-value:3.75E-7 ID:SGTC_2930|Compound:9013230|FD-Score:3.94|P-value:1.05E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.68|P-value:2.66E-4 ID:SGTC_2965|Compound:9082772|FD-Score:4.26|P-value:2.95E-5 ID:SGTC_2991|Compound:9074669|FD-Score:7.22|P-value:3.73E-12 ID:SGTC_3018|Compound:9082602|FD-Score:6.31|P-value:1.17E-9 ID:SGTC_3062|Compound:9077494|FD-Score:5.90|P-value:1.15E-8 ID:SGTC_3227|Compound:9130768|FD-Score:5.81|P-value:1.96E-8 ID:SGTC_3245|Compound:9134821|FD-Score:3.76|P-value:2.04E-4 ID:SGTC_3314|Compound:9135860|FD-Score:-3.27|P-value:7.06E-4 ID:SGTC_3317|Compound:9138495|FD-Score:4.57|P-value:8.13E-6

Top fitness defect scores for YPL170W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_526 4469-0568 14.10 170.0 µM 2.19E-41 azole & statin 1 2.00E-45
2 SGTC_116 0155-0182 13.90 31.8 µM 5.08E-40 mitochondrial response to ROS 2 6.31E-44
3 SGTC_227 fluconazole 9.75 33.5 µM 9.44E-21 azole & statin 17 9.02E-23
4 SGTC_141 0443-0274 9.15 32.3 µM 1.76E-18 mitochondrial response to ROS 8 2.83E-20
5 SGTC_1788 fluconazole 8.96 20.0 µM 8.59E-18 azole & statin 14 1.61E-19
6 SGTC_1055 3448-0672 8.76 86.0 µM 4.37E-17 4 9.63E-19
7 SGTC_273 hydroxyurea 8.70 18.1 mM 7.19E-17 heme biosynthesis & mitochondrial translocase 2 1.67E-18
8 SGTC_1036 k216-0215 8.30 33.5 µM 1.61E-15 mitochondrial response to ROS 5 5.09E-17
9 SGTC_383 2324-0395 8.10 7.4 µM 7.59E-15 azole & statin 3 2.79E-16
10 SGTC_2816 7982706 7.76 58.4 µM 9.21E-14 azole & statin 8 4.35E-15
11 SGTC_778 3456-2434 7.75 196.0 µM 9.73E-14 mitochondrial response to ROS 9 4.62E-15
12 SGTC_208 k072-0098 7.63 12.4 µM 2.20E-13 heme biosynthesis & mitochondrial translocase 4 1.14E-14
13 SGTC_2991 9074669 7.22 71.4 µM 3.73E-12 azole & statin 11 2.55E-13
14 SGTC_346 4513-0042 7.16 7.2 µM 5.63E-12 azole & statin 5 4.02E-13
15 SGTC_1044 1222-0021 6.99 1.8 µM 1.74E-11 heme biosynthesis & mitochondrial translocase 9 1.39E-12
16 SGTC_547 1120-0019 6.96 610.0 nM 2.07E-11 azole & statin 6 1.68E-12
17 SGTC_1102 cgs 12066b 6.91 26.1 µM 2.89E-11 endomembrane recycling 2 2.43E-12
18 SGTC_902 1120-0002 6.81 2.1 µM 5.56E-11 azole & statin 15 4.99E-12
19 SGTC_1098 clofazimine 6.71 15.1 µM 1.03E-10 heme biosynthesis & mitochondrial translocase 2 9.80E-12
20 SGTC_1310 1188-0297 6.40 994.0 nM 6.62E-10 azole & statin 7 7.63E-11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.644 0 YHR045W_p YHR045W_p hom Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.316 1.39E-78 YDL118W_d YDL118W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein
0.292 1.01E-66 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.289 1.07E-65 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.275 4.76E-59 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.265 3.60E-55 YLR188W MDL1 hom Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress
0.258 6.90E-52 YMR063W RIM9 hom Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;
0.233 1.05E-42 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.222 7.34E-39 YDL119C_p YDL119C_p hom Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria
0.217 3.30E-37 YGR270W YTA7 hom Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p
0.216 9.71E-37 YFL016C MDJ1 hom Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
0.211 3.61E-35 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.199 2.65E-31 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.194 1.12E-29 YDL205C HEM3 het Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.191 5.26E-29 YDR047W HEM12 het Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda