HIPHOP chemogenomics database
YPL172C / COX10 
Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YPL172C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.296 | 5.87E-69 | YPL132W | COX11 | hom | Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p |
| 0.275 | 3.58E-59 | YDR231C | COX20 | hom | Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase |
| 0.269 | 1.57E-56 | YNR045W | PET494 | hom | Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane |
| 0.268 | 2.62E-56 | YJL166W | QCR8 | hom | Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p |
| 0.266 | 2.01E-55 | YDL107W | MSS2 | hom | Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p |
| 0.266 | 3.57E-55 | YJL062W-A | COA3 | hom | Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly |
| 0.264 | 1.58E-54 | YLL009C | COX17 | hom | Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs |
| 0.257 | 7.91E-52 | YEL059C-A | SOM1 | hom | Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs |
| 0.256 | 2.11E-51 | YDR230W_d | YDR230W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20 |
| 0.255 | 6.20E-51 | YER058W | PET117 | hom | Protein required for assembly of cytochrome c oxidase |
| 0.255 | 9.64E-51 | YJL209W | CBP1 | hom | Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress |
| 0.251 | 2.46E-49 | YML129C | COX14 | hom | Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes |
| 0.250 | 5.05E-49 | YJL022W_d | YJL022W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130 |
| 0.244 | 1.14E-46 | YMR035W | IMP2 | hom | Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p |
| 0.240 | 3.68E-45 | YER141W | COX15 | hom | Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase |