YPL172C / COX10

Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL172C / COX10

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:5.63|P-value:1.41E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:-4.23|P-value:4.51E-5 ID:SGTC_74|Compound:000s-0487|FD-Score:4.75|P-value:7.44E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:9.38|P-value:5.02E-18 ID:SGTC_160|Compound:3453-0671|FD-Score:5.17|P-value:1.23E-6 ID:SGTC_176|Compound:1486-1328|FD-Score:3.62|P-value:5.07E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:3.67|P-value:4.21E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:8.27|P-value:2.04E-14 ID:SGTC_297|Compound:0986-0032|FD-Score:3.67|P-value:4.32E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.49|P-value:6.05E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:6.29|P-value:4.76E-9 ID:SGTC_446|Compound:go6976|FD-Score:3.41|P-value:9.75E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.81|P-value:2.67E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:9.35|P-value:6.34E-18 ID:SGTC_552|Compound:k242-0005|FD-Score:4.64|P-value:1.20E-5 ID:SGTC_592|Compound:k241-0073|FD-Score:6.41|P-value:2.45E-9 ID:SGTC_607|Compound:4491-0986|FD-Score:4.95|P-value:3.25E-6 ID:SGTC_710|Compound:3448-4187|FD-Score:3.52|P-value:7.04E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:4.36|P-value:3.57E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:5.42|P-value:3.96E-7 ID:SGTC_806|Compound:3966-4455|FD-Score:4.32|P-value:4.23E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:5.34|P-value:5.64E-7 ID:SGTC_1149|Compound:3909-7961|FD-Score:4.25|P-value:5.45E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.95|P-value:1.63E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.69|P-value:3.96E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.68|P-value:4.13E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:4.07|P-value:1.06E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:4.11|P-value:9.36E-5 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.80|P-value:2.73E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.57|P-value:5.98E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.54|P-value:6.49E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.79|P-value:2.83E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:-3.57|P-value:4.65E-4 ID:SGTC_1518|Compound:st038567|FD-Score:3.54|P-value:6.56E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.50|P-value:7.28E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.62|P-value:1.32E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.75|P-value:7.65E-6 ID:SGTC_1725|Compound:st036284|FD-Score:3.73|P-value:3.48E-4 ID:SGTC_1802|Compound:st050112|FD-Score:4.33|P-value:4.00E-5 ID:SGTC_1824|Compound:st053723|FD-Score:3.80|P-value:2.78E-4 ID:SGTC_1850|Compound:st056238|FD-Score:4.76|P-value:7.29E-6 ID:SGTC_1886|Compound:st057356|FD-Score:4.49|P-value:2.19E-5 ID:SGTC_1892|Compound:st058411|FD-Score:4.30|P-value:4.63E-5 ID:SGTC_1939|Compound:st074455|FD-Score:-3.99|P-value:1.12E-4 ID:SGTC_1952|Compound:st077036|FD-Score:6.99|P-value:8.71E-11 ID:SGTC_1970|Compound:st070122|FD-Score:-3.37|P-value:8.99E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.82|P-value:2.05E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.48|P-value:7.87E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-4.02|P-value:9.98E-5 ID:SGTC_2289|Compound:7946404|FD-Score:5.71|P-value:9.41E-8 ID:SGTC_2320|Compound:7373003|FD-Score:4.64|P-value:1.21E-5 ID:SGTC_2324|Compound:6149169|FD-Score:4.74|P-value:7.95E-6 ID:SGTC_2452|Compound:5863136|FD-Score:3.54|P-value:6.49E-4 ID:SGTC_2459|Compound:5811157|FD-Score:3.50|P-value:7.42E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.72|P-value:3.55E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.32|P-value:4.24E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.87|P-value:2.17E-4 ID:SGTC_2691|Compound:st077356|FD-Score:5.80|P-value:6.20E-8 ID:SGTC_2730|Compound:imipramine|FD-Score:4.15|P-value:8.12E-5 ID:SGTC_2793|Compound:7325131|FD-Score:-4.13|P-value:6.68E-5 ID:SGTC_2795|Compound:7780010|FD-Score:-5.57|P-value:1.40E-7 ID:SGTC_2797|Compound:7859098|FD-Score:4.63|P-value:1.27E-5 ID:SGTC_2798|Compound:7813637|FD-Score:-3.70|P-value:3.11E-4 ID:SGTC_2801|Compound:7907800|FD-Score:7.26|P-value:1.68E-11 ID:SGTC_2802|Compound:7925815|FD-Score:5.83|P-value:5.23E-8 ID:SGTC_2817|Compound:7995342|FD-Score:5.19|P-value:1.11E-6 ID:SGTC_2831|Compound:7999036|FD-Score:3.93|P-value:1.78E-4 ID:SGTC_2841|Compound:9004761|FD-Score:4.26|P-value:5.29E-5 ID:SGTC_2865|Compound:9030313|FD-Score:3.44|P-value:8.95E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-4.01|P-value:1.03E-4 ID:SGTC_2923|Compound:7992654|FD-Score:4.13|P-value:8.60E-5 ID:SGTC_2996|Compound:9066192|FD-Score:4.55|P-value:1.72E-5 ID:SGTC_3017|Compound:9080681|FD-Score:5.71|P-value:9.78E-8 ID:SGTC_3026|Compound:9090633|FD-Score:3.77|P-value:3.05E-4 ID:SGTC_3049|Compound:9092223|FD-Score:4.12|P-value:9.04E-5 ID:SGTC_3154|Compound:9100113|FD-Score:4.41|P-value:2.96E-5 ID:SGTC_3280|Compound:9140961|FD-Score:3.70|P-value:3.88E-4 ID:SGTC_3294|Compound:9122953|FD-Score:-3.50|P-value:5.84E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:5.63|P-value:1.41E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:-4.23|P-value:4.51E-5 ID:SGTC_74|Compound:000s-0487|FD-Score:4.75|P-value:7.44E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:9.38|P-value:5.02E-18 ID:SGTC_160|Compound:3453-0671|FD-Score:5.17|P-value:1.23E-6 ID:SGTC_176|Compound:1486-1328|FD-Score:3.62|P-value:5.07E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:3.67|P-value:4.21E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:8.27|P-value:2.04E-14 ID:SGTC_297|Compound:0986-0032|FD-Score:3.67|P-value:4.32E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.49|P-value:6.05E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:6.29|P-value:4.76E-9 ID:SGTC_446|Compound:go6976|FD-Score:3.41|P-value:9.75E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.81|P-value:2.67E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:9.35|P-value:6.34E-18 ID:SGTC_552|Compound:k242-0005|FD-Score:4.64|P-value:1.20E-5 ID:SGTC_592|Compound:k241-0073|FD-Score:6.41|P-value:2.45E-9 ID:SGTC_607|Compound:4491-0986|FD-Score:4.95|P-value:3.25E-6 ID:SGTC_710|Compound:3448-4187|FD-Score:3.52|P-value:7.04E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:4.36|P-value:3.57E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:5.42|P-value:3.96E-7 ID:SGTC_806|Compound:3966-4455|FD-Score:4.32|P-value:4.23E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:5.34|P-value:5.64E-7 ID:SGTC_1149|Compound:3909-7961|FD-Score:4.25|P-value:5.45E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.95|P-value:1.63E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.69|P-value:3.96E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.68|P-value:4.13E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:4.07|P-value:1.06E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:4.11|P-value:9.36E-5 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.80|P-value:2.73E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.57|P-value:5.98E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.54|P-value:6.49E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.79|P-value:2.83E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:-3.57|P-value:4.65E-4 ID:SGTC_1518|Compound:st038567|FD-Score:3.54|P-value:6.56E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.50|P-value:7.28E-4 ID:SGTC_1635|Compound:st007035|FD-Score:4.62|P-value:1.32E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.75|P-value:7.65E-6 ID:SGTC_1725|Compound:st036284|FD-Score:3.73|P-value:3.48E-4 ID:SGTC_1802|Compound:st050112|FD-Score:4.33|P-value:4.00E-5 ID:SGTC_1824|Compound:st053723|FD-Score:3.80|P-value:2.78E-4 ID:SGTC_1850|Compound:st056238|FD-Score:4.76|P-value:7.29E-6 ID:SGTC_1886|Compound:st057356|FD-Score:4.49|P-value:2.19E-5 ID:SGTC_1892|Compound:st058411|FD-Score:4.30|P-value:4.63E-5 ID:SGTC_1939|Compound:st074455|FD-Score:-3.99|P-value:1.12E-4 ID:SGTC_1952|Compound:st077036|FD-Score:6.99|P-value:8.71E-11 ID:SGTC_1970|Compound:st070122|FD-Score:-3.37|P-value:8.99E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.82|P-value:2.05E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.48|P-value:7.87E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-4.02|P-value:9.98E-5 ID:SGTC_2289|Compound:7946404|FD-Score:5.71|P-value:9.41E-8 ID:SGTC_2320|Compound:7373003|FD-Score:4.64|P-value:1.21E-5 ID:SGTC_2324|Compound:6149169|FD-Score:4.74|P-value:7.95E-6 ID:SGTC_2452|Compound:5863136|FD-Score:3.54|P-value:6.49E-4 ID:SGTC_2459|Compound:5811157|FD-Score:3.50|P-value:7.42E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.72|P-value:3.55E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.32|P-value:4.24E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.87|P-value:2.17E-4 ID:SGTC_2691|Compound:st077356|FD-Score:5.80|P-value:6.20E-8 ID:SGTC_2730|Compound:imipramine|FD-Score:4.15|P-value:8.12E-5 ID:SGTC_2793|Compound:7325131|FD-Score:-4.13|P-value:6.68E-5 ID:SGTC_2795|Compound:7780010|FD-Score:-5.57|P-value:1.40E-7 ID:SGTC_2797|Compound:7859098|FD-Score:4.63|P-value:1.27E-5 ID:SGTC_2798|Compound:7813637|FD-Score:-3.70|P-value:3.11E-4 ID:SGTC_2801|Compound:7907800|FD-Score:7.26|P-value:1.68E-11 ID:SGTC_2802|Compound:7925815|FD-Score:5.83|P-value:5.23E-8 ID:SGTC_2817|Compound:7995342|FD-Score:5.19|P-value:1.11E-6 ID:SGTC_2831|Compound:7999036|FD-Score:3.93|P-value:1.78E-4 ID:SGTC_2841|Compound:9004761|FD-Score:4.26|P-value:5.29E-5 ID:SGTC_2865|Compound:9030313|FD-Score:3.44|P-value:8.95E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-4.01|P-value:1.03E-4 ID:SGTC_2923|Compound:7992654|FD-Score:4.13|P-value:8.60E-5 ID:SGTC_2996|Compound:9066192|FD-Score:4.55|P-value:1.72E-5 ID:SGTC_3017|Compound:9080681|FD-Score:5.71|P-value:9.78E-8 ID:SGTC_3026|Compound:9090633|FD-Score:3.77|P-value:3.05E-4 ID:SGTC_3049|Compound:9092223|FD-Score:4.12|P-value:9.04E-5 ID:SGTC_3154|Compound:9100113|FD-Score:4.41|P-value:2.96E-5 ID:SGTC_3280|Compound:9140961|FD-Score:3.70|P-value:3.88E-4 ID:SGTC_3294|Compound:9122953|FD-Score:-3.50|P-value:5.84E-4

Top fitness defect scores for YPL172C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_134 0269-0018 9.38 6.9 µM 5.02E-18 43 3.30E-21
2 SGTC_549 1661-1316 9.35 519.0 µM 6.34E-18 1 4.35E-21
3 SGTC_236 1509-0011 8.27 5.3 µM 2.04E-14 242 6.51E-17
4 SGTC_2801 7907800 7.26 81.8 µM 1.68E-11 4 1.92E-13
5 SGTC_1952 st077036 6.99 64.1 µM 8.71E-11 5 1.36E-12
6 SGTC_592 k241-0073 6.41 46.5 µM 2.45E-9 5 7.20E-11
7 SGTC_386 1509-0011 6.29 3.1 µM 4.76E-9 86 1.58E-10
8 SGTC_2802 7925815 5.83 54.5 µM 5.23E-8 8 2.74E-9
9 SGTC_2691 st077356 5.80 60.2 µM 6.20E-8 9 3.35E-9
10 SGTC_2289 7946404 5.71 165.1 µM 9.41E-8 40 5.50E-9
11 SGTC_3017 9080681 5.71 49.5 µM 9.78E-8 1 5.76E-9
12 SGTC_44 0929-0055 5.63 61.2 µM 1.41E-7 12 8.93E-9
13 SGTC_768 0384-0033 5.42 77.3 µM 3.96E-7 fatty acid desaturase (OLE1) 45 3.04E-8
14 SGTC_1147 3809-1045 5.34 12.3 µM 5.64E-7 2 4.63E-8
15 SGTC_2817 7995342 5.19 71.4 µM 1.11E-6 9 1.04E-7
16 SGTC_160 3453-0671 5.17 289.7 µM 1.23E-6 19 1.17E-7
17 SGTC_607 4491-0986 4.95 66.8 µM 3.25E-6 heme requiring 11 3.71E-7
18 SGTC_1850 st056238 4.76 17.0 µM 7.29E-6 RPP1 & pyrimidine depletion 10 9.68E-7
19 SGTC_74 000s-0487 4.75 160.3 µM 7.44E-6 14 9.93E-7
20 SGTC_1680 diphenhydramine 4.75 100.0 µM 7.65E-6 NEO1 15 1.03E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.296 5.87E-69 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.275 3.58E-59 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.269 1.57E-56 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.268 2.62E-56 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.266 2.01E-55 YDL107W MSS2 hom Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p
0.266 3.57E-55 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.264 1.58E-54 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.257 7.91E-52 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.256 2.11E-51 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.255 6.20E-51 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.255 9.64E-51 YJL209W CBP1 hom Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress
0.251 2.46E-49 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.250 5.05E-49 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.244 1.14E-46 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.240 3.68E-45 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase