HIPHOP chemogenomics database

YPL173W / MRPL40

Mitochondrial ribosomal protein of the large subunit

Zygosity: Homozygous strain

fixedexpanded
Profile for YPL173W / MRPL40

Click on Significant Values for Screen Details

Top fitness defect scores for YPL173W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_310	1273-0058	6.69	1.1 µM	6.73E-11	mitochondrial stress	126	1.13E-11
2	SGTC_688	0527-0193	6.35	473.0 µM	5.59E-10	fatty acid desaturase (OLE1)	2	1.11E-10
3	SGTC_119	0121-0043	6.07	24.8 µM	2.84E-9	mitochondrial stress	27	6.38E-10
4	SGTC_2283	7944793	6.07	200.0 µM	2.86E-9		6	6.44E-10
5	SGTC_236	1509-0011	5.76	5.3 µM	1.61E-8		299	4.14E-9
6	SGTC_1318	1280-3875	5.74	124.0 µM	1.87E-8		4	4.87E-9
7	SGTC_1901	st060216	4.81	58.6 µM	2.02E-6		14	7.55E-7
8	SGTC_118	0083-0097	4.56	135.3 µM	6.37E-6	translation	83	2.61E-6
9	SGTC_10	0279-0212	4.43	42.6 µM	1.11E-5	TRP & mitochondrial translation	101	4.76E-6
10	SGTC_19	0279-0214	4.41	38.4 µM	1.18E-5	TRP & mitochondrial translation	32	5.07E-6
11	SGTC_761	k216-0224	4.18	480.0 µM	3.14E-5		14	1.45E-5
12	SGTC_2250	alverine citrate	4.16	130.0 µM	3.43E-5		141	1.60E-5
13	SGTC_767	0929-0023	4.09	86.0 µM	4.55E-5	TRP & mitochondrial translation	71	2.17E-5
14	SGTC_1018	4259-0013	4.04	28.1 µM	5.49E-5		13	2.66E-5
15	SGTC_2165	5727197	4.00	32.1 µM	6.48E-5		30	3.18E-5
16	SGTC_2703	st077852	3.98	53.4 µM	6.99E-5		22	3.45E-5
17	SGTC_1907	st060210	3.94	83.7 µM	8.21E-5		22	4.10E-5
18	SGTC_449	xestospongin c	3.92	11.2 µM	8.71E-5	NEO1-PIK1	70	4.38E-5
19	SGTC_120	rhodamine 6G	3.92	52.3 µM	8.82E-5	mitochondrial processes	32	4.43E-5
20	SGTC_70	0141-0289	3.91	43.3 µM	9.14E-5	mitochondrial stress	178	4.61E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.266	1.68E-55	YCR024C	SLM5	hom	Mitochondrial asparaginyl-tRNA synthetase
0.259	3.98E-52	YMR287C	DSS1	hom	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.258	3.22E-52	YDR509W_d	YDR509W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.257	9.79E-52	YPR166C	MRP2	hom	Mitochondrial ribosomal protein of the small subunit
0.255	8.64E-51	YER050C	RSM18	hom	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.252	9.86E-50	YGR219W_d	YGR219W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C
0.249	1.79E-48	YDR533C	HSP31	hom	Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress
0.248	2.65E-48	YIL014C-A_p	YIL014C-A_p	hom	Putative protein of unknown function
0.247	8.73E-48	YOL095C	HMI1	hom	Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
0.246	2.70E-47	YLR260W	LCB5	hom	Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.246	2.10E-47	YNL252C	MRPL17	hom	Mitochondrial ribosomal protein of the large subunit
0.246	2.24E-47	YGR171C	MSM1	hom	Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p
0.245	3.29E-47	YNL005C	MRP7	hom	Mitochondrial ribosomal protein of the large subunit
0.244	1.40E-46	YDR337W	MRPS28	hom	Mitochondrial ribosomal protein of the small subunit
0.241	1.62E-45	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress