YPL173W / MRPL40

Mitochondrial ribosomal protein of the large subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL173W / MRPL40

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.43|P-value:1.11E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:4.41|P-value:1.18E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:3.91|P-value:9.14E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:-3.19|P-value:9.36E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:3.50|P-value:4.15E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.56|P-value:6.37E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:6.07|P-value:2.84E-9 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.92|P-value:8.82E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:5.76|P-value:1.61E-8 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.32|P-value:7.53E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.69|P-value:2.12E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.73|P-value:1.78E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:6.69|P-value:6.73E-11 ID:SGTC_342|Compound:k048-0088|FD-Score:3.26|P-value:9.29E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.38|P-value:6.17E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.92|P-value:8.71E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.73|P-value:3.30E-11 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.32|P-value:6.03E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:3.59|P-value:2.98E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.78|P-value:1.52E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-3.25|P-value:7.65E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:6.35|P-value:5.59E-10 ID:SGTC_761|Compound:k216-0224|FD-Score:4.18|P-value:3.14E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:4.09|P-value:4.55E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:3.46|P-value:4.76E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.89|P-value:9.99E-5 ID:SGTC_984|Compound:1492-0255|FD-Score:-3.17|P-value:9.84E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.85|P-value:1.13E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:4.04|P-value:5.49E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.96|P-value:5.93E-5 ID:SGTC_1124|Compound:fisetin|FD-Score:-4.79|P-value:1.65E-6 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.67|P-value:2.25E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.40|P-value:5.80E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:5.74|P-value:1.87E-8 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.60|P-value:2.87E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.19|P-value:9.27E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:3.48|P-value:4.45E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.32|P-value:7.62E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.45|P-value:4.87E-4 ID:SGTC_1901|Compound:st060216|FD-Score:4.81|P-value:2.02E-6 ID:SGTC_1907|Compound:st060210|FD-Score:3.94|P-value:8.21E-5 ID:SGTC_2083|Compound:5306046|FD-Score:3.80|P-value:1.39E-4 ID:SGTC_2165|Compound:5727197|FD-Score:4.00|P-value:6.48E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.16|P-value:3.43E-5 ID:SGTC_2273|Compound:7815444|FD-Score:-3.37|P-value:5.12E-4 ID:SGTC_2283|Compound:7944793|FD-Score:6.07|P-value:2.86E-9 ID:SGTC_2325|Compound:6158266|FD-Score:3.36|P-value:6.66E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.80|P-value:1.39E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.65|P-value:2.42E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.67|P-value:2.21E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.98|P-value:6.99E-5 ID:SGTC_2944|Compound:9067346|FD-Score:3.67|P-value:2.24E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.38|P-value:6.18E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.82|P-value:1.27E-4 ID:SGTC_3290|Compound:9121031|FD-Score:3.89|P-value:9.73E-5 ID:SGTC_3309|Compound:9129340|FD-Score:3.29|P-value:8.24E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.43|P-value:1.11E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:4.41|P-value:1.18E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:3.91|P-value:9.14E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:-3.19|P-value:9.36E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:3.50|P-value:4.15E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.56|P-value:6.37E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:6.07|P-value:2.84E-9 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.92|P-value:8.82E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:5.76|P-value:1.61E-8 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.32|P-value:7.53E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.69|P-value:2.12E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.73|P-value:1.78E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:6.69|P-value:6.73E-11 ID:SGTC_342|Compound:k048-0088|FD-Score:3.26|P-value:9.29E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.38|P-value:6.17E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.92|P-value:8.71E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.73|P-value:3.30E-11 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.32|P-value:6.03E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:3.59|P-value:2.98E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.78|P-value:1.52E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-3.25|P-value:7.65E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:6.35|P-value:5.59E-10 ID:SGTC_761|Compound:k216-0224|FD-Score:4.18|P-value:3.14E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:4.09|P-value:4.55E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:3.46|P-value:4.76E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.89|P-value:9.99E-5 ID:SGTC_984|Compound:1492-0255|FD-Score:-3.17|P-value:9.84E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.85|P-value:1.13E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:4.04|P-value:5.49E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.96|P-value:5.93E-5 ID:SGTC_1124|Compound:fisetin|FD-Score:-4.79|P-value:1.65E-6 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.67|P-value:2.25E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.40|P-value:5.80E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:5.74|P-value:1.87E-8 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.60|P-value:2.87E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.19|P-value:9.27E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:3.48|P-value:4.45E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.32|P-value:7.62E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.45|P-value:4.87E-4 ID:SGTC_1901|Compound:st060216|FD-Score:4.81|P-value:2.02E-6 ID:SGTC_1907|Compound:st060210|FD-Score:3.94|P-value:8.21E-5 ID:SGTC_2083|Compound:5306046|FD-Score:3.80|P-value:1.39E-4 ID:SGTC_2165|Compound:5727197|FD-Score:4.00|P-value:6.48E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.16|P-value:3.43E-5 ID:SGTC_2273|Compound:7815444|FD-Score:-3.37|P-value:5.12E-4 ID:SGTC_2283|Compound:7944793|FD-Score:6.07|P-value:2.86E-9 ID:SGTC_2325|Compound:6158266|FD-Score:3.36|P-value:6.66E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.80|P-value:1.39E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.65|P-value:2.42E-4 ID:SGTC_2701|Compound:st077767|FD-Score:3.67|P-value:2.21E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.98|P-value:6.99E-5 ID:SGTC_2944|Compound:9067346|FD-Score:3.67|P-value:2.24E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.38|P-value:6.18E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.82|P-value:1.27E-4 ID:SGTC_3290|Compound:9121031|FD-Score:3.89|P-value:9.73E-5 ID:SGTC_3309|Compound:9129340|FD-Score:3.29|P-value:8.24E-4

Top fitness defect scores for YPL173W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 6.69 1.1 µM 6.73E-11 mitochondrial stress 126 1.13E-11
2 SGTC_688 0527-0193 6.35 473.0 µM 5.59E-10 fatty acid desaturase (OLE1) 2 1.11E-10
3 SGTC_119 0121-0043 6.07 24.8 µM 2.84E-9 mitochondrial stress 27 6.38E-10
4 SGTC_2283 7944793 6.07 200.0 µM 2.86E-9 6 6.44E-10
5 SGTC_236 1509-0011 5.76 5.3 µM 1.61E-8 299 4.14E-9
6 SGTC_1318 1280-3875 5.74 124.0 µM 1.87E-8 4 4.87E-9
7 SGTC_1901 st060216 4.81 58.6 µM 2.02E-6 14 7.55E-7
8 SGTC_118 0083-0097 4.56 135.3 µM 6.37E-6 translation 83 2.61E-6
9 SGTC_10 0279-0212 4.43 42.6 µM 1.11E-5 TRP & mitochondrial translation 101 4.76E-6
10 SGTC_19 0279-0214 4.41 38.4 µM 1.18E-5 TRP & mitochondrial translation 32 5.07E-6
11 SGTC_761 k216-0224 4.18 480.0 µM 3.14E-5 14 1.45E-5
12 SGTC_2250 alverine citrate 4.16 130.0 µM 3.43E-5 141 1.60E-5
13 SGTC_767 0929-0023 4.09 86.0 µM 4.55E-5 TRP & mitochondrial translation 71 2.17E-5
14 SGTC_1018 4259-0013 4.04 28.1 µM 5.49E-5 13 2.66E-5
15 SGTC_2165 5727197 4.00 32.1 µM 6.48E-5 30 3.18E-5
16 SGTC_2703 st077852 3.98 53.4 µM 6.99E-5 22 3.45E-5
17 SGTC_1907 st060210 3.94 83.7 µM 8.21E-5 22 4.10E-5
18 SGTC_449 xestospongin c 3.92 11.2 µM 8.71E-5 NEO1-PIK1 70 4.38E-5
19 SGTC_120 rhodamine 6G 3.92 52.3 µM 8.82E-5 mitochondrial processes 32 4.43E-5
20 SGTC_70 0141-0289 3.91 43.3 µM 9.14E-5 mitochondrial stress 178 4.61E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.266 1.68E-55 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase
0.259 3.98E-52 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.258 3.22E-52 YDR509W_d YDR509W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.257 9.79E-52 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.255 8.64E-51 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.252 9.86E-50 YGR219W_d YGR219W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C
0.249 1.79E-48 YDR533C HSP31 hom Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress
0.248 2.65E-48 YIL014C-A_p YIL014C-A_p hom Putative protein of unknown function
0.247 8.73E-48 YOL095C HMI1 hom Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
0.246 2.70E-47 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.246 2.10E-47 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.246 2.24E-47 YGR171C MSM1 hom Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p
0.245 3.29E-47 YNL005C MRP7 hom Mitochondrial ribosomal protein of the large subunit
0.244 1.40E-46 YDR337W MRPS28 hom Mitochondrial ribosomal protein of the small subunit
0.241 1.62E-45 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress