YPL174C / NIP100

Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL174C / NIP100

Click on Significant Values for Screen Details ID:SGTC_13|Compound:0199-0087|FD-Score:3.42|P-value:7.34E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:3.39|P-value:7.99E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:-4.83|P-value:3.64E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:4.32|P-value:2.96E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.57|P-value:4.51E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.98|P-value:1.05E-4 ID:SGTC_276|Compound:colchicine|FD-Score:4.03|P-value:8.83E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:3.43|P-value:7.16E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.41|P-value:2.01E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.55|P-value:4.71E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:-4.20|P-value:4.64E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:3.65|P-value:3.43E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:-3.75|P-value:2.46E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:4.29|P-value:3.27E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:8.84|P-value:1.02E-16 ID:SGTC_909|Compound:3448-9333|FD-Score:5.74|P-value:4.74E-8 ID:SGTC_926|Compound:2268-1401|FD-Score:3.52|P-value:5.23E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.84|P-value:1.74E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.58|P-value:4.38E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:5.57|P-value:1.11E-7 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.52|P-value:5.21E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.34|P-value:9.38E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.97|P-value:1.13E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-5.90|P-value:2.09E-8 ID:SGTC_1111|Compound:tnp00062|FD-Score:-4.31|P-value:3.06E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.63|P-value:8.37E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:3.67|P-value:3.15E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.72|P-value:2.68E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:4.02|P-value:9.22E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.42|P-value:1.96E-5 ID:SGTC_1368|Compound:1852-0141|FD-Score:6.65|P-value:3.16E-10 ID:SGTC_1400|Compound:3771-8998|FD-Score:4.60|P-value:9.51E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.99|P-value:1.75E-6 ID:SGTC_1602|Compound:st001878|FD-Score:4.37|P-value:2.41E-5 ID:SGTC_1616|Compound:st002734|FD-Score:4.90|P-value:2.53E-6 ID:SGTC_1617|Compound:st002906|FD-Score:3.34|P-value:9.58E-4 ID:SGTC_1640|Compound:st009078|FD-Score:-3.46|P-value:6.60E-4 ID:SGTC_1647|Compound:st011722|FD-Score:-3.40|P-value:7.96E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.53|P-value:5.23E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.77|P-value:2.30E-4 ID:SGTC_1804|Compound:st050076|FD-Score:4.22|P-value:4.34E-5 ID:SGTC_1886|Compound:st057356|FD-Score:4.14|P-value:5.85E-5 ID:SGTC_1892|Compound:st058411|FD-Score:4.94|P-value:2.13E-6 ID:SGTC_1909|Compound:st060837|FD-Score:4.11|P-value:6.49E-5 ID:SGTC_2059|Compound:5238311|FD-Score:4.33|P-value:2.80E-5 ID:SGTC_2078|Compound:5212016|FD-Score:3.80|P-value:2.02E-4 ID:SGTC_2083|Compound:5306046|FD-Score:3.86|P-value:1.66E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.36|P-value:8.76E-4 ID:SGTC_2142|Compound:5622915|FD-Score:-3.53|P-value:5.10E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.41|P-value:7.57E-4 ID:SGTC_2164|Compound:5685496|FD-Score:8.26|P-value:7.56E-15 ID:SGTC_2186|Compound:6124449|FD-Score:3.89|P-value:1.50E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-3.35|P-value:9.38E-4 ID:SGTC_2396|Compound:5342950|FD-Score:13.20|P-value:9.98E-35 ID:SGTC_2400|Compound:5203494|FD-Score:8.85|P-value:9.56E-17 ID:SGTC_2401|Compound:5128683|FD-Score:12.10|P-value:1.29E-29 ID:SGTC_2464|Compound:5717415|FD-Score:-3.66|P-value:3.32E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:5.16|P-value:7.88E-7 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.71|P-value:2.81E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-4.86|P-value:3.17E-6 ID:SGTC_2600|Compound:tangeritin|FD-Score:5.36|P-value:3.12E-7 ID:SGTC_2601|Compound:securinine|FD-Score:5.96|P-value:1.51E-8 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.24|P-value:3.96E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-4.52|P-value:1.35E-5 ID:SGTC_2719|Compound:novobiocin|FD-Score:-4.17|P-value:5.22E-5 ID:SGTC_2837|Compound:9008476|FD-Score:-3.56|P-value:4.67E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.50|P-value:5.67E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.60|P-value:4.11E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.35|P-value:9.02E-4 ID:SGTC_3128|Compound:9127691|FD-Score:6.69|P-value:2.43E-10 ID:SGTC_3141|Compound:9094609|FD-Score:3.47|P-value:6.32E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.72|P-value:2.73E-4 ID:SGTC_13|Compound:0199-0087|FD-Score:3.42|P-value:7.34E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:3.39|P-value:7.99E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:-4.83|P-value:3.64E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:4.32|P-value:2.96E-5 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.57|P-value:4.51E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.98|P-value:1.05E-4 ID:SGTC_276|Compound:colchicine|FD-Score:4.03|P-value:8.83E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:3.43|P-value:7.16E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.41|P-value:2.01E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.55|P-value:4.71E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:-4.20|P-value:4.64E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:3.65|P-value:3.43E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:-3.75|P-value:2.46E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:4.29|P-value:3.27E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:8.84|P-value:1.02E-16 ID:SGTC_909|Compound:3448-9333|FD-Score:5.74|P-value:4.74E-8 ID:SGTC_926|Compound:2268-1401|FD-Score:3.52|P-value:5.23E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.84|P-value:1.74E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.58|P-value:4.38E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:5.57|P-value:1.11E-7 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.52|P-value:5.21E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.34|P-value:9.38E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.97|P-value:1.13E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-5.90|P-value:2.09E-8 ID:SGTC_1111|Compound:tnp00062|FD-Score:-4.31|P-value:3.06E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.63|P-value:8.37E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:3.67|P-value:3.15E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.72|P-value:2.68E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:4.02|P-value:9.22E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.42|P-value:1.96E-5 ID:SGTC_1368|Compound:1852-0141|FD-Score:6.65|P-value:3.16E-10 ID:SGTC_1400|Compound:3771-8998|FD-Score:4.60|P-value:9.51E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.99|P-value:1.75E-6 ID:SGTC_1602|Compound:st001878|FD-Score:4.37|P-value:2.41E-5 ID:SGTC_1616|Compound:st002734|FD-Score:4.90|P-value:2.53E-6 ID:SGTC_1617|Compound:st002906|FD-Score:3.34|P-value:9.58E-4 ID:SGTC_1640|Compound:st009078|FD-Score:-3.46|P-value:6.60E-4 ID:SGTC_1647|Compound:st011722|FD-Score:-3.40|P-value:7.96E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-3.53|P-value:5.23E-4 ID:SGTC_1746|Compound:st038117|FD-Score:3.77|P-value:2.30E-4 ID:SGTC_1804|Compound:st050076|FD-Score:4.22|P-value:4.34E-5 ID:SGTC_1886|Compound:st057356|FD-Score:4.14|P-value:5.85E-5 ID:SGTC_1892|Compound:st058411|FD-Score:4.94|P-value:2.13E-6 ID:SGTC_1909|Compound:st060837|FD-Score:4.11|P-value:6.49E-5 ID:SGTC_2059|Compound:5238311|FD-Score:4.33|P-value:2.80E-5 ID:SGTC_2078|Compound:5212016|FD-Score:3.80|P-value:2.02E-4 ID:SGTC_2083|Compound:5306046|FD-Score:3.86|P-value:1.66E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.36|P-value:8.76E-4 ID:SGTC_2142|Compound:5622915|FD-Score:-3.53|P-value:5.10E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.41|P-value:7.57E-4 ID:SGTC_2164|Compound:5685496|FD-Score:8.26|P-value:7.56E-15 ID:SGTC_2186|Compound:6124449|FD-Score:3.89|P-value:1.50E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-3.35|P-value:9.38E-4 ID:SGTC_2396|Compound:5342950|FD-Score:13.20|P-value:9.98E-35 ID:SGTC_2400|Compound:5203494|FD-Score:8.85|P-value:9.56E-17 ID:SGTC_2401|Compound:5128683|FD-Score:12.10|P-value:1.29E-29 ID:SGTC_2464|Compound:5717415|FD-Score:-3.66|P-value:3.32E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:5.16|P-value:7.88E-7 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.71|P-value:2.81E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-4.86|P-value:3.17E-6 ID:SGTC_2600|Compound:tangeritin|FD-Score:5.36|P-value:3.12E-7 ID:SGTC_2601|Compound:securinine|FD-Score:5.96|P-value:1.51E-8 ID:SGTC_2689|Compound:tacrolimus|FD-Score:4.24|P-value:3.96E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-4.52|P-value:1.35E-5 ID:SGTC_2719|Compound:novobiocin|FD-Score:-4.17|P-value:5.22E-5 ID:SGTC_2837|Compound:9008476|FD-Score:-3.56|P-value:4.67E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.50|P-value:5.67E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.60|P-value:4.11E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.35|P-value:9.02E-4 ID:SGTC_3128|Compound:9127691|FD-Score:6.69|P-value:2.43E-10 ID:SGTC_3141|Compound:9094609|FD-Score:3.47|P-value:6.32E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.72|P-value:2.73E-4

Top fitness defect scores for YPL174C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2396 5342950 13.20 42.8 µM 9.98E-35 RSC complex & mRNA processing 1 7.81E-40
2 SGTC_2401 5128683 12.10 200.0 µM 1.29E-29 2 6.27E-34
3 SGTC_2400 5203494 8.85 178.7 µM 9.56E-17 RSC complex & mRNA processing 2 4.54E-19
4 SGTC_908 3448-7491 8.84 47.7 µM 1.02E-16 mitochondrial stress 14 4.88E-19
5 SGTC_2164 5685496 8.26 200.0 µM 7.56E-15 1 7.03E-17
6 SGTC_3128 9127691 6.69 49.5 µM 2.43E-10 2 1.11E-11
7 SGTC_1368 1852-0141 6.65 284.0 µM 3.16E-10 ERG2 4 1.50E-11
8 SGTC_2601 securinine 5.96 100.0 µM 1.51E-8 5 1.29E-9
9 SGTC_909 3448-9333 5.74 149.0 µM 4.74E-8 3 4.82E-9
10 SGTC_1021 4476-0760 5.57 85.3 µM 1.11E-7 6 1.29E-8
11 SGTC_2600 tangeritin 5.36 88.0 µM 3.12E-7 11 4.22E-8
12 SGTC_2499 avocadenofuran 5.16 51.5 µM 7.88E-7 12 1.22E-7
13 SGTC_1573 oleylamine 4.99 1.1 µM 1.75E-6 12 3.07E-7
14 SGTC_1892 st058411 4.94 7.4 µM 2.13E-6 9 3.85E-7
15 SGTC_1616 st002734 4.90 56.1 µM 2.53E-6 10 4.68E-7
16 SGTC_1129 3453-1384 4.63 223.0 µM 8.37E-6 23 1.85E-6
17 SGTC_1400 3771-8998 4.60 51.5 µM 9.51E-6 2 2.15E-6
18 SGTC_1365 1672-3266 4.42 55.4 µM 1.96E-5 9 4.92E-6
19 SGTC_379 3970-0972 4.41 5.9 µM 2.01E-5 tubulin folding & SWR complex 27 5.07E-6
20 SGTC_1602 st001878 4.37 87.6 µM 2.41E-5 14 6.23E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.15E-15 YOR156C NFI1 hom SUMO E3 ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; primary E3 ligase for Sir4p; sumoylates Yku70p/Yku80p and Sir4p in vivo to promote chromatin anchoring; promotes telomere anchoring to the nuclear envelope; involved in maintenance of proper telomere length
0.134 7.51E-15 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.119 5.61E-12 YLR232W_d YLR232W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5
0.099 9.54E-9 YKL159C RCN1 hom Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region
0.097 1.62E-8 YGR020C VMA7 hom Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
0.095 4.15E-8 YCR085W_d YCR085W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.095 4.16E-8 YIL138C TPM2 hom Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication
0.091 1.15E-7 YKL101W HSL1 hom Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
0.090 1.78E-7 YMR039C SUB1 hom Transcriptional coactivator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; protein abundance increases in response to DNA replication stress
0.090 1.84E-7 YHR031C RRM3 hom DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p
0.088 3.41E-7 YPL038W MET31 hom Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET31 has a paralog, MET32, that arose from the whole genome duplication
0.086 5.77E-7 YLR370C ARC18 hom Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
0.085 8.97E-7 YLR338W_d OPI9_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C
0.084 1.15E-6 YER022W SRB4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination
0.083 1.62E-6 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation