YPL176C / TRE1

Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL176C / TRE1

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:4.39|P-value:8.38E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:4.06|P-value:2.49E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:5.16|P-value:5.08E-6 ID:SGTC_175|Compound:3793-3120|FD-Score:4.87|P-value:1.57E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:4.06|P-value:2.49E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:4.03|P-value:2.75E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.77|P-value:5.93E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:4.05|P-value:2.56E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.58|P-value:4.46E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:3.97|P-value:3.27E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:4.26|P-value:1.29E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.90|P-value:4.13E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:-5.12|P-value:1.03E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:3.97|P-value:3.28E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.78|P-value:5.76E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.95|P-value:3.53E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:6.59|P-value:9.93E-9 ID:SGTC_1153|Compound:4055-0057|FD-Score:7.34|P-value:2.13E-10 ID:SGTC_1163|Compound:k060-0048|FD-Score:-4.51|P-value:9.06E-5 ID:SGTC_1235|Compound:benzylparaben|FD-Score:-3.79|P-value:8.66E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:4.16|P-value:1.79E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:4.54|P-value:5.03E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.19|P-value:1.66E-4 ID:SGTC_1602|Compound:st001878|FD-Score:5.49|P-value:1.38E-6 ID:SGTC_1616|Compound:st002734|FD-Score:4.07|P-value:2.38E-4 ID:SGTC_1712|Compound:st032288|FD-Score:6.73|P-value:4.79E-9 ID:SGTC_1720|Compound:st037298|FD-Score:-4.05|P-value:3.92E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-7.11|P-value:1.47E-9 ID:SGTC_1754|Compound:st042065|FD-Score:5.02|P-value:8.71E-6 ID:SGTC_1798|Compound:st045719|FD-Score:-3.88|P-value:6.54E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.80|P-value:1.98E-5 ID:SGTC_1818|Compound:st052136|FD-Score:3.84|P-value:4.82E-4 ID:SGTC_1821|Compound:st053465|FD-Score:-4.49|P-value:9.76E-5 ID:SGTC_1871|Compound:st057448|FD-Score:4.46|P-value:6.68E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:4.74|P-value:2.51E-5 ID:SGTC_2021|Compound:4019055|FD-Score:8.95|P-value:1.46E-14 ID:SGTC_2038|Compound:4100038|FD-Score:4.24|P-value:1.38E-4 ID:SGTC_2083|Compound:5306046|FD-Score:3.73|P-value:6.72E-4 ID:SGTC_2096|Compound:5468907|FD-Score:5.19|P-value:4.67E-6 ID:SGTC_2163|Compound:5671233|FD-Score:3.65|P-value:8.62E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:13.00|P-value:1.45E-28 ID:SGTC_2300|Compound:7976697|FD-Score:4.83|P-value:1.82E-5 ID:SGTC_2325|Compound:6158266|FD-Score:-4.15|P-value:2.91E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-4.64|P-value:5.89E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.91|P-value:1.35E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.19|P-value:1.64E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.75|P-value:4.02E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.97|P-value:5.09E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:7.95|P-value:6.81E-12 ID:SGTC_2591|Compound:skatole|FD-Score:-4.83|P-value:2.98E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.89|P-value:4.22E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.30|P-value:1.16E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.74|P-value:9.95E-4 ID:SGTC_2800|Compound:7887935|FD-Score:-5.92|P-value:4.08E-7 ID:SGTC_2823|Compound:7987624|FD-Score:-3.75|P-value:9.56E-4 ID:SGTC_2845|Compound:9003024|FD-Score:-4.11|P-value:3.32E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.20|P-value:1.61E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.74|P-value:6.56E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-5.43|P-value:3.11E-6 ID:SGTC_3152|Compound:9099253|FD-Score:4.68|P-value:3.08E-5 ID:SGTC_3170|Compound:9103054|FD-Score:3.68|P-value:7.85E-4 ID:SGTC_3175|Compound:9106517|FD-Score:-4.17|P-value:2.76E-4 ID:SGTC_3194|Compound:9111903|FD-Score:4.41|P-value:7.94E-5 ID:SGTC_3281|Compound:9140613|FD-Score:3.61|P-value:9.54E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:4.39|P-value:8.38E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:4.06|P-value:2.49E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:5.16|P-value:5.08E-6 ID:SGTC_175|Compound:3793-3120|FD-Score:4.87|P-value:1.57E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:4.06|P-value:2.49E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:4.03|P-value:2.75E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.77|P-value:5.93E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:4.05|P-value:2.56E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.58|P-value:4.46E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:3.97|P-value:3.27E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:4.26|P-value:1.29E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.90|P-value:4.13E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:-5.12|P-value:1.03E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:3.97|P-value:3.28E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.78|P-value:5.76E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.95|P-value:3.53E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:6.59|P-value:9.93E-9 ID:SGTC_1153|Compound:4055-0057|FD-Score:7.34|P-value:2.13E-10 ID:SGTC_1163|Compound:k060-0048|FD-Score:-4.51|P-value:9.06E-5 ID:SGTC_1235|Compound:benzylparaben|FD-Score:-3.79|P-value:8.66E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:4.16|P-value:1.79E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:4.54|P-value:5.03E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.19|P-value:1.66E-4 ID:SGTC_1602|Compound:st001878|FD-Score:5.49|P-value:1.38E-6 ID:SGTC_1616|Compound:st002734|FD-Score:4.07|P-value:2.38E-4 ID:SGTC_1712|Compound:st032288|FD-Score:6.73|P-value:4.79E-9 ID:SGTC_1720|Compound:st037298|FD-Score:-4.05|P-value:3.92E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-7.11|P-value:1.47E-9 ID:SGTC_1754|Compound:st042065|FD-Score:5.02|P-value:8.71E-6 ID:SGTC_1798|Compound:st045719|FD-Score:-3.88|P-value:6.54E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.80|P-value:1.98E-5 ID:SGTC_1818|Compound:st052136|FD-Score:3.84|P-value:4.82E-4 ID:SGTC_1821|Compound:st053465|FD-Score:-4.49|P-value:9.76E-5 ID:SGTC_1871|Compound:st057448|FD-Score:4.46|P-value:6.68E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:4.74|P-value:2.51E-5 ID:SGTC_2021|Compound:4019055|FD-Score:8.95|P-value:1.46E-14 ID:SGTC_2038|Compound:4100038|FD-Score:4.24|P-value:1.38E-4 ID:SGTC_2083|Compound:5306046|FD-Score:3.73|P-value:6.72E-4 ID:SGTC_2096|Compound:5468907|FD-Score:5.19|P-value:4.67E-6 ID:SGTC_2163|Compound:5671233|FD-Score:3.65|P-value:8.62E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:13.00|P-value:1.45E-28 ID:SGTC_2300|Compound:7976697|FD-Score:4.83|P-value:1.82E-5 ID:SGTC_2325|Compound:6158266|FD-Score:-4.15|P-value:2.91E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:-4.64|P-value:5.89E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.91|P-value:1.35E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.19|P-value:1.64E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.75|P-value:4.02E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.97|P-value:5.09E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:7.95|P-value:6.81E-12 ID:SGTC_2591|Compound:skatole|FD-Score:-4.83|P-value:2.98E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.89|P-value:4.22E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.30|P-value:1.16E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.74|P-value:9.95E-4 ID:SGTC_2800|Compound:7887935|FD-Score:-5.92|P-value:4.08E-7 ID:SGTC_2823|Compound:7987624|FD-Score:-3.75|P-value:9.56E-4 ID:SGTC_2845|Compound:9003024|FD-Score:-4.11|P-value:3.32E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.20|P-value:1.61E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.74|P-value:6.56E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-5.43|P-value:3.11E-6 ID:SGTC_3152|Compound:9099253|FD-Score:4.68|P-value:3.08E-5 ID:SGTC_3170|Compound:9103054|FD-Score:3.68|P-value:7.85E-4 ID:SGTC_3175|Compound:9106517|FD-Score:-4.17|P-value:2.76E-4 ID:SGTC_3194|Compound:9111903|FD-Score:4.41|P-value:7.94E-5 ID:SGTC_3281|Compound:9140613|FD-Score:3.61|P-value:9.54E-4

Top fitness defect scores for YPL176C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2249 haloperidol 13.00 116.4 µM 1.45E-28 ergosterol depletion effects on membrane 4 5.68E-39
2 SGTC_2021 4019055 8.95 173.0 µM 1.46E-14 endomembrane recycling 16 1.85E-19
3 SGTC_2583 asiatic acid 7.95 100.0 µM 6.81E-12 2 9.38E-16
4 SGTC_1153 4055-0057 7.34 267.0 µM 2.13E-10 1 1.11E-13
5 SGTC_1712 st032288 6.73 53.4 µM 4.79E-9 calcium & mitochondrial duress 59 8.20E-12
6 SGTC_1127 asiatic acid 6.59 681.4 nM 9.93E-9 3 2.25E-11
7 SGTC_1602 st001878 5.49 87.6 µM 1.38E-6 6 2.02E-8
8 SGTC_2096 5468907 5.19 200.0 µM 4.67E-6 1 1.08E-7
9 SGTC_114 0364-0001 5.16 490.3 µM 5.08E-6 13 1.21E-7
10 SGTC_1754 st042065 5.02 16.1 µM 8.71E-6 NEO1-PIK1 125 2.53E-7
11 SGTC_2566 crystal violet carbinol 4.91 226.0 nM 1.35E-5 21 4.62E-7
12 SGTC_175 3793-3120 4.87 23.7 µM 1.57E-5 4 5.65E-7
13 SGTC_2300 7976697 4.83 71.6 µM 1.82E-5 ERG2 15 6.95E-7
14 SGTC_1800 st050079 4.80 29.1 µM 1.98E-5 NEO1-PIK1 82 7.77E-7
15 SGTC_1876 myriocin 4.74 605.0 nM 2.51E-5 19 1.08E-6
16 SGTC_3152 9099253 4.68 49.5 µM 3.08E-5 NEO1-PIK1 90 1.43E-6
17 SGTC_580 1123-0028 4.58 41.0 µM 4.46E-5 DNA damage response 17 2.36E-6
18 SGTC_1513 0337-0559 4.54 19.0 µM 5.03E-5 10 2.78E-6
19 SGTC_1871 st057448 4.46 67.3 µM 6.68E-5 14 4.10E-6
20 SGTC_3194 9111903 4.41 49.5 µM 7.94E-5 13 5.20E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.210 9.63E-35 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.207 5.75E-34 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.202 3.80E-32 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.197 1.51E-30 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.191 7.64E-29 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.186 1.64E-27 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.186 1.99E-27 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.171 2.56E-23 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.167 1.65E-22 YEL022W GEA2 hom Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication
0.165 8.79E-22 YNL070W TOM7 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.163 2.12E-21 YOR030W DFG16 hom Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p
0.163 2.47E-21 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.161 7.39E-21 YOL081W IRA2 hom GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; similar to human neurofibromin; IRA2 has a paralog, IRA1, that arose from the whole genome duplication
0.160 1.15E-20 YMR099C YMR099C hom Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
0.157 6.04E-20 YDL167C NRP1 hom Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis