YPL177C / CUP9

Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL177C / CUP9

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-5.09|P-value:2.80E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:3.74|P-value:1.22E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:4.83|P-value:1.06E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:4.62|P-value:2.89E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:4.14|P-value:2.48E-5 ID:SGTC_578|Compound:3460-0051|FD-Score:4.17|P-value:2.13E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:3.65|P-value:1.70E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.38|P-value:4.57E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:4.24|P-value:1.61E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:5.07|P-value:3.36E-7 ID:SGTC_860|Compound:0443-0016|FD-Score:3.55|P-value:2.53E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:4.40|P-value:8.05E-6 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.32|P-value:5.58E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.35|P-value:5.17E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.11|P-value:2.72E-5 ID:SGTC_1408|Compound:3909-7976|FD-Score:6.72|P-value:2.16E-11 ID:SGTC_1426|Compound:4048-4480|FD-Score:5.08|P-value:3.21E-7 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.17|P-value:9.31E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.85|P-value:7.97E-5 ID:SGTC_1663|Compound:st014140|FD-Score:3.49|P-value:3.08E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.41|P-value:4.12E-4 ID:SGTC_1705|Compound:st027868|FD-Score:3.45|P-value:3.64E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.93|P-value:5.71E-5 ID:SGTC_1756|Compound:st041558|FD-Score:4.20|P-value:1.90E-5 ID:SGTC_1812|Compound:st052057|FD-Score:-4.21|P-value:1.73E-5 ID:SGTC_1815|Compound:st051655|FD-Score:3.38|P-value:4.60E-4 ID:SGTC_1820|Compound:st053765|FD-Score:-3.53|P-value:2.63E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.83|P-value:8.47E-5 ID:SGTC_1953|Compound:st076800|FD-Score:-3.65|P-value:1.66E-4 ID:SGTC_1954|Compound:st077032|FD-Score:3.88|P-value:7.13E-5 ID:SGTC_2113|Compound:5491891|FD-Score:3.94|P-value:5.63E-5 ID:SGTC_2177|Compound:5811945|FD-Score:3.45|P-value:3.54E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.44|P-value:3.75E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.50|P-value:3.05E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.77|P-value:1.09E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.74|P-value:1.21E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.49|P-value:3.10E-4 ID:SGTC_2744|Compound:captopril|FD-Score:3.73|P-value:1.28E-4 ID:SGTC_2780|Compound:5215298|FD-Score:4.81|P-value:1.18E-6 ID:SGTC_2783|Compound:7738165|FD-Score:8.49|P-value:4.07E-17 ID:SGTC_2786|Compound:7743617|FD-Score:3.59|P-value:2.13E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.60|P-value:2.08E-4 ID:SGTC_3065|Compound:9113888|FD-Score:-3.57|P-value:2.30E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.53|P-value:2.72E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-3.28|P-value:6.27E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.25|P-value:7.04E-4 ID:SGTC_3254|Compound:9136651|FD-Score:3.61|P-value:1.98E-4 ID:SGTC_3288|Compound:9119690|FD-Score:3.38|P-value:4.62E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.72|P-value:1.33E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-5.09|P-value:2.80E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:3.74|P-value:1.22E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:4.83|P-value:1.06E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:4.62|P-value:2.89E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:4.14|P-value:2.48E-5 ID:SGTC_578|Compound:3460-0051|FD-Score:4.17|P-value:2.13E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:3.65|P-value:1.70E-4 ID:SGTC_657|Compound:3534-0529|FD-Score:3.38|P-value:4.57E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:4.24|P-value:1.61E-5 ID:SGTC_794|Compound:k038-0031|FD-Score:5.07|P-value:3.36E-7 ID:SGTC_860|Compound:0443-0016|FD-Score:3.55|P-value:2.53E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:4.40|P-value:8.05E-6 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.32|P-value:5.58E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.35|P-value:5.17E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.11|P-value:2.72E-5 ID:SGTC_1408|Compound:3909-7976|FD-Score:6.72|P-value:2.16E-11 ID:SGTC_1426|Compound:4048-4480|FD-Score:5.08|P-value:3.21E-7 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.17|P-value:9.31E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.85|P-value:7.97E-5 ID:SGTC_1663|Compound:st014140|FD-Score:3.49|P-value:3.08E-4 ID:SGTC_1671|Compound:st016596|FD-Score:3.41|P-value:4.12E-4 ID:SGTC_1705|Compound:st027868|FD-Score:3.45|P-value:3.64E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.93|P-value:5.71E-5 ID:SGTC_1756|Compound:st041558|FD-Score:4.20|P-value:1.90E-5 ID:SGTC_1812|Compound:st052057|FD-Score:-4.21|P-value:1.73E-5 ID:SGTC_1815|Compound:st051655|FD-Score:3.38|P-value:4.60E-4 ID:SGTC_1820|Compound:st053765|FD-Score:-3.53|P-value:2.63E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.83|P-value:8.47E-5 ID:SGTC_1953|Compound:st076800|FD-Score:-3.65|P-value:1.66E-4 ID:SGTC_1954|Compound:st077032|FD-Score:3.88|P-value:7.13E-5 ID:SGTC_2113|Compound:5491891|FD-Score:3.94|P-value:5.63E-5 ID:SGTC_2177|Compound:5811945|FD-Score:3.45|P-value:3.54E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.44|P-value:3.75E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.50|P-value:3.05E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.77|P-value:1.09E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.74|P-value:1.21E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.49|P-value:3.10E-4 ID:SGTC_2744|Compound:captopril|FD-Score:3.73|P-value:1.28E-4 ID:SGTC_2780|Compound:5215298|FD-Score:4.81|P-value:1.18E-6 ID:SGTC_2783|Compound:7738165|FD-Score:8.49|P-value:4.07E-17 ID:SGTC_2786|Compound:7743617|FD-Score:3.59|P-value:2.13E-4 ID:SGTC_2867|Compound:9039098|FD-Score:3.60|P-value:2.08E-4 ID:SGTC_3065|Compound:9113888|FD-Score:-3.57|P-value:2.30E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.53|P-value:2.72E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-3.28|P-value:6.27E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.25|P-value:7.04E-4 ID:SGTC_3254|Compound:9136651|FD-Score:3.61|P-value:1.98E-4 ID:SGTC_3288|Compound:9119690|FD-Score:3.38|P-value:4.62E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.72|P-value:1.33E-4

Top fitness defect scores for YPL177C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2783 7738165 8.49 71.4 µM 4.07E-17 2 1.04E-17
2 SGTC_1408 3909-7976 6.72 48.8 µM 2.16E-11 Golgi 6 9.10E-12
3 SGTC_1426 4048-4480 5.08 71.7 µM 3.21E-7 60S ribosome export 5 1.93E-7
4 SGTC_794 k038-0031 5.07 316.0 µM 3.36E-7 ubiquinone biosynthesis & proteasome 80 2.03E-7
5 SGTC_142 0335-0849 4.83 62.7 µM 1.06E-6 ubiquinone biosynthesis & proteasome 89 6.67E-7
6 SGTC_2780 5215298 4.81 71.4 µM 1.18E-6 18 7.46E-7
7 SGTC_158 k038-0087 4.62 26.4 µM 2.89E-6 ubiquinone biosynthesis & proteasome 104 1.89E-6
8 SGTC_886 0866-0150 4.40 153.0 µM 8.05E-6 16 5.47E-6
9 SGTC_697 0508-1955 4.24 564.0 µM 1.61E-5 26 1.13E-5
10 SGTC_1756 st041558 4.20 35.5 µM 1.90E-5 7 1.33E-5
11 SGTC_578 3460-0051 4.17 92.0 µM 2.13E-5 8 1.50E-5
12 SGTC_383 2324-0395 4.14 7.4 µM 2.48E-5 azole & statin 30 1.76E-5
13 SGTC_1353 1498-1206 4.11 8.1 µM 2.72E-5 mitochondrial response to ROS 46 1.94E-5
14 SGTC_2113 5491891 3.94 107.0 µM 5.63E-5 TSC3-RPN4 21 4.11E-5
15 SGTC_1740 st038286 3.93 13.2 µM 5.71E-5 28 4.18E-5
16 SGTC_1954 st077032 3.88 68.9 µM 7.13E-5 23 5.25E-5
17 SGTC_1534 6-azauridine 3.85 81.6 µM 7.97E-5 RNA pol III & RNase P/MRP 24 5.89E-5
18 SGTC_1948 st076329 3.83 66.6 µM 8.47E-5 34 6.28E-5
19 SGTC_2447 5741742 3.77 33.8 µM 1.09E-4 27 8.17E-5
20 SGTC_2479 5617353 3.74 43.9 µM 1.21E-4 45 9.10E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.187 9.20E-28 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.186 1.99E-27 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.156 8.26E-20 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.153 3.88E-19 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.152 8.04E-19 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.152 1.06E-18 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.146 1.88E-17 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.146 1.98E-17 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.143 7.10E-17 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.143 8.65E-17 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.143 9.97E-17 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.141 2.17E-16 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.141 2.20E-16 YOL008W COQ10 hom Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
0.139 6.54E-16 YBR275C RIF1 hom Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.139 6.99E-16 YJR129C_p YJR129C_p hom Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm