YPL178W / CBC2

Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL178W / CBC2

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:3.13|P-value:8.89E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:3.25|P-value:5.94E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.85|P-value:1.12E-11 ID:SGTC_88|Compound:0180-0332|FD-Score:3.50|P-value:2.50E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.14|P-value:8.71E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.55|P-value:2.10E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:3.36|P-value:4.16E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.34|P-value:4.45E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:3.19|P-value:7.32E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.97|P-value:4.32E-5 ID:SGTC_292|Compound:k038-0015|FD-Score:3.40|P-value:3.55E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.06|P-value:8.47E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.38|P-value:9.36E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:5.97|P-value:2.46E-9 ID:SGTC_572|Compound:0960-0087|FD-Score:-3.63|P-value:4.05E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.56|P-value:2.04E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.26|P-value:1.31E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.35|P-value:4.18E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.42|P-value:3.32E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.43|P-value:6.23E-6 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.96|P-value:4.49E-5 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.25|P-value:6.02E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.72|P-value:1.12E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:-4.67|P-value:6.99E-6 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.36|P-value:4.06E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-3.37|P-value:9.88E-4 ID:SGTC_1700|Compound:st030840|FD-Score:6.74|P-value:2.37E-11 ID:SGTC_1703|Compound:st026983|FD-Score:4.00|P-value:3.84E-5 ID:SGTC_1712|Compound:st032288|FD-Score:4.47|P-value:5.23E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.38|P-value:9.47E-4 ID:SGTC_1822|Compound:st052468|FD-Score:-3.62|P-value:4.22E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.30|P-value:5.12E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.14|P-value:8.49E-4 ID:SGTC_1910|Compound:st062352|FD-Score:4.40|P-value:7.11E-6 ID:SGTC_2078|Compound:5212016|FD-Score:3.34|P-value:4.40E-4 ID:SGTC_2261|Compound:9010538|FD-Score:3.60|P-value:1.72E-4 ID:SGTC_2311|Compound:7694451|FD-Score:8.93|P-value:1.97E-18 ID:SGTC_2412|Compound:st077135|FD-Score:3.42|P-value:3.30E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.58|P-value:1.91E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.79|P-value:8.68E-5 ID:SGTC_2656|Compound:pseudo-anisatin|FD-Score:3.44|P-value:3.08E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:4.03|P-value:3.32E-5 ID:SGTC_2683|Compound:piperine|FD-Score:-3.38|P-value:9.53E-4 ID:SGTC_2781|Compound:5567276|FD-Score:5.32|P-value:8.95E-8 ID:SGTC_2790|Compound:5423970|FD-Score:3.25|P-value:6.05E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.30|P-value:5.02E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.46|P-value:2.93E-4 ID:SGTC_2948|Compound:9070189|FD-Score:3.62|P-value:1.60E-4 ID:SGTC_2971|Compound:9092186|FD-Score:4.08|P-value:2.69E-5 ID:SGTC_2975|Compound:9084847|FD-Score:-3.49|P-value:6.57E-4 ID:SGTC_3039|Compound:9090270|FD-Score:4.17|P-value:1.88E-5 ID:SGTC_3142|Compound:9086498|FD-Score:3.45|P-value:3.00E-4 ID:SGTC_3178|Compound:9107506|FD-Score:3.23|P-value:6.48E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.25|P-value:5.87E-4 ID:SGTC_3319|Compound:9138450|FD-Score:-3.51|P-value:6.05E-4 ID:SGTC_3321|Compound:9137793|FD-Score:5.00|P-value:4.34E-7 ID:SGTC_16|Compound:erodoxin|FD-Score:3.13|P-value:8.89E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:3.25|P-value:5.94E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.85|P-value:1.12E-11 ID:SGTC_88|Compound:0180-0332|FD-Score:3.50|P-value:2.50E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.14|P-value:8.71E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.55|P-value:2.10E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:3.36|P-value:4.16E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.34|P-value:4.45E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:3.19|P-value:7.32E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.97|P-value:4.32E-5 ID:SGTC_292|Compound:k038-0015|FD-Score:3.40|P-value:3.55E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.06|P-value:8.47E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.38|P-value:9.36E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:5.97|P-value:2.46E-9 ID:SGTC_572|Compound:0960-0087|FD-Score:-3.63|P-value:4.05E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.56|P-value:2.04E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.26|P-value:1.31E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.35|P-value:4.18E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.42|P-value:3.32E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.43|P-value:6.23E-6 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.96|P-value:4.49E-5 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.25|P-value:6.02E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.72|P-value:1.12E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:-4.67|P-value:6.99E-6 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.36|P-value:4.06E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-3.37|P-value:9.88E-4 ID:SGTC_1700|Compound:st030840|FD-Score:6.74|P-value:2.37E-11 ID:SGTC_1703|Compound:st026983|FD-Score:4.00|P-value:3.84E-5 ID:SGTC_1712|Compound:st032288|FD-Score:4.47|P-value:5.23E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.38|P-value:9.47E-4 ID:SGTC_1822|Compound:st052468|FD-Score:-3.62|P-value:4.22E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.30|P-value:5.12E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.14|P-value:8.49E-4 ID:SGTC_1910|Compound:st062352|FD-Score:4.40|P-value:7.11E-6 ID:SGTC_2078|Compound:5212016|FD-Score:3.34|P-value:4.40E-4 ID:SGTC_2261|Compound:9010538|FD-Score:3.60|P-value:1.72E-4 ID:SGTC_2311|Compound:7694451|FD-Score:8.93|P-value:1.97E-18 ID:SGTC_2412|Compound:st077135|FD-Score:3.42|P-value:3.30E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.58|P-value:1.91E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.79|P-value:8.68E-5 ID:SGTC_2656|Compound:pseudo-anisatin|FD-Score:3.44|P-value:3.08E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:4.03|P-value:3.32E-5 ID:SGTC_2683|Compound:piperine|FD-Score:-3.38|P-value:9.53E-4 ID:SGTC_2781|Compound:5567276|FD-Score:5.32|P-value:8.95E-8 ID:SGTC_2790|Compound:5423970|FD-Score:3.25|P-value:6.05E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.30|P-value:5.02E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.46|P-value:2.93E-4 ID:SGTC_2948|Compound:9070189|FD-Score:3.62|P-value:1.60E-4 ID:SGTC_2971|Compound:9092186|FD-Score:4.08|P-value:2.69E-5 ID:SGTC_2975|Compound:9084847|FD-Score:-3.49|P-value:6.57E-4 ID:SGTC_3039|Compound:9090270|FD-Score:4.17|P-value:1.88E-5 ID:SGTC_3142|Compound:9086498|FD-Score:3.45|P-value:3.00E-4 ID:SGTC_3178|Compound:9107506|FD-Score:3.23|P-value:6.48E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.25|P-value:5.87E-4 ID:SGTC_3319|Compound:9138450|FD-Score:-3.51|P-value:6.05E-4 ID:SGTC_3321|Compound:9137793|FD-Score:5.00|P-value:4.34E-7

Top fitness defect scores for YPL178W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2311 7694451 8.93 200.0 µM 1.97E-18 1 2.10E-19
2 SGTC_58 0957-0393 6.85 9.0 µM 1.12E-11 cell wall 169 3.63E-12
3 SGTC_1700 st030840 6.74 7.9 µM 2.37E-11 PDR1 5 8.09E-12
4 SGTC_368 fentichlor 5.97 4.6 µM 2.46E-9 3 1.15E-9
5 SGTC_2781 5567276 5.32 71.4 µM 8.95E-8 18 5.26E-8
6 SGTC_3321 9137793 5.00 26.8 µM 4.34E-7 cell wall 43 2.82E-7
7 SGTC_1712 st032288 4.47 53.4 µM 5.23E-6 calcium & mitochondrial duress 149 3.94E-6
8 SGTC_1243 0416-0003 4.43 5.7 µM 6.23E-6 PDR1 17 4.73E-6
9 SGTC_1910 st062352 4.40 60.4 µM 7.11E-6 20 5.44E-6
10 SGTC_831 k061-1017 4.26 217.0 µM 1.31E-5 translation 44 1.04E-5
11 SGTC_3039 9090270 4.17 49.5 µM 1.88E-5 RPP1 & pyrimidine depletion 6 1.52E-5
12 SGTC_2971 9092186 4.08 9.9 µM 2.69E-5 ergosterol biosynthesis 27 2.22E-5
13 SGTC_2661 dactinomycin 4.03 13.0 µM 3.32E-5 redox potentiating 18 2.77E-5
14 SGTC_1703 st026983 4.00 48.3 µM 3.84E-5 9 3.23E-5
15 SGTC_270 tamoxifen 3.97 5.5 µM 4.32E-5 NEO1 27 3.66E-5
16 SGTC_1304 1165-0502 3.96 251.0 µM 4.49E-5 57 3.81E-5
17 SGTC_2612 dictamnine 3.79 15.5 µM 8.68E-5 RNA pol III & RNase P/MRP 46 7.63E-5
18 SGTC_1428 4049-0204 3.72 61.7 µM 1.12E-4 18 9.98E-5
19 SGTC_2948 9070189 3.62 9.4 µM 1.60E-4 plasma membrane duress 48 1.45E-4
20 SGTC_2261 9010538 3.60 184.7 µM 1.72E-4 25 1.57E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.155 1.42E-19 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.142 1.20E-16 YOR127W RGA1 hom GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.142 1.27E-16 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.139 5.43E-16 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.139 7.67E-16 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.132 2.20E-14 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.128 1.25E-13 YMR283C RIT1 hom 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA
0.126 2.64E-13 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.125 3.74E-13 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.124 5.28E-13 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.124 5.97E-13 YNL211C_p YNL211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene
0.123 7.31E-13 YNL115C_p YNL115C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.122 1.10E-12 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.119 4.41E-12 YPR159W KRE6 hom Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p
0.119 4.36E-12 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1