YPL180W / TCO89

Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL180W / TCO89

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:3.47|P-value:7.53E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:4.74|P-value:7.05E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:4.57|P-value:1.41E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:3.85|P-value:2.15E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:10.20|P-value:4.18E-21 ID:SGTC_228|Compound:caffeine|FD-Score:7.33|P-value:9.76E-12 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.34|P-value:3.48E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.97|P-value:1.36E-4 ID:SGTC_487|Compound:nimodipine|FD-Score:3.42|P-value:8.76E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.49|P-value:6.97E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:5.01|P-value:2.23E-6 ID:SGTC_727|Compound:3032-0951|FD-Score:3.57|P-value:5.41E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-3.86|P-value:2.00E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.39|P-value:9.69E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.44|P-value:8.11E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:4.29|P-value:4.37E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:5.35|P-value:4.82E-7 ID:SGTC_1005|Compound:4092-0690|FD-Score:-4.13|P-value:7.66E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.20|P-value:5.96E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:4.70|P-value:8.48E-6 ID:SGTC_1064|Compound:honokiol|FD-Score:3.58|P-value:5.26E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.94|P-value:1.57E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.34|P-value:5.12E-7 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.42|P-value:8.83E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.41|P-value:8.95E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:-3.42|P-value:8.45E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.61|P-value:4.73E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.45|P-value:2.32E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.81|P-value:2.42E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.59|P-value:4.91E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:5.49|P-value:2.48E-7 ID:SGTC_1612|Compound:st002233|FD-Score:4.15|P-value:7.17E-5 ID:SGTC_1618|Compound:st003135|FD-Score:-3.69|P-value:3.62E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.58|P-value:5.31E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.76|P-value:2.88E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-4.53|P-value:1.63E-5 ID:SGTC_1658|Compound:st012944|FD-Score:-3.58|P-value:5.22E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.46|P-value:7.64E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.98|P-value:1.32E-4 ID:SGTC_1772|Compound:st048439|FD-Score:5.12|P-value:1.36E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.65|P-value:5.52E-10 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.73|P-value:7.45E-6 ID:SGTC_2044|Compound:5102272|FD-Score:4.25|P-value:4.99E-5 ID:SGTC_2078|Compound:5212016|FD-Score:4.46|P-value:2.24E-5 ID:SGTC_2110|Compound:5483698|FD-Score:-3.75|P-value:2.97E-4 ID:SGTC_2194|Compound:5927483|FD-Score:4.04|P-value:1.08E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:6.50|P-value:1.36E-9 ID:SGTC_2323|Compound:6148992|FD-Score:4.03|P-value:1.13E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.78|P-value:2.72E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.23|P-value:1.81E-11 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.87|P-value:4.08E-6 ID:SGTC_2743|Compound:auranofin|FD-Score:4.09|P-value:9.00E-5 ID:SGTC_2804|Compound:7954240|FD-Score:-4.05|P-value:1.04E-4 ID:SGTC_2883|Compound:9059145|FD-Score:4.61|P-value:1.21E-5 ID:SGTC_2884|Compound:9058502|FD-Score:4.04|P-value:1.10E-4 ID:SGTC_2912|Compound:7964298|FD-Score:6.60|P-value:7.54E-10 ID:SGTC_3142|Compound:9086498|FD-Score:-3.38|P-value:9.70E-4 ID:SGTC_3148|Compound:9097893|FD-Score:6.96|P-value:9.15E-11 ID:SGTC_3152|Compound:9099253|FD-Score:-3.64|P-value:4.25E-4 ID:SGTC_3186|Compound:9110464|FD-Score:3.93|P-value:1.62E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:3.47|P-value:7.53E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:4.74|P-value:7.05E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:4.57|P-value:1.41E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:3.85|P-value:2.15E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:10.20|P-value:4.18E-21 ID:SGTC_228|Compound:caffeine|FD-Score:7.33|P-value:9.76E-12 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.34|P-value:3.48E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.97|P-value:1.36E-4 ID:SGTC_487|Compound:nimodipine|FD-Score:3.42|P-value:8.76E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.49|P-value:6.97E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:5.01|P-value:2.23E-6 ID:SGTC_727|Compound:3032-0951|FD-Score:3.57|P-value:5.41E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-3.86|P-value:2.00E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.39|P-value:9.69E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.44|P-value:8.11E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:4.29|P-value:4.37E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:5.35|P-value:4.82E-7 ID:SGTC_1005|Compound:4092-0690|FD-Score:-4.13|P-value:7.66E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:4.20|P-value:5.96E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:4.70|P-value:8.48E-6 ID:SGTC_1064|Compound:honokiol|FD-Score:3.58|P-value:5.26E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.94|P-value:1.57E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.34|P-value:5.12E-7 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.42|P-value:8.83E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.41|P-value:8.95E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:-3.42|P-value:8.45E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.61|P-value:4.73E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.45|P-value:2.32E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.81|P-value:2.42E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.59|P-value:4.91E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:5.49|P-value:2.48E-7 ID:SGTC_1612|Compound:st002233|FD-Score:4.15|P-value:7.17E-5 ID:SGTC_1618|Compound:st003135|FD-Score:-3.69|P-value:3.62E-4 ID:SGTC_1619|Compound:st003326|FD-Score:3.58|P-value:5.31E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.76|P-value:2.88E-4 ID:SGTC_1635|Compound:st007035|FD-Score:-4.53|P-value:1.63E-5 ID:SGTC_1658|Compound:st012944|FD-Score:-3.58|P-value:5.22E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.46|P-value:7.64E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.98|P-value:1.32E-4 ID:SGTC_1772|Compound:st048439|FD-Score:5.12|P-value:1.36E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.65|P-value:5.52E-10 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.73|P-value:7.45E-6 ID:SGTC_2044|Compound:5102272|FD-Score:4.25|P-value:4.99E-5 ID:SGTC_2078|Compound:5212016|FD-Score:4.46|P-value:2.24E-5 ID:SGTC_2110|Compound:5483698|FD-Score:-3.75|P-value:2.97E-4 ID:SGTC_2194|Compound:5927483|FD-Score:4.04|P-value:1.08E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:6.50|P-value:1.36E-9 ID:SGTC_2323|Compound:6148992|FD-Score:4.03|P-value:1.13E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.78|P-value:2.72E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.23|P-value:1.81E-11 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.87|P-value:4.08E-6 ID:SGTC_2743|Compound:auranofin|FD-Score:4.09|P-value:9.00E-5 ID:SGTC_2804|Compound:7954240|FD-Score:-4.05|P-value:1.04E-4 ID:SGTC_2883|Compound:9059145|FD-Score:4.61|P-value:1.21E-5 ID:SGTC_2884|Compound:9058502|FD-Score:4.04|P-value:1.10E-4 ID:SGTC_2912|Compound:7964298|FD-Score:6.60|P-value:7.54E-10 ID:SGTC_3142|Compound:9086498|FD-Score:-3.38|P-value:9.70E-4 ID:SGTC_3148|Compound:9097893|FD-Score:6.96|P-value:9.15E-11 ID:SGTC_3152|Compound:9099253|FD-Score:-3.64|P-value:4.25E-4 ID:SGTC_3186|Compound:9110464|FD-Score:3.93|P-value:1.62E-4

Top fitness defect scores for YPL180W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_166 k072-0058 10.20 166.4 µM 4.18E-21 DNA intercalators 1 8.52E-25
2 SGTC_228 caffeine 7.33 993.1 µM 9.76E-12 3 1.18E-13
3 SGTC_2679 rapamycin 7.23 1.0 nM 1.81E-11 53 2.45E-13
4 SGTC_3148 9097893 6.96 49.5 µM 9.15E-11 8 1.68E-12
5 SGTC_1844 rapamycin 6.65 4.0 nM 5.52E-10 77 1.42E-11
6 SGTC_2912 7964298 6.60 10.9 µM 7.54E-10 cell wall 39 2.06E-11
7 SGTC_2232 chlorophetanol 6.50 41.5 µM 1.36E-9 TRP & mitochondrial translation 34 4.14E-11
8 SGTC_1601 4'-hydroxyflavanone 5.49 55.5 µM 2.48E-7 RPP1 & pyrimidine depletion 15 1.99E-8
9 SGTC_974 1326-0144 5.35 138.0 µM 4.82E-7 ERG2 15 4.38E-8
10 SGTC_1133 3473-0247 5.34 50.0 µM 5.12E-7 RSC complex & mRNA processing 17 4.71E-8
11 SGTC_1772 st048439 5.12 82.2 µM 1.36E-6 17 1.50E-7
12 SGTC_666 0272-0154 5.01 136.0 µM 2.23E-6 cell wall 32 2.70E-7
13 SGTC_2688 kanamycin b 4.87 96.7 µM 4.08E-6 calcium & mitochondrial duress 254 5.51E-7
14 SGTC_56 0957-0365 4.74 83.2 µM 7.05E-6 Golgi 30 1.05E-6
15 SGTC_1877 wortmannin 4.73 25.0 µM 7.45E-6 71 1.12E-6
16 SGTC_1057 3448-5381 4.70 134.0 µM 8.48E-6 calcium & mitochondrial duress 16 1.31E-6
17 SGTC_2883 9059145 4.61 45.5 µM 1.21E-5 5 1.99E-6
18 SGTC_138 0850-0259 4.57 40.9 µM 1.41E-5 cell wall 161 2.39E-6
19 SGTC_2078 5212016 4.46 200.0 µM 2.24E-5 60S ribosome export 8 4.15E-6
20 SGTC_1468 k284-1086 4.45 134.0 µM 2.32E-5 DNA intercalators 22 4.31E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.353 7.23E-99 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.352 3.12E-98 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.324 8.01E-83 YBR077C SLM4 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
0.296 5.52E-69 YKR007W MEH1 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification
0.232 3.08E-42 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.206 1.83E-33 YCR075W-A_p YCR075W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication
0.192 3.72E-29 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.187 6.90E-28 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.177 4.96E-25 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.174 4.05E-24 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.168 1.53E-22 YKL176C LST4 hom Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.166 2.88E-22 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.164 1.55E-21 YDR162C NBP2 hom Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM)
0.163 1.80E-21 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.161 5.75E-21 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2