HIPHOP chemogenomics database

YPL181W / CTI6

Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain

Zygosity: Homozygous strain

fixedexpanded
Profile for YPL181W / CTI6

Click on Significant Values for Screen Details

Top fitness defect scores for YPL181W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_137	0438-0332	7.79	85.4 µM	3.30E-13	ubiquinone biosynthesis & proteasome	40	3.25E-15
2	SGTC_142	0335-0849	7.16	62.7 µM	2.03E-11	ubiquinone biosynthesis & proteasome	50	4.12E-13
3	SGTC_3144	9087057	6.05	49.5 µM	1.20E-8		2	7.39E-10
4	SGTC_3136	9095672	5.85	49.5 µM	3.26E-8		3	2.39E-9
5	SGTC_1326	1431-2094	5.72	10.8 µM	6.48E-8	tubulin folding & SWR complex	15	5.37E-9
6	SGTC_2042	p-Dimethylaminoacetophenone	4.99	200.0 µM	2.05E-6		5	3.08E-7
7	SGTC_310	1273-0058	4.79	1.1 µM	4.91E-6	mitochondrial stress	189	8.54E-7
8	SGTC_2807	7945238	4.76	52.0 µM	5.39E-6		13	9.53E-7
9	SGTC_3003	9075612	4.68	71.4 µM	7.60E-6		10	1.42E-6
10	SGTC_36	0335-0881	4.66	14.2 µM	8.30E-6	ubiquinone biosynthesis & proteasome	89	1.58E-6
11	SGTC_1541	2',3',6-trimethoxyflavone	4.51	64.0 µM	1.52E-5		9	3.21E-6
12	SGTC_86	0417-1630	4.47	471.9 µM	1.78E-5	ubiquinone biosynthesis & proteasome	126	3.84E-6
13	SGTC_635	k038-0028	4.38	24.7 µM	2.58E-5	ubiquinone biosynthesis & proteasome	39	5.94E-6
14	SGTC_1333	1482-0047	4.37	286.0 µM	2.69E-5		10	6.24E-6
15	SGTC_1576	erythromycin ethylsuccinate	4.33	23.2 µM	3.12E-5		17	7.42E-6
16	SGTC_3054	9094397	4.32	49.5 µM	3.31E-5	fatty acid desaturase (OLE1)	21	7.95E-6
17	SGTC_2183	6420625	4.10	130.5 µM	7.47E-5	mitochondrial processes	48	2.06E-5
18	SGTC_2421	5690543	4.07	90.7 µM	8.37E-5		15	2.35E-5
19	SGTC_251	melphalan	4.05	456.5 µM	8.93E-5	DNA damage response	20	2.53E-5
20	SGTC_1946	st076057	4.04	65.1 µM	9.42E-5		3	2.70E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.230	2.68E-41	YJL193W_p	YJL193W_p	hom	Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.226	4.41E-40	YML034C-A_d	YML034C-A_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.211	4.49E-35	YOR254C	SEC63	het	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.211	4.52E-35	YDR086C	SSS1	het	Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
0.205	4.85E-33	YOR165W	SEY1	hom	Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3
0.196	2.71E-30	YOL096C	COQ3	hom	O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.194	8.67E-30	YDL183C	YDL183C	hom	Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.194	1.16E-29	YJL155C	FBP26	hom	Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.190	1.68E-28	YBR275C	RIF1	hom	Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.189	3.38E-28	YOL008W	COQ10	hom	Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q₆ to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
0.182	1.65E-26	YIL090W	ICE2	hom	Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells
0.181	4.88E-26	YPR064W_d	YPR064W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.180	6.57E-26	YPL182C_d	YPL182C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W
0.174	3.11E-24	YLR379W_d	YLR379W_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C
0.173	5.64E-24	YPR065W	ROX1	hom	Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance