YPL181W / CTI6

Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL181W / CTI6

Click on Significant Values for Screen Details ID:SGTC_26|Compound:0302-0163|FD-Score:3.60|P-value:4.26E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.66|P-value:8.30E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:4.47|P-value:1.78E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:7.79|P-value:3.30E-13 ID:SGTC_142|Compound:0335-0849|FD-Score:7.16|P-value:2.03E-11 ID:SGTC_251|Compound:melphalan|FD-Score:4.05|P-value:8.93E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:4.79|P-value:4.91E-6 ID:SGTC_327|Compound:1273-0057|FD-Score:3.39|P-value:8.45E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.47|P-value:6.61E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:3.75|P-value:2.61E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.54|P-value:5.30E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.49|P-value:6.28E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:4.38|P-value:2.58E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:3.47|P-value:6.57E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.81|P-value:2.12E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.71|P-value:2.99E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:5.72|P-value:6.48E-8 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.37|P-value:2.69E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.87|P-value:1.72E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.48|P-value:6.38E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:4.51|P-value:1.52E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.33|P-value:3.12E-5 ID:SGTC_1633|Compound:st005664|FD-Score:3.37|P-value:9.04E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.60|P-value:4.26E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.43|P-value:7.45E-4 ID:SGTC_1945|Compound:st075991|FD-Score:-4.07|P-value:1.01E-4 ID:SGTC_1946|Compound:st076057|FD-Score:4.04|P-value:9.42E-5 ID:SGTC_2020|Compound:4017018|FD-Score:3.74|P-value:2.67E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:4.99|P-value:2.05E-6 ID:SGTC_2100|Compound:5377183|FD-Score:-3.67|P-value:3.94E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.56|P-value:4.89E-4 ID:SGTC_2142|Compound:5622915|FD-Score:3.66|P-value:3.55E-4 ID:SGTC_2178|Compound:5812956|FD-Score:3.39|P-value:8.48E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.10|P-value:7.47E-5 ID:SGTC_2245|Compound:6637752|FD-Score:-3.56|P-value:5.79E-4 ID:SGTC_2421|Compound:5690543|FD-Score:4.07|P-value:8.37E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:3.51|P-value:5.77E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.81|P-value:2.11E-4 ID:SGTC_2807|Compound:7945238|FD-Score:4.76|P-value:5.39E-6 ID:SGTC_3003|Compound:9075612|FD-Score:4.68|P-value:7.60E-6 ID:SGTC_3054|Compound:9094397|FD-Score:4.32|P-value:3.31E-5 ID:SGTC_3111|Compound:9122088|FD-Score:3.65|P-value:3.64E-4 ID:SGTC_3136|Compound:9095672|FD-Score:5.85|P-value:3.26E-8 ID:SGTC_3144|Compound:9087057|FD-Score:6.05|P-value:1.20E-8 ID:SGTC_3199|Compound:9111318|FD-Score:3.93|P-value:1.38E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.49|P-value:6.22E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.52|P-value:5.64E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-4.95|P-value:2.98E-6 ID:SGTC_26|Compound:0302-0163|FD-Score:3.60|P-value:4.26E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.66|P-value:8.30E-6 ID:SGTC_86|Compound:0417-1630|FD-Score:4.47|P-value:1.78E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:7.79|P-value:3.30E-13 ID:SGTC_142|Compound:0335-0849|FD-Score:7.16|P-value:2.03E-11 ID:SGTC_251|Compound:melphalan|FD-Score:4.05|P-value:8.93E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:4.79|P-value:4.91E-6 ID:SGTC_327|Compound:1273-0057|FD-Score:3.39|P-value:8.45E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.47|P-value:6.61E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:3.75|P-value:2.61E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.54|P-value:5.30E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.49|P-value:6.28E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:4.38|P-value:2.58E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:3.47|P-value:6.57E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.81|P-value:2.12E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.71|P-value:2.99E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:5.72|P-value:6.48E-8 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.37|P-value:2.69E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.87|P-value:1.72E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.48|P-value:6.38E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:4.51|P-value:1.52E-5 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.33|P-value:3.12E-5 ID:SGTC_1633|Compound:st005664|FD-Score:3.37|P-value:9.04E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.60|P-value:4.26E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.43|P-value:7.45E-4 ID:SGTC_1945|Compound:st075991|FD-Score:-4.07|P-value:1.01E-4 ID:SGTC_1946|Compound:st076057|FD-Score:4.04|P-value:9.42E-5 ID:SGTC_2020|Compound:4017018|FD-Score:3.74|P-value:2.67E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:4.99|P-value:2.05E-6 ID:SGTC_2100|Compound:5377183|FD-Score:-3.67|P-value:3.94E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.56|P-value:4.89E-4 ID:SGTC_2142|Compound:5622915|FD-Score:3.66|P-value:3.55E-4 ID:SGTC_2178|Compound:5812956|FD-Score:3.39|P-value:8.48E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.10|P-value:7.47E-5 ID:SGTC_2245|Compound:6637752|FD-Score:-3.56|P-value:5.79E-4 ID:SGTC_2421|Compound:5690543|FD-Score:4.07|P-value:8.37E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:3.51|P-value:5.77E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.81|P-value:2.11E-4 ID:SGTC_2807|Compound:7945238|FD-Score:4.76|P-value:5.39E-6 ID:SGTC_3003|Compound:9075612|FD-Score:4.68|P-value:7.60E-6 ID:SGTC_3054|Compound:9094397|FD-Score:4.32|P-value:3.31E-5 ID:SGTC_3111|Compound:9122088|FD-Score:3.65|P-value:3.64E-4 ID:SGTC_3136|Compound:9095672|FD-Score:5.85|P-value:3.26E-8 ID:SGTC_3144|Compound:9087057|FD-Score:6.05|P-value:1.20E-8 ID:SGTC_3199|Compound:9111318|FD-Score:3.93|P-value:1.38E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.49|P-value:6.22E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.52|P-value:5.64E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-4.95|P-value:2.98E-6

Top fitness defect scores for YPL181W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_137 0438-0332 7.79 85.4 µM 3.30E-13 ubiquinone biosynthesis & proteasome 40 3.25E-15
2 SGTC_142 0335-0849 7.16 62.7 µM 2.03E-11 ubiquinone biosynthesis & proteasome 50 4.12E-13
3 SGTC_3144 9087057 6.05 49.5 µM 1.20E-8 2 7.39E-10
4 SGTC_3136 9095672 5.85 49.5 µM 3.26E-8 3 2.39E-9
5 SGTC_1326 1431-2094 5.72 10.8 µM 6.48E-8 tubulin folding & SWR complex 15 5.37E-9
6 SGTC_2042 p-Dimethylaminoacetophenone 4.99 200.0 µM 2.05E-6 5 3.08E-7
7 SGTC_310 1273-0058 4.79 1.1 µM 4.91E-6 mitochondrial stress 189 8.54E-7
8 SGTC_2807 7945238 4.76 52.0 µM 5.39E-6 13 9.53E-7
9 SGTC_3003 9075612 4.68 71.4 µM 7.60E-6 10 1.42E-6
10 SGTC_36 0335-0881 4.66 14.2 µM 8.30E-6 ubiquinone biosynthesis & proteasome 89 1.58E-6
11 SGTC_1541 2',3',6-trimethoxyflavone 4.51 64.0 µM 1.52E-5 9 3.21E-6
12 SGTC_86 0417-1630 4.47 471.9 µM 1.78E-5 ubiquinone biosynthesis & proteasome 126 3.84E-6
13 SGTC_635 k038-0028 4.38 24.7 µM 2.58E-5 ubiquinone biosynthesis & proteasome 39 5.94E-6
14 SGTC_1333 1482-0047 4.37 286.0 µM 2.69E-5 10 6.24E-6
15 SGTC_1576 erythromycin ethylsuccinate 4.33 23.2 µM 3.12E-5 17 7.42E-6
16 SGTC_3054 9094397 4.32 49.5 µM 3.31E-5 fatty acid desaturase (OLE1) 21 7.95E-6
17 SGTC_2183 6420625 4.10 130.5 µM 7.47E-5 mitochondrial processes 48 2.06E-5
18 SGTC_2421 5690543 4.07 90.7 µM 8.37E-5 15 2.35E-5
19 SGTC_251 melphalan 4.05 456.5 µM 8.93E-5 DNA damage response 20 2.53E-5
20 SGTC_1946 st076057 4.04 65.1 µM 9.42E-5 3 2.70E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.230 2.68E-41 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.226 4.41E-40 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.211 4.49E-35 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.211 4.52E-35 YDR086C SSS1 het Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
0.205 4.85E-33 YOR165W SEY1 hom Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3
0.196 2.71E-30 YOL096C COQ3 hom O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
0.194 8.67E-30 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.194 1.16E-29 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.190 1.68E-28 YBR275C RIF1 hom Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.189 3.38E-28 YOL008W COQ10 hom Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
0.182 1.65E-26 YIL090W ICE2 hom Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells
0.181 4.88E-26 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.180 6.57E-26 YPL182C_d YPL182C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W
0.174 3.11E-24 YLR379W_d YLR379W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C
0.173 5.64E-24 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance