YPL182C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL182C / YPL182C

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:3.69|P-value:9.87E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:9.02|P-value:4.45E-20 ID:SGTC_115|Compound:0527-0192|FD-Score:3.44|P-value:2.67E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:5.48|P-value:1.68E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:4.78|P-value:7.22E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:4.82|P-value:5.76E-7 ID:SGTC_174|Compound:3553-0389|FD-Score:3.29|P-value:4.54E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.12|P-value:8.51E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.71|P-value:9.29E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:3.86|P-value:4.94E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:4.95|P-value:3.02E-7 ID:SGTC_654|Compound:1124-0271|FD-Score:4.66|P-value:1.30E-6 ID:SGTC_909|Compound:3448-9333|FD-Score:-4.26|P-value:8.03E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.80|P-value:5.94E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.68|P-value:1.03E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.85|P-value:5.21E-5 ID:SGTC_1080|Compound:nisoldipine|FD-Score:-3.66|P-value:1.05E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:-3.10|P-value:8.47E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.22|P-value:5.92E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:-3.63|P-value:1.18E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.36|P-value:3.58E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.46|P-value:2.47E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.55|P-value:1.72E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.08|P-value:9.64E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.16|P-value:7.31E-4 ID:SGTC_1729|Compound:st035615|FD-Score:5.83|P-value:2.02E-9 ID:SGTC_1767|Compound:st044992|FD-Score:-3.43|P-value:2.57E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.35|P-value:3.71E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.59|P-value:1.47E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.24|P-value:5.44E-4 ID:SGTC_2335|Compound:9018011|FD-Score:4.83|P-value:5.67E-7 ID:SGTC_2336|Compound:9001819|FD-Score:4.97|P-value:2.70E-7 ID:SGTC_2337|Compound:9009472|FD-Score:5.29|P-value:4.73E-8 ID:SGTC_2338|Compound:7999974|FD-Score:-4.12|P-value:1.53E-5 ID:SGTC_2370|Compound:9071495|FD-Score:3.92|P-value:3.87E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.13|P-value:8.22E-4 ID:SGTC_2461|Compound:5755302|FD-Score:5.12|P-value:1.24E-7 ID:SGTC_2464|Compound:5717415|FD-Score:3.21|P-value:6.13E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-3.47|P-value:2.20E-4 ID:SGTC_2696|Compound:st077691|FD-Score:4.11|P-value:1.71E-5 ID:SGTC_2706|Compound:st078239|FD-Score:3.16|P-value:7.25E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-3.92|P-value:3.66E-5 ID:SGTC_2805|Compound:7950783|FD-Score:-5.24|P-value:5.83E-8 ID:SGTC_2806|Compound:7952793|FD-Score:5.82|P-value:2.17E-9 ID:SGTC_2829|Compound:7992743|FD-Score:3.45|P-value:2.52E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-3.46|P-value:2.31E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.60|P-value:1.36E-4 ID:SGTC_2893|Compound:9048488|FD-Score:-3.41|P-value:2.81E-4 ID:SGTC_2897|Compound:9048598|FD-Score:-3.40|P-value:2.87E-4 ID:SGTC_2932|Compound:9016711|FD-Score:4.27|P-value:8.40E-6 ID:SGTC_2953|Compound:9074162|FD-Score:3.80|P-value:6.31E-5 ID:SGTC_3047|Compound:9092122|FD-Score:-3.28|P-value:4.50E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.32|P-value:4.17E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.42|P-value:2.80E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.17|P-value:6.96E-4 ID:SGTC_3316|Compound:9136639|FD-Score:-3.31|P-value:4.05E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.69|P-value:9.87E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:9.02|P-value:4.45E-20 ID:SGTC_115|Compound:0527-0192|FD-Score:3.44|P-value:2.67E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:5.48|P-value:1.68E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:4.78|P-value:7.22E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:4.82|P-value:5.76E-7 ID:SGTC_174|Compound:3553-0389|FD-Score:3.29|P-value:4.54E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.12|P-value:8.51E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.71|P-value:9.29E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:3.86|P-value:4.94E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:4.95|P-value:3.02E-7 ID:SGTC_654|Compound:1124-0271|FD-Score:4.66|P-value:1.30E-6 ID:SGTC_909|Compound:3448-9333|FD-Score:-4.26|P-value:8.03E-6 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.80|P-value:5.94E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.68|P-value:1.03E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.85|P-value:5.21E-5 ID:SGTC_1080|Compound:nisoldipine|FD-Score:-3.66|P-value:1.05E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:-3.10|P-value:8.47E-4 ID:SGTC_1088|Compound:bifonazole|FD-Score:3.22|P-value:5.92E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:-3.63|P-value:1.18E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.36|P-value:3.58E-4 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.46|P-value:2.47E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.55|P-value:1.72E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.08|P-value:9.64E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.16|P-value:7.31E-4 ID:SGTC_1729|Compound:st035615|FD-Score:5.83|P-value:2.02E-9 ID:SGTC_1767|Compound:st044992|FD-Score:-3.43|P-value:2.57E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.35|P-value:3.71E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.59|P-value:1.47E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.24|P-value:5.44E-4 ID:SGTC_2335|Compound:9018011|FD-Score:4.83|P-value:5.67E-7 ID:SGTC_2336|Compound:9001819|FD-Score:4.97|P-value:2.70E-7 ID:SGTC_2337|Compound:9009472|FD-Score:5.29|P-value:4.73E-8 ID:SGTC_2338|Compound:7999974|FD-Score:-4.12|P-value:1.53E-5 ID:SGTC_2370|Compound:9071495|FD-Score:3.92|P-value:3.87E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.13|P-value:8.22E-4 ID:SGTC_2461|Compound:5755302|FD-Score:5.12|P-value:1.24E-7 ID:SGTC_2464|Compound:5717415|FD-Score:3.21|P-value:6.13E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-3.47|P-value:2.20E-4 ID:SGTC_2696|Compound:st077691|FD-Score:4.11|P-value:1.71E-5 ID:SGTC_2706|Compound:st078239|FD-Score:3.16|P-value:7.25E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-3.92|P-value:3.66E-5 ID:SGTC_2805|Compound:7950783|FD-Score:-5.24|P-value:5.83E-8 ID:SGTC_2806|Compound:7952793|FD-Score:5.82|P-value:2.17E-9 ID:SGTC_2829|Compound:7992743|FD-Score:3.45|P-value:2.52E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-3.46|P-value:2.31E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.60|P-value:1.36E-4 ID:SGTC_2893|Compound:9048488|FD-Score:-3.41|P-value:2.81E-4 ID:SGTC_2897|Compound:9048598|FD-Score:-3.40|P-value:2.87E-4 ID:SGTC_2932|Compound:9016711|FD-Score:4.27|P-value:8.40E-6 ID:SGTC_2953|Compound:9074162|FD-Score:3.80|P-value:6.31E-5 ID:SGTC_3047|Compound:9092122|FD-Score:-3.28|P-value:4.50E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.32|P-value:4.17E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.42|P-value:2.80E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.17|P-value:6.96E-4 ID:SGTC_3316|Compound:9136639|FD-Score:-3.31|P-value:4.05E-4

Top fitness defect scores for YPL182C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_86 0417-1630 9.02 471.9 µM 4.45E-20 ubiquinone biosynthesis & proteasome 49 9.41E-20
2 SGTC_1729 st035615 5.83 46.0 µM 2.02E-9 9 2.72E-9
3 SGTC_2806 7952793 5.82 58.4 µM 2.17E-9 6 2.92E-9
4 SGTC_137 0438-0332 5.48 85.4 µM 1.68E-8 ubiquinone biosynthesis & proteasome 67 2.18E-8
5 SGTC_2337 9009472 5.29 200.0 µM 4.73E-8 10 6.03E-8
6 SGTC_2461 5755302 5.12 26.1 µM 1.24E-7 17 1.55E-7
7 SGTC_2336 9001819 4.97 198.7 µM 2.70E-7 heme biosynthesis & mitochondrial translocase 20 3.34E-7
8 SGTC_513 4245-1575 4.95 41.7 µM 3.02E-7 unfolded protein response 75 3.72E-7
9 SGTC_2335 9018011 4.83 154.2 µM 5.67E-7 14 6.91E-7
10 SGTC_158 k038-0087 4.82 26.4 µM 5.76E-7 ubiquinone biosynthesis & proteasome 93 7.02E-7
11 SGTC_142 0335-0849 4.78 62.7 µM 7.22E-7 ubiquinone biosynthesis & proteasome 90 8.77E-7
12 SGTC_654 1124-0271 4.66 80.9 µM 1.30E-6 12 1.56E-6
13 SGTC_2932 9016711 4.27 44.5 µM 8.40E-6 39 9.78E-6
14 SGTC_2696 st077691 4.11 74.3 µM 1.71E-5 25 1.97E-5
15 SGTC_2370 9071495 3.92 200.0 µM 3.87E-5 mitochondrial processes 27 4.39E-5
16 SGTC_310 1273-0058 3.86 1.1 µM 4.94E-5 mitochondrial stress 251 5.58E-5
17 SGTC_1072 oxiconazole 3.85 14.9 nM 5.21E-5 ergosterol depletion effects on membrane 56 5.89E-5
18 SGTC_2953 9074162 3.80 66.5 µM 6.31E-5 29 7.10E-5
19 SGTC_264 promethazine 3.71 12.5 mM 9.29E-5 DNA intercalators 59 1.04E-4
20 SGTC_36 0335-0881 3.69 14.2 µM 9.87E-5 ubiquinone biosynthesis & proteasome 135 1.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.265 3.79E-55 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.258 2.93E-52 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.249 1.54E-48 YIL090W ICE2 hom Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells
0.239 6.81E-45 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.235 1.99E-43 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.233 2.11E-42 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.232 2.78E-42 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.223 6.31E-39 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.221 1.68E-38 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.217 4.86E-37 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.216 1.37E-36 YOL008W COQ10 hom Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
0.215 2.08E-36 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.208 3.78E-34 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.201 8.28E-32 YLR292C SEC72 hom Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.200 1.22E-31 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication