HIPHOP chemogenomics database

YPL182C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W

Zygosity: Homozygous strain

fixedexpanded
Profile for YPL182C / YPL182C

Click on Significant Values for Screen Details

Top fitness defect scores for YPL182C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_86	0417-1630	9.02	471.9 µM	4.45E-20	ubiquinone biosynthesis & proteasome	49	9.41E-20
2	SGTC_1729	st035615	5.83	46.0 µM	2.02E-9		9	2.72E-9
3	SGTC_2806	7952793	5.82	58.4 µM	2.17E-9		6	2.92E-9
4	SGTC_137	0438-0332	5.48	85.4 µM	1.68E-8	ubiquinone biosynthesis & proteasome	67	2.18E-8
5	SGTC_2337	9009472	5.29	200.0 µM	4.73E-8		10	6.03E-8
6	SGTC_2461	5755302	5.12	26.1 µM	1.24E-7		17	1.55E-7
7	SGTC_2336	9001819	4.97	198.7 µM	2.70E-7	heme biosynthesis & mitochondrial translocase	20	3.34E-7
8	SGTC_513	4245-1575	4.95	41.7 µM	3.02E-7	unfolded protein response	75	3.72E-7
9	SGTC_2335	9018011	4.83	154.2 µM	5.67E-7		14	6.91E-7
10	SGTC_158	k038-0087	4.82	26.4 µM	5.76E-7	ubiquinone biosynthesis & proteasome	93	7.02E-7
11	SGTC_142	0335-0849	4.78	62.7 µM	7.22E-7	ubiquinone biosynthesis & proteasome	90	8.77E-7
12	SGTC_654	1124-0271	4.66	80.9 µM	1.30E-6		12	1.56E-6
13	SGTC_2932	9016711	4.27	44.5 µM	8.40E-6		39	9.78E-6
14	SGTC_2696	st077691	4.11	74.3 µM	1.71E-5		25	1.97E-5
15	SGTC_2370	9071495	3.92	200.0 µM	3.87E-5	mitochondrial processes	27	4.39E-5
16	SGTC_310	1273-0058	3.86	1.1 µM	4.94E-5	mitochondrial stress	251	5.58E-5
17	SGTC_1072	oxiconazole	3.85	14.9 nM	5.21E-5	ergosterol depletion effects on membrane	56	5.89E-5
18	SGTC_2953	9074162	3.80	66.5 µM	6.31E-5		29	7.10E-5
19	SGTC_264	promethazine	3.71	12.5 mM	9.29E-5	DNA intercalators	59	1.04E-4
20	SGTC_36	0335-0881	3.69	14.2 µM	9.87E-5	ubiquinone biosynthesis & proteasome	135	1.10E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.265	3.79E-55	YOR254C	SEC63	het	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.258	2.93E-52	YML034C-A_d	YML034C-A_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.249	1.54E-48	YIL090W	ICE2	hom	Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells
0.239	6.81E-45	YPR064W_d	YPR064W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.235	1.99E-43	YLR201C	COQ9	hom	Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.233	2.11E-42	YJL193W_p	YJL193W_p	hom	Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.232	2.78E-42	YLR202C_d	YLR202C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.223	6.31E-39	YJL155C	FBP26	hom	Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.221	1.68E-38	YDL183C	YDL183C	hom	Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.217	4.86E-37	YER019C-A	SBH2	hom	Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.216	1.37E-36	YOL008W	COQ10	hom	Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q₆ to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
0.215	2.08E-36	YNR042W_d	YNR042W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.208	3.78E-34	YDR204W	COQ4	hom	Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.201	8.28E-32	YLR292C	SEC72	hom	Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.200	1.22E-31	YGL119W	COQ8	hom	Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication