YPL183W-A / RTC6

Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL183W-A / RTC6

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.77|P-value:2.80E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.47|P-value:2.22E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:3.61|P-value:4.62E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.24|P-value:5.17E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.94|P-value:2.14E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.35|P-value:1.13E-11 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.49|P-value:6.80E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:13.70|P-value:6.68E-36 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.32|P-value:1.35E-11 ID:SGTC_310|Compound:1273-0058|FD-Score:17.10|P-value:7.47E-55 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.55|P-value:7.83E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-4.33|P-value:5.44E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:3.39|P-value:9.41E-4 ID:SGTC_394|Compound:menadione|FD-Score:-4.65|P-value:1.61E-5 ID:SGTC_397|Compound:arbidol|FD-Score:3.74|P-value:3.10E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:5.18|P-value:1.14E-6 ID:SGTC_408|Compound:cantharidin|FD-Score:-6.49|P-value:2.91E-9 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:7.84|P-value:4.98E-13 ID:SGTC_431|Compound:k089-0097|FD-Score:-6.53|P-value:2.36E-9 ID:SGTC_432|Compound:NS 1619|FD-Score:4.53|P-value:1.71E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:3.64|P-value:4.17E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:4.14|P-value:7.61E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:4.79|P-value:6.01E-6 ID:SGTC_671|Compound:0560-0003|FD-Score:4.27|P-value:4.68E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:3.71|P-value:3.43E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.87|P-value:1.97E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:4.17|P-value:6.71E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:4.24|P-value:5.24E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:3.85|P-value:2.12E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:4.13|P-value:7.81E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:3.70|P-value:3.44E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.95|P-value:3.06E-6 ID:SGTC_892|Compound:0929-0076|FD-Score:4.86|P-value:4.48E-6 ID:SGTC_899|Compound:1083-0020|FD-Score:4.77|P-value:6.50E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:4.43|P-value:2.54E-5 ID:SGTC_979|Compound:1426-2828|FD-Score:3.50|P-value:6.55E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.89|P-value:4.03E-6 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-3.95|P-value:2.08E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:-3.57|P-value:7.33E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.81|P-value:2.44E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.91|P-value:2.43E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:4.30|P-value:4.13E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:-4.08|P-value:1.32E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:4.61|P-value:1.24E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.50|P-value:8.91E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:4.04|P-value:1.07E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.89|P-value:1.81E-4 ID:SGTC_1614|Compound:st002383|FD-Score:3.47|P-value:7.21E-4 ID:SGTC_1615|Compound:st002656|FD-Score:4.13|P-value:7.80E-5 ID:SGTC_1621|Compound:st003705|FD-Score:4.75|P-value:7.08E-6 ID:SGTC_1623|Compound:st003709|FD-Score:4.11|P-value:8.53E-5 ID:SGTC_1695|Compound:st026914|FD-Score:3.77|P-value:2.78E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-4.10|P-value:1.24E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.40|P-value:4.21E-5 ID:SGTC_1730|Compound:st033808|FD-Score:3.57|P-value:5.33E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-3.62|P-value:6.23E-4 ID:SGTC_1742|Compound:st038235|FD-Score:7.82|P-value:5.66E-13 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.49|P-value:3.00E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.03|P-value:1.11E-4 ID:SGTC_1907|Compound:st060210|FD-Score:7.93|P-value:2.63E-13 ID:SGTC_1911|Compound:st060208|FD-Score:3.81|P-value:2.43E-4 ID:SGTC_1912|Compound:st060209|FD-Score:5.56|P-value:1.93E-7 ID:SGTC_2013|Compound:4024628|FD-Score:-4.18|P-value:9.24E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-5.15|P-value:1.95E-6 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-4.53|P-value:2.58E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.69|P-value:3.64E-4 ID:SGTC_2278|Compound:7948257|FD-Score:3.82|P-value:2.34E-4 ID:SGTC_2361|Compound:9034121|FD-Score:3.94|P-value:1.57E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:4.12|P-value:8.25E-5 ID:SGTC_2560|Compound:caryophyllene|FD-Score:-3.68|P-value:5.14E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.80|P-value:6.02E-8 ID:SGTC_2703|Compound:st077852|FD-Score:-3.96|P-value:2.05E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.57|P-value:7.20E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-7.44|P-value:1.17E-11 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.50|P-value:2.80E-5 ID:SGTC_2812|Compound:7970281|FD-Score:3.43|P-value:8.19E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.69|P-value:3.66E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.54|P-value:3.40E-7 ID:SGTC_2916|Compound:7875993|FD-Score:4.09|P-value:9.14E-5 ID:SGTC_2917|Compound:7979103|FD-Score:-3.55|P-value:7.81E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.55|P-value:5.62E-4 ID:SGTC_3000|Compound:9075062|FD-Score:-4.56|P-value:2.24E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.28|P-value:6.55E-5 ID:SGTC_3127|Compound:9126946|FD-Score:4.93|P-value:3.40E-6 ID:SGTC_3193|Compound:9111931|FD-Score:4.51|P-value:1.90E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-5.46|P-value:4.98E-7 ID:SGTC_3251|Compound:9135047|FD-Score:-4.19|P-value:9.13E-5 ID:SGTC_3264|Compound:9137442|FD-Score:-4.01|P-value:1.71E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.34|P-value:5.30E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:3.77|P-value:2.80E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.47|P-value:2.22E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:3.61|P-value:4.62E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.24|P-value:5.17E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.94|P-value:2.14E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:7.35|P-value:1.13E-11 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.49|P-value:6.80E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:13.70|P-value:6.68E-36 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.32|P-value:1.35E-11 ID:SGTC_310|Compound:1273-0058|FD-Score:17.10|P-value:7.47E-55 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.55|P-value:7.83E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-4.33|P-value:5.44E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:3.39|P-value:9.41E-4 ID:SGTC_394|Compound:menadione|FD-Score:-4.65|P-value:1.61E-5 ID:SGTC_397|Compound:arbidol|FD-Score:3.74|P-value:3.10E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:5.18|P-value:1.14E-6 ID:SGTC_408|Compound:cantharidin|FD-Score:-6.49|P-value:2.91E-9 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:7.84|P-value:4.98E-13 ID:SGTC_431|Compound:k089-0097|FD-Score:-6.53|P-value:2.36E-9 ID:SGTC_432|Compound:NS 1619|FD-Score:4.53|P-value:1.71E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:3.64|P-value:4.17E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:4.14|P-value:7.61E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:4.79|P-value:6.01E-6 ID:SGTC_671|Compound:0560-0003|FD-Score:4.27|P-value:4.68E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:3.71|P-value:3.43E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.87|P-value:1.97E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:4.17|P-value:6.71E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:4.24|P-value:5.24E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:3.85|P-value:2.12E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:4.13|P-value:7.81E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:3.70|P-value:3.44E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.95|P-value:3.06E-6 ID:SGTC_892|Compound:0929-0076|FD-Score:4.86|P-value:4.48E-6 ID:SGTC_899|Compound:1083-0020|FD-Score:4.77|P-value:6.50E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:4.43|P-value:2.54E-5 ID:SGTC_979|Compound:1426-2828|FD-Score:3.50|P-value:6.55E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.89|P-value:4.03E-6 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-3.95|P-value:2.08E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:-3.57|P-value:7.33E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.81|P-value:2.44E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.91|P-value:2.43E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:4.30|P-value:4.13E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:-4.08|P-value:1.32E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:4.61|P-value:1.24E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.50|P-value:8.91E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:4.04|P-value:1.07E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.89|P-value:1.81E-4 ID:SGTC_1614|Compound:st002383|FD-Score:3.47|P-value:7.21E-4 ID:SGTC_1615|Compound:st002656|FD-Score:4.13|P-value:7.80E-5 ID:SGTC_1621|Compound:st003705|FD-Score:4.75|P-value:7.08E-6 ID:SGTC_1623|Compound:st003709|FD-Score:4.11|P-value:8.53E-5 ID:SGTC_1695|Compound:st026914|FD-Score:3.77|P-value:2.78E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-4.10|P-value:1.24E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.40|P-value:4.21E-5 ID:SGTC_1730|Compound:st033808|FD-Score:3.57|P-value:5.33E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-3.62|P-value:6.23E-4 ID:SGTC_1742|Compound:st038235|FD-Score:7.82|P-value:5.66E-13 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.49|P-value:3.00E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.03|P-value:1.11E-4 ID:SGTC_1907|Compound:st060210|FD-Score:7.93|P-value:2.63E-13 ID:SGTC_1911|Compound:st060208|FD-Score:3.81|P-value:2.43E-4 ID:SGTC_1912|Compound:st060209|FD-Score:5.56|P-value:1.93E-7 ID:SGTC_2013|Compound:4024628|FD-Score:-4.18|P-value:9.24E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-5.15|P-value:1.95E-6 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-4.53|P-value:2.58E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.69|P-value:3.64E-4 ID:SGTC_2278|Compound:7948257|FD-Score:3.82|P-value:2.34E-4 ID:SGTC_2361|Compound:9034121|FD-Score:3.94|P-value:1.57E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:4.12|P-value:8.25E-5 ID:SGTC_2560|Compound:caryophyllene|FD-Score:-3.68|P-value:5.14E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.80|P-value:6.02E-8 ID:SGTC_2703|Compound:st077852|FD-Score:-3.96|P-value:2.05E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.57|P-value:7.20E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-7.44|P-value:1.17E-11 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.50|P-value:2.80E-5 ID:SGTC_2812|Compound:7970281|FD-Score:3.43|P-value:8.19E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.69|P-value:3.66E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-5.54|P-value:3.40E-7 ID:SGTC_2916|Compound:7875993|FD-Score:4.09|P-value:9.14E-5 ID:SGTC_2917|Compound:7979103|FD-Score:-3.55|P-value:7.81E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.55|P-value:5.62E-4 ID:SGTC_3000|Compound:9075062|FD-Score:-4.56|P-value:2.24E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.28|P-value:6.55E-5 ID:SGTC_3127|Compound:9126946|FD-Score:4.93|P-value:3.40E-6 ID:SGTC_3193|Compound:9111931|FD-Score:4.51|P-value:1.90E-5 ID:SGTC_3197|Compound:9113331|FD-Score:-5.46|P-value:4.98E-7 ID:SGTC_3251|Compound:9135047|FD-Score:-4.19|P-value:9.13E-5 ID:SGTC_3264|Compound:9137442|FD-Score:-4.01|P-value:1.71E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.34|P-value:5.30E-5

Top fitness defect scores for YPL183W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 17.10 1.1 µM 7.47E-55 mitochondrial stress 2 3.19E-66
2 SGTC_236 1509-0011 13.70 5.3 µM 6.68E-36 125 3.81E-43
3 SGTC_1907 st060210 7.93 83.7 µM 2.63E-13 2 1.07E-15
4 SGTC_415 dibenzyl ketone 7.84 100.0 µM 4.98E-13 1 2.33E-15
5 SGTC_1742 st038235 7.82 28.9 µM 5.66E-13 mitochondrial stress 21 2.72E-15
6 SGTC_173 1273-0061 7.35 2.7 µM 1.13E-11 mitochondrial stress 81 1.03E-13
7 SGTC_275 trichlorophene 7.32 5.7 µM 1.35E-11 mitochondrial stress 89 1.26E-13
8 SGTC_2688 kanamycin b 5.80 96.7 µM 6.02E-8 calcium & mitochondrial duress 166 3.25E-9
9 SGTC_1912 st060209 5.56 90.8 µM 1.93E-7 11 1.33E-8
10 SGTC_404 fumagillin 5.18 50.0 µM 1.14E-6 3 1.12E-7
11 SGTC_832 4083-0019 4.95 164.0 µM 3.06E-6 translation 43 3.69E-7
12 SGTC_3127 9126946 4.93 49.5 µM 3.40E-6 ERG2 6 4.19E-7
13 SGTC_1036 k216-0215 4.89 33.5 µM 4.03E-6 mitochondrial response to ROS 27 5.14E-7
14 SGTC_892 0929-0076 4.86 29.0 µM 4.48E-6 TRP & mitochondrial translation 17 5.83E-7
15 SGTC_614 0462-0418 4.79 107.0 µM 6.01E-6 12 8.31E-7
16 SGTC_899 1083-0020 4.77 478.0 µM 6.50E-6 9 9.14E-7
17 SGTC_1621 st003705 4.75 32.4 µM 7.08E-6 calcium & mitochondrial duress 9 1.01E-6
18 SGTC_1430 4049-0248 4.61 69.1 µM 1.24E-5 9 1.98E-6
19 SGTC_432 NS 1619 4.53 61.3 µM 1.71E-5 16 2.91E-6
20 SGTC_3193 9111931 4.51 49.5 µM 1.90E-5 12 3.32E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.491 7.01E-203 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.467 1.45E-181 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.463 9.22E-178 YDR114C_p YDR114C_p hom Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium
0.462 1.91E-177 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.462 3.36E-177 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.456 3.67E-171 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.455 3.40E-171 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.452 7.02E-169 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.451 5.38E-167 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.448 1.74E-165 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.448 3.94E-165 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.448 3.97E-165 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.446 1.69E-163 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.441 1.21E-159 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.440 1.60E-158 YDR298C ATP5 hom Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated