YPL184C / MRN1

RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL184C / MRN1

Click on Significant Values for Screen Details ID:SGTC_145|Compound:3737-0113|FD-Score:-5.30|P-value:8.83E-8 ID:SGTC_245|Compound:methotrexate|FD-Score:4.51|P-value:4.34E-6 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.10|P-value:2.61E-5 ID:SGTC_284|Compound:0988-0104|FD-Score:3.69|P-value:1.38E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.41|P-value:3.78E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.83|P-value:8.00E-5 ID:SGTC_456|Compound:gingerol|FD-Score:3.81|P-value:8.60E-5 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.91|P-value:5.81E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.56|P-value:2.24E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:-3.83|P-value:8.21E-5 ID:SGTC_580|Compound:1123-0028|FD-Score:3.83|P-value:8.00E-5 ID:SGTC_598|Compound:3937-0236|FD-Score:3.98|P-value:4.37E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:-3.22|P-value:7.60E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.27|P-value:6.34E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:4.16|P-value:2.07E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:3.27|P-value:6.30E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.70|P-value:1.32E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.66|P-value:1.53E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.88|P-value:6.45E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.33|P-value:9.76E-6 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.55|P-value:2.29E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:4.28|P-value:1.20E-5 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:6.55|P-value:5.42E-11 ID:SGTC_1606|Compound:st000094|FD-Score:3.32|P-value:5.23E-4 ID:SGTC_1608|Compound:st001473|FD-Score:4.00|P-value:4.05E-5 ID:SGTC_1697|Compound:st025554|FD-Score:6.23|P-value:4.16E-10 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.20|P-value:8.01E-4 ID:SGTC_1702|Compound:st027038|FD-Score:4.16|P-value:2.03E-5 ID:SGTC_1828|Compound:st055811|FD-Score:3.47|P-value:3.15E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.90|P-value:6.07E-5 ID:SGTC_1866|Compound:st057638|FD-Score:4.02|P-value:3.73E-5 ID:SGTC_1871|Compound:st057448|FD-Score:5.54|P-value:2.30E-8 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.37|P-value:4.37E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.58|P-value:2.03E-4 ID:SGTC_1960|Compound:st011366|FD-Score:-3.37|P-value:4.47E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-4.23|P-value:1.54E-5 ID:SGTC_2023|Compound:5144124|FD-Score:4.84|P-value:9.11E-7 ID:SGTC_2025|Compound:5147754|FD-Score:3.50|P-value:2.77E-4 ID:SGTC_2276|Compound:7947513|FD-Score:-3.49|P-value:2.93E-4 ID:SGTC_2323|Compound:6148992|FD-Score:5.75|P-value:6.98E-9 ID:SGTC_2399|Compound:5884133|FD-Score:-3.32|P-value:5.45E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.15|P-value:9.55E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.98|P-value:4.32E-5 ID:SGTC_2780|Compound:5215298|FD-Score:3.68|P-value:1.44E-4 ID:SGTC_2785|Compound:7756463|FD-Score:5.20|P-value:1.46E-7 ID:SGTC_2788|Compound:5282734|FD-Score:6.26|P-value:3.26E-10 ID:SGTC_2923|Compound:7992654|FD-Score:3.78|P-value:9.54E-5 ID:SGTC_2988|Compound:9073640|FD-Score:-3.62|P-value:1.82E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.83|P-value:7.94E-5 ID:SGTC_2997|Compound:9067075|FD-Score:5.77|P-value:6.30E-9 ID:SGTC_3009|Compound:9080819|FD-Score:3.33|P-value:5.04E-4 ID:SGTC_3011|Compound:9081274|FD-Score:4.21|P-value:1.62E-5 ID:SGTC_3081|Compound:9117243|FD-Score:4.14|P-value:2.23E-5 ID:SGTC_3155|Compound:9099265|FD-Score:-3.33|P-value:5.12E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-6.22|P-value:4.43E-10 ID:SGTC_3251|Compound:9135047|FD-Score:3.65|P-value:1.62E-4 ID:SGTC_3325|Compound:9138760|FD-Score:4.34|P-value:9.27E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:-5.30|P-value:8.83E-8 ID:SGTC_245|Compound:methotrexate|FD-Score:4.51|P-value:4.34E-6 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.10|P-value:2.61E-5 ID:SGTC_284|Compound:0988-0104|FD-Score:3.69|P-value:1.38E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.41|P-value:3.78E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.83|P-value:8.00E-5 ID:SGTC_456|Compound:gingerol|FD-Score:3.81|P-value:8.60E-5 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.91|P-value:5.81E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.56|P-value:2.24E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:-3.83|P-value:8.21E-5 ID:SGTC_580|Compound:1123-0028|FD-Score:3.83|P-value:8.00E-5 ID:SGTC_598|Compound:3937-0236|FD-Score:3.98|P-value:4.37E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:-3.22|P-value:7.60E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.27|P-value:6.34E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:4.16|P-value:2.07E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:3.27|P-value:6.30E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.70|P-value:1.32E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.66|P-value:1.53E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.88|P-value:6.45E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.33|P-value:9.76E-6 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.55|P-value:2.29E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:4.28|P-value:1.20E-5 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:6.55|P-value:5.42E-11 ID:SGTC_1606|Compound:st000094|FD-Score:3.32|P-value:5.23E-4 ID:SGTC_1608|Compound:st001473|FD-Score:4.00|P-value:4.05E-5 ID:SGTC_1697|Compound:st025554|FD-Score:6.23|P-value:4.16E-10 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.20|P-value:8.01E-4 ID:SGTC_1702|Compound:st027038|FD-Score:4.16|P-value:2.03E-5 ID:SGTC_1828|Compound:st055811|FD-Score:3.47|P-value:3.15E-4 ID:SGTC_1835|Compound:st008666|FD-Score:3.90|P-value:6.07E-5 ID:SGTC_1866|Compound:st057638|FD-Score:4.02|P-value:3.73E-5 ID:SGTC_1871|Compound:st057448|FD-Score:5.54|P-value:2.30E-8 ID:SGTC_1872|Compound:amphotericin b|FD-Score:3.37|P-value:4.37E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.58|P-value:2.03E-4 ID:SGTC_1960|Compound:st011366|FD-Score:-3.37|P-value:4.47E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-4.23|P-value:1.54E-5 ID:SGTC_2023|Compound:5144124|FD-Score:4.84|P-value:9.11E-7 ID:SGTC_2025|Compound:5147754|FD-Score:3.50|P-value:2.77E-4 ID:SGTC_2276|Compound:7947513|FD-Score:-3.49|P-value:2.93E-4 ID:SGTC_2323|Compound:6148992|FD-Score:5.75|P-value:6.98E-9 ID:SGTC_2399|Compound:5884133|FD-Score:-3.32|P-value:5.45E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.15|P-value:9.55E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.98|P-value:4.32E-5 ID:SGTC_2780|Compound:5215298|FD-Score:3.68|P-value:1.44E-4 ID:SGTC_2785|Compound:7756463|FD-Score:5.20|P-value:1.46E-7 ID:SGTC_2788|Compound:5282734|FD-Score:6.26|P-value:3.26E-10 ID:SGTC_2923|Compound:7992654|FD-Score:3.78|P-value:9.54E-5 ID:SGTC_2988|Compound:9073640|FD-Score:-3.62|P-value:1.82E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.83|P-value:7.94E-5 ID:SGTC_2997|Compound:9067075|FD-Score:5.77|P-value:6.30E-9 ID:SGTC_3009|Compound:9080819|FD-Score:3.33|P-value:5.04E-4 ID:SGTC_3011|Compound:9081274|FD-Score:4.21|P-value:1.62E-5 ID:SGTC_3081|Compound:9117243|FD-Score:4.14|P-value:2.23E-5 ID:SGTC_3155|Compound:9099265|FD-Score:-3.33|P-value:5.12E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-6.22|P-value:4.43E-10 ID:SGTC_3251|Compound:9135047|FD-Score:3.65|P-value:1.62E-4 ID:SGTC_3325|Compound:9138760|FD-Score:4.34|P-value:9.27E-6

Top fitness defect scores for YPL184C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1539 benzyladenosine 6.55 56.0 µM 5.42E-11 1 2.96E-11
2 SGTC_2788 5282734 6.26 71.4 µM 3.26E-10 9 1.87E-10
3 SGTC_1697 st025554 6.23 27.7 µM 4.16E-10 12 2.40E-10
4 SGTC_2997 9067075 5.77 71.4 µM 6.30E-9 unfolded protein response 22 3.93E-9
5 SGTC_2323 6148992 5.75 148.3 µM 6.98E-9 7 4.36E-9
6 SGTC_1871 st057448 5.54 67.3 µM 2.30E-8 4 1.49E-8
7 SGTC_2785 7756463 5.20 72.7 µM 1.46E-7 8 9.92E-8
8 SGTC_2023 5144124 4.84 124.0 µM 9.11E-7 11 6.53E-7
9 SGTC_245 methotrexate 4.51 289.6 µM 4.34E-6 30 3.24E-6
10 SGTC_3325 9138760 4.34 55.2 µM 9.27E-6 Golgi 19 7.08E-6
11 SGTC_1451 4152-0210 4.33 104.0 µM 9.76E-6 16 7.47E-6
12 SGTC_1534 6-azauridine 4.28 81.6 µM 1.20E-5 RNA pol III & RNase P/MRP 17 9.25E-6
13 SGTC_3011 9081274 4.21 71.4 µM 1.62E-5 10 1.25E-5
14 SGTC_1702 st027038 4.16 51.0 µM 2.03E-5 6 1.59E-5
15 SGTC_875 0709-0210 4.16 25.7 µM 2.07E-5 fatty acid desaturase (OLE1) 27 1.62E-5
16 SGTC_3081 9117243 4.14 49.5 µM 2.23E-5 fatty acid desaturase (OLE1) 17 1.75E-5
17 SGTC_255 tunicamycin 4.10 200.5 nM 2.61E-5 unfolded protein response 67 2.05E-5
18 SGTC_1866 st057638 4.02 64.0 µM 3.73E-5 12 2.96E-5
19 SGTC_1608 st001473 4.00 40.5 µM 4.05E-5 33 3.22E-5
20 SGTC_2430 5571206 3.98 200.0 µM 4.32E-5 54 3.44E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.091 1.45E-7 YER093C-A AIM11 hom Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication
0.086 5.80E-7 YNL209W SSB2 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication
0.085 8.75E-7 YNL110C NOP15 het Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm
0.085 8.66E-7 YJR083C ACF4 hom Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate
0.085 8.75E-7 YEL010W_d YEL010W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082 1.85E-6 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.082 1.93E-6 YHR078W_p YHR078W_p hom High osmolarity-regulated gene of unknown function
0.082 2.13E-6 YER066C-A_d YER066C-A_d hom Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W
0.080 3.51E-6 YNR060W FRE4 hom Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
0.077 7.21E-6 YJR038C_d YJR038C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.073 2.13E-5 YKL160W ELF1 hom Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression
0.071 4.02E-5 YCL050C APA1 hom AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication
0.070 4.52E-5 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.070 4.75E-5 YPL136W_d YPL136W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C
0.070 5.58E-5 YPL137C GIP3 hom Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication