YPL185W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL185W / YPL185W

Click on Significant Values for Screen Details ID:SGTC_669|Compound:0108-0021|FD-Score:-4.95|P-value:4.73E-7 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.74|P-value:1.02E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:3.16|P-value:9.46E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:4.49|P-value:5.07E-6 ID:SGTC_848|Compound:0368-0089|FD-Score:-3.42|P-value:3.45E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:5.15|P-value:2.02E-7 ID:SGTC_978|Compound:1416-0512|FD-Score:4.12|P-value:2.55E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:-3.20|P-value:7.47E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.80|P-value:9.30E-5 ID:SGTC_1217|Compound:1183-1422|FD-Score:-3.51|P-value:2.44E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.69|P-value:1.27E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.35|P-value:5.08E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.77|P-value:1.07E-4 ID:SGTC_1498|Compound:4478-3555|FD-Score:3.61|P-value:1.96E-4 ID:SGTC_1739|Compound:st037196|FD-Score:6.04|P-value:1.38E-9 ID:SGTC_1743|Compound:st037606|FD-Score:-3.94|P-value:4.67E-5 ID:SGTC_1984|Compound:st072354|FD-Score:-3.71|P-value:1.14E-4 ID:SGTC_1993|Compound:st073995|FD-Score:3.30|P-value:5.94E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.58|P-value:2.15E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.24|P-value:7.32E-4 ID:SGTC_2139|Compound:5578692|FD-Score:3.24|P-value:7.40E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.23|P-value:7.68E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.68|P-value:1.28E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.61|P-value:1.71E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.19|P-value:8.59E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.81|P-value:9.04E-5 ID:SGTC_2855|Compound:9016525|FD-Score:-3.29|P-value:5.49E-4 ID:SGTC_2893|Compound:9048488|FD-Score:5.24|P-value:1.25E-7 ID:SGTC_2898|Compound:9056270|FD-Score:-3.80|P-value:8.16E-5 ID:SGTC_2990|Compound:9074105|FD-Score:3.23|P-value:7.71E-4 ID:SGTC_2992|Compound:9074591|FD-Score:3.57|P-value:2.27E-4 ID:SGTC_2997|Compound:9067075|FD-Score:-4.36|P-value:7.56E-6 ID:SGTC_3103|Compound:9120822|FD-Score:3.50|P-value:2.92E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.22|P-value:7.71E-4 ID:SGTC_3264|Compound:9137442|FD-Score:-3.27|P-value:5.85E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.19|P-value:7.77E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-4.95|P-value:4.73E-7 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.74|P-value:1.02E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:3.16|P-value:9.46E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:4.49|P-value:5.07E-6 ID:SGTC_848|Compound:0368-0089|FD-Score:-3.42|P-value:3.45E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:5.15|P-value:2.02E-7 ID:SGTC_978|Compound:1416-0512|FD-Score:4.12|P-value:2.55E-5 ID:SGTC_986|Compound:1493-0483|FD-Score:-3.20|P-value:7.47E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.80|P-value:9.30E-5 ID:SGTC_1217|Compound:1183-1422|FD-Score:-3.51|P-value:2.44E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.69|P-value:1.27E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.35|P-value:5.08E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.77|P-value:1.07E-4 ID:SGTC_1498|Compound:4478-3555|FD-Score:3.61|P-value:1.96E-4 ID:SGTC_1739|Compound:st037196|FD-Score:6.04|P-value:1.38E-9 ID:SGTC_1743|Compound:st037606|FD-Score:-3.94|P-value:4.67E-5 ID:SGTC_1984|Compound:st072354|FD-Score:-3.71|P-value:1.14E-4 ID:SGTC_1993|Compound:st073995|FD-Score:3.30|P-value:5.94E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.58|P-value:2.15E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.24|P-value:7.32E-4 ID:SGTC_2139|Compound:5578692|FD-Score:3.24|P-value:7.40E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.23|P-value:7.68E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.68|P-value:1.28E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.61|P-value:1.71E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.19|P-value:8.59E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.81|P-value:9.04E-5 ID:SGTC_2855|Compound:9016525|FD-Score:-3.29|P-value:5.49E-4 ID:SGTC_2893|Compound:9048488|FD-Score:5.24|P-value:1.25E-7 ID:SGTC_2898|Compound:9056270|FD-Score:-3.80|P-value:8.16E-5 ID:SGTC_2990|Compound:9074105|FD-Score:3.23|P-value:7.71E-4 ID:SGTC_2992|Compound:9074591|FD-Score:3.57|P-value:2.27E-4 ID:SGTC_2997|Compound:9067075|FD-Score:-4.36|P-value:7.56E-6 ID:SGTC_3103|Compound:9120822|FD-Score:3.50|P-value:2.92E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.22|P-value:7.71E-4 ID:SGTC_3264|Compound:9137442|FD-Score:-3.27|P-value:5.85E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.19|P-value:7.77E-4

Top fitness defect scores for YPL185W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1739 st037196 6.04 92.5 µM 1.38E-9 2 7.77E-10
2 SGTC_2893 9048488 5.24 26.0 µM 1.25E-7 fatty acid desaturase (OLE1) 6 7.94E-8
3 SGTC_878 0828-0289 5.15 13.7 µM 2.02E-7 21 1.31E-7
4 SGTC_842 0271-0008 4.49 11.1 µM 5.07E-6 heme biosynthesis & mitochondrial translocase 15 3.59E-6
5 SGTC_978 1416-0512 4.12 87.4 µM 2.55E-5 redox potentiating 27 1.89E-5
6 SGTC_2784 7567673 3.81 72.7 µM 9.04E-5 iron homeostasis 33 6.95E-5
7 SGTC_1214 0358-0031 3.80 63.7 µM 9.30E-5 24 7.15E-5
8 SGTC_1236 0330-0013 3.77 258.0 µM 1.07E-4 13 8.23E-5
9 SGTC_1498 4478-3555 3.61 97.6 µM 1.96E-4 8 1.54E-4
10 SGTC_2005 4024620 3.58 188.0 µM 2.15E-4 32 1.70E-4
11 SGTC_2992 9074591 3.57 71.4 µM 2.27E-4 24 1.79E-4
12 SGTC_3103 9120822 3.50 49.5 µM 2.92E-4 27 2.32E-4
13 SGTC_1228 0124-0032 3.35 52.5 µM 5.08E-4 37 4.10E-4
14 SGTC_1993 st073995 3.30 70.8 µM 5.94E-4 37 4.81E-4
15 SGTC_2018 5133068 3.24 143.0 µM 7.32E-4 55 5.97E-4
16 SGTC_2139 5578692 3.24 56.5 µM 7.40E-4 superoxide 39 6.03E-4
17 SGTC_2410 aloe-emodin-8-o-glycoside 3.23 46.3 µM 7.68E-4 mitochondrial processes 69 6.28E-4
18 SGTC_2990 9074105 3.23 71.4 µM 7.71E-4 26 6.30E-4
19 SGTC_3203 9113543 3.22 49.5 µM 7.71E-4 62 6.30E-4
20 SGTC_2724 maprotiline 3.19 69.6 µM 8.59E-4 ERG2 40 7.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.04E-15 YKL154W SRP102 het Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane
0.116 1.52E-11 YLL030C_d RRT7_d hom Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.112 7.21E-11 YPL091W GLR1 hom Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress
0.106 7.47E-10 YGL262W_p YGL262W_p hom Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene
0.104 1.67E-9 YML064C TEM1 het GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
0.100 6.19E-9 YOL149W DCP1 het Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress
0.095 3.32E-8 YPR082C DIB1 het 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein
0.093 6.06E-8 YAR031W PRM9 hom Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family
0.093 6.49E-8 YMR183C SSO2 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
0.093 7.88E-8 YKL196C YKT6 het Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus
0.090 1.67E-7 YOR219C STE13 hom Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor
0.089 2.40E-7 YLL028W TPO1 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane
0.088 3.08E-7 YOR176W HEM15 het Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway
0.085 7.28E-7 YBL044W_p YBL044W_p hom Putative protein of unknown function; YBL044W is not an essential protein
0.084 1.02E-6 YDL242W_d YDL242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data