YPL186C / UIP4

Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL186C / UIP4

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:-4.03|P-value:1.28E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.60|P-value:5.39E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.49|P-value:8.58E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.78|P-value:3.48E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:3.96|P-value:1.89E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-7.94|P-value:3.40E-13 ID:SGTC_428|Compound:3448-4153|FD-Score:3.53|P-value:7.64E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:4.35|P-value:4.61E-5 ID:SGTC_533|Compound:1222-0222|FD-Score:4.69|P-value:1.24E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:3.75|P-value:3.79E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:4.45|P-value:3.18E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:5.11|P-value:2.18E-6 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.87|P-value:2.52E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.55|P-value:7.24E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.53|P-value:7.62E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:3.73|P-value:4.06E-4 ID:SGTC_1697|Compound:st025554|FD-Score:4.26|P-value:6.44E-5 ID:SGTC_1832|Compound:st054113|FD-Score:-3.96|P-value:1.65E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.48|P-value:9.02E-4 ID:SGTC_2003|Compound:4023581|FD-Score:-3.78|P-value:2.97E-4 ID:SGTC_2105|Compound:5350118|FD-Score:4.43|P-value:3.40E-5 ID:SGTC_2139|Compound:5578692|FD-Score:-3.80|P-value:2.82E-4 ID:SGTC_2479|Compound:5617353|FD-Score:4.17|P-value:9.00E-5 ID:SGTC_2485|Compound:5633444|FD-Score:5.57|P-value:2.76E-7 ID:SGTC_2607|Compound:solasodine|FD-Score:3.90|P-value:2.28E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-4.62|P-value:1.40E-5 ID:SGTC_2692|Compound:st077426|FD-Score:-6.04|P-value:2.25E-8 ID:SGTC_2944|Compound:9067346|FD-Score:-4.72|P-value:9.45E-6 ID:SGTC_2946|Compound:9065502|FD-Score:-4.59|P-value:1.56E-5 ID:SGTC_3190|Compound:9110366|FD-Score:-3.51|P-value:7.15E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:-4.03|P-value:1.28E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.60|P-value:5.39E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.49|P-value:8.58E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.78|P-value:3.48E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:3.96|P-value:1.89E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-7.94|P-value:3.40E-13 ID:SGTC_428|Compound:3448-4153|FD-Score:3.53|P-value:7.64E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:4.35|P-value:4.61E-5 ID:SGTC_533|Compound:1222-0222|FD-Score:4.69|P-value:1.24E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:3.75|P-value:3.79E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:4.45|P-value:3.18E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:5.11|P-value:2.18E-6 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.87|P-value:2.52E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.55|P-value:7.24E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.53|P-value:7.62E-4 ID:SGTC_1478|Compound:0453-0656|FD-Score:3.73|P-value:4.06E-4 ID:SGTC_1697|Compound:st025554|FD-Score:4.26|P-value:6.44E-5 ID:SGTC_1832|Compound:st054113|FD-Score:-3.96|P-value:1.65E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.48|P-value:9.02E-4 ID:SGTC_2003|Compound:4023581|FD-Score:-3.78|P-value:2.97E-4 ID:SGTC_2105|Compound:5350118|FD-Score:4.43|P-value:3.40E-5 ID:SGTC_2139|Compound:5578692|FD-Score:-3.80|P-value:2.82E-4 ID:SGTC_2479|Compound:5617353|FD-Score:4.17|P-value:9.00E-5 ID:SGTC_2485|Compound:5633444|FD-Score:5.57|P-value:2.76E-7 ID:SGTC_2607|Compound:solasodine|FD-Score:3.90|P-value:2.28E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-4.62|P-value:1.40E-5 ID:SGTC_2692|Compound:st077426|FD-Score:-6.04|P-value:2.25E-8 ID:SGTC_2944|Compound:9067346|FD-Score:-4.72|P-value:9.45E-6 ID:SGTC_2946|Compound:9065502|FD-Score:-4.59|P-value:1.56E-5 ID:SGTC_3190|Compound:9110366|FD-Score:-3.51|P-value:7.15E-4

Top fitness defect scores for YPL186C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2485 5633444 5.57 17.8 µM 2.76E-7 redox potentiating 16 1.31E-8
2 SGTC_1034 k072-0165 5.11 12.7 µM 2.18E-6 Golgi 7 1.63E-7
3 SGTC_533 1222-0222 4.69 6.7 µM 1.24E-5 PDR1 16 1.36E-6
4 SGTC_860 0443-0016 4.45 25.1 µM 3.18E-5 20 4.32E-6
5 SGTC_2105 5350118 4.43 200.0 µM 3.40E-5 17 4.69E-6
6 SGTC_496 calpeptin 4.35 138.0 µM 4.61E-5 11 6.81E-6
7 SGTC_1697 st025554 4.26 27.7 µM 6.44E-5 20 1.02E-5
8 SGTC_2479 5617353 4.17 43.9 µM 9.00E-5 32 1.54E-5
9 SGTC_334 1502-1024 3.96 68.5 µM 1.89E-4 13 3.79E-5
10 SGTC_2607 solasodine 3.90 47.4 µM 2.28E-4 61 4.78E-5
11 SGTC_1203 3992-3522 3.87 103.0 µM 2.52E-4 37 5.39E-5
12 SGTC_237 nikkomycin 3.78 200.0 µM 3.48E-4 RSC complex & mRNA processing 17 7.99E-5
13 SGTC_617 3770-0098 3.75 35.0 µM 3.79E-4 exosome 19 8.87E-5
14 SGTC_1478 0453-0656 3.73 35.7 µM 4.06E-4 23 9.64E-5
15 SGTC_1236 0330-0013 3.55 258.0 µM 7.24E-4 26 1.95E-4
16 SGTC_1337 1486-1011 3.53 40.3 µM 7.62E-4 29 2.07E-4
17 SGTC_428 3448-4153 3.53 16.5 µM 7.64E-4 TSC3-RPN4 46 2.08E-4
18 SGTC_166 k072-0058 3.49 166.4 µM 8.58E-4 DNA intercalators 55 2.40E-4
19 SGTC_1934 st074720 3.48 32.6 µM 9.02E-4 77 2.55E-4
20 SGTC_805 3852-0218 3.40 479.0 µM 0.00113 ERAD & cell cycle 91 3.36E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.03E-11 YPR082C DIB1 het 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein
0.106 7.11E-10 YMR181C_p YMR181C_p hom Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); not an essential gene; YMR181C has a paralog, YPL229W, that arose from the whole genome duplication
0.090 1.77E-7 YLR144C ACF2 hom Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress
0.087 4.28E-7 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.086 6.80E-7 YLR143W DPH6 hom Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene
0.085 7.98E-7 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.085 8.97E-7 YDL028C MPS1 het Dual-specificity kinase; required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p
0.079 4.03E-6 YLR354C TAL1 hom Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate
0.079 5.33E-6 YLR152C_p YLR152C_p hom Putative protein of unknown function; YLR152C is not an essential gene
0.078 5.69E-6 YJL196C ELO1 hom Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, FEN1, that arose from the whole genome duplication
0.077 8.94E-6 YOL112W MSB4 hom GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization
0.073 2.07E-5 YGR247W CPD1 hom Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress
0.073 2.61E-5 YGL152C_d YGL152C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W
0.070 5.24E-5 YPL185W_d YPL185W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
0.069 6.45E-5 YGR110W CLD1 hom Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58