YPL188W / POS5

Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL188W / POS5

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.24|P-value:5.70E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:3.58|P-value:1.64E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:3.76|P-value:7.94E-5 ID:SGTC_100|Compound:0086-0128|FD-Score:5.93|P-value:1.28E-9 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-4.07|P-value:2.02E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:3.14|P-value:8.14E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:3.27|P-value:5.16E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:3.75|P-value:8.50E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:3.40|P-value:3.16E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.53|P-value:2.00E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.43|P-value:2.73E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.17|P-value:7.27E-4 ID:SGTC_401|Compound:neomycin|FD-Score:3.40|P-value:3.27E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:4.56|P-value:2.31E-6 ID:SGTC_534|Compound:k292-0788|FD-Score:3.77|P-value:7.75E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:6.86|P-value:2.68E-12 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.30|P-value:4.56E-8 ID:SGTC_570|Compound:0987-0065|FD-Score:-5.83|P-value:2.10E-9 ID:SGTC_572|Compound:0960-0087|FD-Score:-3.41|P-value:2.94E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.23|P-value:5.87E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.95|P-value:3.43E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:3.52|P-value:2.08E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:4.16|P-value:1.50E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:3.83|P-value:5.96E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:5.26|P-value:6.50E-8 ID:SGTC_931|Compound:2812-0076|FD-Score:3.34|P-value:4.00E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:4.69|P-value:1.24E-6 ID:SGTC_967|Compound:1306-0166|FD-Score:3.60|P-value:1.50E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.29|P-value:4.77E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.14|P-value:8.19E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:4.43|P-value:4.33E-6 ID:SGTC_1150|Compound:3909-7983|FD-Score:4.89|P-value:4.48E-7 ID:SGTC_1267|Compound:0828-0272|FD-Score:4.27|P-value:9.21E-6 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.16|P-value:7.62E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.44|P-value:2.80E-4 ID:SGTC_1682|Compound:st012968|FD-Score:5.85|P-value:2.05E-9 ID:SGTC_1763|Compound:st044482|FD-Score:3.56|P-value:1.75E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.58|P-value:1.56E-4 ID:SGTC_1871|Compound:st057448|FD-Score:4.84|P-value:5.92E-7 ID:SGTC_1914|Compound:st062367|FD-Score:3.62|P-value:1.40E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.34|P-value:6.44E-6 ID:SGTC_2022|Compound:5136654|FD-Score:6.25|P-value:1.67E-10 ID:SGTC_2137|Compound:5261020|FD-Score:3.61|P-value:1.47E-4 ID:SGTC_2208|Compound:7283366|FD-Score:3.67|P-value:1.13E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.28|P-value:5.04E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.59|P-value:1.57E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.49|P-value:2.27E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.07|P-value:9.79E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:6.56|P-value:2.14E-11 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.32|P-value:4.38E-4 ID:SGTC_2681|Compound:menadione|FD-Score:5.00|P-value:2.59E-7 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.37|P-value:3.62E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.61|P-value:1.43E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.44|P-value:2.80E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.17|P-value:7.30E-4 ID:SGTC_2816|Compound:7982706|FD-Score:5.28|P-value:5.77E-8 ID:SGTC_2876|Compound:9059903|FD-Score:-4.00|P-value:2.76E-5 ID:SGTC_2966|Compound:9084041|FD-Score:3.46|P-value:2.56E-4 ID:SGTC_3113|Compound:9123498|FD-Score:3.66|P-value:1.17E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.41|P-value:3.08E-4 ID:SGTC_3211|Compound:9128781|FD-Score:5.58|P-value:1.02E-8 ID:SGTC_3330|Compound:9141424|FD-Score:-3.25|P-value:5.31E-4 ID:SGTC_3331|Compound:9141060|FD-Score:3.35|P-value:3.83E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.24|P-value:5.70E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:3.58|P-value:1.64E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:3.76|P-value:7.94E-5 ID:SGTC_100|Compound:0086-0128|FD-Score:5.93|P-value:1.28E-9 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:-4.07|P-value:2.02E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:3.14|P-value:8.14E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:3.27|P-value:5.16E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:3.75|P-value:8.50E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:3.40|P-value:3.16E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.53|P-value:2.00E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.43|P-value:2.73E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.17|P-value:7.27E-4 ID:SGTC_401|Compound:neomycin|FD-Score:3.40|P-value:3.27E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:4.56|P-value:2.31E-6 ID:SGTC_534|Compound:k292-0788|FD-Score:3.77|P-value:7.75E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:6.86|P-value:2.68E-12 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.30|P-value:4.56E-8 ID:SGTC_570|Compound:0987-0065|FD-Score:-5.83|P-value:2.10E-9 ID:SGTC_572|Compound:0960-0087|FD-Score:-3.41|P-value:2.94E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.23|P-value:5.87E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.95|P-value:3.43E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:3.52|P-value:2.08E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:4.16|P-value:1.50E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:3.83|P-value:5.96E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:5.26|P-value:6.50E-8 ID:SGTC_931|Compound:2812-0076|FD-Score:3.34|P-value:4.00E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:4.69|P-value:1.24E-6 ID:SGTC_967|Compound:1306-0166|FD-Score:3.60|P-value:1.50E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.29|P-value:4.77E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.14|P-value:8.19E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:4.43|P-value:4.33E-6 ID:SGTC_1150|Compound:3909-7983|FD-Score:4.89|P-value:4.48E-7 ID:SGTC_1267|Compound:0828-0272|FD-Score:4.27|P-value:9.21E-6 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.16|P-value:7.62E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.44|P-value:2.80E-4 ID:SGTC_1682|Compound:st012968|FD-Score:5.85|P-value:2.05E-9 ID:SGTC_1763|Compound:st044482|FD-Score:3.56|P-value:1.75E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.58|P-value:1.56E-4 ID:SGTC_1871|Compound:st057448|FD-Score:4.84|P-value:5.92E-7 ID:SGTC_1914|Compound:st062367|FD-Score:3.62|P-value:1.40E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.34|P-value:6.44E-6 ID:SGTC_2022|Compound:5136654|FD-Score:6.25|P-value:1.67E-10 ID:SGTC_2137|Compound:5261020|FD-Score:3.61|P-value:1.47E-4 ID:SGTC_2208|Compound:7283366|FD-Score:3.67|P-value:1.13E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.28|P-value:5.04E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.59|P-value:1.57E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.49|P-value:2.27E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.07|P-value:9.79E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:6.56|P-value:2.14E-11 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.32|P-value:4.38E-4 ID:SGTC_2681|Compound:menadione|FD-Score:5.00|P-value:2.59E-7 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.37|P-value:3.62E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.61|P-value:1.43E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.44|P-value:2.80E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:3.17|P-value:7.30E-4 ID:SGTC_2816|Compound:7982706|FD-Score:5.28|P-value:5.77E-8 ID:SGTC_2876|Compound:9059903|FD-Score:-4.00|P-value:2.76E-5 ID:SGTC_2966|Compound:9084041|FD-Score:3.46|P-value:2.56E-4 ID:SGTC_3113|Compound:9123498|FD-Score:3.66|P-value:1.17E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.41|P-value:3.08E-4 ID:SGTC_3211|Compound:9128781|FD-Score:5.58|P-value:1.02E-8 ID:SGTC_3330|Compound:9141424|FD-Score:-3.25|P-value:5.31E-4 ID:SGTC_3331|Compound:9141060|FD-Score:3.35|P-value:3.83E-4

Top fitness defect scores for YPL188W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_535 2293-4129 6.86 48.2 µM 2.68E-12 NEO1 21 3.40E-12
2 SGTC_2617 dihydrotanshinone i 6.56 20.8 µM 2.14E-11 copper-dependent oxidative stress 11 2.65E-11
3 SGTC_2022 5136654 6.25 200.0 µM 1.67E-10 6 2.03E-10
4 SGTC_100 0086-0128 5.93 49.6 µM 1.28E-9 copper-dependent oxidative stress 15 1.52E-9
5 SGTC_1682 st012968 5.85 530.0 nM 2.05E-9 2 2.42E-9
6 SGTC_3211 9128781 5.58 49.5 µM 1.02E-8 23 1.19E-8
7 SGTC_2816 7982706 5.28 58.4 µM 5.77E-8 azole & statin 25 6.58E-8
8 SGTC_923 1900-2434 5.26 73.3 µM 6.50E-8 RNA processing & uracil transport 12 7.40E-8
9 SGTC_2681 menadione 5.00 3.2 µM 2.59E-7 superoxide 19 2.90E-7
10 SGTC_1150 3909-7983 4.89 10.9 µM 4.48E-7 8 5.00E-7
11 SGTC_1871 st057448 4.84 67.3 µM 5.92E-7 7 6.59E-7
12 SGTC_953 1188-0045 4.69 9.7 µM 1.24E-6 60S ribosome export 12 1.37E-6
13 SGTC_530 4358-1714 4.56 28.0 µM 2.31E-6 28 2.54E-6
14 SGTC_1015 4130-4525 4.43 82.0 µM 4.33E-6 60S ribosome export 12 4.73E-6
15 SGTC_2016 5121758 4.34 140.0 µM 6.44E-6 redox potentiating 38 7.00E-6
16 SGTC_1267 0828-0272 4.27 9.5 µM 9.21E-6 16 9.97E-6
17 SGTC_695 3505-6186 4.16 243.0 µM 1.50E-5 21 1.61E-5
18 SGTC_751 0833-0568 3.83 350.0 µM 5.96E-5 24 6.34E-5
19 SGTC_534 k292-0788 3.77 63.4 µM 7.75E-5 mitochondrial processes 31 8.22E-5
20 SGTC_55 0767-0285 3.76 6.6 µM 7.94E-5 46 8.42E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.145 2.56E-17 YHR008C SOD2 hom Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
0.125 4.17E-13 YNL241C ZWF1 hom Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress
0.124 5.16E-13 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.111 1.09E-10 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.107 5.29E-10 YJR104C SOD1 hom Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid
0.101 4.84E-9 YBR163W EXO5 hom Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2
0.100 7.76E-9 YJR122W IBA57 hom Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system
0.098 1.25E-8 YMR021C MAC1 hom Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
0.095 3.03E-8 YCL052C PBN1 het Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X
0.095 3.58E-8 YPR123C_d YPR123C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR
0.094 4.31E-8 YHR035W_p YHR035W_p hom Putative protein of unknown function; not an essential gene
0.094 5.35E-8 YML007W YAP1 hom Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.093 6.65E-8 YLR044C PDC1 hom Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism
0.089 2.25E-7 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
0.087 4.45E-7 YPL097W MSY1 hom Mitochondrial tyrosyl-tRNA synthetase