YPL189W / GUP2

Probable membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; Gup1p homolog

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL189W / GUP2

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-2.84|P-value:5.19E-4 ID:SGTC_57|Compound:miconazole|FD-Score:2.71|P-value:5.83E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:-2.86|P-value:4.82E-4 ID:SGTC_229|Compound:benomyl|FD-Score:2.82|P-value:3.75E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:3.03|P-value:1.44E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:-2.87|P-value:4.67E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.18|P-value:1.22E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:2.94|P-value:2.16E-4 ID:SGTC_499|Compound:genistein|FD-Score:3.51|P-value:1.45E-5 ID:SGTC_512|Compound:prima-1|FD-Score:4.76|P-value:7.64E-9 ID:SGTC_547|Compound:1120-0019|FD-Score:2.97|P-value:1.88E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.03|P-value:2.34E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.89|P-value:1.80E-6 ID:SGTC_602|Compound:3130-1533|FD-Score:2.76|P-value:4.82E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:2.80|P-value:3.98E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.47|P-value:3.01E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:3.31|P-value:3.94E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.06|P-value:2.07E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.39|P-value:2.69E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:3.16|P-value:8.01E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:-3.41|P-value:3.91E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:3.86|P-value:2.16E-6 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.22|P-value:9.67E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:2.90|P-value:2.59E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.85|P-value:2.29E-6 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.58|P-value:1.70E-5 ID:SGTC_981|Compound:1488-1094|FD-Score:-2.92|P-value:3.83E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.30|P-value:6.92E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:2.80|P-value:4.01E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.89|P-value:3.20E-6 ID:SGTC_1271|Compound:0832-2808|FD-Score:2.58|P-value:9.77E-4 ID:SGTC_1614|Compound:st002383|FD-Score:-2.69|P-value:9.56E-4 ID:SGTC_1839|Compound:st053978|FD-Score:-3.32|P-value:6.22E-5 ID:SGTC_2052|Compound:5265182|FD-Score:3.09|P-value:1.11E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.96|P-value:1.21E-6 ID:SGTC_2338|Compound:7999974|FD-Score:2.61|P-value:8.82E-4 ID:SGTC_2358|Compound:9037157|FD-Score:2.71|P-value:5.78E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.25|P-value:2.17E-7 ID:SGTC_2782|Compound:7736369|FD-Score:-2.88|P-value:4.45E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.77|P-value:6.25E-6 ID:SGTC_2848|Compound:9016370|FD-Score:-4.67|P-value:2.90E-8 ID:SGTC_2854|Compound:9024559|FD-Score:3.97|P-value:1.12E-6 ID:SGTC_2855|Compound:9016525|FD-Score:-4.19|P-value:5.90E-7 ID:SGTC_2922|Compound:7999257|FD-Score:-2.83|P-value:5.45E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-2.82|P-value:5.68E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.43|P-value:2.12E-5 ID:SGTC_3136|Compound:9095672|FD-Score:3.70|P-value:5.13E-6 ID:SGTC_3316|Compound:9136639|FD-Score:2.75|P-value:5.04E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-2.84|P-value:5.19E-4 ID:SGTC_57|Compound:miconazole|FD-Score:2.71|P-value:5.83E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:-2.86|P-value:4.82E-4 ID:SGTC_229|Compound:benomyl|FD-Score:2.82|P-value:3.75E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:3.03|P-value:1.44E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:-2.87|P-value:4.67E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.18|P-value:1.22E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:2.94|P-value:2.16E-4 ID:SGTC_499|Compound:genistein|FD-Score:3.51|P-value:1.45E-5 ID:SGTC_512|Compound:prima-1|FD-Score:4.76|P-value:7.64E-9 ID:SGTC_547|Compound:1120-0019|FD-Score:2.97|P-value:1.88E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.03|P-value:2.34E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.89|P-value:1.80E-6 ID:SGTC_602|Compound:3130-1533|FD-Score:2.76|P-value:4.82E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:2.80|P-value:3.98E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.47|P-value:3.01E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:3.31|P-value:3.94E-5 ID:SGTC_691|Compound:1548-0686|FD-Score:-3.06|P-value:2.07E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.39|P-value:2.69E-5 ID:SGTC_697|Compound:0508-1955|FD-Score:3.16|P-value:8.01E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:-3.41|P-value:3.91E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:3.86|P-value:2.16E-6 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.22|P-value:9.67E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:2.90|P-value:2.59E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.85|P-value:2.29E-6 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.58|P-value:1.70E-5 ID:SGTC_981|Compound:1488-1094|FD-Score:-2.92|P-value:3.83E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.30|P-value:6.92E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:2.80|P-value:4.01E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.89|P-value:3.20E-6 ID:SGTC_1271|Compound:0832-2808|FD-Score:2.58|P-value:9.77E-4 ID:SGTC_1614|Compound:st002383|FD-Score:-2.69|P-value:9.56E-4 ID:SGTC_1839|Compound:st053978|FD-Score:-3.32|P-value:6.22E-5 ID:SGTC_2052|Compound:5265182|FD-Score:3.09|P-value:1.11E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.96|P-value:1.21E-6 ID:SGTC_2338|Compound:7999974|FD-Score:2.61|P-value:8.82E-4 ID:SGTC_2358|Compound:9037157|FD-Score:2.71|P-value:5.78E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.25|P-value:2.17E-7 ID:SGTC_2782|Compound:7736369|FD-Score:-2.88|P-value:4.45E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.77|P-value:6.25E-6 ID:SGTC_2848|Compound:9016370|FD-Score:-4.67|P-value:2.90E-8 ID:SGTC_2854|Compound:9024559|FD-Score:3.97|P-value:1.12E-6 ID:SGTC_2855|Compound:9016525|FD-Score:-4.19|P-value:5.90E-7 ID:SGTC_2922|Compound:7999257|FD-Score:-2.83|P-value:5.45E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-2.82|P-value:5.68E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.43|P-value:2.12E-5 ID:SGTC_3136|Compound:9095672|FD-Score:3.70|P-value:5.13E-6 ID:SGTC_3316|Compound:9136639|FD-Score:2.75|P-value:5.04E-4

Top fitness defect scores for YPL189W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_512 prima-1 4.76 270.0 µM 7.64E-9 DNA intercalators 12 9.51E-7
2 SGTC_2420 aureobasidin a 4.25 50.0 nM 2.17E-7 32 1.08E-5
3 SGTC_2854 9024559 3.97 71.4 µM 1.12E-6 19 3.53E-5
4 SGTC_2056 5235370 3.96 200.0 µM 1.21E-6 39 3.74E-5
5 SGTC_562 3772-2733 3.89 112.0 µM 1.80E-6 ERG2 81 5.00E-5
6 SGTC_739 1486-1183 3.86 203.0 µM 2.16E-6 19 5.70E-5
7 SGTC_910 3454-3003 3.85 490.0 µM 2.29E-6 17 5.94E-5
8 SGTC_3136 9095672 3.70 49.5 µM 5.13E-6 30 1.07E-4
9 SGTC_499 genistein 3.51 192.0 µM 1.45E-5 5 2.27E-4
10 SGTC_2967 9089538 3.43 49.9 µM 2.12E-5 53 2.99E-4
11 SGTC_696 1560-0013 3.39 611.0 µM 2.69E-5 42 3.56E-4
12 SGTC_676 falcarinol 3.31 140.0 µM 3.94E-5 78 4.70E-4
13 SGTC_697 0508-1955 3.16 564.0 µM 8.01E-5 70 7.88E-4
14 SGTC_2052 5265182 3.09 7.1 µM 1.11E-4 68 0.00100
15 SGTC_279 1273-0055 3.03 2.9 µM 1.44E-4 azole & statin 77 0.00121
16 SGTC_547 1120-0019 2.97 610.0 nM 1.88E-4 azole & statin 72 0.00147
17 SGTC_496 calpeptin 2.94 138.0 µM 2.16E-4 56 0.00162
18 SGTC_822 1487-0950 2.90 154.0 µM 2.59E-4 54 0.00185
19 SGTC_229 benomyl 2.82 22.9 µM 3.75E-4 tubulin folding & SWR complex 75 0.00243
20 SGTC_627 1391-0720 2.80 175.0 µM 3.98E-4 61 0.00253

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.61E-13 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.112 8.12E-11 YKL207W EMC3 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111
0.107 4.92E-10 YNL006W LST8 het Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat
0.105 9.68E-10 YLL014W EMC6 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93
0.090 1.54E-7 YEL025C_p YEL025C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.090 2.05E-7 YKL105C SEG2 hom Eisosome component and paralog of Seg1p; likely plays only minor role in eisosome assembly; shown to interact with Seg1p; similar to A. gossypii SEG gene which is important for stabilizing eisosomes
0.089 2.54E-7 YHR022C-A_p YHR022C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.088 2.91E-7 YLL023C POM33 hom Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress
0.088 3.25E-7 YFR033C QCR6 hom Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space
0.088 3.37E-7 YOL075C_p YOL075C_p hom Putative ABC transporter
0.086 6.97E-7 YJR153W PGU1 hom Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins
0.085 8.07E-7 YKL189W HYM1 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
0.085 8.62E-7 YMR007W_d YMR007W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.084 1.11E-6 YBR294W SUL1 hom High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
0.084 1.10E-6 YER092W IES5 hom Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions