YPL190C / NAB3

RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL190C / NAB3

Click on Significant Values for Screen Details ID:SGTC_425|Compound:3825-7017|FD-Score:3.83|P-value:2.70E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:7.18|P-value:1.88E-14 ID:SGTC_593|Compound:1203-0218|FD-Score:3.41|P-value:1.62E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:2.94|P-value:9.57E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.19|P-value:3.79E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:2.96|P-value:9.04E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.66|P-value:5.89E-5 ID:SGTC_1716|Compound:st033144|FD-Score:3.74|P-value:3.97E-5 ID:SGTC_1747|Compound:st037496|FD-Score:3.82|P-value:2.88E-5 ID:SGTC_1763|Compound:st044482|FD-Score:-3.97|P-value:1.49E-5 ID:SGTC_1853|Compound:st056710|FD-Score:3.05|P-value:6.42E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.06|P-value:6.19E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.48|P-value:1.23E-4 ID:SGTC_2022|Compound:5136654|FD-Score:4.16|P-value:5.92E-6 ID:SGTC_2087|Compound:5276107|FD-Score:3.79|P-value:3.17E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:2.98|P-value:8.43E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.07|P-value:6.13E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.36|P-value:2.02E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-4.61|P-value:6.06E-7 ID:SGTC_2868|Compound:9035608|FD-Score:-3.17|P-value:4.31E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.07|P-value:6.11E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-2.94|P-value:9.80E-4 ID:SGTC_2990|Compound:9074105|FD-Score:3.87|P-value:2.30E-5 ID:SGTC_2992|Compound:9074591|FD-Score:3.49|P-value:1.17E-4 ID:SGTC_2998|Compound:9066762|FD-Score:7.04|P-value:5.84E-14 ID:SGTC_3139|Compound:9095020|FD-Score:-3.24|P-value:3.32E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-4.19|P-value:5.22E-6 ID:SGTC_3215|Compound:9129942|FD-Score:-3.34|P-value:2.16E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.35|P-value:2.10E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.83|P-value:2.70E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:7.18|P-value:1.88E-14 ID:SGTC_593|Compound:1203-0218|FD-Score:3.41|P-value:1.62E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:2.94|P-value:9.57E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.19|P-value:3.79E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:2.96|P-value:9.04E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.66|P-value:5.89E-5 ID:SGTC_1716|Compound:st033144|FD-Score:3.74|P-value:3.97E-5 ID:SGTC_1747|Compound:st037496|FD-Score:3.82|P-value:2.88E-5 ID:SGTC_1763|Compound:st044482|FD-Score:-3.97|P-value:1.49E-5 ID:SGTC_1853|Compound:st056710|FD-Score:3.05|P-value:6.42E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.06|P-value:6.19E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.48|P-value:1.23E-4 ID:SGTC_2022|Compound:5136654|FD-Score:4.16|P-value:5.92E-6 ID:SGTC_2087|Compound:5276107|FD-Score:3.79|P-value:3.17E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:2.98|P-value:8.43E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.07|P-value:6.13E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.36|P-value:2.02E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-4.61|P-value:6.06E-7 ID:SGTC_2868|Compound:9035608|FD-Score:-3.17|P-value:4.31E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.07|P-value:6.11E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-2.94|P-value:9.80E-4 ID:SGTC_2990|Compound:9074105|FD-Score:3.87|P-value:2.30E-5 ID:SGTC_2992|Compound:9074591|FD-Score:3.49|P-value:1.17E-4 ID:SGTC_2998|Compound:9066762|FD-Score:7.04|P-value:5.84E-14 ID:SGTC_3139|Compound:9095020|FD-Score:-3.24|P-value:3.32E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-4.19|P-value:5.22E-6 ID:SGTC_3215|Compound:9129942|FD-Score:-3.34|P-value:2.16E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.35|P-value:2.10E-4

Top fitness defect scores for YPL190C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_429 1112-0049 7.18 25.5 µM 1.88E-14 DNA damage response 2 3.39E-13 2.04
2 SGTC_2998 9066762 7.04 71.4 µM 5.84E-14 RPP1 & pyrimidine depletion 2 9.43E-13 1.06
3 SGTC_2022 5136654 4.16 200.0 µM 5.92E-6 3 1.62E-5 0.00
4 SGTC_2990 9074105 3.87 71.4 µM 2.30E-5 5 5.53E-5 0.30
5 SGTC_425 3825-7017 3.83 13.1 µM 2.70E-5 9 6.38E-5 0.07
6 SGTC_1747 st037496 3.82 66.6 µM 2.88E-5 8 6.77E-5 0.03
7 SGTC_2087 5276107 3.79 200.0 µM 3.17E-5 7 7.39E-5 0.19
8 SGTC_1716 st033144 3.74 30.6 µM 3.97E-5 8 9.05E-5 0.19
9 SGTC_2992 9074591 3.49 71.4 µM 1.17E-4 6 2.42E-4 0.17
10 SGTC_593 1203-0218 3.41 61.7 µM 1.62E-4 7 3.24E-4 0.03
11 SGTC_631 k072-0230 3.19 41.5 µM 3.79E-4 60S ribosome export 12 7.00E-4 0.17
12 SGTC_2894 9048625 3.07 32.5 µM 6.11E-4 20 0.00108 0.07
13 SGTC_1911 st060208 3.06 74.3 µM 6.19E-4 15 0.00109 0.14
14 SGTC_1853 st056710 3.05 91.2 µM 6.42E-4 amide catabolism 15 0.00113 0.15
15 SGTC_2520 obtusaquinone 2.98 4.7 µM 8.43E-4 17 0.00145 0.07
16 SGTC_829 1635-0120 2.96 117.0 µM 9.04E-4 DNA damage response 68 0.00154 0.05
17 SGTC_623 k072-0108 2.94 16.9 µM 9.57E-4 heme biosynthesis & mitochondrial translocase 30 0.00162 0.00
18 SGTC_431 k089-0097 2.92 107.0 µM 0.00104 iron homeostasis 30 0.00175 0.08
19 SGTC_2612 dictamnine 2.85 15.5 µM 0.00131 RNA pol III & RNase P/MRP 51 0.00216 0.02
20 SGTC_3035 9091303 2.83 49.5 µM 0.00141 7 0.00231 0.20

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.149 4.59E-18 YKL154W SRP102 het Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane
0.125 4.45E-13 YOR227W HER1 hom Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication
0.120 3.19E-12 YPL147W PXA1 hom Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder
0.120 3.19E-12 YDL236W PHO13 hom Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity
0.118 7.09E-12 YGL087C MMS2 hom Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress
0.116 1.46E-11 YJL217W REE1 hom Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle
0.112 7.84E-11 YJR022W LSM8 het Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA
0.111 1.28E-10 YGR152C RSR1 hom GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases
0.110 1.46E-10 YLR126C YLR126C hom Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.108 2.96E-10 YDR004W RAD57 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
0.108 3.33E-10 YDR091C RLI1 het Essential iron-sulfur protein required for ribosome biogenesis and translation initiation and termination; facilitates binding of a multifactor complex (MFC) of initiation factors to the small ribosomal subunit; predicted ABC family ATPase; forms a complex with Lto1p and Yae1p that may be involved in protection of the ribosome from damage due to reactive oxygen species
0.108 3.73E-10 YDR057W YOS9 hom ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family
0.104 1.49E-9 YMR119W-A_d YMR119W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.097 2.06E-8 YPR083W MDM36 hom Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission
0.095 3.94E-8 YDR206W EBS1 hom Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors