YPL191C_p

Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL191C / YPL191C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.07|P-value:1.42E-5 ID:SGTC_248|Compound:streptozotocin|FD-Score:4.08|P-value:1.38E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:3.93|P-value:2.67E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:4.28|P-value:5.56E-6 ID:SGTC_821|Compound:1114-0266|FD-Score:3.65|P-value:8.88E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.01|P-value:9.90E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:3.49|P-value:1.64E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.09|P-value:7.37E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:4.17|P-value:9.01E-6 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.28|P-value:3.74E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:3.91|P-value:2.90E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:4.96|P-value:1.75E-7 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.57|P-value:1.24E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:5.33|P-value:2.21E-8 ID:SGTC_1347|Compound:1493-0251|FD-Score:5.63|P-value:3.64E-9 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.46|P-value:1.93E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.36|P-value:2.80E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:4.00|P-value:1.94E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.15|P-value:6.05E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.24|P-value:4.29E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.14|P-value:6.21E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.43|P-value:2.11E-4 ID:SGTC_1940|Compound:st075990|FD-Score:4.73|P-value:5.77E-7 ID:SGTC_2058|Compound:5236698|FD-Score:5.51|P-value:7.40E-9 ID:SGTC_2067|Compound:5224629|FD-Score:3.54|P-value:1.36E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-3.96|P-value:2.37E-5 ID:SGTC_2202|Compound:7226349|FD-Score:3.69|P-value:7.42E-5 ID:SGTC_2207|Compound:7258803|FD-Score:-3.64|P-value:9.30E-5 ID:SGTC_2213|Compound:7173844|FD-Score:-3.23|P-value:4.51E-4 ID:SGTC_2215|Compound:7188065|FD-Score:-3.70|P-value:7.21E-5 ID:SGTC_2444|Compound:5485484|FD-Score:-4.33|P-value:4.44E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.11|P-value:6.87E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:5.83|P-value:1.05E-9 ID:SGTC_2786|Compound:7743617|FD-Score:3.58|P-value:1.18E-4 ID:SGTC_2822|Compound:7994718|FD-Score:6.51|P-value:1.10E-11 ID:SGTC_2862|Compound:9027634|FD-Score:-5.23|P-value:3.95E-8 ID:SGTC_2875|Compound:9039966|FD-Score:3.18|P-value:5.42E-4 ID:SGTC_2953|Compound:9074162|FD-Score:-3.22|P-value:4.79E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-4.16|P-value:9.47E-6 ID:SGTC_3343|Compound:9148379|FD-Score:4.74|P-value:5.59E-7 ID:SGTC_6|Compound:0844-0013|FD-Score:4.07|P-value:1.42E-5 ID:SGTC_248|Compound:streptozotocin|FD-Score:4.08|P-value:1.38E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:3.93|P-value:2.67E-5 ID:SGTC_557|Compound:1315-0110|FD-Score:4.28|P-value:5.56E-6 ID:SGTC_821|Compound:1114-0266|FD-Score:3.65|P-value:8.88E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.01|P-value:9.90E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:3.49|P-value:1.64E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.09|P-value:7.37E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:4.17|P-value:9.01E-6 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.28|P-value:3.74E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:3.91|P-value:2.90E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:4.96|P-value:1.75E-7 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.57|P-value:1.24E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:5.33|P-value:2.21E-8 ID:SGTC_1347|Compound:1493-0251|FD-Score:5.63|P-value:3.64E-9 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.46|P-value:1.93E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.36|P-value:2.80E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:4.00|P-value:1.94E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.15|P-value:6.05E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.24|P-value:4.29E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.14|P-value:6.21E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.43|P-value:2.11E-4 ID:SGTC_1940|Compound:st075990|FD-Score:4.73|P-value:5.77E-7 ID:SGTC_2058|Compound:5236698|FD-Score:5.51|P-value:7.40E-9 ID:SGTC_2067|Compound:5224629|FD-Score:3.54|P-value:1.36E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-3.96|P-value:2.37E-5 ID:SGTC_2202|Compound:7226349|FD-Score:3.69|P-value:7.42E-5 ID:SGTC_2207|Compound:7258803|FD-Score:-3.64|P-value:9.30E-5 ID:SGTC_2213|Compound:7173844|FD-Score:-3.23|P-value:4.51E-4 ID:SGTC_2215|Compound:7188065|FD-Score:-3.70|P-value:7.21E-5 ID:SGTC_2444|Compound:5485484|FD-Score:-4.33|P-value:4.44E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.11|P-value:6.87E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:5.83|P-value:1.05E-9 ID:SGTC_2786|Compound:7743617|FD-Score:3.58|P-value:1.18E-4 ID:SGTC_2822|Compound:7994718|FD-Score:6.51|P-value:1.10E-11 ID:SGTC_2862|Compound:9027634|FD-Score:-5.23|P-value:3.95E-8 ID:SGTC_2875|Compound:9039966|FD-Score:3.18|P-value:5.42E-4 ID:SGTC_2953|Compound:9074162|FD-Score:-3.22|P-value:4.79E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-4.16|P-value:9.47E-6 ID:SGTC_3343|Compound:9148379|FD-Score:4.74|P-value:5.59E-7

Top fitness defect scores for YPL191C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2822 7994718 6.51 71.4 µM 1.10E-11 4 3.69E-11
2 SGTC_2507 purpurin 5.83 79.7 µM 1.05E-9 copper-dependent oxidative stress 13 2.78E-9
3 SGTC_1347 1493-0251 5.63 600.0 nM 3.64E-9 mitochondrial response to ROS 3 9.06E-9
4 SGTC_2058 5236698 5.51 133.0 µM 7.40E-9 11 1.78E-8
5 SGTC_1264 0783-0040 5.33 158.0 µM 2.21E-8 6 5.01E-8
6 SGTC_1120 ficusin 4.96 1.8 µM 1.75E-7 8 3.57E-7
7 SGTC_3343 9148379 4.74 19.0 µM 5.59E-7 3 1.08E-6
8 SGTC_1940 st075990 4.73 51.1 µM 5.77E-7 60S ribosome export 7 1.11E-6
9 SGTC_557 1315-0110 4.28 16.2 µM 5.56E-6 Golgi 17 9.53E-6
10 SGTC_934 2950-0684 4.17 338.0 µM 9.01E-6 17 1.51E-5
11 SGTC_248 streptozotocin 4.08 5.2 mM 1.38E-5 DNA damage response 24 2.25E-5
12 SGTC_6 0844-0013 4.07 19.8 µM 1.42E-5 77 2.31E-5
13 SGTC_1467 k284-1082 4.00 293.0 µM 1.94E-5 15 3.12E-5
14 SGTC_427 1354-0053 3.93 47.3 µM 2.67E-5 21 4.22E-5
15 SGTC_949 1165-0505 3.91 146.0 µM 2.90E-5 20 4.58E-5
16 SGTC_2202 7226349 3.69 200.0 µM 7.42E-5 13 1.11E-4
17 SGTC_821 1114-0266 3.65 29.2 µM 8.88E-5 27 1.32E-4
18 SGTC_2786 7743617 3.58 45.5 µM 1.18E-4 41 1.73E-4
19 SGTC_1147 3809-1045 3.57 12.3 µM 1.24E-4 35 1.82E-4
20 SGTC_2067 5224629 3.54 34.1 µM 1.36E-4 34 1.99E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 4.34E-13 YNL176C_p TDA7_p hom Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele
0.105 1.01E-9 YHR021W-A_p ECM12_p hom Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
0.101 4.31E-9 YPR008W HAA1 hom Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress
0.101 4.82E-9 YDR068W DOS2 hom Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.100 5.67E-9 YNL094W APP1 hom Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway
0.097 1.83E-8 YOR233W KIN4 hom Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication
0.092 8.85E-8 YKR009C FOX2 hom Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
0.089 2.11E-7 YER068C-A_d YER068C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.089 2.10E-7 YHL002W HSE1 hom Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
0.089 2.15E-7 YPL258C THI21 hom Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p
0.087 4.10E-7 YOL073C YOL073C hom Subunit of the DSC ubiquitin ligase complex; ortholog of fission yeast dsc2
0.087 4.35E-7 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.084 1.08E-6 YHR140W_p YHR140W_p hom Putative integral membrane protein of unknown function
0.084 1.10E-6 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.083 1.57E-6 YLR257W YLR257W hom Protein of unknown function; protein abundance increases in response to DNA replication stress