YPL192C / PRM3

Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL192C / PRM3

Click on Significant Values for Screen Details ID:SGTC_158|Compound:k038-0087|FD-Score:3.77|P-value:1.76E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:3.52|P-value:5.57E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:5.30|P-value:2.90E-9 ID:SGTC_703|Compound:3875-0075|FD-Score:4.27|P-value:1.40E-6 ID:SGTC_706|Compound:4262-0057|FD-Score:-5.56|P-value:4.53E-10 ID:SGTC_828|Compound:2074-0507|FD-Score:3.55|P-value:4.99E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:2.83|P-value:9.57E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:4.78|P-value:7.62E-8 ID:SGTC_1029|Compound:k015-0030|FD-Score:6.87|P-value:2.16E-14 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.40|P-value:9.53E-5 ID:SGTC_1573|Compound:oleylamine|FD-Score:-2.87|P-value:7.69E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.89|P-value:9.64E-6 ID:SGTC_1630|Compound:st005209|FD-Score:2.95|P-value:6.04E-4 ID:SGTC_1714|Compound:st033236|FD-Score:2.88|P-value:7.94E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.78|P-value:7.62E-8 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.13|P-value:3.03E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-2.86|P-value:7.82E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.45|P-value:5.08E-7 ID:SGTC_2014|Compound:4013930|FD-Score:3.65|P-value:3.07E-5 ID:SGTC_2026|Compound:5148700|FD-Score:-2.81|P-value:9.74E-4 ID:SGTC_2207|Compound:7258803|FD-Score:2.84|P-value:9.13E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.25|P-value:1.83E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.01|P-value:4.81E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-2.95|P-value:5.65E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.00|P-value:5.10E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.74|P-value:1.99E-5 ID:SGTC_2947|Compound:9072639|FD-Score:3.90|P-value:9.29E-6 ID:SGTC_2966|Compound:9084041|FD-Score:6.19|P-value:5.26E-12 ID:SGTC_2967|Compound:9089538|FD-Score:-5.01|P-value:1.62E-8 ID:SGTC_3007|Compound:9078383|FD-Score:2.90|P-value:7.31E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.01|P-value:4.84E-4 ID:SGTC_3032|Compound:9089427|FD-Score:3.51|P-value:5.98E-5 ID:SGTC_3308|Compound:9128332|FD-Score:3.27|P-value:1.65E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-2.92|P-value:6.28E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.39|P-value:1.02E-4 ID:SGTC_3329|Compound:9141233|FD-Score:2.87|P-value:8.22E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.77|P-value:1.76E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:3.52|P-value:5.57E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:5.30|P-value:2.90E-9 ID:SGTC_703|Compound:3875-0075|FD-Score:4.27|P-value:1.40E-6 ID:SGTC_706|Compound:4262-0057|FD-Score:-5.56|P-value:4.53E-10 ID:SGTC_828|Compound:2074-0507|FD-Score:3.55|P-value:4.99E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:2.83|P-value:9.57E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:4.78|P-value:7.62E-8 ID:SGTC_1029|Compound:k015-0030|FD-Score:6.87|P-value:2.16E-14 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.40|P-value:9.53E-5 ID:SGTC_1573|Compound:oleylamine|FD-Score:-2.87|P-value:7.69E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.89|P-value:9.64E-6 ID:SGTC_1630|Compound:st005209|FD-Score:2.95|P-value:6.04E-4 ID:SGTC_1714|Compound:st033236|FD-Score:2.88|P-value:7.94E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.78|P-value:7.62E-8 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.13|P-value:3.03E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-2.86|P-value:7.82E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.45|P-value:5.08E-7 ID:SGTC_2014|Compound:4013930|FD-Score:3.65|P-value:3.07E-5 ID:SGTC_2026|Compound:5148700|FD-Score:-2.81|P-value:9.74E-4 ID:SGTC_2207|Compound:7258803|FD-Score:2.84|P-value:9.13E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.25|P-value:1.83E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.01|P-value:4.81E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-2.95|P-value:5.65E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.00|P-value:5.10E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.74|P-value:1.99E-5 ID:SGTC_2947|Compound:9072639|FD-Score:3.90|P-value:9.29E-6 ID:SGTC_2966|Compound:9084041|FD-Score:6.19|P-value:5.26E-12 ID:SGTC_2967|Compound:9089538|FD-Score:-5.01|P-value:1.62E-8 ID:SGTC_3007|Compound:9078383|FD-Score:2.90|P-value:7.31E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.01|P-value:4.84E-4 ID:SGTC_3032|Compound:9089427|FD-Score:3.51|P-value:5.98E-5 ID:SGTC_3308|Compound:9128332|FD-Score:3.27|P-value:1.65E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-2.92|P-value:6.28E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.39|P-value:1.02E-4 ID:SGTC_3329|Compound:9141233|FD-Score:2.87|P-value:8.22E-4

Top fitness defect scores for YPL192C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1029 k015-0030 6.87 64.7 µM 2.16E-14 3 3.15E-12
2 SGTC_2966 9084041 6.19 48.0 µM 5.26E-12 5 3.02E-10
3 SGTC_701 4424-0219 5.30 185.0 µM 2.90E-9 calcium & mitochondrial duress 5 5.75E-8
4 SGTC_1744 st037937 4.78 38.9 µM 7.62E-8 8 8.73E-7
5 SGTC_968 1309-0633 4.78 340.0 µM 7.62E-8 6 8.73E-7
6 SGTC_1912 st060209 4.45 90.8 µM 5.08E-7 29 4.24E-6
7 SGTC_703 3875-0075 4.27 71.8 µM 1.40E-6 5 9.89E-6
8 SGTC_2947 9072639 3.90 7.7 µM 9.29E-6 tubulin folding & SWR complex 45 4.79E-5
9 SGTC_1592 4',5'-dihydroxyflavone 3.89 8.8 µM 9.64E-6 60S ribosome export 11 4.94E-5
10 SGTC_158 k038-0087 3.77 26.4 µM 1.76E-5 ubiquinone biosynthesis & proteasome 152 8.19E-5
11 SGTC_2621 lithochol-11-enic acid 3.74 100.0 µM 1.99E-5 32 9.07E-5
12 SGTC_2014 4013930 3.65 200.0 µM 3.07E-5 51 1.30E-4
13 SGTC_828 2074-0507 3.55 139.0 µM 4.99E-5 RPP1 & pyrimidine depletion 33 1.95E-4
14 SGTC_182 3448-4371 3.52 550.5 µM 5.57E-5 35 2.14E-4
15 SGTC_3032 9089427 3.51 49.5 µM 5.98E-5 60S ribosome export 24 2.27E-4
16 SGTC_1472 k841-0093 3.40 193.0 µM 9.53E-5 35 3.36E-4
17 SGTC_3327 9140648 3.39 26.9 µM 1.02E-4 22 3.54E-4
18 SGTC_3308 9128332 3.27 17.6 µM 1.65E-4 plasma membrane duress 110 5.32E-4
19 SGTC_2290 7904846 3.25 200.0 µM 1.83E-4 57 5.81E-4
20 SGTC_1787 fluconazole 3.13 80.0 µM 3.03E-4 iron homeostasis 78 8.86E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 2.71E-18 YJL131C AIM23 hom Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss
0.126 2.43E-13 YKR053C YSR3 hom Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication
0.117 9.95E-12 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.114 4.19E-11 YMR081C ISF1 hom Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
0.113 5.36E-11 YPL166W ATG29 hom Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.103 2.23E-9 YKL146W AVT3 hom Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.100 6.97E-9 YDR416W SYF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans
0.096 2.21E-8 YER023W PRO3 het Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis
0.096 2.26E-8 YBR158W AMN1 hom Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
0.094 5.04E-8 YMR156C TPP1 hom DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3′-phosphatase
0.092 8.04E-8 YEL055C POL5 het DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA
0.092 8.98E-8 YOL010W RCL1 het Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected
0.091 1.36E-7 YCL050C APA1 hom AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication
0.089 2.32E-7 YOL104C NDJ1 hom Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement
0.089 2.62E-7 YPL224C MMT2 hom Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p