YPL193W / RSA1

Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL193W / RSA1

Click on Significant Values for Screen Details ID:SGTC_26|Compound:0302-0163|FD-Score:4.07|P-value:1.95E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:4.65|P-value:2.50E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:5.42|P-value:1.09E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.54|P-value:8.63E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:4.18|P-value:1.34E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:-3.82|P-value:3.61E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:3.60|P-value:8.52E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:8.75|P-value:9.47E-15 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:4.91|P-value:9.14E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:5.00|P-value:6.39E-6 ID:SGTC_252|Compound:miconazole|FD-Score:-3.50|P-value:9.82E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.87|P-value:3.07E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:5.34|P-value:1.53E-6 ID:SGTC_713|Compound:1488-1073|FD-Score:-3.55|P-value:8.47E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.86|P-value:1.09E-5 ID:SGTC_836|Compound:0330-0104|FD-Score:3.85|P-value:3.89E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:-3.98|P-value:2.21E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:5.02|P-value:5.71E-6 ID:SGTC_963|Compound:1269-2853|FD-Score:3.77|P-value:5.07E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:5.34|P-value:1.53E-6 ID:SGTC_1192|Compound:1488-0095|FD-Score:4.94|P-value:8.08E-6 ID:SGTC_1268|Compound:0828-0275|FD-Score:4.37|P-value:6.77E-5 ID:SGTC_1275|Compound:0867-0008|FD-Score:4.93|P-value:8.42E-6 ID:SGTC_1276|Compound:0871-0068|FD-Score:4.73|P-value:1.81E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:5.47|P-value:8.93E-7 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.29|P-value:9.01E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:4.11|P-value:1.67E-4 ID:SGTC_1623|Compound:st003709|FD-Score:5.33|P-value:1.64E-6 ID:SGTC_1729|Compound:st035615|FD-Score:3.71|P-value:6.02E-4 ID:SGTC_1762|Compound:st045503|FD-Score:5.58|P-value:5.32E-7 ID:SGTC_1769|Compound:st044406|FD-Score:3.57|P-value:9.26E-4 ID:SGTC_1850|Compound:st056238|FD-Score:5.15|P-value:3.43E-6 ID:SGTC_1912|Compound:st060209|FD-Score:3.91|P-value:3.25E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.52|P-value:4.00E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-5.07|P-value:3.78E-6 ID:SGTC_2063|Compound:5246145|FD-Score:4.00|P-value:2.45E-4 ID:SGTC_2117|Compound:5521686|FD-Score:4.88|P-value:1.02E-5 ID:SGTC_2190|Compound:6049624|FD-Score:3.59|P-value:8.67E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.58|P-value:8.97E-4 ID:SGTC_2215|Compound:7188065|FD-Score:3.64|P-value:7.52E-4 ID:SGTC_2313|Compound:7726885|FD-Score:5.03|P-value:5.50E-6 ID:SGTC_2451|Compound:5856223|FD-Score:4.96|P-value:7.43E-6 ID:SGTC_2477|Compound:5967686|FD-Score:3.59|P-value:8.81E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:-4.23|P-value:9.23E-5 ID:SGTC_2517|Compound:totarol|FD-Score:5.33|P-value:1.64E-6 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.80|P-value:4.67E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.13|P-value:1.57E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.40|P-value:5.00E-5 ID:SGTC_3024|Compound:9090631|FD-Score:-3.71|P-value:5.25E-4 ID:SGTC_3029|Compound:9088683|FD-Score:4.38|P-value:6.60E-5 ID:SGTC_3137|Compound:9097352|FD-Score:4.76|P-value:1.64E-5 ID:SGTC_3143|Compound:9086658|FD-Score:-5.06|P-value:4.04E-6 ID:SGTC_3235|Compound:9132602|FD-Score:3.74|P-value:5.51E-4 ID:SGTC_3236|Compound:9132701|FD-Score:-4.11|P-value:1.40E-4 ID:SGTC_3245|Compound:9134821|FD-Score:4.66|P-value:2.38E-5 ID:SGTC_3249|Compound:9135183|FD-Score:4.00|P-value:2.40E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-7.07|P-value:2.32E-10 ID:SGTC_26|Compound:0302-0163|FD-Score:4.07|P-value:1.95E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:4.65|P-value:2.50E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:5.42|P-value:1.09E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.54|P-value:8.63E-4 ID:SGTC_190|Compound:3970-0790|FD-Score:4.18|P-value:1.34E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:-3.82|P-value:3.61E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:3.60|P-value:8.52E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:8.75|P-value:9.47E-15 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:4.91|P-value:9.14E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:5.00|P-value:6.39E-6 ID:SGTC_252|Compound:miconazole|FD-Score:-3.50|P-value:9.82E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.87|P-value:3.07E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:5.34|P-value:1.53E-6 ID:SGTC_713|Compound:1488-1073|FD-Score:-3.55|P-value:8.47E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.86|P-value:1.09E-5 ID:SGTC_836|Compound:0330-0104|FD-Score:3.85|P-value:3.89E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:-3.98|P-value:2.21E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:5.02|P-value:5.71E-6 ID:SGTC_963|Compound:1269-2853|FD-Score:3.77|P-value:5.07E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:5.34|P-value:1.53E-6 ID:SGTC_1192|Compound:1488-0095|FD-Score:4.94|P-value:8.08E-6 ID:SGTC_1268|Compound:0828-0275|FD-Score:4.37|P-value:6.77E-5 ID:SGTC_1275|Compound:0867-0008|FD-Score:4.93|P-value:8.42E-6 ID:SGTC_1276|Compound:0871-0068|FD-Score:4.73|P-value:1.81E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:5.47|P-value:8.93E-7 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.29|P-value:9.01E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:4.11|P-value:1.67E-4 ID:SGTC_1623|Compound:st003709|FD-Score:5.33|P-value:1.64E-6 ID:SGTC_1729|Compound:st035615|FD-Score:3.71|P-value:6.02E-4 ID:SGTC_1762|Compound:st045503|FD-Score:5.58|P-value:5.32E-7 ID:SGTC_1769|Compound:st044406|FD-Score:3.57|P-value:9.26E-4 ID:SGTC_1850|Compound:st056238|FD-Score:5.15|P-value:3.43E-6 ID:SGTC_1912|Compound:st060209|FD-Score:3.91|P-value:3.25E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.52|P-value:4.00E-5 ID:SGTC_2021|Compound:4019055|FD-Score:-5.07|P-value:3.78E-6 ID:SGTC_2063|Compound:5246145|FD-Score:4.00|P-value:2.45E-4 ID:SGTC_2117|Compound:5521686|FD-Score:4.88|P-value:1.02E-5 ID:SGTC_2190|Compound:6049624|FD-Score:3.59|P-value:8.67E-4 ID:SGTC_2213|Compound:7173844|FD-Score:3.58|P-value:8.97E-4 ID:SGTC_2215|Compound:7188065|FD-Score:3.64|P-value:7.52E-4 ID:SGTC_2313|Compound:7726885|FD-Score:5.03|P-value:5.50E-6 ID:SGTC_2451|Compound:5856223|FD-Score:4.96|P-value:7.43E-6 ID:SGTC_2477|Compound:5967686|FD-Score:3.59|P-value:8.81E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:-4.23|P-value:9.23E-5 ID:SGTC_2517|Compound:totarol|FD-Score:5.33|P-value:1.64E-6 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.80|P-value:4.67E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.13|P-value:1.57E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.40|P-value:5.00E-5 ID:SGTC_3024|Compound:9090631|FD-Score:-3.71|P-value:5.25E-4 ID:SGTC_3029|Compound:9088683|FD-Score:4.38|P-value:6.60E-5 ID:SGTC_3137|Compound:9097352|FD-Score:4.76|P-value:1.64E-5 ID:SGTC_3143|Compound:9086658|FD-Score:-5.06|P-value:4.04E-6 ID:SGTC_3235|Compound:9132602|FD-Score:3.74|P-value:5.51E-4 ID:SGTC_3236|Compound:9132701|FD-Score:-4.11|P-value:1.40E-4 ID:SGTC_3245|Compound:9134821|FD-Score:4.66|P-value:2.38E-5 ID:SGTC_3249|Compound:9135183|FD-Score:4.00|P-value:2.40E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-7.07|P-value:2.32E-10

Top fitness defect scores for YPL193W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.75 8.9 µM 9.47E-15 heat shock/prefoldin 9 1.09E-18
2 SGTC_1762 st045503 5.58 25.5 µM 5.32E-7 7 1.17E-8
3 SGTC_1278 0874-0585 5.47 172.0 µM 8.93E-7 2 2.30E-8
4 SGTC_118 0083-0097 5.42 135.3 µM 1.09E-6 translation 41 2.96E-8
5 SGTC_665 3914-0008 5.34 307.0 µM 1.53E-6 3 4.62E-8
6 SGTC_1107 amlodipine 5.34 47.0 µM 1.53E-6 9 4.62E-8
7 SGTC_1623 st003709 5.33 20.3 µM 1.64E-6 calcium & mitochondrial duress 21 5.03E-8
8 SGTC_2517 totarol 5.33 10.0 µM 1.64E-6 3 5.05E-8
9 SGTC_1850 st056238 5.15 17.0 µM 3.43E-6 RPP1 & pyrimidine depletion 8 1.30E-7
10 SGTC_2313 7726885 5.03 200.0 µM 5.50E-6 RPP1 & pyrimidine depletion 15 2.40E-7
11 SGTC_855 0428-0020 5.02 25.0 µM 5.71E-6 Golgi 11 2.52E-7
12 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 5.00 4.6 µM 6.39E-6 heat shock/prefoldin 23 2.92E-7
13 SGTC_2451 5856223 4.96 45.7 µM 7.43E-6 9 3.54E-7
14 SGTC_1192 1488-0095 4.94 21.4 µM 8.08E-6 7 3.94E-7
15 SGTC_1275 0867-0008 4.93 21.1 µM 8.42E-6 4 4.16E-7
16 SGTC_240 5hr heat shock (37°C) + Streptovitacin 4.91 300.0 µM 9.14E-6 heat shock/prefoldin 27 4.63E-7
17 SGTC_2117 5521686 4.88 200.0 µM 1.02E-5 5 5.31E-7
18 SGTC_831 k061-1017 4.86 217.0 µM 1.09E-5 translation 25 5.84E-7
19 SGTC_3137 9097352 4.76 49.5 µM 1.64E-5 19 9.81E-7
20 SGTC_1276 0871-0068 4.73 94.2 µM 1.81E-5 9 1.12E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.166 4.15E-22 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.135 3.55E-15 YOR309C_d YOR309C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
0.117 1.05E-11 YOR001W RRP6 hom Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.108 3.14E-10 YKL007W CAP1 hom Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress
0.107 4.74E-10 YHR168W MTG2 hom Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
0.104 1.38E-9 YCR063W BUD31 hom Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis
0.101 4.10E-9 YDR457W TOM1 hom E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.097 1.79E-8 YDR069C DOA4 hom Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
0.094 5.20E-8 YGL135W RPL1B hom Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal
0.094 5.70E-8 YDR260C SWM1 hom Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
0.093 5.75E-8 YCR031C RPS14A hom Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14A has a paralog, RPS14B, that arose from the whole genome duplication
0.092 9.02E-8 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
0.092 9.10E-8 YDL081C RPP1A hom Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
0.091 1.22E-7 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.090 1.80E-7 YMR143W RPS16A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication