YPL196W / OXR1

Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL196W / OXR1

Click on Significant Values for Screen Details ID:SGTC_80|Compound:0159-0065|FD-Score:3.24|P-value:3.24E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:4.43|P-value:1.58E-6 ID:SGTC_230|Compound:MPP+|FD-Score:-2.99|P-value:8.83E-4 ID:SGTC_232|Compound:clozapine|FD-Score:4.27|P-value:3.52E-6 ID:SGTC_237|Compound:nikkomycin|FD-Score:-3.21|P-value:3.85E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.29|P-value:2.67E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:4.98|P-value:8.26E-8 ID:SGTC_372|Compound:0155-0182|FD-Score:3.24|P-value:3.28E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.52|P-value:1.02E-6 ID:SGTC_718|Compound:1130-0073|FD-Score:3.23|P-value:3.42E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.98|P-value:1.41E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:2.97|P-value:8.85E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:3.27|P-value:2.89E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.14|P-value:4.97E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.24|P-value:3.27E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.02|P-value:7.49E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.57|P-value:8.56E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.47|P-value:1.30E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:6.40|P-value:8.78E-12 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.87|P-value:2.36E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.73|P-value:4.48E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:-2.96|P-value:9.53E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.00|P-value:8.10E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.03|P-value:7.14E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.74|P-value:3.12E-7 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.82|P-value:3.01E-5 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.26|P-value:2.98E-4 ID:SGTC_1798|Compound:st045719|FD-Score:-3.29|P-value:2.85E-4 ID:SGTC_1822|Compound:st052468|FD-Score:3.20|P-value:3.81E-4 ID:SGTC_1826|Compound:st055655|FD-Score:4.23|P-value:4.30E-6 ID:SGTC_1868|Compound:st057644|FD-Score:-3.35|P-value:2.24E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.01|P-value:1.24E-5 ID:SGTC_1980|Compound:st071811|FD-Score:3.75|P-value:4.06E-5 ID:SGTC_2003|Compound:4023581|FD-Score:3.24|P-value:3.24E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.86|P-value:2.45E-5 ID:SGTC_2021|Compound:4019055|FD-Score:6.72|P-value:8.31E-13 ID:SGTC_2123|Compound:5259487|FD-Score:-4.82|P-value:2.23E-7 ID:SGTC_2149|Compound:5554786|FD-Score:3.54|P-value:9.96E-5 ID:SGTC_2165|Compound:5727197|FD-Score:-5.82|P-value:5.25E-10 ID:SGTC_2201|Compound:6605497|FD-Score:3.68|P-value:5.43E-5 ID:SGTC_2263|Compound:7948595|FD-Score:3.80|P-value:3.18E-5 ID:SGTC_2279|Compound:7948423|FD-Score:-3.22|P-value:3.73E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.08|P-value:5.92E-4 ID:SGTC_2412|Compound:st077135|FD-Score:4.18|P-value:5.43E-6 ID:SGTC_2463|Compound:5473429|FD-Score:2.95|P-value:9.54E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.19|P-value:4.10E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.41|P-value:1.68E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:4.32|P-value:2.73E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:5.58|P-value:2.31E-9 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.00|P-value:8.48E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.33|P-value:2.30E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.24|P-value:3.29E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.55|P-value:9.92E-5 ID:SGTC_3343|Compound:9148379|FD-Score:2.94|P-value:9.87E-4 ID:SGTC_3345|Compound:9148410|FD-Score:-4.32|P-value:2.98E-6 ID:SGTC_3350|Compound:9150499|FD-Score:-3.64|P-value:6.92E-5 ID:SGTC_80|Compound:0159-0065|FD-Score:3.24|P-value:3.24E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:4.43|P-value:1.58E-6 ID:SGTC_230|Compound:MPP+|FD-Score:-2.99|P-value:8.83E-4 ID:SGTC_232|Compound:clozapine|FD-Score:4.27|P-value:3.52E-6 ID:SGTC_237|Compound:nikkomycin|FD-Score:-3.21|P-value:3.85E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.29|P-value:2.67E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:4.98|P-value:8.26E-8 ID:SGTC_372|Compound:0155-0182|FD-Score:3.24|P-value:3.28E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.52|P-value:1.02E-6 ID:SGTC_718|Compound:1130-0073|FD-Score:3.23|P-value:3.42E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.98|P-value:1.41E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:2.97|P-value:8.85E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:3.27|P-value:2.89E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.14|P-value:4.97E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.24|P-value:3.27E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.02|P-value:7.49E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.57|P-value:8.56E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.47|P-value:1.30E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:6.40|P-value:8.78E-12 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.87|P-value:2.36E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.73|P-value:4.48E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:-2.96|P-value:9.53E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.00|P-value:8.10E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.03|P-value:7.14E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.74|P-value:3.12E-7 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.82|P-value:3.01E-5 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.26|P-value:2.98E-4 ID:SGTC_1798|Compound:st045719|FD-Score:-3.29|P-value:2.85E-4 ID:SGTC_1822|Compound:st052468|FD-Score:3.20|P-value:3.81E-4 ID:SGTC_1826|Compound:st055655|FD-Score:4.23|P-value:4.30E-6 ID:SGTC_1868|Compound:st057644|FD-Score:-3.35|P-value:2.24E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.01|P-value:1.24E-5 ID:SGTC_1980|Compound:st071811|FD-Score:3.75|P-value:4.06E-5 ID:SGTC_2003|Compound:4023581|FD-Score:3.24|P-value:3.24E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.86|P-value:2.45E-5 ID:SGTC_2021|Compound:4019055|FD-Score:6.72|P-value:8.31E-13 ID:SGTC_2123|Compound:5259487|FD-Score:-4.82|P-value:2.23E-7 ID:SGTC_2149|Compound:5554786|FD-Score:3.54|P-value:9.96E-5 ID:SGTC_2165|Compound:5727197|FD-Score:-5.82|P-value:5.25E-10 ID:SGTC_2201|Compound:6605497|FD-Score:3.68|P-value:5.43E-5 ID:SGTC_2263|Compound:7948595|FD-Score:3.80|P-value:3.18E-5 ID:SGTC_2279|Compound:7948423|FD-Score:-3.22|P-value:3.73E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.08|P-value:5.92E-4 ID:SGTC_2412|Compound:st077135|FD-Score:4.18|P-value:5.43E-6 ID:SGTC_2463|Compound:5473429|FD-Score:2.95|P-value:9.54E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.19|P-value:4.10E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.41|P-value:1.68E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:4.32|P-value:2.73E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:5.58|P-value:2.31E-9 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.00|P-value:8.48E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.33|P-value:2.30E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.24|P-value:3.29E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.55|P-value:9.92E-5 ID:SGTC_3343|Compound:9148379|FD-Score:2.94|P-value:9.87E-4 ID:SGTC_3345|Compound:9148410|FD-Score:-4.32|P-value:2.98E-6 ID:SGTC_3350|Compound:9150499|FD-Score:-3.64|P-value:6.92E-5

Top fitness defect scores for YPL196W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2021 4019055 6.72 173.0 µM 8.31E-13 endomembrane recycling 31 9.13E-12
2 SGTC_1083 didemethylchlorpromazine sulfoxide 6.40 707.4 nM 8.78E-12 redox potentiating 20 7.77E-11
3 SGTC_2610 ononetin 5.58 44.2 µM 2.31E-9 10 1.23E-8
4 SGTC_366 0181-0206 4.98 4.3 µM 8.26E-8 Golgi 17 3.17E-7
5 SGTC_1370 2001-0092 4.74 44.6 µM 3.12E-7 14 1.06E-6
6 SGTC_632 0781-2353 4.52 4.7 µM 1.02E-6 Golgi 24 3.12E-6
7 SGTC_167 3672-0051 4.43 66.2 µM 1.58E-6 32 4.65E-6
8 SGTC_2506 ethyl hematommate 4.32 54.2 µM 2.73E-6 RPP1 & pyrimidine depletion 10 7.64E-6
9 SGTC_232 clozapine 4.27 119.0 µM 3.52E-6 NEO1 59 9.64E-6
10 SGTC_1826 st055655 4.23 41.6 µM 4.30E-6 ERG2 34 1.16E-5
11 SGTC_2412 st077135 4.18 33.4 µM 5.43E-6 21 1.43E-5
12 SGTC_1952 st077036 4.01 64.1 µM 1.24E-5 33 3.03E-5
13 SGTC_731 3966-0296 3.98 387.0 µM 1.41E-5 15 3.42E-5
14 SGTC_1105 epirubicin 3.87 18.1 µM 2.36E-5 anthracycline transcription coupled DNA repair 22 5.45E-5
15 SGTC_2020 4017018 3.86 200.0 µM 2.45E-5 22 5.63E-5
16 SGTC_1376 2910-0861 3.82 41.3 µM 3.01E-5 22 6.80E-5
17 SGTC_2263 7948595 3.80 193.3 µM 3.18E-5 8 7.13E-5
18 SGTC_1980 st071811 3.75 45.7 µM 4.06E-5 RPP1 & pyrimidine depletion 22 8.91E-5
19 SGTC_1223 0764-0573 3.73 147.0 µM 4.48E-5 27 9.76E-5
20 SGTC_2201 6605497 3.68 169.9 µM 5.43E-5 ergosterol biosynthesis 11 1.16E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.193 1.24E-29 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.168 1.30E-22 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.152 1.01E-18 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.126 1.96E-13 YDR430C CYM1 hom Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology
0.125 4.00E-13 YGL079W_p KXD1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome
0.119 4.60E-12 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.108 4.05E-10 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.106 8.87E-10 YKR065C PAM17 hom Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress
0.104 1.76E-9 YPL265W DIP5 hom Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress
0.102 3.22E-9 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.100 5.83E-9 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.095 3.69E-8 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.094 4.67E-8 YDR490C PKH1 hom Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p
0.091 1.23E-7 YDR420W HKR1 hom Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection
0.091 1.27E-7 YGR206W MVB12 hom ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin