YPL197C_d

Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL197C / YPL197C

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.56|P-value:3.71E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:3.72|P-value:2.07E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:4.62|P-value:5.81E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:3.86|P-value:1.25E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.61|P-value:3.08E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.23|P-value:3.01E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:4.47|P-value:1.12E-5 ID:SGTC_171|Compound:k064-0041|FD-Score:3.42|P-value:5.94E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.94|P-value:1.36E-6 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.23|P-value:3.04E-5 ID:SGTC_259|Compound:usnic acid|FD-Score:3.71|P-value:2.19E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:-3.86|P-value:1.22E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:-3.29|P-value:8.87E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.33|P-value:2.02E-5 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.90|P-value:1.08E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.57|P-value:3.56E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.51|P-value:4.28E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.36|P-value:7.10E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:-3.26|P-value:9.80E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.29|P-value:8.99E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.51|P-value:4.35E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.58|P-value:3.26E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.36|P-value:7.06E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:-3.94|P-value:9.08E-5 ID:SGTC_1522|Compound:st012842|FD-Score:3.32|P-value:8.10E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-3.38|P-value:6.45E-4 ID:SGTC_1719|Compound:st032227|FD-Score:-4.47|P-value:1.07E-5 ID:SGTC_1720|Compound:st037298|FD-Score:5.66|P-value:4.00E-8 ID:SGTC_1721|Compound:st082152|FD-Score:3.93|P-value:9.67E-5 ID:SGTC_1790|Compound:st045711|FD-Score:3.48|P-value:4.86E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.29|P-value:8.99E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:6.62|P-value:1.65E-10 ID:SGTC_1931|Compound:st074438|FD-Score:4.60|P-value:6.29E-6 ID:SGTC_1953|Compound:st076800|FD-Score:-3.57|P-value:3.44E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.84|P-value:1.33E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.37|P-value:6.92E-4 ID:SGTC_2036|Compound:5160441|FD-Score:-3.35|P-value:7.31E-4 ID:SGTC_2041|Compound:5107442|FD-Score:8.92|P-value:1.24E-17 ID:SGTC_2568|Compound:diosmetin|FD-Score:-3.86|P-value:1.21E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.53|P-value:4.01E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.59|P-value:3.21E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.50|P-value:4.39E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:5.52|P-value:8.29E-8 ID:SGTC_2883|Compound:9059145|FD-Score:-3.42|P-value:5.72E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.82|P-value:1.47E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.56|P-value:3.71E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:3.72|P-value:2.07E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:4.62|P-value:5.81E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:3.86|P-value:1.25E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:3.61|P-value:3.08E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.23|P-value:3.01E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:4.47|P-value:1.12E-5 ID:SGTC_171|Compound:k064-0041|FD-Score:3.42|P-value:5.94E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.94|P-value:1.36E-6 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.23|P-value:3.04E-5 ID:SGTC_259|Compound:usnic acid|FD-Score:3.71|P-value:2.19E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:-3.86|P-value:1.22E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:-3.29|P-value:8.87E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.33|P-value:2.02E-5 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.90|P-value:1.08E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.57|P-value:3.56E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.51|P-value:4.28E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.36|P-value:7.10E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:-3.26|P-value:9.80E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.29|P-value:8.99E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.51|P-value:4.35E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.58|P-value:3.26E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.36|P-value:7.06E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:-3.94|P-value:9.08E-5 ID:SGTC_1522|Compound:st012842|FD-Score:3.32|P-value:8.10E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-3.38|P-value:6.45E-4 ID:SGTC_1719|Compound:st032227|FD-Score:-4.47|P-value:1.07E-5 ID:SGTC_1720|Compound:st037298|FD-Score:5.66|P-value:4.00E-8 ID:SGTC_1721|Compound:st082152|FD-Score:3.93|P-value:9.67E-5 ID:SGTC_1790|Compound:st045711|FD-Score:3.48|P-value:4.86E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.29|P-value:8.99E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:6.62|P-value:1.65E-10 ID:SGTC_1931|Compound:st074438|FD-Score:4.60|P-value:6.29E-6 ID:SGTC_1953|Compound:st076800|FD-Score:-3.57|P-value:3.44E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.84|P-value:1.33E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.37|P-value:6.92E-4 ID:SGTC_2036|Compound:5160441|FD-Score:-3.35|P-value:7.31E-4 ID:SGTC_2041|Compound:5107442|FD-Score:8.92|P-value:1.24E-17 ID:SGTC_2568|Compound:diosmetin|FD-Score:-3.86|P-value:1.21E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.53|P-value:4.01E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.59|P-value:3.21E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.50|P-value:4.39E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:5.52|P-value:8.29E-8 ID:SGTC_2883|Compound:9059145|FD-Score:-3.42|P-value:5.72E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.82|P-value:1.47E-4

Top fitness defect scores for YPL197C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2041 5107442 8.92 45.3 µM 1.24E-17 RSC complex & mRNA processing 4 2.31E-19
2 SGTC_1926 methyl fluorone black 6.62 53.6 µM 1.65E-10 DNA intercalators 15 1.78E-11
3 SGTC_1720 st037298 5.66 9.5 µM 4.00E-8 15 7.78E-9
4 SGTC_2764 methyldopa 5.52 94.7 µM 8.29E-8 7 1.74E-8
5 SGTC_184 1494-0393 4.94 24.7 µM 1.36E-6 33 3.85E-7
6 SGTC_42 0133-0086 4.62 60.6 µM 5.81E-6 11 1.91E-6
7 SGTC_1931 st074438 4.60 57.1 µM 6.29E-6 8 2.08E-6
8 SGTC_166 k072-0058 4.47 166.4 µM 1.12E-5 DNA intercalators 23 3.93E-6
9 SGTC_402 epigallocatechin gallate 4.33 10.0 µM 2.02E-5 17 7.56E-6
10 SGTC_145 3737-0113 4.23 38.4 µM 3.01E-5 DNA intercalators 64 1.18E-5
11 SGTC_219 mitoxanthrone 4.23 164.4 µM 3.04E-5 DNA intercalators 46 1.19E-5
12 SGTC_1721 st082152 3.93 9.3 µM 9.67E-5 60S ribosome export 19 4.26E-5
13 SGTC_412 gemfibrozil 3.90 100.0 µM 1.08E-4 DNA intercalators 9 4.83E-5
14 SGTC_115 0527-0192 3.86 112.0 µM 1.25E-4 76 5.67E-5
15 SGTC_1955 wogonin 3.84 32.4 µM 1.33E-4 19 6.08E-5
16 SGTC_2919 7978188 3.82 46.4 µM 1.47E-4 24 6.76E-5
17 SGTC_17 0960-0276 3.72 49.8 µM 2.07E-4 46 9.88E-5
18 SGTC_259 usnic acid 3.71 108.9 µM 2.19E-4 25 1.05E-4
19 SGTC_126 0417-1624 3.61 672.5 µM 3.08E-4 DNA intercalators 47 1.53E-4
20 SGTC_429 1112-0049 3.57 25.5 µM 3.56E-4 DNA damage response 50 1.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.197 8.67E-31 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.195 6.16E-30 YPL038W MET31 hom Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET31 has a paralog, MET32, that arose from the whole genome duplication
0.189 3.44E-28 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.184 4.85E-27 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.177 4.56E-25 YMR044W IOC4 hom Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing
0.170 3.61E-23 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.170 5.03E-23 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.167 1.73E-22 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.160 1.72E-20 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.159 2.20E-20 YER099C PRS2 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication
0.157 6.87E-20 YPR059C_d YPR059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W
0.155 2.17E-19 YGR156W PTI1 het Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
0.152 1.12E-18 YDR524W-C_p YDR524W-C_p hom Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin
0.146 1.89E-17 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.141 2.36E-16 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene