YPL198W / RPL7B

Ribosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL198W / RPL7B

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:-4.22|P-value:2.16E-5 ID:SGTC_25|Compound:0118-0223|FD-Score:-3.63|P-value:2.18E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:3.26|P-value:7.97E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:-4.06|P-value:4.27E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:3.22|P-value:9.08E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:4.58|P-value:4.48E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:3.44|P-value:4.31E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.32|P-value:6.50E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-6.32|P-value:4.66E-10 ID:SGTC_408|Compound:cantharidin|FD-Score:3.84|P-value:9.91E-5 ID:SGTC_420|Compound:mitomycin C|FD-Score:4.74|P-value:2.18E-6 ID:SGTC_663|Compound:1486-0733|FD-Score:-3.28|P-value:7.46E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-3.63|P-value:2.16E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:3.42|P-value:4.61E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.88|P-value:8.30E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:3.50|P-value:3.46E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.23|P-value:8.68E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.90|P-value:7.81E-5 ID:SGTC_1855|Compound:st056195|FD-Score:3.24|P-value:8.26E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.73|P-value:1.49E-4 ID:SGTC_1978|Compound:st071761|FD-Score:4.26|P-value:1.84E-5 ID:SGTC_2087|Compound:5276107|FD-Score:3.29|P-value:7.17E-4 ID:SGTC_2173|Compound:5763948|FD-Score:3.55|P-value:2.91E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.55|P-value:2.86E-4 ID:SGTC_2295|Compound:7971645|FD-Score:6.76|P-value:2.85E-11 ID:SGTC_2297|Compound:7971671|FD-Score:3.49|P-value:3.51E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.22|P-value:2.05E-7 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.31|P-value:6.74E-4 ID:SGTC_2423|Compound:st077119|FD-Score:6.20|P-value:9.12E-10 ID:SGTC_2428|Compound:5615643|FD-Score:5.03|P-value:5.48E-7 ID:SGTC_2433|Compound:5607874|FD-Score:-3.58|P-value:2.63E-4 ID:SGTC_2434|Compound:5670830|FD-Score:5.78|P-value:1.08E-8 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.10|P-value:3.82E-7 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-4.07|P-value:4.09E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.35|P-value:5.73E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.47|P-value:3.84E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.19|P-value:9.94E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-4.20|P-value:2.38E-5 ID:SGTC_3151|Compound:9099821|FD-Score:-3.25|P-value:8.15E-4 ID:SGTC_3326|Compound:9140064|FD-Score:4.29|P-value:1.58E-5 ID:SGTC_20|Compound:0481-0013|FD-Score:-4.22|P-value:2.16E-5 ID:SGTC_25|Compound:0118-0223|FD-Score:-3.63|P-value:2.18E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:3.26|P-value:7.97E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:-4.06|P-value:4.27E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:3.22|P-value:9.08E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:4.58|P-value:4.48E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:3.44|P-value:4.31E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.32|P-value:6.50E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-6.32|P-value:4.66E-10 ID:SGTC_408|Compound:cantharidin|FD-Score:3.84|P-value:9.91E-5 ID:SGTC_420|Compound:mitomycin C|FD-Score:4.74|P-value:2.18E-6 ID:SGTC_663|Compound:1486-0733|FD-Score:-3.28|P-value:7.46E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-3.63|P-value:2.16E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:3.42|P-value:4.61E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.88|P-value:8.30E-5 ID:SGTC_817|Compound:1391-0715|FD-Score:3.50|P-value:3.46E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.23|P-value:8.68E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.90|P-value:7.81E-5 ID:SGTC_1855|Compound:st056195|FD-Score:3.24|P-value:8.26E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.73|P-value:1.49E-4 ID:SGTC_1978|Compound:st071761|FD-Score:4.26|P-value:1.84E-5 ID:SGTC_2087|Compound:5276107|FD-Score:3.29|P-value:7.17E-4 ID:SGTC_2173|Compound:5763948|FD-Score:3.55|P-value:2.91E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.55|P-value:2.86E-4 ID:SGTC_2295|Compound:7971645|FD-Score:6.76|P-value:2.85E-11 ID:SGTC_2297|Compound:7971671|FD-Score:3.49|P-value:3.51E-4 ID:SGTC_2322|Compound:7413319|FD-Score:5.22|P-value:2.05E-7 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.31|P-value:6.74E-4 ID:SGTC_2423|Compound:st077119|FD-Score:6.20|P-value:9.12E-10 ID:SGTC_2428|Compound:5615643|FD-Score:5.03|P-value:5.48E-7 ID:SGTC_2433|Compound:5607874|FD-Score:-3.58|P-value:2.63E-4 ID:SGTC_2434|Compound:5670830|FD-Score:5.78|P-value:1.08E-8 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.10|P-value:3.82E-7 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-4.07|P-value:4.09E-5 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.35|P-value:5.73E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.47|P-value:3.84E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.19|P-value:9.94E-4 ID:SGTC_3144|Compound:9087057|FD-Score:-4.20|P-value:2.38E-5 ID:SGTC_3151|Compound:9099821|FD-Score:-3.25|P-value:8.15E-4 ID:SGTC_3326|Compound:9140064|FD-Score:4.29|P-value:1.58E-5

Top fitness defect scores for YPL198W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2295 7971645 6.76 200.0 µM 2.85E-11 3 6.98E-12
2 SGTC_2423 st077119 6.20 87.2 µM 9.12E-10 1 2.78E-10
3 SGTC_2434 5670830 5.78 169.9 µM 1.08E-8 4 3.83E-9
4 SGTC_2322 7413319 5.22 38.2 µM 2.05E-7 ERAD & cell cycle 86 8.79E-8
5 SGTC_2752 diclazuril 5.10 33.1 µM 3.82E-7 73 1.70E-7
6 SGTC_2428 5615643 5.03 7.8 µM 5.48E-7 19 2.49E-7
7 SGTC_420 mitomycin C 4.74 81.9 mM 2.18E-6 9 1.08E-6
8 SGTC_132 0417-1715 4.58 25.8 µM 4.48E-6 RPP1 & pyrimidine depletion 11 2.32E-6
9 SGTC_3326 9140064 4.29 16.4 µM 1.58E-5 16 8.83E-6
10 SGTC_1978 st071761 4.26 42.0 µM 1.84E-5 TSC3-RPN4 10 1.04E-5
11 SGTC_1116 jasmonic acid 3.90 1.6 µM 7.81E-5 24 4.82E-5
12 SGTC_810 3825-7150 3.88 143.0 µM 8.30E-5 60S ribosome export 10 5.14E-5
13 SGTC_408 cantharidin 3.84 100.0 µM 9.91E-5 cell wall signaling 26 6.20E-5
14 SGTC_1973 st070275 3.73 50.2 µM 1.49E-4 15 9.60E-5
15 SGTC_2294 7971431 3.55 200.0 µM 2.86E-4 22 1.91E-4
16 SGTC_2173 5763948 3.55 167.0 µM 2.91E-4 tubulin folding & SWR complex 21 1.94E-4
17 SGTC_817 1391-0715 3.50 46.0 µM 3.46E-4 28 2.34E-4
18 SGTC_2297 7971671 3.49 152.3 µM 3.51E-4 RNA processing & uracil transport 44 2.37E-4
19 SGTC_2873 9040596 3.47 71.4 µM 3.84E-4 69 2.61E-4
20 SGTC_171 k064-0041 3.44 9.7 µM 4.31E-4 heme requiring 34 2.95E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 7.42E-17 YKL099C UTP11 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.123 9.20E-13 YCR048W ARE1 hom Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication
0.105 9.07E-10 YDR120C TRM1 hom tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.103 2.19E-9 YKL072W STB6 hom Protein that binds Sin3p in a two-hybrid assay
0.094 4.49E-8 YER170W ADK2 hom Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background
0.093 6.56E-8 YLR220W CCC1 hom Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress
0.086 6.69E-7 YOL159C YOL159C hom Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA
0.084 1.14E-6 YGR169C PUS6 hom tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability
0.082 1.71E-6 YKL045W PRI2 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.078 5.69E-6 YPL190C NAB3 het RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing
0.076 9.26E-6 YEL060C PRB1 hom Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress
0.076 9.62E-6 YOL051W GAL11 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator
0.075 1.36E-5 YMR193C-A_d YMR193C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.074 1.93E-5 YBR226C_d YBR226C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W
0.073 2.64E-5 YNL188W KAR1 het Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p