YPL200W / CSM4

Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL200W / CSM4

Click on Significant Values for Screen Details ID:SGTC_136|Compound:0097-0015|FD-Score:-3.33|P-value:2.61E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.63|P-value:7.91E-5 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.10|P-value:7.84E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.37|P-value:2.20E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.69|P-value:7.98E-5 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.04|P-value:9.53E-4 ID:SGTC_441|Compound:propafenone|FD-Score:3.23|P-value:4.87E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.26|P-value:4.38E-4 ID:SGTC_462|Compound:ag-879|FD-Score:-3.41|P-value:1.89E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.68|P-value:8.30E-5 ID:SGTC_662|Compound:k832-1615|FD-Score:3.65|P-value:9.72E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:3.94|P-value:2.76E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:3.08|P-value:8.39E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:5.21|P-value:4.53E-8 ID:SGTC_777|Compound:1315-0167|FD-Score:5.62|P-value:4.11E-9 ID:SGTC_782|Compound:0083-0095|FD-Score:3.67|P-value:8.71E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:4.41|P-value:3.10E-6 ID:SGTC_925|Compound:2064-1272|FD-Score:4.43|P-value:2.90E-6 ID:SGTC_947|Compound:3447-0010|FD-Score:3.46|P-value:2.04E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.09|P-value:8.16E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:5.48|P-value:9.51E-9 ID:SGTC_1216|Compound:1165-0504|FD-Score:-3.14|P-value:5.20E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.65|P-value:9.50E-5 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.10|P-value:7.71E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.89|P-value:3.46E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:4.67|P-value:8.67E-7 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.40|P-value:1.94E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:4.11|P-value:1.30E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.81|P-value:4.80E-5 ID:SGTC_1852|Compound:st056254|FD-Score:3.43|P-value:2.32E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.15|P-value:6.54E-4 ID:SGTC_2020|Compound:4017018|FD-Score:-3.75|P-value:4.69E-5 ID:SGTC_2022|Compound:5136654|FD-Score:3.40|P-value:2.62E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.61|P-value:1.11E-4 ID:SGTC_2069|Compound:5228469|FD-Score:4.06|P-value:1.63E-5 ID:SGTC_2075|Compound:5212009|FD-Score:3.55|P-value:1.45E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.91|P-value:3.12E-5 ID:SGTC_2330|Compound:7979373|FD-Score:3.96|P-value:2.51E-5 ID:SGTC_2343|Compound:7990716|FD-Score:3.97|P-value:2.42E-5 ID:SGTC_2401|Compound:5128683|FD-Score:3.14|P-value:6.69E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.49|P-value:1.79E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.09|P-value:8.12E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.19|P-value:5.60E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:4.26|P-value:6.41E-6 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.20|P-value:5.38E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.40|P-value:2.56E-4 ID:SGTC_2852|Compound:9023854|FD-Score:5.44|P-value:1.24E-8 ID:SGTC_2878|Compound:9043973|FD-Score:5.37|P-value:1.87E-8 ID:SGTC_2939|Compound:9044578|FD-Score:4.29|P-value:5.75E-6 ID:SGTC_3010|Compound:9080089|FD-Score:3.41|P-value:2.52E-4 ID:SGTC_3041|Compound:9091929|FD-Score:-3.89|P-value:2.56E-5 ID:SGTC_3270|Compound:9137563|FD-Score:3.22|P-value:5.12E-4 ID:SGTC_3326|Compound:9140064|FD-Score:6.48|P-value:1.46E-11 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.33|P-value:2.61E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.63|P-value:7.91E-5 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.10|P-value:7.84E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.37|P-value:2.20E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.69|P-value:7.98E-5 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.04|P-value:9.53E-4 ID:SGTC_441|Compound:propafenone|FD-Score:3.23|P-value:4.87E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.26|P-value:4.38E-4 ID:SGTC_462|Compound:ag-879|FD-Score:-3.41|P-value:1.89E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.68|P-value:8.30E-5 ID:SGTC_662|Compound:k832-1615|FD-Score:3.65|P-value:9.72E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:3.94|P-value:2.76E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:3.08|P-value:8.39E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:5.21|P-value:4.53E-8 ID:SGTC_777|Compound:1315-0167|FD-Score:5.62|P-value:4.11E-9 ID:SGTC_782|Compound:0083-0095|FD-Score:3.67|P-value:8.71E-5 ID:SGTC_819|Compound:1013-0258|FD-Score:4.41|P-value:3.10E-6 ID:SGTC_925|Compound:2064-1272|FD-Score:4.43|P-value:2.90E-6 ID:SGTC_947|Compound:3447-0010|FD-Score:3.46|P-value:2.04E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.09|P-value:8.16E-4 ID:SGTC_1113|Compound:artemisinin|FD-Score:5.48|P-value:9.51E-9 ID:SGTC_1216|Compound:1165-0504|FD-Score:-3.14|P-value:5.20E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.65|P-value:9.50E-5 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.10|P-value:7.71E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.89|P-value:3.46E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:4.67|P-value:8.67E-7 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.40|P-value:1.94E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:4.11|P-value:1.30E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.81|P-value:4.80E-5 ID:SGTC_1852|Compound:st056254|FD-Score:3.43|P-value:2.32E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.15|P-value:6.54E-4 ID:SGTC_2020|Compound:4017018|FD-Score:-3.75|P-value:4.69E-5 ID:SGTC_2022|Compound:5136654|FD-Score:3.40|P-value:2.62E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.61|P-value:1.11E-4 ID:SGTC_2069|Compound:5228469|FD-Score:4.06|P-value:1.63E-5 ID:SGTC_2075|Compound:5212009|FD-Score:3.55|P-value:1.45E-4 ID:SGTC_2080|Compound:5212524|FD-Score:3.91|P-value:3.12E-5 ID:SGTC_2330|Compound:7979373|FD-Score:3.96|P-value:2.51E-5 ID:SGTC_2343|Compound:7990716|FD-Score:3.97|P-value:2.42E-5 ID:SGTC_2401|Compound:5128683|FD-Score:3.14|P-value:6.69E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.49|P-value:1.79E-4 ID:SGTC_2601|Compound:securinine|FD-Score:3.09|P-value:8.12E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.19|P-value:5.60E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:4.26|P-value:6.41E-6 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.20|P-value:5.38E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.40|P-value:2.56E-4 ID:SGTC_2852|Compound:9023854|FD-Score:5.44|P-value:1.24E-8 ID:SGTC_2878|Compound:9043973|FD-Score:5.37|P-value:1.87E-8 ID:SGTC_2939|Compound:9044578|FD-Score:4.29|P-value:5.75E-6 ID:SGTC_3010|Compound:9080089|FD-Score:3.41|P-value:2.52E-4 ID:SGTC_3041|Compound:9091929|FD-Score:-3.89|P-value:2.56E-5 ID:SGTC_3270|Compound:9137563|FD-Score:3.22|P-value:5.12E-4 ID:SGTC_3326|Compound:9140064|FD-Score:6.48|P-value:1.46E-11

Top fitness defect scores for YPL200W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3326 9140064 6.48 16.4 µM 1.46E-11 4 4.60E-11
2 SGTC_777 1315-0167 5.62 517.0 µM 4.11E-9 Golgi 10 9.55E-9
3 SGTC_1113 artemisinin 5.48 1.2 µM 9.51E-9 heme biosynthesis & mitochondrial translocase 5 2.11E-8
4 SGTC_2852 9023854 5.44 52.0 µM 1.24E-8 14 2.72E-8
5 SGTC_2878 9043973 5.37 26.0 µM 1.87E-8 4 4.00E-8
6 SGTC_772 k072-0172 5.21 35.3 µM 4.53E-8 3 9.25E-8
7 SGTC_1406 3909-7906 4.67 11.9 µM 8.67E-7 60S ribosome export 3 1.52E-6
8 SGTC_925 2064-1272 4.43 59.6 µM 2.90E-6 16 4.75E-6
9 SGTC_819 1013-0258 4.41 27.7 µM 3.10E-6 27 5.07E-6
10 SGTC_2939 9044578 4.29 71.4 µM 5.75E-6 32 9.10E-6
11 SGTC_2660 2',4'-dihydroxychalcone 4.26 17.1 µM 6.41E-6 11 1.01E-5
12 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 4.11 66.5 µM 1.30E-5 16 1.98E-5
13 SGTC_2069 5228469 4.06 200.0 µM 1.63E-5 11 2.45E-5
14 SGTC_2343 7990716 3.97 14.8 µM 2.42E-5 19 3.56E-5
15 SGTC_2330 7979373 3.96 200.0 µM 2.51E-5 60S ribosome export 34 3.68E-5
16 SGTC_737 1950-0117 3.94 57.9 µM 2.76E-5 23 4.04E-5
17 SGTC_2080 5212524 3.91 12.4 µM 3.12E-5 copper-dependent oxidative stress 14 4.53E-5
18 SGTC_1330 1469-0054 3.89 61.8 µM 3.46E-5 iron homeostasis 19 5.00E-5
19 SGTC_1728 st035614 3.81 33.8 µM 4.80E-5 59 6.82E-5
20 SGTC_429 1112-0049 3.69 25.5 µM 7.98E-5 DNA damage response 38 1.11E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.084 1.23E-6 YDL243C AAD4 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.083 1.48E-6 YMR292W GOT1 hom Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition
0.082 2.17E-6 YPL071C_p YPL071C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.079 4.84E-6 YFR035C_p YFR035C_p hom Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein
0.077 8.04E-6 YPL190C NAB3 het RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing
0.073 2.30E-5 YNL035C YNL035C hom Protein of unknown function; contains WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; protein abundance increases in response to DNA replication stress
0.073 2.44E-5 YBR063C_p YBR063C_p hom Putative protein of unknown function; YBR063C is not an essential gene
0.073 2.62E-5 YCR099C_p YCR099C_p hom Putative protein of unknown function
0.070 4.71E-5 YPR121W THI22 hom Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis
0.070 4.80E-5 YNL066W SUN4 hom Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
0.066 1.43E-4 YHR124W NDT80 hom Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)
0.065 1.79E-4 YGL224C SDT1 hom Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives
0.064 2.10E-4 YMR094W CTF13 het Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis
0.064 2.28E-4 YOL022C TSR4 het Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2
0.063 2.53E-4 YHR181W SVP26 hom Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment