YPL201C / YIG1

Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL201C / YIG1

Click on Significant Values for Screen Details ID:SGTC_90|Compound:0870-0863|FD-Score:-4.22|P-value:1.71E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:4.38|P-value:8.14E-6 ID:SGTC_101|Compound:0490-5701|FD-Score:-3.67|P-value:1.58E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.63|P-value:1.84E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:4.46|P-value:5.76E-6 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.78|P-value:1.03E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:3.53|P-value:2.54E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.75|P-value:1.11E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:4.17|P-value:2.03E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.04|P-value:3.45E-5 ID:SGTC_443|Compound:clozapine|FD-Score:-3.69|P-value:1.48E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:3.84|P-value:7.97E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:3.30|P-value:5.75E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:5.50|P-value:3.13E-8 ID:SGTC_933|Compound:2914-0560|FD-Score:4.21|P-value:1.70E-5 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.26|P-value:6.70E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.28|P-value:6.31E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.50|P-value:2.82E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.61|P-value:1.87E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:5.31|P-value:8.89E-8 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.66|P-value:1.59E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:4.55|P-value:3.78E-6 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-3.49|P-value:3.13E-4 ID:SGTC_1793|Compound:st048256|FD-Score:4.02|P-value:3.85E-5 ID:SGTC_1829|Compound:berberine|FD-Score:5.70|P-value:1.06E-8 ID:SGTC_1833|Compound:st055984|FD-Score:3.23|P-value:7.41E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.68|P-value:1.49E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.81|P-value:8.87E-5 ID:SGTC_2014|Compound:4013930|FD-Score:5.29|P-value:9.59E-8 ID:SGTC_2026|Compound:5148700|FD-Score:3.47|P-value:3.22E-4 ID:SGTC_2276|Compound:7947513|FD-Score:4.84|P-value:9.73E-7 ID:SGTC_2283|Compound:7944793|FD-Score:6.96|P-value:3.76E-12 ID:SGTC_2301|Compound:7769476|FD-Score:3.53|P-value:2.58E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-3.22|P-value:7.84E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.89|P-value:6.46E-5 ID:SGTC_2365|Compound:9042475|FD-Score:4.14|P-value:2.33E-5 ID:SGTC_2411|Compound:st077133|FD-Score:3.35|P-value:4.85E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.35|P-value:4.94E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.66|P-value:1.68E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.38|P-value:4.42E-4 ID:SGTC_2919|Compound:7978188|FD-Score:-4.02|P-value:4.07E-5 ID:SGTC_2924|Compound:9010168|FD-Score:6.96|P-value:3.85E-12 ID:SGTC_3036|Compound:9090181|FD-Score:4.10|P-value:2.70E-5 ID:SGTC_3191|Compound:9110352|FD-Score:3.62|P-value:1.83E-4 ID:SGTC_3196|Compound:9111891|FD-Score:3.78|P-value:1.00E-4 ID:SGTC_3198|Compound:9112019|FD-Score:4.68|P-value:2.08E-6 ID:SGTC_3200|Compound:9114385|FD-Score:-3.66|P-value:1.68E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:-4.22|P-value:1.71E-5 ID:SGTC_93|Compound:0109-0045|FD-Score:4.38|P-value:8.14E-6 ID:SGTC_101|Compound:0490-5701|FD-Score:-3.67|P-value:1.58E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:-3.63|P-value:1.84E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:4.46|P-value:5.76E-6 ID:SGTC_154|Compound:3389-1638|FD-Score:-3.78|P-value:1.03E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:3.53|P-value:2.54E-4 ID:SGTC_271|Compound:rotenone|FD-Score:3.75|P-value:1.11E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:4.17|P-value:2.03E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.04|P-value:3.45E-5 ID:SGTC_443|Compound:clozapine|FD-Score:-3.69|P-value:1.48E-4 ID:SGTC_681|Compound:1642-0006|FD-Score:3.84|P-value:7.97E-5 ID:SGTC_777|Compound:1315-0167|FD-Score:3.30|P-value:5.75E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:5.50|P-value:3.13E-8 ID:SGTC_933|Compound:2914-0560|FD-Score:4.21|P-value:1.70E-5 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.26|P-value:6.70E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.28|P-value:6.31E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.50|P-value:2.82E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.61|P-value:1.87E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:5.31|P-value:8.89E-8 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.66|P-value:1.59E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:4.55|P-value:3.78E-6 ID:SGTC_1596|Compound:piperlongumine|FD-Score:-3.49|P-value:3.13E-4 ID:SGTC_1793|Compound:st048256|FD-Score:4.02|P-value:3.85E-5 ID:SGTC_1829|Compound:berberine|FD-Score:5.70|P-value:1.06E-8 ID:SGTC_1833|Compound:st055984|FD-Score:3.23|P-value:7.41E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.68|P-value:1.49E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.81|P-value:8.87E-5 ID:SGTC_2014|Compound:4013930|FD-Score:5.29|P-value:9.59E-8 ID:SGTC_2026|Compound:5148700|FD-Score:3.47|P-value:3.22E-4 ID:SGTC_2276|Compound:7947513|FD-Score:4.84|P-value:9.73E-7 ID:SGTC_2283|Compound:7944793|FD-Score:6.96|P-value:3.76E-12 ID:SGTC_2301|Compound:7769476|FD-Score:3.53|P-value:2.58E-4 ID:SGTC_2323|Compound:6148992|FD-Score:-3.22|P-value:7.84E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.89|P-value:6.46E-5 ID:SGTC_2365|Compound:9042475|FD-Score:4.14|P-value:2.33E-5 ID:SGTC_2411|Compound:st077133|FD-Score:3.35|P-value:4.85E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.35|P-value:4.94E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.66|P-value:1.68E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.38|P-value:4.42E-4 ID:SGTC_2919|Compound:7978188|FD-Score:-4.02|P-value:4.07E-5 ID:SGTC_2924|Compound:9010168|FD-Score:6.96|P-value:3.85E-12 ID:SGTC_3036|Compound:9090181|FD-Score:4.10|P-value:2.70E-5 ID:SGTC_3191|Compound:9110352|FD-Score:3.62|P-value:1.83E-4 ID:SGTC_3196|Compound:9111891|FD-Score:3.78|P-value:1.00E-4 ID:SGTC_3198|Compound:9112019|FD-Score:4.68|P-value:2.08E-6 ID:SGTC_3200|Compound:9114385|FD-Score:-3.66|P-value:1.68E-4

Top fitness defect scores for YPL201C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2283 7944793 6.96 200.0 µM 3.76E-12 3 1.65E-12
2 SGTC_2924 9010168 6.96 62.8 µM 3.85E-12 cell wall signaling 6 1.69E-12
3 SGTC_1829 berberine 5.70 14.4 µM 1.06E-8 60S ribosome export 4 6.14E-9
4 SGTC_870 0573-2213 5.50 57.6 µM 3.13E-8 ERG2 4 1.87E-8
5 SGTC_1241 0364-0022 5.31 50.8 µM 8.89E-8 ERG2 10 5.52E-8
6 SGTC_2014 4013930 5.29 200.0 µM 9.59E-8 5 5.97E-8
7 SGTC_2276 7947513 4.84 42.1 µM 9.73E-7 13 6.55E-7
8 SGTC_3198 9112019 4.68 49.5 µM 2.08E-6 mitochondrial processes 6 1.44E-6
9 SGTC_1592 4',5'-dihydroxyflavone 4.55 8.8 µM 3.78E-6 60S ribosome export 5 2.66E-6
10 SGTC_152 4469-0003 4.46 551.2 µM 5.76E-6 15 4.12E-6
11 SGTC_93 0109-0045 4.38 59.2 µM 8.14E-6 DNA damage response 27 5.88E-6
12 SGTC_933 2914-0560 4.21 114.0 µM 1.70E-5 21 1.26E-5
13 SGTC_334 1502-1024 4.17 68.5 µM 2.03E-5 8 1.52E-5
14 SGTC_2365 9042475 4.14 200.0 µM 2.33E-5 29 1.74E-5
15 SGTC_3036 9090181 4.10 49.5 µM 2.70E-5 6 2.03E-5
16 SGTC_402 epigallocatechin gallate 4.04 10.0 µM 3.45E-5 22 2.62E-5
17 SGTC_1793 st048256 4.02 72.2 µM 3.85E-5 3 2.93E-5
18 SGTC_2357 9067248 3.89 200.0 µM 6.46E-5 17 5.00E-5
19 SGTC_681 1642-0006 3.84 26.6 µM 7.97E-5 6 6.21E-5
20 SGTC_1970 st070122 3.81 35.8 µM 8.87E-5 TSC3-RPN4 29 6.94E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.80E-9 YER152C YER152C hom Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene
0.095 4.15E-8 YOR311C DGK1 hom Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain
0.083 1.57E-6 YOR131C YOR131C hom Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress
0.074 1.66E-5 YGR242W_d YGR242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
0.074 1.75E-5 YGR071C ENV11 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.074 1.98E-5 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.073 2.62E-5 YPL064C CWC27 hom Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress
0.072 3.05E-5 YMR246W FAA4 hom Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication
0.068 8.94E-5 YOL160W_d YOL160W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.067 9.40E-5 YBL073W_d YBL073W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene AAR2/YBL074C
0.067 1.04E-4 YLR409C UTP21 het Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma
0.066 1.37E-4 YPR114W_p YPR114W_p hom Putative protein of unknown function
0.065 1.50E-4 YPR161C SGV1 het Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p; similar to metazoan CDK9 proteins
0.065 1.71E-4 YKR048C NAP1 hom Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress
0.064 1.90E-4 YDR020C_p DAS2_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases