YPL202C / AFT2

Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL202C / AFT2

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:-3.67|P-value:1.80E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:4.14|P-value:1.04E-5 ID:SGTC_21|Compound:0849-0113|FD-Score:4.74|P-value:6.04E-7 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.03|P-value:8.31E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.99|P-value:4.91E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:3.12|P-value:6.22E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:3.12|P-value:6.14E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.37|P-value:2.46E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.91|P-value:1.06E-12 ID:SGTC_341|Compound:1486-1430|FD-Score:4.10|P-value:1.27E-5 ID:SGTC_362|Compound:0310-0100|FD-Score:-4.01|P-value:4.67E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:3.70|P-value:6.91E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:7.34|P-value:4.33E-14 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:4.89|P-value:2.74E-7 ID:SGTC_481|Compound:bay k-8644|FD-Score:-3.88|P-value:7.81E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:3.45|P-value:1.80E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:4.16|P-value:9.56E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:3.80|P-value:4.56E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:-3.31|P-value:6.75E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:4.47|P-value:2.30E-6 ID:SGTC_1035|Compound:k081-0041|FD-Score:6.16|P-value:1.71E-10 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.35|P-value:2.65E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.00|P-value:9.22E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.61|P-value:9.74E-5 ID:SGTC_1530|Compound:rhein|FD-Score:4.87|P-value:3.01E-7 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.20|P-value:4.61E-4 ID:SGTC_1644|Compound:st010134|FD-Score:3.42|P-value:2.03E-4 ID:SGTC_1662|Compound:st014054|FD-Score:3.61|P-value:9.83E-5 ID:SGTC_1715|Compound:st032160|FD-Score:4.27|P-value:5.76E-6 ID:SGTC_1724|Compound:st037281|FD-Score:5.50|P-value:9.74E-9 ID:SGTC_1754|Compound:st042065|FD-Score:5.13|P-value:7.70E-8 ID:SGTC_1760|Compound:st045453|FD-Score:6.46|P-value:2.41E-11 ID:SGTC_1800|Compound:st050079|FD-Score:11.10|P-value:8.33E-30 ID:SGTC_1801|Compound:st050089|FD-Score:10.60|P-value:4.45E-27 ID:SGTC_1803|Compound:st050068|FD-Score:6.56|P-value:1.18E-11 ID:SGTC_1818|Compound:st052136|FD-Score:5.82|P-value:1.46E-9 ID:SGTC_1827|Compound:berberine|FD-Score:3.83|P-value:4.06E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.92|P-value:9.27E-13 ID:SGTC_1851|Compound:st056236|FD-Score:3.33|P-value:2.87E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.61|P-value:1.14E-6 ID:SGTC_2003|Compound:4023581|FD-Score:3.49|P-value:1.56E-4 ID:SGTC_2257|Compound:7960413|FD-Score:3.65|P-value:8.37E-5 ID:SGTC_2348|Compound:9022543|FD-Score:3.51|P-value:1.47E-4 ID:SGTC_2350|Compound:9023895|FD-Score:2.98|P-value:9.88E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.05|P-value:7.76E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.86|P-value:3.54E-5 ID:SGTC_2415|Compound:st077333|FD-Score:4.91|P-value:2.49E-7 ID:SGTC_2461|Compound:5755302|FD-Score:2.98|P-value:9.94E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.41|P-value:2.09E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.21|P-value:4.37E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.01|P-value:8.84E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.65|P-value:9.36E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.45|P-value:1.86E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.75|P-value:5.60E-5 ID:SGTC_2787|Compound:5284540|FD-Score:3.71|P-value:6.57E-5 ID:SGTC_2953|Compound:9074162|FD-Score:3.91|P-value:2.88E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.36|P-value:2.55E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:-3.67|P-value:1.80E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:4.14|P-value:1.04E-5 ID:SGTC_21|Compound:0849-0113|FD-Score:4.74|P-value:6.04E-7 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.03|P-value:8.31E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.99|P-value:4.91E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:3.12|P-value:6.22E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:3.12|P-value:6.14E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.37|P-value:2.46E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.91|P-value:1.06E-12 ID:SGTC_341|Compound:1486-1430|FD-Score:4.10|P-value:1.27E-5 ID:SGTC_362|Compound:0310-0100|FD-Score:-4.01|P-value:4.67E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:3.70|P-value:6.91E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:7.34|P-value:4.33E-14 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:4.89|P-value:2.74E-7 ID:SGTC_481|Compound:bay k-8644|FD-Score:-3.88|P-value:7.81E-5 ID:SGTC_527|Compound:4476-4215|FD-Score:3.45|P-value:1.80E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:4.16|P-value:9.56E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:3.80|P-value:4.56E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:-3.31|P-value:6.75E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:4.47|P-value:2.30E-6 ID:SGTC_1035|Compound:k081-0041|FD-Score:6.16|P-value:1.71E-10 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.35|P-value:2.65E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.00|P-value:9.22E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.61|P-value:9.74E-5 ID:SGTC_1530|Compound:rhein|FD-Score:4.87|P-value:3.01E-7 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.20|P-value:4.61E-4 ID:SGTC_1644|Compound:st010134|FD-Score:3.42|P-value:2.03E-4 ID:SGTC_1662|Compound:st014054|FD-Score:3.61|P-value:9.83E-5 ID:SGTC_1715|Compound:st032160|FD-Score:4.27|P-value:5.76E-6 ID:SGTC_1724|Compound:st037281|FD-Score:5.50|P-value:9.74E-9 ID:SGTC_1754|Compound:st042065|FD-Score:5.13|P-value:7.70E-8 ID:SGTC_1760|Compound:st045453|FD-Score:6.46|P-value:2.41E-11 ID:SGTC_1800|Compound:st050079|FD-Score:11.10|P-value:8.33E-30 ID:SGTC_1801|Compound:st050089|FD-Score:10.60|P-value:4.45E-27 ID:SGTC_1803|Compound:st050068|FD-Score:6.56|P-value:1.18E-11 ID:SGTC_1818|Compound:st052136|FD-Score:5.82|P-value:1.46E-9 ID:SGTC_1827|Compound:berberine|FD-Score:3.83|P-value:4.06E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.92|P-value:9.27E-13 ID:SGTC_1851|Compound:st056236|FD-Score:3.33|P-value:2.87E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.61|P-value:1.14E-6 ID:SGTC_2003|Compound:4023581|FD-Score:3.49|P-value:1.56E-4 ID:SGTC_2257|Compound:7960413|FD-Score:3.65|P-value:8.37E-5 ID:SGTC_2348|Compound:9022543|FD-Score:3.51|P-value:1.47E-4 ID:SGTC_2350|Compound:9023895|FD-Score:2.98|P-value:9.88E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.05|P-value:7.76E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.86|P-value:3.54E-5 ID:SGTC_2415|Compound:st077333|FD-Score:4.91|P-value:2.49E-7 ID:SGTC_2461|Compound:5755302|FD-Score:2.98|P-value:9.94E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.41|P-value:2.09E-4 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.21|P-value:4.37E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.01|P-value:8.84E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.65|P-value:9.36E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.45|P-value:1.86E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.75|P-value:5.60E-5 ID:SGTC_2787|Compound:5284540|FD-Score:3.71|P-value:6.57E-5 ID:SGTC_2953|Compound:9074162|FD-Score:3.91|P-value:2.88E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.36|P-value:2.55E-4

Top fitness defect scores for YPL202C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1800 st050079 11.10 29.1 µM 8.33E-30 NEO1-PIK1 1 3.60E-29
2 SGTC_1801 st050089 10.60 28.4 µM 4.45E-27 NEO1-PIK1 11 1.77E-26
3 SGTC_467 ro 31-8220 7.34 72.8 µM 4.33E-14 calcium & mitochondrial duress 18 1.08E-13
4 SGTC_1844 rapamycin 6.92 4.0 nM 9.27E-13 73 2.20E-12
5 SGTC_221 trifluoperazine 6.91 10.3 µM 1.06E-12 NEO1-PIK1 103 2.50E-12
6 SGTC_1803 st050068 6.56 52.4 µM 1.18E-11 NEO1-PIK1 64 2.67E-11
7 SGTC_1760 st045453 6.46 10.4 µM 2.41E-11 NEO1-PIK1 74 5.36E-11
8 SGTC_1035 k081-0041 6.16 55.2 µM 1.71E-10 Golgi 4 3.67E-10
9 SGTC_1818 st052136 5.82 56.3 µM 1.46E-9 NEO1-PIK1 14 2.99E-9
10 SGTC_1724 st037281 5.50 8.3 µM 9.74E-9 13 1.92E-8
11 SGTC_1754 st042065 5.13 16.1 µM 7.70E-8 NEO1-PIK1 121 1.45E-7
12 SGTC_2415 st077333 4.91 57.7 µM 2.49E-7 20 4.56E-7
13 SGTC_475 α-linolenic acid 4.89 10.0 µM 2.74E-7 excess fatty acid 8 4.99E-7
14 SGTC_1530 rhein 4.87 70.4 µM 3.01E-7 9 5.48E-7
15 SGTC_21 0849-0113 4.74 23.0 µM 6.04E-7 14 1.08E-6
16 SGTC_2679 rapamycin 4.65 1.0 nM 9.36E-7 109 1.66E-6
17 SGTC_1873 rapamycin 4.61 2.0 nM 1.14E-6 56 2.01E-6
18 SGTC_1033 k072-0102 4.47 21.3 µM 2.30E-6 60S ribosome export 9 3.99E-6
19 SGTC_1715 st032160 4.27 10.2 µM 5.76E-6 38 9.75E-6
20 SGTC_722 3534-0461 4.16 190.0 µM 9.56E-6 PDR1 30 1.60E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.364 1.20E-105 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.338 3.12E-90 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.326 6.71E-84 YDR492W IZH1 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
0.314 1.50E-77 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.309 4.02E-75 YJL052W TDH1 hom Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress
0.309 4.64E-75 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.305 4.07E-73 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.301 5.04E-71 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.300 1.02E-70 YAR042W SWH1 hom Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction
0.297 5.65E-69 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.294 9.79E-68 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.293 2.44E-67 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.288 3.64E-65 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.279 4.83E-61 YPR092W_d YPR092W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.274 5.69E-59 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p