YPL206C / PGC1

Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL206C / PGC1

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:-3.56|P-value:4.37E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.35|P-value:4.32E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:-3.78|P-value:1.99E-4 ID:SGTC_269|Compound:exalamide|FD-Score:3.55|P-value:2.13E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.61|P-value:1.71E-4 ID:SGTC_456|Compound:gingerol|FD-Score:4.25|P-value:1.38E-5 ID:SGTC_501|Compound:nsc-95397|FD-Score:4.23|P-value:1.52E-5 ID:SGTC_504|Compound:lovastatin|FD-Score:3.10|P-value:0.00100 ID:SGTC_578|Compound:3460-0051|FD-Score:3.15|P-value:8.59E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.72|P-value:1.14E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.83|P-value:7.67E-5 ID:SGTC_756|Compound:0508-1999|FD-Score:5.13|P-value:2.27E-7 ID:SGTC_765|Compound:1319-0117|FD-Score:3.49|P-value:2.65E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.51|P-value:5.10E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:6.49|P-value:1.04E-10 ID:SGTC_1295|Compound:1013-0063|FD-Score:4.05|P-value:3.13E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.22|P-value:1.53E-5 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.26|P-value:6.02E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:4.15|P-value:2.05E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:6.58|P-value:6.06E-11 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.61|P-value:3.60E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:-3.77|P-value:2.06E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.28|P-value:5.53E-4 ID:SGTC_1638|Compound:st008370|FD-Score:4.21|P-value:1.65E-5 ID:SGTC_1806|Compound:st050005|FD-Score:4.03|P-value:3.40E-5 ID:SGTC_1822|Compound:st052468|FD-Score:4.19|P-value:1.79E-5 ID:SGTC_1829|Compound:berberine|FD-Score:3.57|P-value:1.98E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.30|P-value:5.18E-4 ID:SGTC_1942|Compound:st076330|FD-Score:4.43|P-value:6.34E-6 ID:SGTC_2011|Compound:4012611|FD-Score:3.96|P-value:4.61E-5 ID:SGTC_2012|Compound:4023501|FD-Score:3.57|P-value:2.03E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-3.51|P-value:5.04E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-3.40|P-value:7.44E-4 ID:SGTC_2345|Compound:9052315|FD-Score:4.68|P-value:2.06E-6 ID:SGTC_2351|Compound:9026858|FD-Score:3.64|P-value:1.57E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.42|P-value:3.49E-4 ID:SGTC_2800|Compound:7887935|FD-Score:3.52|P-value:2.41E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.52|P-value:2.43E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.11|P-value:9.94E-4 ID:SGTC_2951|Compound:9072950|FD-Score:4.01|P-value:3.65E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.42|P-value:3.46E-4 ID:SGTC_3073|Compound:9114972|FD-Score:4.68|P-value:2.01E-6 ID:SGTC_3166|Compound:9102297|FD-Score:4.64|P-value:2.47E-6 ID:SGTC_3167|Compound:9103034|FD-Score:3.15|P-value:8.74E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.19|P-value:7.63E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:-3.56|P-value:4.37E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.35|P-value:4.32E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:-3.78|P-value:1.99E-4 ID:SGTC_269|Compound:exalamide|FD-Score:3.55|P-value:2.13E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.61|P-value:1.71E-4 ID:SGTC_456|Compound:gingerol|FD-Score:4.25|P-value:1.38E-5 ID:SGTC_501|Compound:nsc-95397|FD-Score:4.23|P-value:1.52E-5 ID:SGTC_504|Compound:lovastatin|FD-Score:3.10|P-value:0.00100 ID:SGTC_578|Compound:3460-0051|FD-Score:3.15|P-value:8.59E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.72|P-value:1.14E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.83|P-value:7.67E-5 ID:SGTC_756|Compound:0508-1999|FD-Score:5.13|P-value:2.27E-7 ID:SGTC_765|Compound:1319-0117|FD-Score:3.49|P-value:2.65E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.51|P-value:5.10E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:6.49|P-value:1.04E-10 ID:SGTC_1295|Compound:1013-0063|FD-Score:4.05|P-value:3.13E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:4.22|P-value:1.53E-5 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.26|P-value:6.02E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:4.15|P-value:2.05E-5 ID:SGTC_1396|Compound:3511-0007|FD-Score:6.58|P-value:6.06E-11 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.61|P-value:3.60E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:-3.77|P-value:2.06E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.28|P-value:5.53E-4 ID:SGTC_1638|Compound:st008370|FD-Score:4.21|P-value:1.65E-5 ID:SGTC_1806|Compound:st050005|FD-Score:4.03|P-value:3.40E-5 ID:SGTC_1822|Compound:st052468|FD-Score:4.19|P-value:1.79E-5 ID:SGTC_1829|Compound:berberine|FD-Score:3.57|P-value:1.98E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.30|P-value:5.18E-4 ID:SGTC_1942|Compound:st076330|FD-Score:4.43|P-value:6.34E-6 ID:SGTC_2011|Compound:4012611|FD-Score:3.96|P-value:4.61E-5 ID:SGTC_2012|Compound:4023501|FD-Score:3.57|P-value:2.03E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-3.51|P-value:5.04E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-3.40|P-value:7.44E-4 ID:SGTC_2345|Compound:9052315|FD-Score:4.68|P-value:2.06E-6 ID:SGTC_2351|Compound:9026858|FD-Score:3.64|P-value:1.57E-4 ID:SGTC_2400|Compound:5203494|FD-Score:3.42|P-value:3.49E-4 ID:SGTC_2800|Compound:7887935|FD-Score:3.52|P-value:2.41E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.52|P-value:2.43E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.11|P-value:9.94E-4 ID:SGTC_2951|Compound:9072950|FD-Score:4.01|P-value:3.65E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.42|P-value:3.46E-4 ID:SGTC_3073|Compound:9114972|FD-Score:4.68|P-value:2.01E-6 ID:SGTC_3166|Compound:9102297|FD-Score:4.64|P-value:2.47E-6 ID:SGTC_3167|Compound:9103034|FD-Score:3.15|P-value:8.74E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.19|P-value:7.63E-4

Top fitness defect scores for YPL206C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1396 3511-0007 6.58 98.6 µM 6.06E-11 mitochondrial processes 2 2.39E-11
2 SGTC_1053 3366-3204 6.49 134.0 µM 1.04E-10 cell wall 5 4.21E-11
3 SGTC_756 0508-1999 5.13 28.3 µM 2.27E-7 RPP1 & pyrimidine depletion 7 1.43E-7
4 SGTC_3073 9114972 4.68 49.5 µM 2.01E-6 60S ribosome export 4 1.43E-6
5 SGTC_2345 9052315 4.68 157.4 µM 2.06E-6 9 1.46E-6
6 SGTC_3166 9102297 4.64 49.5 µM 2.47E-6 Golgi 23 1.77E-6
7 SGTC_1942 st076330 4.43 65.2 µM 6.34E-6 17 4.76E-6
8 SGTC_456 gingerol 4.25 170.0 µM 1.38E-5 15 1.08E-5
9 SGTC_501 nsc-95397 4.23 161.0 µM 1.52E-5 9 1.19E-5
10 SGTC_1331 1472-0049 4.22 76.2 µM 1.53E-5 13 1.20E-5
11 SGTC_1638 st008370 4.21 60.6 µM 1.65E-5 ergosterol biosynthesis 28 1.30E-5
12 SGTC_1822 st052468 4.19 42.0 µM 1.79E-5 8 1.42E-5
13 SGTC_1366 1683-0113 4.15 21.9 µM 2.05E-5 9 1.63E-5
14 SGTC_1295 1013-0063 4.05 9.8 µM 3.13E-5 8 2.54E-5
15 SGTC_1806 st050005 4.03 60.3 µM 3.40E-5 8 2.78E-5
16 SGTC_2951 9072950 4.01 58.1 µM 3.65E-5 ERG2 21 2.99E-5
17 SGTC_2011 4012611 3.96 177.0 µM 4.61E-5 mitochondrial processes 30 3.83E-5
18 SGTC_665 3914-0008 3.83 307.0 µM 7.67E-5 24 6.52E-5
19 SGTC_579 4491-1009 3.72 110.0 µM 1.14E-4 60S ribosome export 28 9.88E-5
20 SGTC_2351 9026858 3.64 72.3 µM 1.57E-4 RNA processing & uracil transport 33 1.37E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.105 1.09E-9 YIR009W MSL1 hom U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members
0.095 3.18E-8 YOR249C APC5 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress
0.094 5.53E-8 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.092 9.12E-8 YDL030W PRP9 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex
0.092 9.33E-8 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.088 3.35E-7 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C
0.085 7.16E-7 YCL050C APA1 hom AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication
0.079 4.08E-6 YGR179C OKP1 het Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7
0.079 4.08E-6 YLL047W_d YLL047W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1
0.079 4.30E-6 YPL224C MMT2 hom Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p
0.075 1.34E-5 YMR234W RNH1 hom Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201)
0.073 2.11E-5 YKR063C LAS1 het Protein required for pre-rRNA processing at both ends of ITS2; may coordinate the action of the Rat1p-Rai1p exoRNAse; required for the G1/S transition of the cell cycle; human ortholog is Las1L; mutants require the SSD1-v allele for viability
0.073 2.28E-5 YGR011W_d YGR011W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.073 2.52E-5 YCL069W VBA3 hom Permease of basic amino acids in the vacuolar membrane
0.073 2.54E-5 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress