YPL207W / TYW1

Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL207W / TYW1

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:3.55|P-value:1.73E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.76|P-value:7.38E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:3.69|P-value:9.89E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:3.12|P-value:8.28E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.63|P-value:1.55E-6 ID:SGTC_273|Compound:hydroxyurea|FD-Score:6.80|P-value:3.55E-12 ID:SGTC_354|Compound:2783-3500|FD-Score:3.19|P-value:6.56E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.16|P-value:7.51E-4 ID:SGTC_394|Compound:menadione|FD-Score:5.43|P-value:2.17E-8 ID:SGTC_400|Compound:oxethazaine|FD-Score:4.29|P-value:7.62E-6 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.19|P-value:6.44E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:-3.38|P-value:3.44E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.54|P-value:1.79E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.16|P-value:7.12E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:4.11|P-value:1.69E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:3.12|P-value:8.26E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.84|P-value:5.37E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:5.68|P-value:5.21E-9 ID:SGTC_839|Compound:0122-0028|FD-Score:4.44|P-value:3.73E-6 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.28|P-value:4.78E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:4.38|P-value:5.04E-6 ID:SGTC_1011|Compound:4112-3381|FD-Score:5.74|P-value:3.66E-9 ID:SGTC_1118|Compound:chelidonine|FD-Score:-3.14|P-value:8.07E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:5.73|P-value:3.74E-9 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.66|P-value:1.10E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:5.12|P-value:1.21E-7 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.39|P-value:3.10E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.36|P-value:3.45E-4 ID:SGTC_1766|Compound:st045414|FD-Score:4.20|P-value:1.16E-5 ID:SGTC_1783|Compound:st039459|FD-Score:3.78|P-value:6.82E-5 ID:SGTC_1845|Compound:st056753|FD-Score:3.78|P-value:7.00E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:4.15|P-value:1.46E-5 ID:SGTC_1941|Compound:st076221|FD-Score:4.28|P-value:7.89E-6 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.08|P-value:9.49E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.23|P-value:5.70E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.23|P-value:5.69E-4 ID:SGTC_2079|Compound:5212404|FD-Score:3.99|P-value:2.84E-5 ID:SGTC_2121|Compound:5257820|FD-Score:-3.29|P-value:4.67E-4 ID:SGTC_2159|Compound:5658611|FD-Score:3.90|P-value:4.13E-5 ID:SGTC_2357|Compound:9067248|FD-Score:3.69|P-value:1.00E-4 ID:SGTC_2436|Compound:5633522|FD-Score:-3.95|P-value:3.52E-5 ID:SGTC_2451|Compound:5856223|FD-Score:3.29|P-value:4.46E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.62|P-value:1.31E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-6.59|P-value:1.69E-11 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.56|P-value:2.16E-6 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:7.02|P-value:7.62E-13 ID:SGTC_2601|Compound:securinine|FD-Score:-3.49|P-value:2.24E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:3.16|P-value:7.26E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:-3.23|P-value:5.90E-4 ID:SGTC_2787|Compound:5284540|FD-Score:6.36|P-value:7.19E-11 ID:SGTC_2817|Compound:7995342|FD-Score:3.88|P-value:4.61E-5 ID:SGTC_2849|Compound:9019321|FD-Score:3.38|P-value:3.21E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.30|P-value:4.34E-4 ID:SGTC_2951|Compound:9072950|FD-Score:4.28|P-value:7.90E-6 ID:SGTC_3044|Compound:9093193|FD-Score:3.92|P-value:3.91E-5 ID:SGTC_3047|Compound:9092122|FD-Score:3.17|P-value:6.92E-4 ID:SGTC_3136|Compound:9095672|FD-Score:4.87|P-value:4.62E-7 ID:SGTC_3221|Compound:9128209|FD-Score:-3.10|P-value:9.08E-4 ID:SGTC_3289|Compound:9119912|FD-Score:-4.09|P-value:1.91E-5 ID:SGTC_49|Compound:0717-0965|FD-Score:3.55|P-value:1.73E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.76|P-value:7.38E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:3.69|P-value:9.89E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:3.12|P-value:8.28E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.63|P-value:1.55E-6 ID:SGTC_273|Compound:hydroxyurea|FD-Score:6.80|P-value:3.55E-12 ID:SGTC_354|Compound:2783-3500|FD-Score:3.19|P-value:6.56E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.16|P-value:7.51E-4 ID:SGTC_394|Compound:menadione|FD-Score:5.43|P-value:2.17E-8 ID:SGTC_400|Compound:oxethazaine|FD-Score:4.29|P-value:7.62E-6 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.19|P-value:6.44E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:-3.38|P-value:3.44E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:3.54|P-value:1.79E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.16|P-value:7.12E-4 ID:SGTC_592|Compound:k241-0073|FD-Score:4.11|P-value:1.69E-5 ID:SGTC_670|Compound:4204-0025|FD-Score:3.12|P-value:8.26E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.84|P-value:5.37E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:5.68|P-value:5.21E-9 ID:SGTC_839|Compound:0122-0028|FD-Score:4.44|P-value:3.73E-6 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.28|P-value:4.78E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:4.38|P-value:5.04E-6 ID:SGTC_1011|Compound:4112-3381|FD-Score:5.74|P-value:3.66E-9 ID:SGTC_1118|Compound:chelidonine|FD-Score:-3.14|P-value:8.07E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:5.73|P-value:3.74E-9 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.66|P-value:1.10E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:5.12|P-value:1.21E-7 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.39|P-value:3.10E-4 ID:SGTC_1627|Compound:st003713|FD-Score:3.36|P-value:3.45E-4 ID:SGTC_1766|Compound:st045414|FD-Score:4.20|P-value:1.16E-5 ID:SGTC_1783|Compound:st039459|FD-Score:3.78|P-value:6.82E-5 ID:SGTC_1845|Compound:st056753|FD-Score:3.78|P-value:7.00E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:4.15|P-value:1.46E-5 ID:SGTC_1941|Compound:st076221|FD-Score:4.28|P-value:7.89E-6 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.08|P-value:9.49E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.23|P-value:5.70E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.23|P-value:5.69E-4 ID:SGTC_2079|Compound:5212404|FD-Score:3.99|P-value:2.84E-5 ID:SGTC_2121|Compound:5257820|FD-Score:-3.29|P-value:4.67E-4 ID:SGTC_2159|Compound:5658611|FD-Score:3.90|P-value:4.13E-5 ID:SGTC_2357|Compound:9067248|FD-Score:3.69|P-value:1.00E-4 ID:SGTC_2436|Compound:5633522|FD-Score:-3.95|P-value:3.52E-5 ID:SGTC_2451|Compound:5856223|FD-Score:3.29|P-value:4.46E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.62|P-value:1.31E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-6.59|P-value:1.69E-11 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:4.56|P-value:2.16E-6 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:7.02|P-value:7.62E-13 ID:SGTC_2601|Compound:securinine|FD-Score:-3.49|P-value:2.24E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:3.16|P-value:7.26E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:-3.23|P-value:5.90E-4 ID:SGTC_2787|Compound:5284540|FD-Score:6.36|P-value:7.19E-11 ID:SGTC_2817|Compound:7995342|FD-Score:3.88|P-value:4.61E-5 ID:SGTC_2849|Compound:9019321|FD-Score:3.38|P-value:3.21E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.30|P-value:4.34E-4 ID:SGTC_2951|Compound:9072950|FD-Score:4.28|P-value:7.90E-6 ID:SGTC_3044|Compound:9093193|FD-Score:3.92|P-value:3.91E-5 ID:SGTC_3047|Compound:9092122|FD-Score:3.17|P-value:6.92E-4 ID:SGTC_3136|Compound:9095672|FD-Score:4.87|P-value:4.62E-7 ID:SGTC_3221|Compound:9128209|FD-Score:-3.10|P-value:9.08E-4 ID:SGTC_3289|Compound:9119912|FD-Score:-4.09|P-value:1.91E-5

Top fitness defect scores for YPL207W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 7.02 100.0 µM 7.62E-13 3 1.13E-12
2 SGTC_273 hydroxyurea 6.80 18.1 mM 3.55E-12 heme biosynthesis & mitochondrial translocase 8 5.17E-12
3 SGTC_2787 5284540 6.36 71.4 µM 7.19E-11 3 1.00E-10
4 SGTC_1011 4112-3381 5.74 17.4 µM 3.66E-9 14 4.81E-9
5 SGTC_1173 0443-0020 5.73 122.0 µM 3.74E-9 TSC3-RPN4 10 4.92E-9
6 SGTC_807 1315-0151 5.68 48.0 µM 5.21E-9 6 6.82E-9
7 SGTC_394 menadione 5.43 8.3 µM 2.17E-8 superoxide 14 2.78E-8
8 SGTC_1249 0481-0015 5.12 10.2 µM 1.21E-7 11 1.52E-7
9 SGTC_3136 9095672 4.87 49.5 µM 4.62E-7 9 5.66E-7
10 SGTC_255 tunicamycin 4.63 200.5 nM 1.55E-6 unfolded protein response 52 1.86E-6
11 SGTC_2597 laccaic acid a 4.56 100.0 µM 2.16E-6 19 2.59E-6
12 SGTC_839 0122-0028 4.44 230.0 µM 3.73E-6 RSC complex & mRNA processing 25 4.44E-6
13 SGTC_883 0850-0245 4.38 24.6 µM 5.04E-6 cell wall 25 5.96E-6
14 SGTC_400 oxethazaine 4.29 37.5 µM 7.62E-6 calcium & mitochondrial duress 13 8.96E-6
15 SGTC_1941 st076221 4.28 61.8 µM 7.89E-6 sphingolipid biosynthesis & PDR1 64 9.27E-6
16 SGTC_2951 9072950 4.28 58.1 µM 7.90E-6 ERG2 17 9.28E-6
17 SGTC_1766 st045414 4.20 44.8 µM 1.16E-5 RPP1 & pyrimidine depletion 17 1.35E-5
18 SGTC_1880 MG-132 4.15 525.0 µM 1.46E-5 14 1.70E-5
19 SGTC_592 k241-0073 4.11 46.5 µM 1.69E-5 19 1.97E-5
20 SGTC_2079 5212404 3.99 121.0 µM 2.84E-5 13 3.27E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.163 1.80E-21 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.118 5.76E-12 YDR047W HEM12 het Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
0.088 3.26E-7 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.086 6.02E-7 YNL236W SIN4 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription
0.083 1.52E-6 YHL032C GUT1 hom Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
0.083 1.65E-6 YOR305W RRG7 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene
0.080 3.65E-6 YNL181W_p YNL181W_p het Putative oxidoreductase; required for cell viability
0.080 3.77E-6 YPR032W SRO7 hom Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication
0.077 8.04E-6 YOR222W ODC2 hom Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
0.077 8.15E-6 YHR022C-A_p YHR022C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.077 8.74E-6 YGL009C LEU1 hom Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
0.074 1.63E-5 YNL270C ALP1 hom Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication
0.073 2.61E-5 YBR080C SEC18 het ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF
0.072 2.77E-5 YKL043W PHD1 hom Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication
0.072 2.84E-5 YKR035W-A DID2 hom Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors