YPL209C / IPL1

Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for SPB cohesion and prevention of multipolar spindle formation; localizes to nuclear foci that become diffuse upon DNA replication stress; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon SAC arrest

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL209C / IPL1

Click on Significant Values for Screen Details ID:SGTC_161|Compound:4065-0411|FD-Score:3.13|P-value:4.57E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:10.00|P-value:1.53E-26 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.89|P-value:1.96E-5 ID:SGTC_641|Compound:4092-0595|FD-Score:3.11|P-value:4.93E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.85|P-value:2.35E-5 ID:SGTC_659|Compound:k018-0002|FD-Score:3.41|P-value:1.54E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:3.30|P-value:2.41E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.19|P-value:3.68E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.91|P-value:1.73E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.21|P-value:3.33E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.03|P-value:6.54E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.16|P-value:4.49E-4 ID:SGTC_1640|Compound:st009078|FD-Score:3.51|P-value:1.02E-4 ID:SGTC_1650|Compound:st011916|FD-Score:3.68|P-value:4.87E-5 ID:SGTC_1655|Compound:st012546|FD-Score:2.96|P-value:8.58E-4 ID:SGTC_1660|Compound:st012960|FD-Score:5.94|P-value:1.69E-10 ID:SGTC_1701|Compound:st028638|FD-Score:3.07|P-value:5.83E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-3.45|P-value:1.43E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:4.33|P-value:2.28E-6 ID:SGTC_2014|Compound:4013930|FD-Score:4.48|P-value:1.07E-6 ID:SGTC_2018|Compound:5133068|FD-Score:-3.97|P-value:1.47E-5 ID:SGTC_2022|Compound:5136654|FD-Score:4.99|P-value:6.45E-8 ID:SGTC_2028|Compound:5153890|FD-Score:-3.06|P-value:6.60E-4 ID:SGTC_2033|Compound:5192550|FD-Score:4.19|P-value:4.71E-6 ID:SGTC_2056|Compound:5235370|FD-Score:3.36|P-value:1.84E-4 ID:SGTC_2075|Compound:5212009|FD-Score:4.30|P-value:2.64E-6 ID:SGTC_2088|Compound:5278280|FD-Score:4.63|P-value:4.88E-7 ID:SGTC_2106|Compound:5357045|FD-Score:3.37|P-value:1.78E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.58|P-value:7.45E-5 ID:SGTC_2114|Compound:5491910|FD-Score:2.99|P-value:7.78E-4 ID:SGTC_2135|Compound:5326629|FD-Score:5.20|P-value:1.88E-8 ID:SGTC_2282|Compound:7944268|FD-Score:3.89|P-value:1.95E-5 ID:SGTC_2285|Compound:7945142|FD-Score:3.44|P-value:1.38E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-3.35|P-value:2.17E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-3.88|P-value:2.28E-5 ID:SGTC_2412|Compound:st077135|FD-Score:3.19|P-value:3.72E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.92|P-value:1.71E-5 ID:SGTC_2644|Compound:guaiazulene|FD-Score:-4.00|P-value:1.29E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.01|P-value:1.11E-5 ID:SGTC_2882|Compound:9058044|FD-Score:3.05|P-value:6.08E-4 ID:SGTC_2885|Compound:9057732|FD-Score:4.21|P-value:4.22E-6 ID:SGTC_2971|Compound:9092186|FD-Score:4.91|P-value:1.05E-7 ID:SGTC_3002|Compound:9075603|FD-Score:-3.10|P-value:5.59E-4 ID:SGTC_3017|Compound:9080681|FD-Score:3.08|P-value:5.64E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.58|P-value:7.59E-5 ID:SGTC_3244|Compound:9134489|FD-Score:3.17|P-value:3.98E-4 ID:SGTC_3289|Compound:9119912|FD-Score:3.01|P-value:7.25E-4 ID:SGTC_3338|Compound:9144300|FD-Score:3.20|P-value:3.58E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.13|P-value:4.57E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:10.00|P-value:1.53E-26 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.89|P-value:1.96E-5 ID:SGTC_641|Compound:4092-0595|FD-Score:3.11|P-value:4.93E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.85|P-value:2.35E-5 ID:SGTC_659|Compound:k018-0002|FD-Score:3.41|P-value:1.54E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:3.30|P-value:2.41E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.19|P-value:3.68E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.91|P-value:1.73E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.21|P-value:3.33E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.03|P-value:6.54E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.16|P-value:4.49E-4 ID:SGTC_1640|Compound:st009078|FD-Score:3.51|P-value:1.02E-4 ID:SGTC_1650|Compound:st011916|FD-Score:3.68|P-value:4.87E-5 ID:SGTC_1655|Compound:st012546|FD-Score:2.96|P-value:8.58E-4 ID:SGTC_1660|Compound:st012960|FD-Score:5.94|P-value:1.69E-10 ID:SGTC_1701|Compound:st028638|FD-Score:3.07|P-value:5.83E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-3.45|P-value:1.43E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:4.33|P-value:2.28E-6 ID:SGTC_2014|Compound:4013930|FD-Score:4.48|P-value:1.07E-6 ID:SGTC_2018|Compound:5133068|FD-Score:-3.97|P-value:1.47E-5 ID:SGTC_2022|Compound:5136654|FD-Score:4.99|P-value:6.45E-8 ID:SGTC_2028|Compound:5153890|FD-Score:-3.06|P-value:6.60E-4 ID:SGTC_2033|Compound:5192550|FD-Score:4.19|P-value:4.71E-6 ID:SGTC_2056|Compound:5235370|FD-Score:3.36|P-value:1.84E-4 ID:SGTC_2075|Compound:5212009|FD-Score:4.30|P-value:2.64E-6 ID:SGTC_2088|Compound:5278280|FD-Score:4.63|P-value:4.88E-7 ID:SGTC_2106|Compound:5357045|FD-Score:3.37|P-value:1.78E-4 ID:SGTC_2108|Compound:5365811|FD-Score:3.58|P-value:7.45E-5 ID:SGTC_2114|Compound:5491910|FD-Score:2.99|P-value:7.78E-4 ID:SGTC_2135|Compound:5326629|FD-Score:5.20|P-value:1.88E-8 ID:SGTC_2282|Compound:7944268|FD-Score:3.89|P-value:1.95E-5 ID:SGTC_2285|Compound:7945142|FD-Score:3.44|P-value:1.38E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-3.35|P-value:2.17E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-3.88|P-value:2.28E-5 ID:SGTC_2412|Compound:st077135|FD-Score:3.19|P-value:3.72E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.92|P-value:1.71E-5 ID:SGTC_2644|Compound:guaiazulene|FD-Score:-4.00|P-value:1.29E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.01|P-value:1.11E-5 ID:SGTC_2882|Compound:9058044|FD-Score:3.05|P-value:6.08E-4 ID:SGTC_2885|Compound:9057732|FD-Score:4.21|P-value:4.22E-6 ID:SGTC_2971|Compound:9092186|FD-Score:4.91|P-value:1.05E-7 ID:SGTC_3002|Compound:9075603|FD-Score:-3.10|P-value:5.59E-4 ID:SGTC_3017|Compound:9080681|FD-Score:3.08|P-value:5.64E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.58|P-value:7.59E-5 ID:SGTC_3244|Compound:9134489|FD-Score:3.17|P-value:3.98E-4 ID:SGTC_3289|Compound:9119912|FD-Score:3.01|P-value:7.25E-4 ID:SGTC_3338|Compound:9144300|FD-Score:3.20|P-value:3.58E-4

Top fitness defect scores for YPL209C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_163 1327-0036 10.00 7.5 µM 1.53E-26 16 5.49E-24 0.14
2 SGTC_1660 st012960 5.94 28.1 µM 1.69E-10 iron homeostasis 1 1.42E-9 1.24
3 SGTC_2135 5326629 5.20 150.4 µM 1.88E-8 RPP1 & pyrimidine depletion 3 9.80E-8 1.08
4 SGTC_2022 5136654 4.99 200.0 µM 6.45E-8 2 2.97E-7 0.84
5 SGTC_2971 9092186 4.91 9.9 µM 1.05E-7 ergosterol biosynthesis 5 4.60E-7 0.03
6 SGTC_2088 5278280 4.63 127.4 µM 4.88E-7 3 1.83E-6 0.86
7 SGTC_2014 4013930 4.48 200.0 µM 1.07E-6 2 3.73E-6 0.50
8 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 4.33 14.9 µM 2.28E-6 3 7.34E-6 0.41
9 SGTC_2075 5212009 4.30 200.0 µM 2.64E-6 5 8.38E-6 0.41
10 SGTC_2885 9057732 4.21 52.0 µM 4.22E-6 4 1.28E-5 0.49
11 SGTC_2033 5192550 4.19 145.0 µM 4.71E-6 4 1.41E-5 0.55
12 SGTC_2651 1327-0036 4.01 5.0 µM 1.11E-5 46 3.07E-5 0.02
13 SGTC_2477 5967686 3.92 25.2 µM 1.71E-5 9 4.52E-5 0.17
14 SGTC_964 1287-0107 3.91 19.4 µM 1.73E-5 cell wall 21 4.56E-5 0.32
15 SGTC_2282 7944268 3.89 200.0 µM 1.95E-5 RPP1 & pyrimidine depletion 9 5.07E-5 0.22
16 SGTC_261 5-fluorouridine 3.89 15.4 µM 1.96E-5 exosome 15 5.10E-5 0.19
17 SGTC_650 1328-0195 3.85 38.0 µM 2.35E-5 3 6.00E-5 0.34
18 SGTC_1650 st011916 3.68 45.8 µM 4.87E-5 2 1.16E-4 0.00
19 SGTC_2108 5365811 3.58 200.0 µM 7.45E-5 9 1.70E-4 0.03
20 SGTC_3026 9090633 3.58 49.5 µM 7.59E-5 9 1.73E-4 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.262 1.04E-53 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.259 9.74E-53 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.248 3.78E-48 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.236 9.88E-44 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.231 9.43E-42 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.202 2.40E-32 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.197 8.06E-31 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.193 1.20E-29 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.188 4.34E-28 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.174 2.40E-24 YER089C PTC2 hom Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication
0.173 6.85E-24 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.168 1.10E-22 YDR502C SAM2 hom S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication
0.162 3.23E-21 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.162 3.34E-21 YIL061C SNP1 het Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein; protein abundance increases in response to DNA replication stress
0.160 1.25E-20 YNL239W LAP3 hom Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH