YPL210C / SRP72

Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL210C / SRP72

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:4.12|P-value:4.30E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:3.73|P-value:1.90E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.25|P-value:9.38E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:8.80|P-value:2.44E-17 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.44|P-value:4.99E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.37|P-value:6.76E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.53|P-value:3.70E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:4.04|P-value:6.08E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:17.80|P-value:1.06E-64 ID:SGTC_352|Compound:k048-0007|FD-Score:3.27|P-value:9.42E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.33|P-value:7.70E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:3.96|P-value:8.30E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:7.51|P-value:4.13E-13 ID:SGTC_673|Compound:1082-0474|FD-Score:-4.07|P-value:4.97E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.38|P-value:6.58E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.44|P-value:5.32E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:-3.81|P-value:1.34E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.12|P-value:5.27E-7 ID:SGTC_1523|Compound:st012844|FD-Score:-7.19|P-value:3.27E-12 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-5.35|P-value:1.55E-7 ID:SGTC_1563|Compound:conessine|FD-Score:-3.30|P-value:7.98E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:6.11|P-value:2.87E-9 ID:SGTC_1780|Compound:st038448|FD-Score:3.84|P-value:1.30E-4 ID:SGTC_2082|Compound:5219693|FD-Score:-3.82|P-value:1.31E-4 ID:SGTC_2156|Compound:5649887|FD-Score:-4.70|P-value:3.46E-6 ID:SGTC_2292|Compound:7671323|FD-Score:-3.34|P-value:7.10E-4 ID:SGTC_2296|Compound:7971656|FD-Score:-4.28|P-value:2.13E-5 ID:SGTC_2303|Compound:7774051|FD-Score:3.84|P-value:1.28E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-4.74|P-value:2.89E-6 ID:SGTC_2414|Compound:st077232|FD-Score:3.70|P-value:2.16E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.60|P-value:3.09E-4 ID:SGTC_2463|Compound:5473429|FD-Score:-3.39|P-value:6.00E-4 ID:SGTC_2484|Compound:5809818|FD-Score:4.37|P-value:1.59E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:5.29|P-value:2.30E-7 ID:SGTC_2905|Compound:7799065|FD-Score:3.47|P-value:4.75E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.42|P-value:5.76E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-4.17|P-value:3.31E-5 ID:SGTC_3206|Compound:9114350|FD-Score:3.66|P-value:2.48E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:4.12|P-value:4.30E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:3.73|P-value:1.90E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.25|P-value:9.38E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:8.80|P-value:2.44E-17 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.44|P-value:4.99E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.37|P-value:6.76E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.53|P-value:3.70E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:4.04|P-value:6.08E-5 ID:SGTC_341|Compound:1486-1430|FD-Score:17.80|P-value:1.06E-64 ID:SGTC_352|Compound:k048-0007|FD-Score:3.27|P-value:9.42E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.33|P-value:7.70E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:3.96|P-value:8.30E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:7.51|P-value:4.13E-13 ID:SGTC_673|Compound:1082-0474|FD-Score:-4.07|P-value:4.97E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.38|P-value:6.58E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.44|P-value:5.32E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:-3.81|P-value:1.34E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.12|P-value:5.27E-7 ID:SGTC_1523|Compound:st012844|FD-Score:-7.19|P-value:3.27E-12 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-5.35|P-value:1.55E-7 ID:SGTC_1563|Compound:conessine|FD-Score:-3.30|P-value:7.98E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:6.11|P-value:2.87E-9 ID:SGTC_1780|Compound:st038448|FD-Score:3.84|P-value:1.30E-4 ID:SGTC_2082|Compound:5219693|FD-Score:-3.82|P-value:1.31E-4 ID:SGTC_2156|Compound:5649887|FD-Score:-4.70|P-value:3.46E-6 ID:SGTC_2292|Compound:7671323|FD-Score:-3.34|P-value:7.10E-4 ID:SGTC_2296|Compound:7971656|FD-Score:-4.28|P-value:2.13E-5 ID:SGTC_2303|Compound:7774051|FD-Score:3.84|P-value:1.28E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-4.74|P-value:2.89E-6 ID:SGTC_2414|Compound:st077232|FD-Score:3.70|P-value:2.16E-4 ID:SGTC_2455|Compound:5377712|FD-Score:3.60|P-value:3.09E-4 ID:SGTC_2463|Compound:5473429|FD-Score:-3.39|P-value:6.00E-4 ID:SGTC_2484|Compound:5809818|FD-Score:4.37|P-value:1.59E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:5.29|P-value:2.30E-7 ID:SGTC_2905|Compound:7799065|FD-Score:3.47|P-value:4.75E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.42|P-value:5.76E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-4.17|P-value:3.31E-5 ID:SGTC_3206|Compound:9114350|FD-Score:3.66|P-value:2.48E-4

Top fitness defect scores for YPL210C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_341 1486-1430 17.80 230.0 µM 1.06E-64 1 6.24E-71 8.66
2 SGTC_103 0844-0104 8.80 51.8 µM 2.44E-17 ERAD & cell cycle 11 6.72E-19 0.39
3 SGTC_568 1193-0097 7.51 7.5 µM 4.13E-13 ERAD & cell cycle 7 2.96E-14 0.16
4 SGTC_1631 benzylvanillin 6.11 81.9 µM 2.87E-9 Golgi 1 4.89E-10 1.38
5 SGTC_2645 abamectin 5.29 100.0 µM 2.30E-7 heme requiring 6 5.98E-8 0.65
6 SGTC_1161 k007-0610 5.12 110.0 µM 5.27E-7 ERAD & cell cycle 24 1.49E-7 0.32
7 SGTC_2484 5809818 4.37 12.0 µM 1.59E-5 2 6.25E-6 0.43
8 SGTC_16 erodoxin 4.12 22.8 µM 4.30E-5 unfolded protein response 28 1.86E-5 0.01
9 SGTC_332 4112-0506 4.04 40.9 µM 6.08E-5 22 2.71E-5 0.15
10 SGTC_547 1120-0019 3.96 610.0 nM 8.30E-5 azole & statin 7 3.81E-5 0.11
11 SGTC_2303 7774051 3.84 200.0 µM 1.28E-4 6 6.11E-5 0.04
12 SGTC_1780 st038448 3.84 24.5 µM 1.30E-4 iron homeostasis 8 6.24E-5 0.04
13 SGTC_35 0133-0054 3.73 64.1 µM 1.90E-4 10 9.45E-5 0.08
14 SGTC_2414 st077232 3.70 92.9 µM 2.16E-4 8 1.09E-4 0.15
15 SGTC_3206 9114350 3.66 49.5 µM 2.48E-4 6 1.26E-4 0.30
16 SGTC_2455 5377712 3.60 9.8 µM 3.09E-4 4 1.61E-4 0.03
17 SGTC_2905 7799065 3.47 20.1 µM 4.75E-4 10 2.57E-4 0.08
18 SGTC_922 1866-0035 3.44 480.0 µM 5.32E-4 excess fatty acid 14 2.92E-4 0.05
19 SGTC_2984 9022109 3.42 39.0 µM 5.76E-4 6 3.18E-4 0.08
20 SGTC_682 0kpi-0099 3.38 17.0 µM 6.58E-4 44 3.68E-4 6.34E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.266 3.06E-55 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.246 1.98E-47 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.209 1.72E-34 YJR117W STE24 hom Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans
0.203 1.66E-32 YDL126C CDC48 het AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP
0.199 3.11E-31 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.195 5.65E-30 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.194 1.10E-29 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.189 2.21E-28 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.188 3.45E-28 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.187 8.89E-28 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.187 8.85E-28 YKL196C YKT6 het Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus
0.176 1.12E-24 YPL243W SRP68 het Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
0.175 1.52E-24 YML105C SEC65 het Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19
0.175 1.98E-24 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.171 2.16E-23 YMR276W DSK2 hom Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress