YPL211W / NIP7

Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL211W / NIP7

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:3.39|P-value:2.24E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:-3.39|P-value:1.82E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.33|P-value:2.83E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.12|P-value:5.15E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.97|P-value:1.92E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:3.00|P-value:9.61E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.20|P-value:6.78E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.68|P-value:6.20E-7 ID:SGTC_248|Compound:streptozotocin|FD-Score:-2.98|P-value:8.69E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.34|P-value:2.28E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:5.39|P-value:1.09E-8 ID:SGTC_793|Compound:0488-0545|FD-Score:4.17|P-value:7.87E-6 ID:SGTC_847|Compound:0342-0274|FD-Score:-3.25|P-value:3.15E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:4.37|P-value:3.01E-6 ID:SGTC_956|Compound:1185-0240|FD-Score:3.46|P-value:1.74E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.09|P-value:7.11E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.78|P-value:4.55E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.21|P-value:4.45E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.32|P-value:2.93E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:-2.94|P-value:9.88E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.81|P-value:3.98E-5 ID:SGTC_1567|Compound:st069303|FD-Score:3.87|P-value:3.05E-5 ID:SGTC_1591|Compound:genipin|FD-Score:-3.36|P-value:2.04E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.33|P-value:2.87E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.46|P-value:1.72E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.92|P-value:2.44E-5 ID:SGTC_1847|Compound:st056231|FD-Score:3.60|P-value:9.83E-5 ID:SGTC_1913|Compound:st060213|FD-Score:3.25|P-value:3.80E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-3.04|P-value:7.07E-4 ID:SGTC_1932|Compound:st074806|FD-Score:5.37|P-value:1.26E-8 ID:SGTC_2019|Compound:4016004|FD-Score:4.29|P-value:4.45E-6 ID:SGTC_2180|Compound:6301957|FD-Score:-3.24|P-value:3.24E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.56|P-value:1.16E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-3.34|P-value:2.26E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:-4.22|P-value:4.72E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:5.37|P-value:1.22E-8 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.29|P-value:3.30E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:6.21|P-value:5.70E-11 ID:SGTC_2560|Compound:caryophyllene|FD-Score:-3.19|P-value:4.01E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.13|P-value:5.94E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.79|P-value:3.48E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.09|P-value:5.72E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.98|P-value:1.49E-5 ID:SGTC_2799|Compound:7812892|FD-Score:-3.11|P-value:5.33E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.61|P-value:9.33E-5 ID:SGTC_2863|Compound:9028737|FD-Score:3.76|P-value:5.01E-5 ID:SGTC_2966|Compound:9084041|FD-Score:-3.50|P-value:1.19E-4 ID:SGTC_2973|Compound:9094665|FD-Score:-3.71|P-value:4.99E-5 ID:SGTC_3056|Compound:9094900|FD-Score:3.42|P-value:1.97E-4 ID:SGTC_3242|Compound:9133940|FD-Score:3.12|P-value:6.18E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:3.39|P-value:2.24E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:-3.39|P-value:1.82E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.33|P-value:2.83E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.12|P-value:5.15E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.97|P-value:1.92E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:3.00|P-value:9.61E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:4.20|P-value:6.78E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:4.68|P-value:6.20E-7 ID:SGTC_248|Compound:streptozotocin|FD-Score:-2.98|P-value:8.69E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.34|P-value:2.28E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:5.39|P-value:1.09E-8 ID:SGTC_793|Compound:0488-0545|FD-Score:4.17|P-value:7.87E-6 ID:SGTC_847|Compound:0342-0274|FD-Score:-3.25|P-value:3.15E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:4.37|P-value:3.01E-6 ID:SGTC_956|Compound:1185-0240|FD-Score:3.46|P-value:1.74E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.09|P-value:7.11E-4 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.78|P-value:4.55E-5 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.21|P-value:4.45E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.32|P-value:2.93E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:-2.94|P-value:9.88E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.81|P-value:3.98E-5 ID:SGTC_1567|Compound:st069303|FD-Score:3.87|P-value:3.05E-5 ID:SGTC_1591|Compound:genipin|FD-Score:-3.36|P-value:2.04E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:3.33|P-value:2.87E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.46|P-value:1.72E-4 ID:SGTC_1824|Compound:st053723|FD-Score:3.92|P-value:2.44E-5 ID:SGTC_1847|Compound:st056231|FD-Score:3.60|P-value:9.83E-5 ID:SGTC_1913|Compound:st060213|FD-Score:3.25|P-value:3.80E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-3.04|P-value:7.07E-4 ID:SGTC_1932|Compound:st074806|FD-Score:5.37|P-value:1.26E-8 ID:SGTC_2019|Compound:4016004|FD-Score:4.29|P-value:4.45E-6 ID:SGTC_2180|Compound:6301957|FD-Score:-3.24|P-value:3.24E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:3.56|P-value:1.16E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-3.34|P-value:2.26E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:-4.22|P-value:4.72E-6 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:5.37|P-value:1.22E-8 ID:SGTC_2555|Compound:cholic acid|FD-Score:3.29|P-value:3.30E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:6.21|P-value:5.70E-11 ID:SGTC_2560|Compound:caryophyllene|FD-Score:-3.19|P-value:4.01E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.13|P-value:5.94E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.79|P-value:3.48E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.09|P-value:5.72E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.98|P-value:1.49E-5 ID:SGTC_2799|Compound:7812892|FD-Score:-3.11|P-value:5.33E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.61|P-value:9.33E-5 ID:SGTC_2863|Compound:9028737|FD-Score:3.76|P-value:5.01E-5 ID:SGTC_2966|Compound:9084041|FD-Score:-3.50|P-value:1.19E-4 ID:SGTC_2973|Compound:9094665|FD-Score:-3.71|P-value:4.99E-5 ID:SGTC_3056|Compound:9094900|FD-Score:3.42|P-value:1.97E-4 ID:SGTC_3242|Compound:9133940|FD-Score:3.12|P-value:6.18E-4

Top fitness defect scores for YPL211W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2557 derrustone 6.21 83.8 µM 5.70E-11 1 2.67E-10 1.44
2 SGTC_769 0302-0231 5.39 76.0 µM 1.09E-8 3 3.47E-8 0.02
3 SGTC_2553 4-methylesculetin 5.37 85.1 µM 1.22E-8 1 3.84E-8 1.14
4 SGTC_1932 st074806 5.37 40.9 µM 1.26E-8 5 3.96E-8 0.67
5 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.68 4.6 µM 6.20E-7 heat shock/prefoldin 17 1.46E-6 0.15
6 SGTC_907 3448-6986 4.37 75.5 µM 3.01E-6 4 6.33E-6 0.23
7 SGTC_2019 4016004 4.29 108.0 µM 4.45E-6 8 9.09E-6 0.47
8 SGTC_184 1494-0393 4.20 24.7 µM 6.78E-6 24 1.34E-5 0.07
9 SGTC_793 0488-0545 4.17 106.0 µM 7.87E-6 1 1.54E-5 0.39
10 SGTC_145 3737-0113 3.97 38.4 µM 1.92E-5 DNA intercalators 49 3.54E-5 0.03
11 SGTC_1824 st053723 3.92 68.6 µM 2.44E-5 4 4.42E-5 0.48
12 SGTC_1567 st069303 3.87 68.4 µM 3.05E-5 mitochondrial processes 13 5.43E-5 0.16
13 SGTC_1565 sinapyl alcohol 3.81 95.1 µM 3.98E-5 4 6.96E-5 0.14
14 SGTC_1137 ixabepilone 3.78 100.0 µM 4.55E-5 7 7.88E-5 0.07
15 SGTC_2863 9028737 3.76 58.4 µM 5.01E-5 2 8.61E-5 0.50
16 SGTC_2802 7925815 3.61 54.5 µM 9.33E-5 12 1.54E-4 0.04
17 SGTC_1847 st056231 3.60 15.0 µM 9.83E-5 5 1.61E-4 0.12
18 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 3.56 63.6 µM 1.16E-4 14 1.89E-4 0.08
19 SGTC_1722 st034304 3.46 3.6 µM 1.72E-4 mitochondrial processes 16 2.71E-4 0.10
20 SGTC_956 1185-0240 3.46 191.0 µM 1.74E-4 5 2.74E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.99E-15 YGR195W SKI6 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.111 9.71E-11 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.105 1.16E-9 YIL032C_d YIL032C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.102 3.28E-9 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.101 4.95E-9 YOL021C DIS3 het Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.100 6.54E-9 YGR158C MTR3 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.092 8.44E-8 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.091 1.16E-7 YDR524W-C_p YDR524W-C_p hom Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin
0.091 1.21E-7 YNR034W SOL1 hom Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.087 5.13E-7 YNL281W HCH1 hom Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.085 8.35E-7 YPL095C EEB1 hom Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication
0.085 9.50E-7 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.083 1.41E-6 YGL063W PUS2 hom Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification
0.082 2.13E-6 YDL238C GUD1 hom Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures
0.080 3.39E-6 YGR001C_p YGR001C_p hom Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae