YPL215W / CBP3

Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL215W / CBP3

Click on Significant Values for Screen Details ID:SGTC_53|Compound:0973-0023|FD-Score:3.03|P-value:4.52E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:4.90|P-value:4.62E-8 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.02|P-value:5.98E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:-4.97|P-value:4.32E-8 ID:SGTC_134|Compound:0269-0018|FD-Score:4.31|P-value:1.28E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:4.04|P-value:5.20E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:4.63|P-value:2.11E-7 ID:SGTC_181|Compound:1447-1644|FD-Score:3.61|P-value:3.92E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:4.00|P-value:6.31E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:27.50|P-value:9.98E-196 ID:SGTC_386|Compound:1509-0011|FD-Score:14.60|P-value:6.18E-57 ID:SGTC_547|Compound:1120-0019|FD-Score:-2.99|P-value:6.60E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:2.85|P-value:8.80E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:-3.03|P-value:5.77E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:4.11|P-value:3.52E-6 ID:SGTC_705|Compound:1124-0212|FD-Score:5.63|P-value:4.10E-10 ID:SGTC_707|Compound:0865-0008|FD-Score:3.19|P-value:2.42E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:-3.06|P-value:5.13E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:5.22|P-value:6.18E-9 ID:SGTC_859|Compound:0439-0102|FD-Score:2.83|P-value:9.56E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.29|P-value:1.57E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:5.08|P-value:1.48E-8 ID:SGTC_912|Compound:3474-0017|FD-Score:2.84|P-value:9.39E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:-2.97|P-value:7.11E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.15|P-value:3.55E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.33|P-value:1.75E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.21|P-value:2.78E-4 ID:SGTC_1635|Compound:st007035|FD-Score:15.10|P-value:1.17E-60 ID:SGTC_1674|Compound:st016616|FD-Score:3.28|P-value:1.65E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-2.93|P-value:8.37E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.20|P-value:2.30E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-2.96|P-value:7.45E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-3.68|P-value:3.87E-5 ID:SGTC_2120|Compound:5538279|FD-Score:3.02|P-value:4.78E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.72|P-value:2.34E-5 ID:SGTC_2307|Compound:7538926|FD-Score:5.42|P-value:1.75E-9 ID:SGTC_2311|Compound:7694451|FD-Score:-4.75|P-value:1.54E-7 ID:SGTC_2329|Compound:6138490|FD-Score:-3.70|P-value:3.40E-5 ID:SGTC_2372|Compound:9071633|FD-Score:3.29|P-value:1.60E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.66|P-value:3.20E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:2.83|P-value:9.49E-4 ID:SGTC_2822|Compound:7994718|FD-Score:2.92|P-value:6.99E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-3.02|P-value:5.95E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.13|P-value:3.08E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-2.89|P-value:9.50E-4 ID:SGTC_2982|Compound:9019404|FD-Score:6.62|P-value:2.70E-13 ID:SGTC_2985|Compound:9022375|FD-Score:4.81|P-value:7.64E-8 ID:SGTC_3038|Compound:9091290|FD-Score:3.40|P-value:9.76E-5 ID:SGTC_3284|Compound:9108171|FD-Score:-3.48|P-value:9.37E-5 ID:SGTC_3302|Compound:9125395|FD-Score:3.49|P-value:6.71E-5 ID:SGTC_3306|Compound:9127676|FD-Score:-6.18|P-value:1.25E-11 ID:SGTC_3307|Compound:9126885|FD-Score:-3.27|P-value:2.19E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-2.90|P-value:9.19E-4 ID:SGTC_3319|Compound:9138450|FD-Score:-2.92|P-value:8.76E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:3.03|P-value:4.52E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:4.90|P-value:4.62E-8 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.02|P-value:5.98E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:-4.97|P-value:4.32E-8 ID:SGTC_134|Compound:0269-0018|FD-Score:4.31|P-value:1.28E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:4.04|P-value:5.20E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:4.63|P-value:2.11E-7 ID:SGTC_181|Compound:1447-1644|FD-Score:3.61|P-value:3.92E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:4.00|P-value:6.31E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:27.50|P-value:9.98E-196 ID:SGTC_386|Compound:1509-0011|FD-Score:14.60|P-value:6.18E-57 ID:SGTC_547|Compound:1120-0019|FD-Score:-2.99|P-value:6.60E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:2.85|P-value:8.80E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:-3.03|P-value:5.77E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:4.11|P-value:3.52E-6 ID:SGTC_705|Compound:1124-0212|FD-Score:5.63|P-value:4.10E-10 ID:SGTC_707|Compound:0865-0008|FD-Score:3.19|P-value:2.42E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:-3.06|P-value:5.13E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:5.22|P-value:6.18E-9 ID:SGTC_859|Compound:0439-0102|FD-Score:2.83|P-value:9.56E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.29|P-value:1.57E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:5.08|P-value:1.48E-8 ID:SGTC_912|Compound:3474-0017|FD-Score:2.84|P-value:9.39E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:-2.97|P-value:7.11E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-3.15|P-value:3.55E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.33|P-value:1.75E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.21|P-value:2.78E-4 ID:SGTC_1635|Compound:st007035|FD-Score:15.10|P-value:1.17E-60 ID:SGTC_1674|Compound:st016616|FD-Score:3.28|P-value:1.65E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-2.93|P-value:8.37E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.20|P-value:2.30E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-2.96|P-value:7.45E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-3.68|P-value:3.87E-5 ID:SGTC_2120|Compound:5538279|FD-Score:3.02|P-value:4.78E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.72|P-value:2.34E-5 ID:SGTC_2307|Compound:7538926|FD-Score:5.42|P-value:1.75E-9 ID:SGTC_2311|Compound:7694451|FD-Score:-4.75|P-value:1.54E-7 ID:SGTC_2329|Compound:6138490|FD-Score:-3.70|P-value:3.40E-5 ID:SGTC_2372|Compound:9071633|FD-Score:3.29|P-value:1.60E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.66|P-value:3.20E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:2.83|P-value:9.49E-4 ID:SGTC_2822|Compound:7994718|FD-Score:2.92|P-value:6.99E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-3.02|P-value:5.95E-4 ID:SGTC_2938|Compound:9059746|FD-Score:3.13|P-value:3.08E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-2.89|P-value:9.50E-4 ID:SGTC_2982|Compound:9019404|FD-Score:6.62|P-value:2.70E-13 ID:SGTC_2985|Compound:9022375|FD-Score:4.81|P-value:7.64E-8 ID:SGTC_3038|Compound:9091290|FD-Score:3.40|P-value:9.76E-5 ID:SGTC_3284|Compound:9108171|FD-Score:-3.48|P-value:9.37E-5 ID:SGTC_3302|Compound:9125395|FD-Score:3.49|P-value:6.71E-5 ID:SGTC_3306|Compound:9127676|FD-Score:-6.18|P-value:1.25E-11 ID:SGTC_3307|Compound:9126885|FD-Score:-3.27|P-value:2.19E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-2.90|P-value:9.19E-4 ID:SGTC_3319|Compound:9138450|FD-Score:-2.92|P-value:8.76E-4

Top fitness defect scores for YPL215W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 27.50 5.3 µM 9.98E-196 22 1.81E-166
2 SGTC_1635 st007035 15.10 42.4 µM 1.17E-60 40 1.05E-51
3 SGTC_386 1509-0011 14.60 3.1 µM 6.18E-57 22 1.52E-48
4 SGTC_2982 9019404 6.62 26.0 µM 2.70E-13 4 1.76E-11
5 SGTC_705 1124-0212 5.63 310.0 µM 4.10E-10 3 8.86E-9
6 SGTC_2307 7538926 5.42 6.3 µM 1.75E-9 11 3.04E-8
7 SGTC_824 1304-0008 5.22 100.0 µM 6.18E-9 DNA damage response 19 8.88E-8
8 SGTC_908 3448-7491 5.08 47.7 µM 1.48E-8 mitochondrial stress 75 1.87E-7
9 SGTC_59 0330-0160 4.90 1.3 µM 4.62E-8 62 4.91E-7
10 SGTC_2985 9022375 4.81 71.4 µM 7.64E-8 RPP1 & pyrimidine depletion 15 7.53E-7
11 SGTC_168 3970-0862 4.63 530.5 µM 2.11E-7 83 1.79E-6
12 SGTC_134 0269-0018 4.31 6.9 µM 1.28E-6 117 8.29E-6
13 SGTC_704 1310-0270 4.11 142.0 µM 3.52E-6 30 1.96E-5
14 SGTC_149 3970-0822 4.04 46.1 µM 5.20E-6 tubulin folding & SWR complex 94 2.73E-5
15 SGTC_214 4373-3496 4.00 70.0 µM 6.31E-6 55 3.22E-5
16 SGTC_2250 alverine citrate 3.72 130.0 µM 2.34E-5 177 9.81E-5
17 SGTC_2602 kawain 3.66 100.0 µM 3.20E-5 36 1.28E-4
18 SGTC_181 1447-1644 3.61 8.1 µM 3.92E-5 endomembrane recycling 42 1.52E-4
19 SGTC_3302 9125395 3.49 16.4 µM 6.71E-5 26 2.41E-4
20 SGTC_3038 9091290 3.40 49.5 µM 9.76E-5 32 3.31E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.759 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.751 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.700 0 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.697 0 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.691 0 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.683 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.678 0 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.674 0 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.672 0 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.672 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.667 0 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.665 0 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.648 0 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.640 0 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.640 0 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p