YPL216W_p

Putative protein of unknown function; YPL216W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL216W / YPL216W

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:5.79|P-value:2.49E-9 ID:SGTC_81|Compound:0411-0046|FD-Score:-4.10|P-value:1.61E-5 ID:SGTC_90|Compound:0870-0863|FD-Score:-3.61|P-value:1.24E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:4.59|P-value:1.78E-6 ID:SGTC_336|Compound:4111-0029|FD-Score:3.77|P-value:7.12E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:4.25|P-value:8.71E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:3.35|P-value:3.61E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.50|P-value:1.87E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-3.39|P-value:2.86E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.29|P-value:4.53E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:3.66|P-value:1.10E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.68|P-value:1.00E-4 ID:SGTC_918|Compound:glabranin|FD-Score:4.72|P-value:9.40E-7 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.34|P-value:3.73E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.22|P-value:5.75E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.82|P-value:5.63E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.61|P-value:1.33E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.47|P-value:2.30E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:8.02|P-value:2.60E-16 ID:SGTC_1389|Compound:3405-0187|FD-Score:5.59|P-value:7.83E-9 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.98|P-value:2.87E-5 ID:SGTC_1609|Compound:st001574|FD-Score:5.71|P-value:3.89E-9 ID:SGTC_1629|Compound:st005085|FD-Score:4.87|P-value:4.33E-7 ID:SGTC_1640|Compound:st009078|FD-Score:3.84|P-value:5.26E-5 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.20|P-value:6.18E-4 ID:SGTC_1653|Compound:st012112|FD-Score:3.52|P-value:1.91E-4 ID:SGTC_1666|Compound:st014829|FD-Score:-3.77|P-value:6.53E-5 ID:SGTC_1765|Compound:st044815|FD-Score:3.27|P-value:4.84E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-4.23|P-value:8.75E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.72|P-value:9.26E-7 ID:SGTC_1934|Compound:st074720|FD-Score:5.08|P-value:1.39E-7 ID:SGTC_1959|Compound:st077091|FD-Score:3.18|P-value:6.69E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.13|P-value:7.47E-4 ID:SGTC_1987|Compound:st072290|FD-Score:3.15|P-value:7.51E-4 ID:SGTC_1991|Compound:st073000|FD-Score:6.00|P-value:6.73E-10 ID:SGTC_2009|Compound:4012297|FD-Score:-3.14|P-value:7.03E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.39|P-value:3.07E-4 ID:SGTC_2303|Compound:7774051|FD-Score:-3.21|P-value:5.57E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-4.04|P-value:2.10E-5 ID:SGTC_2403|Compound:6032726|FD-Score:3.25|P-value:5.14E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.88|P-value:1.20E-9 ID:SGTC_2448|Compound:5185112|FD-Score:3.54|P-value:1.73E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.15|P-value:7.41E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:3.80|P-value:6.20E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.88|P-value:4.12E-7 ID:SGTC_2525|Compound:harmine|FD-Score:7.06|P-value:4.79E-13 ID:SGTC_2526|Compound:patulin|FD-Score:6.01|P-value:6.15E-10 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.07|P-value:1.94E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:-4.15|P-value:1.28E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-9.73|P-value:2.95E-23 ID:SGTC_2591|Compound:skatole|FD-Score:-4.89|P-value:3.50E-7 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.44|P-value:2.62E-4 ID:SGTC_2907|Compound:7721985|FD-Score:-3.66|P-value:1.02E-4 ID:SGTC_2990|Compound:9074105|FD-Score:3.10|P-value:8.74E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:5.79|P-value:2.49E-9 ID:SGTC_81|Compound:0411-0046|FD-Score:-4.10|P-value:1.61E-5 ID:SGTC_90|Compound:0870-0863|FD-Score:-3.61|P-value:1.24E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:4.59|P-value:1.78E-6 ID:SGTC_336|Compound:4111-0029|FD-Score:3.77|P-value:7.12E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:4.25|P-value:8.71E-6 ID:SGTC_367|Compound:0335-0881|FD-Score:3.35|P-value:3.61E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.50|P-value:1.87E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-3.39|P-value:2.86E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.29|P-value:4.53E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:3.66|P-value:1.10E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.68|P-value:1.00E-4 ID:SGTC_918|Compound:glabranin|FD-Score:4.72|P-value:9.40E-7 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.34|P-value:3.73E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.22|P-value:5.75E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.82|P-value:5.63E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.61|P-value:1.33E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.47|P-value:2.30E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:8.02|P-value:2.60E-16 ID:SGTC_1389|Compound:3405-0187|FD-Score:5.59|P-value:7.83E-9 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.98|P-value:2.87E-5 ID:SGTC_1609|Compound:st001574|FD-Score:5.71|P-value:3.89E-9 ID:SGTC_1629|Compound:st005085|FD-Score:4.87|P-value:4.33E-7 ID:SGTC_1640|Compound:st009078|FD-Score:3.84|P-value:5.26E-5 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.20|P-value:6.18E-4 ID:SGTC_1653|Compound:st012112|FD-Score:3.52|P-value:1.91E-4 ID:SGTC_1666|Compound:st014829|FD-Score:-3.77|P-value:6.53E-5 ID:SGTC_1765|Compound:st044815|FD-Score:3.27|P-value:4.84E-4 ID:SGTC_1780|Compound:st038448|FD-Score:-4.23|P-value:8.75E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.72|P-value:9.26E-7 ID:SGTC_1934|Compound:st074720|FD-Score:5.08|P-value:1.39E-7 ID:SGTC_1959|Compound:st077091|FD-Score:3.18|P-value:6.69E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-3.13|P-value:7.47E-4 ID:SGTC_1987|Compound:st072290|FD-Score:3.15|P-value:7.51E-4 ID:SGTC_1991|Compound:st073000|FD-Score:6.00|P-value:6.73E-10 ID:SGTC_2009|Compound:4012297|FD-Score:-3.14|P-value:7.03E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.39|P-value:3.07E-4 ID:SGTC_2303|Compound:7774051|FD-Score:-3.21|P-value:5.57E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-4.04|P-value:2.10E-5 ID:SGTC_2403|Compound:6032726|FD-Score:3.25|P-value:5.14E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.88|P-value:1.20E-9 ID:SGTC_2448|Compound:5185112|FD-Score:3.54|P-value:1.73E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.15|P-value:7.41E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:3.80|P-value:6.20E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:4.88|P-value:4.12E-7 ID:SGTC_2525|Compound:harmine|FD-Score:7.06|P-value:4.79E-13 ID:SGTC_2526|Compound:patulin|FD-Score:6.01|P-value:6.15E-10 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.07|P-value:1.94E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:-4.15|P-value:1.28E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-9.73|P-value:2.95E-23 ID:SGTC_2591|Compound:skatole|FD-Score:-4.89|P-value:3.50E-7 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.44|P-value:2.62E-4 ID:SGTC_2907|Compound:7721985|FD-Score:-3.66|P-value:1.02E-4 ID:SGTC_2990|Compound:9074105|FD-Score:3.10|P-value:8.74E-4

Top fitness defect scores for YPL216W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1272 0839-0021 8.02 27.0 µM 2.60E-16 1 5.39E-16
2 SGTC_2525 harmine 7.06 47.9 µM 4.79E-13 ergosterol biosynthesis 2 8.39E-13
3 SGTC_2526 patulin 6.01 37.6 µM 6.15E-10 28 9.17E-10
4 SGTC_1991 st073000 6.00 8.9 µM 6.73E-10 NEO1 36 1.00E-9
5 SGTC_44 0929-0055 5.79 61.2 µM 2.49E-9 10 3.60E-9
6 SGTC_1609 st001574 5.71 46.4 µM 3.89E-9 1 5.57E-9
7 SGTC_1389 3405-0187 5.59 19.0 µM 7.83E-9 4 1.10E-8
8 SGTC_1934 st074720 5.08 32.6 µM 1.39E-7 26 1.84E-7
9 SGTC_2520 obtusaquinone 4.88 4.7 µM 4.12E-7 5 5.33E-7
10 SGTC_1629 st005085 4.87 44.9 µM 4.33E-7 RPP1 & pyrimidine depletion 14 5.59E-7
11 SGTC_1787 fluconazole 4.72 80.0 µM 9.26E-7 iron homeostasis 12 1.18E-6
12 SGTC_918 glabranin 4.72 770.7 nM 9.40E-7 15 1.19E-6
13 SGTC_330 1488-0319 4.59 80.1 µM 1.78E-6 RPP1 & pyrimidine depletion 5 2.23E-6
14 SGTC_361 000s-0510 4.25 1.4 µM 8.71E-6 26 1.05E-5
15 SGTC_2565 isoliquiritigenin 4.07 100.0 µM 1.94E-5 34 2.32E-5
16 SGTC_1480 1070-0044 3.98 41.2 µM 2.87E-5 19 3.39E-5
17 SGTC_1640 st009078 3.84 66.4 µM 5.26E-5 10 6.13E-5
18 SGTC_1129 3453-1384 3.82 223.0 µM 5.63E-5 41 6.55E-5
19 SGTC_2515 chrysin 3.80 20.8 µM 6.20E-5 RPP1 & pyrimidine depletion 11 7.21E-5
20 SGTC_336 4111-0029 3.77 111.0 µM 7.12E-5 9 8.25E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 4.74E-10 YER085C_p YER085C_p hom Putative protein of unknown function
0.101 4.54E-9 YDR538W PAD1 hom Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX
0.096 2.39E-8 YOR180C DCI1 hom Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed
0.086 5.89E-7 YJR008W MHO1 hom Protein of unknown function; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility
0.083 1.38E-6 YKL040C NFU1 hom Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria
0.080 3.36E-6 YEL011W GLC3 hom Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.076 1.09E-5 YHR150W PEX28 hom Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p
0.074 1.65E-5 YML111W BUL2 hom Component of the Rsp5p E3-ubiquitin ligase complex; involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication
0.074 1.82E-5 YJR044C VPS55 hom Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP)
0.073 2.03E-5 YKR098C UBP11 hom Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins
0.073 2.05E-5 YNL087W TCB2 hom ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud
0.072 2.70E-5 YMR233W TRI1 hom Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication
0.071 3.53E-5 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.071 3.75E-5 YPL236C ENV7 hom Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16)
0.071 3.98E-5 YDL115C IWR1 hom RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress