HIPHOP chemogenomics database

YPL217C / BMS1

GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p

Zygosity: Heterozygous strain

fixedexpanded
Profile for YPL217C / BMS1

Click on Significant Values for Screen Details

Top fitness defect scores for YPL217C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_1125	tnp00248	12.00	1.3 µM	1.39E-27		1	1.44E-33	3.19
2	SGTC_2858	9025781	7.74	9.0 µM	1.73E-12	sphingolipid biosynthesis & PDR1	2	5.09E-15	0.76
3	SGTC_1525	8-methoxypsoralen	7.64	92.5 µM	3.31E-12	DNA damage response	4	1.13E-14	1.47
4	SGTC_3152	9099253	7.10	49.5 µM	8.52E-11	NEO1-PIK1	10	6.08E-13	0.76
5	SGTC_3141	9094609	6.13	49.5 µM	1.81E-8	iron homeostasis	6	4.37E-10	0.94
6	SGTC_2507	purpurin	6.04	79.7 µM	2.84E-8	copper-dependent oxidative stress	5	7.58E-10	0.76
7	SGTC_2147	5545932	5.91	89.7 µM	5.44E-8	ergosterol biosynthesis	5	1.68E-9	0.75
8	SGTC_58	0957-0393	5.65	9.0 µM	1.94E-7	cell wall	30	7.99E-9	0.09
9	SGTC_1050	3232-1156	4.81	69.3 µM	7.99E-6	RSC complex & mRNA processing	15	7.62E-7	0.01
10	SGTC_1337	1486-1011	4.31	40.3 µM	5.52E-5		1	8.11E-6	0.54
11	SGTC_1250	0485-0349	4.27	40.2 µM	6.48E-5		8	9.87E-6	0.12
12	SGTC_1377	2944-0135	4.11	198.0 µM	1.13E-4	calcium & mitochondrial duress	6	1.96E-5	0.35
13	SGTC_769	0302-0231	4.06	76.0 µM	1.38E-4		10	2.49E-5	0.06
14	SGTC_1356	1502-0781	4.01	85.8 µM	1.63E-4	fatty acid desaturase (OLE1)	3	3.05E-5	0.05
15	SGTC_3301	9125354	4.00	19.8 µM	1.69E-4		2	3.18E-5	0.56
16	SGTC_682	0kpi-0099	3.99	17.0 µM	1.73E-4		28	3.28E-5	0.03
17	SGTC_3286	9117135	3.88	37.2 µM	2.51E-4		12	5.17E-5	0.06
18	SGTC_3247	9135149	3.86	49.5 µM	2.73E-4	DNA damage response	23	5.72E-5	0.02
19	SGTC_1046	2001-0062	3.86	216.0 µM	2.75E-4		2	5.78E-5	0.21
20	SGTC_1981	st071826	3.85	47.0 µM	2.84E-4		6	6.01E-5	0.10

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.156	1.19E-19	YKL115C_d	YKL115C_d	hom	Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.151	1.14E-18	YML103C	NUP188	hom	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.149	4.67E-18	YDR499W	LCD1	het	Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress
0.139	6.68E-16	YNL215W	IES2	hom	Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.138	7.94E-16	YGL066W	SGF73	hom	SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.137	1.49E-15	YKL005C	BYE1	hom	Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit
0.125	3.41E-13	YML102W	CAC2	hom	Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.124	5.85E-13	YDR257C	RKM4	hom	Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein
0.120	3.34E-12	YDR205W	MSC2	hom	Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.120	3.39E-12	YDR413C_d	YDR413C_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing
0.116	1.58E-11	YBR020W	GAL1	hom	Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.116	1.59E-11	YOR231W	MKK1	hom	MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.116	1.64E-11	YPL158C	AIM44	hom	Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.115	2.77E-11	YDR404C	RPB7	het	RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation
0.114	3.87E-11	YIL160C	POT1	hom	3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids