YPL217C / BMS1

GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL217C / BMS1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:5.65|P-value:1.94E-7 ID:SGTC_188|Compound:3229-0966|FD-Score:3.61|P-value:6.19E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.99|P-value:1.73E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.06|P-value:1.38E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:3.49|P-value:8.80E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.69|P-value:4.79E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.86|P-value:2.75E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:4.81|P-value:7.99E-6 ID:SGTC_1125|Compound:tnp00248|FD-Score:12.00|P-value:1.39E-27 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-6.24|P-value:7.84E-9 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.92|P-value:1.86E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.74|P-value:4.03E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.27|P-value:6.48E-5 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.79|P-value:3.37E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:4.31|P-value:5.52E-5 ID:SGTC_1356|Compound:1502-0781|FD-Score:4.01|P-value:1.63E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.11|P-value:1.13E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:7.64|P-value:3.31E-12 ID:SGTC_1527|Compound:coumarin|FD-Score:3.54|P-value:7.65E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.90|P-value:1.96E-4 ID:SGTC_1946|Compound:st076057|FD-Score:-3.81|P-value:2.71E-4 ID:SGTC_1981|Compound:st071826|FD-Score:3.85|P-value:2.84E-4 ID:SGTC_2143|Compound:5623677|FD-Score:-3.40|P-value:9.93E-4 ID:SGTC_2147|Compound:5545932|FD-Score:5.91|P-value:5.44E-8 ID:SGTC_2278|Compound:7948257|FD-Score:-3.89|P-value:2.04E-4 ID:SGTC_2383|Compound:9036125|FD-Score:3.50|P-value:8.64E-4 ID:SGTC_2479|Compound:5617353|FD-Score:-3.44|P-value:8.91E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:6.04|P-value:2.84E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.56|P-value:7.07E-4 ID:SGTC_2714|Compound:st079313|FD-Score:3.63|P-value:5.74E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.65|P-value:5.43E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-5.82|P-value:6.58E-8 ID:SGTC_2850|Compound:9015429|FD-Score:-3.73|P-value:3.49E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-7.17|P-value:4.22E-11 ID:SGTC_2858|Compound:9025781|FD-Score:7.74|P-value:1.73E-12 ID:SGTC_2896|Compound:9052656|FD-Score:-3.67|P-value:4.25E-4 ID:SGTC_3141|Compound:9094609|FD-Score:6.13|P-value:1.81E-8 ID:SGTC_3143|Compound:9086658|FD-Score:3.82|P-value:3.09E-4 ID:SGTC_3152|Compound:9099253|FD-Score:7.10|P-value:8.52E-11 ID:SGTC_3247|Compound:9135149|FD-Score:3.86|P-value:2.73E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.88|P-value:2.51E-4 ID:SGTC_3301|Compound:9125354|FD-Score:4.00|P-value:1.69E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.65|P-value:1.94E-7 ID:SGTC_188|Compound:3229-0966|FD-Score:3.61|P-value:6.19E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.99|P-value:1.73E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.06|P-value:1.38E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:3.49|P-value:8.80E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.69|P-value:4.79E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.86|P-value:2.75E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:4.81|P-value:7.99E-6 ID:SGTC_1125|Compound:tnp00248|FD-Score:12.00|P-value:1.39E-27 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-6.24|P-value:7.84E-9 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.92|P-value:1.86E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.74|P-value:4.03E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.27|P-value:6.48E-5 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.79|P-value:3.37E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:4.31|P-value:5.52E-5 ID:SGTC_1356|Compound:1502-0781|FD-Score:4.01|P-value:1.63E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.11|P-value:1.13E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:7.64|P-value:3.31E-12 ID:SGTC_1527|Compound:coumarin|FD-Score:3.54|P-value:7.65E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.90|P-value:1.96E-4 ID:SGTC_1946|Compound:st076057|FD-Score:-3.81|P-value:2.71E-4 ID:SGTC_1981|Compound:st071826|FD-Score:3.85|P-value:2.84E-4 ID:SGTC_2143|Compound:5623677|FD-Score:-3.40|P-value:9.93E-4 ID:SGTC_2147|Compound:5545932|FD-Score:5.91|P-value:5.44E-8 ID:SGTC_2278|Compound:7948257|FD-Score:-3.89|P-value:2.04E-4 ID:SGTC_2383|Compound:9036125|FD-Score:3.50|P-value:8.64E-4 ID:SGTC_2479|Compound:5617353|FD-Score:-3.44|P-value:8.91E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:6.04|P-value:2.84E-8 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.56|P-value:7.07E-4 ID:SGTC_2714|Compound:st079313|FD-Score:3.63|P-value:5.74E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.65|P-value:5.43E-4 ID:SGTC_2849|Compound:9019321|FD-Score:-5.82|P-value:6.58E-8 ID:SGTC_2850|Compound:9015429|FD-Score:-3.73|P-value:3.49E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-7.17|P-value:4.22E-11 ID:SGTC_2858|Compound:9025781|FD-Score:7.74|P-value:1.73E-12 ID:SGTC_2896|Compound:9052656|FD-Score:-3.67|P-value:4.25E-4 ID:SGTC_3141|Compound:9094609|FD-Score:6.13|P-value:1.81E-8 ID:SGTC_3143|Compound:9086658|FD-Score:3.82|P-value:3.09E-4 ID:SGTC_3152|Compound:9099253|FD-Score:7.10|P-value:8.52E-11 ID:SGTC_3247|Compound:9135149|FD-Score:3.86|P-value:2.73E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.88|P-value:2.51E-4 ID:SGTC_3301|Compound:9125354|FD-Score:4.00|P-value:1.69E-4

Top fitness defect scores for YPL217C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1125 tnp00248 12.00 1.3 µM 1.39E-27 1 1.44E-33 3.19
2 SGTC_2858 9025781 7.74 9.0 µM 1.73E-12 sphingolipid biosynthesis & PDR1 2 5.09E-15 0.76
3 SGTC_1525 8-methoxypsoralen 7.64 92.5 µM 3.31E-12 DNA damage response 4 1.13E-14 1.47
4 SGTC_3152 9099253 7.10 49.5 µM 8.52E-11 NEO1-PIK1 10 6.08E-13 0.76
5 SGTC_3141 9094609 6.13 49.5 µM 1.81E-8 iron homeostasis 6 4.37E-10 0.94
6 SGTC_2507 purpurin 6.04 79.7 µM 2.84E-8 copper-dependent oxidative stress 5 7.58E-10 0.76
7 SGTC_2147 5545932 5.91 89.7 µM 5.44E-8 ergosterol biosynthesis 5 1.68E-9 0.75
8 SGTC_58 0957-0393 5.65 9.0 µM 1.94E-7 cell wall 30 7.99E-9 0.09
9 SGTC_1050 3232-1156 4.81 69.3 µM 7.99E-6 RSC complex & mRNA processing 15 7.62E-7 0.01
10 SGTC_1337 1486-1011 4.31 40.3 µM 5.52E-5 1 8.11E-6 0.54
11 SGTC_1250 0485-0349 4.27 40.2 µM 6.48E-5 8 9.87E-6 0.12
12 SGTC_1377 2944-0135 4.11 198.0 µM 1.13E-4 calcium & mitochondrial duress 6 1.96E-5 0.35
13 SGTC_769 0302-0231 4.06 76.0 µM 1.38E-4 10 2.49E-5 0.06
14 SGTC_1356 1502-0781 4.01 85.8 µM 1.63E-4 fatty acid desaturase (OLE1) 3 3.05E-5 0.05
15 SGTC_3301 9125354 4.00 19.8 µM 1.69E-4 2 3.18E-5 0.56
16 SGTC_682 0kpi-0099 3.99 17.0 µM 1.73E-4 28 3.28E-5 0.03
17 SGTC_3286 9117135 3.88 37.2 µM 2.51E-4 12 5.17E-5 0.06
18 SGTC_3247 9135149 3.86 49.5 µM 2.73E-4 DNA damage response 23 5.72E-5 0.02
19 SGTC_1046 2001-0062 3.86 216.0 µM 2.75E-4 2 5.78E-5 0.21
20 SGTC_1981 st071826 3.85 47.0 µM 2.84E-4 6 6.01E-5 0.10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.156 1.19E-19 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.151 1.14E-18 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.149 4.67E-18 YDR499W LCD1 het Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress
0.139 6.68E-16 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.138 7.94E-16 YGL066W SGF73 hom SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.137 1.49E-15 YKL005C BYE1 hom Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit
0.125 3.41E-13 YML102W CAC2 hom Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription
0.124 5.85E-13 YDR257C RKM4 hom Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein
0.120 3.34E-12 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.120 3.39E-12 YDR413C_d YDR413C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing
0.116 1.58E-11 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.116 1.59E-11 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.116 1.64E-11 YPL158C AIM44 hom Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.115 2.77E-11 YDR404C RPB7 het RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation
0.114 3.87E-11 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids