YPL219W / PCL8

Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL219W / PCL8

Click on Significant Values for Screen Details ID:SGTC_88|Compound:0180-0332|FD-Score:5.15|P-value:8.02E-7 ID:SGTC_89|Compound:0302-0250|FD-Score:3.74|P-value:2.45E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.43|P-value:6.88E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:4.32|P-value:2.83E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:3.67|P-value:3.12E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.37|P-value:8.36E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.38|P-value:8.11E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:4.44|P-value:1.75E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:4.38|P-value:2.18E-5 ID:SGTC_323|Compound:4013-0906|FD-Score:-3.65|P-value:3.17E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.66|P-value:3.20E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:5.79|P-value:3.33E-8 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.50|P-value:5.29E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.60|P-value:4.03E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:4.18|P-value:4.95E-5 ID:SGTC_783|Compound:0848-0141|FD-Score:3.41|P-value:7.39E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.72|P-value:2.60E-4 ID:SGTC_1633|Compound:st005664|FD-Score:6.22|P-value:3.36E-9 ID:SGTC_1710|Compound:st031758|FD-Score:4.52|P-value:1.27E-5 ID:SGTC_1802|Compound:st050112|FD-Score:4.07|P-value:7.31E-5 ID:SGTC_1886|Compound:st057356|FD-Score:4.63|P-value:7.79E-6 ID:SGTC_2081|Compound:5214970|FD-Score:4.40|P-value:2.02E-5 ID:SGTC_2109|Compound:5483026|FD-Score:-3.70|P-value:2.69E-4 ID:SGTC_2123|Compound:5259487|FD-Score:-3.49|P-value:5.39E-4 ID:SGTC_2307|Compound:7538926|FD-Score:5.26|P-value:4.74E-7 ID:SGTC_2370|Compound:9071495|FD-Score:-3.37|P-value:7.96E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.52|P-value:5.12E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.98|P-value:1.69E-6 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.95|P-value:1.16E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.53|P-value:4.70E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:-3.41|P-value:6.96E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.81|P-value:1.90E-4 ID:SGTC_2830|Compound:7992007|FD-Score:4.87|P-value:2.78E-6 ID:SGTC_2833|Compound:9001315|FD-Score:3.46|P-value:6.32E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.67|P-value:3.13E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-4.20|P-value:4.26E-5 ID:SGTC_2943|Compound:9068529|FD-Score:5.25|P-value:4.79E-7 ID:SGTC_3057|Compound:9095946|FD-Score:3.53|P-value:5.07E-4 ID:SGTC_3149|Compound:9097855|FD-Score:4.15|P-value:5.46E-5 ID:SGTC_3180|Compound:9109287|FD-Score:3.78|P-value:2.11E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.61|P-value:3.88E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:5.15|P-value:8.02E-7 ID:SGTC_89|Compound:0302-0250|FD-Score:3.74|P-value:2.45E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.43|P-value:6.88E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:4.32|P-value:2.83E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:3.67|P-value:3.12E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:3.37|P-value:8.36E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.38|P-value:8.11E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:4.44|P-value:1.75E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:4.38|P-value:2.18E-5 ID:SGTC_323|Compound:4013-0906|FD-Score:-3.65|P-value:3.17E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.66|P-value:3.20E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:5.79|P-value:3.33E-8 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.50|P-value:5.29E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.60|P-value:4.03E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:4.18|P-value:4.95E-5 ID:SGTC_783|Compound:0848-0141|FD-Score:3.41|P-value:7.39E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.72|P-value:2.60E-4 ID:SGTC_1633|Compound:st005664|FD-Score:6.22|P-value:3.36E-9 ID:SGTC_1710|Compound:st031758|FD-Score:4.52|P-value:1.27E-5 ID:SGTC_1802|Compound:st050112|FD-Score:4.07|P-value:7.31E-5 ID:SGTC_1886|Compound:st057356|FD-Score:4.63|P-value:7.79E-6 ID:SGTC_2081|Compound:5214970|FD-Score:4.40|P-value:2.02E-5 ID:SGTC_2109|Compound:5483026|FD-Score:-3.70|P-value:2.69E-4 ID:SGTC_2123|Compound:5259487|FD-Score:-3.49|P-value:5.39E-4 ID:SGTC_2307|Compound:7538926|FD-Score:5.26|P-value:4.74E-7 ID:SGTC_2370|Compound:9071495|FD-Score:-3.37|P-value:7.96E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.52|P-value:5.12E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.98|P-value:1.69E-6 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.95|P-value:1.16E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.53|P-value:4.70E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:-3.41|P-value:6.96E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.81|P-value:1.90E-4 ID:SGTC_2830|Compound:7992007|FD-Score:4.87|P-value:2.78E-6 ID:SGTC_2833|Compound:9001315|FD-Score:3.46|P-value:6.32E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.67|P-value:3.13E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-4.20|P-value:4.26E-5 ID:SGTC_2943|Compound:9068529|FD-Score:5.25|P-value:4.79E-7 ID:SGTC_3057|Compound:9095946|FD-Score:3.53|P-value:5.07E-4 ID:SGTC_3149|Compound:9097855|FD-Score:4.15|P-value:5.46E-5 ID:SGTC_3180|Compound:9109287|FD-Score:3.78|P-value:2.11E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.61|P-value:3.88E-4

Top fitness defect scores for YPL219W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1633 st005664 6.22 67.9 µM 3.36E-9 5 2.56E-10
2 SGTC_552 k242-0005 5.79 476.0 µM 3.33E-8 1 3.52E-9
3 SGTC_2307 7538926 5.26 6.3 µM 4.74E-7 14 7.33E-8
4 SGTC_2943 9068529 5.25 45.3 µM 4.79E-7 6 7.43E-8
5 SGTC_88 0180-0332 5.15 8.7 µM 8.02E-7 6 1.34E-7
6 SGTC_2500 5-alpha-androstan-3,17-dione 4.98 61.4 µM 1.69E-6 21 3.14E-7
7 SGTC_2830 7992007 4.87 71.4 µM 2.78E-6 10 5.53E-7
8 SGTC_1886 st057356 4.63 49.9 µM 7.79E-6 60S ribosome export 6 1.80E-6
9 SGTC_1710 st031758 4.52 61.5 µM 1.27E-5 10 3.14E-6
10 SGTC_245 methotrexate 4.44 289.6 µM 1.75E-5 33 4.52E-6
11 SGTC_2081 5214970 4.40 32.3 µM 2.02E-5 15 5.32E-6
12 SGTC_272 doxorubicin 4.38 8.1 µM 2.18E-5 anthracycline transcription coupled DNA repair 15 5.80E-6
13 SGTC_98 0074-0023 4.32 107.7 µM 2.83E-5 Golgi 32 7.84E-6
14 SGTC_749 1000-0129 4.18 128.0 µM 4.95E-5 amide catabolism 16 1.48E-5
15 SGTC_3149 9097855 4.15 49.5 µM 5.46E-5 Golgi 24 1.66E-5
16 SGTC_1802 st050112 4.07 57.9 µM 7.31E-5 10 2.31E-5
17 SGTC_2540 epiandrosterone 3.95 100.0 µM 1.16E-4 58 3.92E-5
18 SGTC_2759 disulfiram 3.81 3.4 µM 1.90E-4 41 6.88E-5
19 SGTC_3180 9109287 3.78 49.5 µM 2.11E-4 16 7.73E-5
20 SGTC_89 0302-0250 3.74 142.1 µM 2.45E-4 24 9.19E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 2.49E-9 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.088 3.42E-7 YLR165C PUS5 hom Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability
0.084 1.19E-6 YCL028W RNQ1 hom [PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate
0.082 1.71E-6 YLR151C PCD1 hom Peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member
0.081 2.41E-6 YIR001C SGN1 hom Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation
0.080 3.51E-6 YBL091C-A SCS22 hom Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; similar to D. melanogaster inturned protein; SCS22 has a paralog, SCS2, that arose from the whole genome duplication
0.080 3.58E-6 YBR039W ATP3 hom Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
0.078 5.87E-6 YGR277C CAB4 het Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved
0.078 6.42E-6 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.073 2.11E-5 YKR022C NTR2 het Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly
0.073 2.50E-5 YOL114C_p YOL114C_p hom Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene
0.072 2.74E-5 YPL101W ELP4 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
0.072 2.89E-5 YHR111W UBA4 hom Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p
0.069 5.96E-5 YMR258C ROY1 hom GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p
0.068 8.17E-5 YDR069C DOA4 hom Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole