YPL220W / RPL1A

Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL220W / RPL1A

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:4.73|P-value:1.56E-7 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.08|P-value:4.27E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.02|P-value:5.52E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.79|P-value:2.08E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:8.44|P-value:3.46E-20 ID:SGTC_740|Compound:k014-0057|FD-Score:3.55|P-value:6.03E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:3.75|P-value:2.55E-5 ID:SGTC_747|Compound:3448-8087|FD-Score:-4.10|P-value:4.37E-6 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.94|P-value:9.79E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:4.37|P-value:1.15E-6 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.14|P-value:3.45E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.93|P-value:1.07E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:2.87|P-value:9.61E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:-3.77|P-value:2.24E-5 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.61|P-value:4.65E-5 ID:SGTC_1704|Compound:st028805|FD-Score:3.21|P-value:2.61E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.53|P-value:6.64E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.11|P-value:3.79E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.04|P-value:5.09E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.93|P-value:1.08E-5 ID:SGTC_2043|Compound:5101342|FD-Score:3.28|P-value:1.93E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.82|P-value:1.84E-5 ID:SGTC_2061|Compound:5245884|FD-Score:3.51|P-value:7.37E-5 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.85|P-value:1.53E-5 ID:SGTC_2253|Compound:7938677|FD-Score:3.39|P-value:1.26E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-3.39|P-value:1.22E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:7.21|P-value:3.13E-15 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-2.87|P-value:9.39E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.07|P-value:4.58E-4 ID:SGTC_2696|Compound:st077691|FD-Score:4.10|P-value:4.55E-6 ID:SGTC_2794|Compound:7785382|FD-Score:5.96|P-value:5.51E-11 ID:SGTC_2796|Compound:7949634|FD-Score:-2.93|P-value:7.55E-4 ID:SGTC_2820|Compound:7989630|FD-Score:4.29|P-value:1.77E-6 ID:SGTC_2821|Compound:7996764|FD-Score:4.03|P-value:6.55E-6 ID:SGTC_2854|Compound:9024559|FD-Score:3.00|P-value:5.83E-4 ID:SGTC_2875|Compound:9039966|FD-Score:3.23|P-value:2.37E-4 ID:SGTC_2944|Compound:9067346|FD-Score:5.40|P-value:2.51E-9 ID:SGTC_2950|Compound:9072895|FD-Score:-4.31|P-value:1.49E-6 ID:SGTC_3000|Compound:9075062|FD-Score:3.06|P-value:4.71E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.12|P-value:3.67E-4 ID:SGTC_3240|Compound:9133527|FD-Score:-2.96|P-value:6.66E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.50|P-value:7.54E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:4.73|P-value:1.56E-7 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.08|P-value:4.27E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.02|P-value:5.52E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.79|P-value:2.08E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:8.44|P-value:3.46E-20 ID:SGTC_740|Compound:k014-0057|FD-Score:3.55|P-value:6.03E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:3.75|P-value:2.55E-5 ID:SGTC_747|Compound:3448-8087|FD-Score:-4.10|P-value:4.37E-6 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.94|P-value:9.79E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:4.37|P-value:1.15E-6 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.14|P-value:3.45E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:3.93|P-value:1.07E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:2.87|P-value:9.61E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:-3.77|P-value:2.24E-5 ID:SGTC_1479|Compound:0549-0158|FD-Score:3.61|P-value:4.65E-5 ID:SGTC_1704|Compound:st028805|FD-Score:3.21|P-value:2.61E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.53|P-value:6.64E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.11|P-value:3.79E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.04|P-value:5.09E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.93|P-value:1.08E-5 ID:SGTC_2043|Compound:5101342|FD-Score:3.28|P-value:1.93E-4 ID:SGTC_2059|Compound:5238311|FD-Score:3.82|P-value:1.84E-5 ID:SGTC_2061|Compound:5245884|FD-Score:3.51|P-value:7.37E-5 ID:SGTC_2251|Compound:lansoprazole|FD-Score:3.85|P-value:1.53E-5 ID:SGTC_2253|Compound:7938677|FD-Score:3.39|P-value:1.26E-4 ID:SGTC_2311|Compound:7694451|FD-Score:-3.39|P-value:1.22E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:7.21|P-value:3.13E-15 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-2.87|P-value:9.39E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.07|P-value:4.58E-4 ID:SGTC_2696|Compound:st077691|FD-Score:4.10|P-value:4.55E-6 ID:SGTC_2794|Compound:7785382|FD-Score:5.96|P-value:5.51E-11 ID:SGTC_2796|Compound:7949634|FD-Score:-2.93|P-value:7.55E-4 ID:SGTC_2820|Compound:7989630|FD-Score:4.29|P-value:1.77E-6 ID:SGTC_2821|Compound:7996764|FD-Score:4.03|P-value:6.55E-6 ID:SGTC_2854|Compound:9024559|FD-Score:3.00|P-value:5.83E-4 ID:SGTC_2875|Compound:9039966|FD-Score:3.23|P-value:2.37E-4 ID:SGTC_2944|Compound:9067346|FD-Score:5.40|P-value:2.51E-9 ID:SGTC_2950|Compound:9072895|FD-Score:-4.31|P-value:1.49E-6 ID:SGTC_3000|Compound:9075062|FD-Score:3.06|P-value:4.71E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.12|P-value:3.67E-4 ID:SGTC_3240|Compound:9133527|FD-Score:-2.96|P-value:6.66E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.50|P-value:7.54E-5

Top fitness defect scores for YPL220W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_734 2023-0417 8.44 80.0 µM 3.46E-20 ergosterol biosynthesis 1 1.64E-17
2 SGTC_2567 aureobasidin a 7.21 60.0 nM 3.13E-15 29 2.85E-13
3 SGTC_2794 7785382 5.96 27.3 µM 5.51E-11 4 1.23E-9
4 SGTC_2944 9067346 5.40 25.6 µM 2.51E-9 6 3.26E-8
5 SGTC_67 0335-0847 4.73 266.0 µM 1.56E-7 ubiquinone biosynthesis & proteasome 89 1.13E-6
6 SGTC_829 1635-0120 4.37 117.0 µM 1.15E-6 DNA damage response 31 6.25E-6
7 SGTC_2820 7989630 4.29 71.4 µM 1.77E-6 ERG2 12 9.10E-6
8 SGTC_2696 st077691 4.10 74.3 µM 4.55E-6 27 2.04E-5
9 SGTC_2821 7996764 4.03 71.4 µM 6.55E-6 32 2.80E-5
10 SGTC_1189 1431-2119 3.93 7.3 µM 1.07E-5 30 4.25E-5
11 SGTC_1940 st075990 3.93 51.1 µM 1.08E-5 60S ribosome export 22 4.30E-5
12 SGTC_2251 lansoprazole 3.85 556.0 µM 1.53E-5 24 5.79E-5
13 SGTC_2059 5238311 3.82 157.0 µM 1.84E-5 30 6.79E-5
14 SGTC_376 3970-0862 3.79 59.1 µM 2.08E-5 25 7.56E-5
15 SGTC_744 1594-0068 3.75 283.0 µM 2.55E-5 amide catabolism 33 9.01E-5
16 SGTC_1479 0549-0158 3.61 134.0 µM 4.65E-5 40 1.51E-4
17 SGTC_740 k014-0057 3.55 261.0 µM 6.03E-5 38 1.89E-4
18 SGTC_1742 st038235 3.53 28.9 µM 6.64E-5 mitochondrial stress 134 2.05E-4
19 SGTC_2061 5245884 3.51 81.0 µM 7.37E-5 tubulin folding & SWR complex 34 2.25E-4
20 SGTC_3286 9117135 3.50 37.2 µM 7.54E-5 28 2.29E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.301 1.70E-71 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.179 1.23E-25 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.141 2.42E-16 YBR110W ALG1 het Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog
0.125 3.29E-13 YDR118W APC4 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress
0.121 2.15E-12 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.114 2.96E-11 YMR211W DML1 het Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
0.109 2.22E-10 YLR262C-A TMA7 hom Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress
0.104 1.38E-9 YJL201W ECM25 hom Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p
0.101 4.01E-9 YBR056W YBR056W hom Putative glycoside hydrolase of the mitochondrial intermembrane space
0.101 5.36E-9 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.100 6.68E-9 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.099 9.40E-9 YDR224C HTB1 het Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
0.095 3.46E-8 YGL169W SUA5 het Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family
0.095 3.62E-8 YOR016C ERP4 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.093 7.01E-8 YOR010C TIR2 hom Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis