YPL222W_p / FMP40

Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL222W / FMP40

Click on Significant Values for Screen Details ID:SGTC_121|Compound:0557-0495|FD-Score:3.43|P-value:2.81E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.32|P-value:3.98E-4 ID:SGTC_222|Compound:nsc-310342|FD-Score:-3.44|P-value:2.52E-4 ID:SGTC_223|Compound:busulfan|FD-Score:3.36|P-value:3.74E-4 ID:SGTC_252|Compound:miconazole|FD-Score:-3.55|P-value:1.63E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.79|P-value:6.46E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:3.59|P-value:1.56E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.09|P-value:9.70E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.62|P-value:1.39E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:4.27|P-value:8.93E-6 ID:SGTC_663|Compound:1486-0733|FD-Score:4.57|P-value:2.21E-6 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.46|P-value:2.58E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.78|P-value:7.21E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.40|P-value:3.16E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.61|P-value:1.42E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:-3.24|P-value:5.26E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.15|P-value:7.68E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-4.03|P-value:2.28E-5 ID:SGTC_1581|Compound:himbacine|FD-Score:-3.10|P-value:8.51E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-4.17|P-value:1.25E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.50|P-value:2.03E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.82|P-value:6.14E-5 ID:SGTC_2013|Compound:4024628|FD-Score:3.80|P-value:6.84E-5 ID:SGTC_2119|Compound:5528445|FD-Score:3.65|P-value:1.21E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.23|P-value:5.91E-4 ID:SGTC_2460|Compound:5552655|FD-Score:4.84|P-value:5.62E-7 ID:SGTC_2467|Compound:5474540|FD-Score:-3.13|P-value:7.60E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.18|P-value:7.07E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.68|P-value:1.08E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.85|P-value:5.34E-7 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.58|P-value:1.64E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:7.47|P-value:2.73E-14 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.09|P-value:9.45E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.53|P-value:1.96E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.32|P-value:4.29E-4 ID:SGTC_2805|Compound:7950783|FD-Score:4.12|P-value:1.76E-5 ID:SGTC_2824|Compound:7998404|FD-Score:3.20|P-value:6.63E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-3.08|P-value:9.25E-4 ID:SGTC_2878|Compound:9043973|FD-Score:4.17|P-value:1.41E-5 ID:SGTC_3047|Compound:9092122|FD-Score:-4.36|P-value:5.32E-6 ID:SGTC_3097|Compound:9117246|FD-Score:3.77|P-value:7.73E-5 ID:SGTC_3154|Compound:9100113|FD-Score:3.32|P-value:4.22E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.43|P-value:2.81E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.32|P-value:3.98E-4 ID:SGTC_222|Compound:nsc-310342|FD-Score:-3.44|P-value:2.52E-4 ID:SGTC_223|Compound:busulfan|FD-Score:3.36|P-value:3.74E-4 ID:SGTC_252|Compound:miconazole|FD-Score:-3.55|P-value:1.63E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.79|P-value:6.46E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:3.59|P-value:1.56E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.09|P-value:9.70E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.62|P-value:1.39E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:4.27|P-value:8.93E-6 ID:SGTC_663|Compound:1486-0733|FD-Score:4.57|P-value:2.21E-6 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.46|P-value:2.58E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.78|P-value:7.21E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.40|P-value:3.16E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.61|P-value:1.42E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:-3.24|P-value:5.26E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.15|P-value:7.68E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-4.03|P-value:2.28E-5 ID:SGTC_1581|Compound:himbacine|FD-Score:-3.10|P-value:8.51E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-4.17|P-value:1.25E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.50|P-value:2.03E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.82|P-value:6.14E-5 ID:SGTC_2013|Compound:4024628|FD-Score:3.80|P-value:6.84E-5 ID:SGTC_2119|Compound:5528445|FD-Score:3.65|P-value:1.21E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.23|P-value:5.91E-4 ID:SGTC_2460|Compound:5552655|FD-Score:4.84|P-value:5.62E-7 ID:SGTC_2467|Compound:5474540|FD-Score:-3.13|P-value:7.60E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.18|P-value:7.07E-4 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:3.68|P-value:1.08E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.85|P-value:5.34E-7 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.58|P-value:1.64E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:7.47|P-value:2.73E-14 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.09|P-value:9.45E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.53|P-value:1.96E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.32|P-value:4.29E-4 ID:SGTC_2805|Compound:7950783|FD-Score:4.12|P-value:1.76E-5 ID:SGTC_2824|Compound:7998404|FD-Score:3.20|P-value:6.63E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-3.08|P-value:9.25E-4 ID:SGTC_2878|Compound:9043973|FD-Score:4.17|P-value:1.41E-5 ID:SGTC_3047|Compound:9092122|FD-Score:-4.36|P-value:5.32E-6 ID:SGTC_3097|Compound:9117246|FD-Score:3.77|P-value:7.73E-5 ID:SGTC_3154|Compound:9100113|FD-Score:3.32|P-value:4.22E-4

Top fitness defect scores for YPL222W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2615 purpurogallin-4-carboxylic acid 7.47 100.0 µM 2.73E-14 redox potentiating 20 3.93E-14
2 SGTC_2607 solasodine 4.85 47.4 µM 5.34E-7 39 6.12E-7
3 SGTC_2460 5552655 4.84 174.2 µM 5.62E-7 amide catabolism 16 6.44E-7
4 SGTC_663 1486-0733 4.57 13.9 µM 2.21E-6 cell wall signaling 37 2.49E-6
5 SGTC_654 1124-0271 4.27 80.9 µM 8.93E-6 18 9.87E-6
6 SGTC_2878 9043973 4.17 26.0 µM 1.41E-5 16 1.55E-5
7 SGTC_2805 7950783 4.12 58.4 µM 1.76E-5 26 1.93E-5
8 SGTC_1917 st066507 3.82 28.5 µM 6.14E-5 Golgi 40 6.63E-5
9 SGTC_2013 4024628 3.80 200.0 µM 6.84E-5 46 7.38E-5
10 SGTC_1135 dihydrocapsaicin 3.78 536.7 nM 7.21E-5 41 7.77E-5
11 SGTC_3097 9117246 3.77 49.5 µM 7.73E-5 15 8.32E-5
12 SGTC_2506 ethyl hematommate 3.68 54.2 µM 1.08E-4 RPP1 & pyrimidine depletion 21 1.16E-4
13 SGTC_2119 5528445 3.65 120.6 µM 1.21E-4 31 1.29E-4
14 SGTC_577 r071-0003 3.62 38.6 µM 1.39E-4 fatty acid desaturase (OLE1) 74 1.49E-4
15 SGTC_1286 0929-0070 3.61 131.0 µM 1.42E-4 26 1.52E-4
16 SGTC_517 1365-0151 3.59 113.0 µM 1.56E-4 40 1.67E-4
17 SGTC_2613 3',4'-dimethoxydalbergione 3.58 24.6 µM 1.64E-4 38 1.75E-4
18 SGTC_2767 sibutramine 3.53 71.5 µM 1.96E-4 32 2.08E-4
19 SGTC_1130 3454-2858 3.46 15.9 µM 2.58E-4 NEO1 112 2.74E-4
20 SGTC_121 0557-0495 3.43 61.3 µM 2.81E-4 calcium & mitochondrial duress 87 2.97E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.156 1.35E-19 YBL059W_p YBL059W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication
0.150 2.49E-18 YJR046W TAH11 het DNA replication licensing factor, required for pre-replication complex assembly
0.133 1.28E-14 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.121 2.03E-12 YOR162C YRR1 hom Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
0.118 6.39E-12 YOR382W FIT2 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.112 7.79E-11 YBR157C ICS2 hom Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
0.099 9.94E-9 YIR009W MSL1 hom U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members
0.098 1.23E-8 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.098 1.45E-8 YDL243C AAD4 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.096 2.85E-8 YKL061W_p BLI1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome
0.093 6.32E-8 YAR029W_p YAR029W_p hom Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.093 6.98E-8 YOL052C SPE2 hom S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
0.082 2.14E-6 YDR245W MNN10 hom Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family
0.081 2.52E-6 YGL168W HUR1 hom Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.080 3.72E-6 YMR279C YMR279C hom Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication