YPL226W / NEW1

ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL226W / NEW1

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:3.51|P-value:2.64E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:5.40|P-value:6.67E-8 ID:SGTC_177|Compound:1327-0068|FD-Score:3.23|P-value:6.93E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:-3.74|P-value:2.54E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.76|P-value:1.08E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.20|P-value:7.80E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:-3.67|P-value:3.25E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:-4.85|P-value:2.89E-6 ID:SGTC_381|Compound:3461-2219|FD-Score:-3.75|P-value:2.48E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:6.50|P-value:1.28E-10 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.30|P-value:5.63E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:-3.41|P-value:7.79E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.31|P-value:1.18E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.49|P-value:1.37E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:4.50|P-value:5.21E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:4.03|P-value:3.72E-5 ID:SGTC_602|Compound:3130-1533|FD-Score:4.87|P-value:9.28E-7 ID:SGTC_625|Compound:k213-0058|FD-Score:3.78|P-value:9.98E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:3.92|P-value:5.72E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:3.55|P-value:2.36E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:6.51|P-value:1.23E-10 ID:SGTC_791|Compound:1348-1292|FD-Score:3.39|P-value:4.08E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.92|P-value:5.86E-5 ID:SGTC_850|Compound:0388-0143|FD-Score:3.41|P-value:3.85E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.97|P-value:1.11E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.43|P-value:7.33E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:4.65|P-value:2.68E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:5.68|P-value:1.50E-8 ID:SGTC_998|Compound:3996-0085|FD-Score:4.56|P-value:3.90E-6 ID:SGTC_999|Compound:4022-0066|FD-Score:3.33|P-value:4.99E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.25|P-value:6.47E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.96|P-value:4.95E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.35|P-value:9.54E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:5.27|P-value:1.36E-7 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.32|P-value:5.26E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.41|P-value:7.79E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:4.55|P-value:4.08E-6 ID:SGTC_1416|Compound:3966-0321|FD-Score:4.17|P-value:2.09E-5 ID:SGTC_1522|Compound:st012842|FD-Score:-4.10|P-value:6.77E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:4.31|P-value:1.18E-5 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.80|P-value:9.35E-5 ID:SGTC_1633|Compound:st005664|FD-Score:3.55|P-value:2.36E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-4.02|P-value:8.91E-5 ID:SGTC_1728|Compound:st035614|FD-Score:4.35|P-value:9.83E-6 ID:SGTC_1752|Compound:st044819|FD-Score:3.23|P-value:6.93E-4 ID:SGTC_1763|Compound:st044482|FD-Score:3.22|P-value:7.24E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.42|P-value:7.67E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.36|P-value:4.47E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.59|P-value:2.04E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-4.21|P-value:4.32E-5 ID:SGTC_2071|Compound:5230951|FD-Score:4.62|P-value:3.07E-6 ID:SGTC_2089|Compound:5281248|FD-Score:3.42|P-value:3.73E-4 ID:SGTC_2094|Compound:5332512|FD-Score:4.25|P-value:1.52E-5 ID:SGTC_2183|Compound:6420625|FD-Score:4.44|P-value:6.75E-6 ID:SGTC_2195|Compound:6536160|FD-Score:4.03|P-value:3.77E-5 ID:SGTC_2204|Compound:7233102|FD-Score:3.43|P-value:3.58E-4 ID:SGTC_2208|Compound:7283366|FD-Score:3.37|P-value:4.35E-4 ID:SGTC_2211|Compound:7117706|FD-Score:5.58|P-value:2.61E-8 ID:SGTC_2447|Compound:5741742|FD-Score:3.81|P-value:8.76E-5 ID:SGTC_2453|Compound:5731132|FD-Score:4.28|P-value:1.35E-5 ID:SGTC_2466|Compound:5983409|FD-Score:4.65|P-value:2.67E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.27|P-value:6.06E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.65|P-value:3.44E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.58|P-value:3.58E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.17|P-value:9.59E-10 ID:SGTC_2704|Compound:st078022|FD-Score:3.85|P-value:7.59E-5 ID:SGTC_2885|Compound:9057732|FD-Score:-3.36|P-value:9.14E-4 ID:SGTC_2917|Compound:7979103|FD-Score:5.84|P-value:6.43E-9 ID:SGTC_2924|Compound:9010168|FD-Score:-4.63|P-value:7.40E-6 ID:SGTC_2932|Compound:9016711|FD-Score:3.84|P-value:8.04E-5 ID:SGTC_2983|Compound:9022671|FD-Score:-5.22|P-value:5.01E-7 ID:SGTC_2985|Compound:9022375|FD-Score:5.84|P-value:6.21E-9 ID:SGTC_2986|Compound:9022445|FD-Score:-3.49|P-value:6.05E-4 ID:SGTC_3021|Compound:9087658|FD-Score:4.55|P-value:4.12E-6 ID:SGTC_3031|Compound:9088762|FD-Score:5.77|P-value:9.07E-9 ID:SGTC_3072|Compound:9116419|FD-Score:4.01|P-value:4.06E-5 ID:SGTC_3148|Compound:9097893|FD-Score:3.15|P-value:9.11E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.13|P-value:9.74E-4 ID:SGTC_3301|Compound:9125354|FD-Score:3.55|P-value:2.33E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.13|P-value:9.66E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:3.51|P-value:2.64E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:5.40|P-value:6.67E-8 ID:SGTC_177|Compound:1327-0068|FD-Score:3.23|P-value:6.93E-4 ID:SGTC_183|Compound:3914-0051|FD-Score:-3.74|P-value:2.54E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.76|P-value:1.08E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.20|P-value:7.80E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:-3.67|P-value:3.25E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:-4.85|P-value:2.89E-6 ID:SGTC_381|Compound:3461-2219|FD-Score:-3.75|P-value:2.48E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:6.50|P-value:1.28E-10 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:3.30|P-value:5.63E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:-3.41|P-value:7.79E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.31|P-value:1.18E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.49|P-value:1.37E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:4.50|P-value:5.21E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:4.03|P-value:3.72E-5 ID:SGTC_602|Compound:3130-1533|FD-Score:4.87|P-value:9.28E-7 ID:SGTC_625|Compound:k213-0058|FD-Score:3.78|P-value:9.98E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:3.92|P-value:5.72E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:3.55|P-value:2.36E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:6.51|P-value:1.23E-10 ID:SGTC_791|Compound:1348-1292|FD-Score:3.39|P-value:4.08E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.92|P-value:5.86E-5 ID:SGTC_850|Compound:0388-0143|FD-Score:3.41|P-value:3.85E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.97|P-value:1.11E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.43|P-value:7.33E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:4.65|P-value:2.68E-6 ID:SGTC_932|Compound:2857-0803|FD-Score:5.68|P-value:1.50E-8 ID:SGTC_998|Compound:3996-0085|FD-Score:4.56|P-value:3.90E-6 ID:SGTC_999|Compound:4022-0066|FD-Score:3.33|P-value:4.99E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.25|P-value:6.47E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.96|P-value:4.95E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.35|P-value:9.54E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:5.27|P-value:1.36E-7 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.32|P-value:5.26E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.41|P-value:7.79E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:4.55|P-value:4.08E-6 ID:SGTC_1416|Compound:3966-0321|FD-Score:4.17|P-value:2.09E-5 ID:SGTC_1522|Compound:st012842|FD-Score:-4.10|P-value:6.77E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:4.31|P-value:1.18E-5 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.80|P-value:9.35E-5 ID:SGTC_1633|Compound:st005664|FD-Score:3.55|P-value:2.36E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-4.02|P-value:8.91E-5 ID:SGTC_1728|Compound:st035614|FD-Score:4.35|P-value:9.83E-6 ID:SGTC_1752|Compound:st044819|FD-Score:3.23|P-value:6.93E-4 ID:SGTC_1763|Compound:st044482|FD-Score:3.22|P-value:7.24E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.42|P-value:7.67E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.36|P-value:4.47E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.59|P-value:2.04E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-4.21|P-value:4.32E-5 ID:SGTC_2071|Compound:5230951|FD-Score:4.62|P-value:3.07E-6 ID:SGTC_2089|Compound:5281248|FD-Score:3.42|P-value:3.73E-4 ID:SGTC_2094|Compound:5332512|FD-Score:4.25|P-value:1.52E-5 ID:SGTC_2183|Compound:6420625|FD-Score:4.44|P-value:6.75E-6 ID:SGTC_2195|Compound:6536160|FD-Score:4.03|P-value:3.77E-5 ID:SGTC_2204|Compound:7233102|FD-Score:3.43|P-value:3.58E-4 ID:SGTC_2208|Compound:7283366|FD-Score:3.37|P-value:4.35E-4 ID:SGTC_2211|Compound:7117706|FD-Score:5.58|P-value:2.61E-8 ID:SGTC_2447|Compound:5741742|FD-Score:3.81|P-value:8.76E-5 ID:SGTC_2453|Compound:5731132|FD-Score:4.28|P-value:1.35E-5 ID:SGTC_2466|Compound:5983409|FD-Score:4.65|P-value:2.67E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.27|P-value:6.06E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-3.65|P-value:3.44E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.58|P-value:3.58E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.17|P-value:9.59E-10 ID:SGTC_2704|Compound:st078022|FD-Score:3.85|P-value:7.59E-5 ID:SGTC_2885|Compound:9057732|FD-Score:-3.36|P-value:9.14E-4 ID:SGTC_2917|Compound:7979103|FD-Score:5.84|P-value:6.43E-9 ID:SGTC_2924|Compound:9010168|FD-Score:-4.63|P-value:7.40E-6 ID:SGTC_2932|Compound:9016711|FD-Score:3.84|P-value:8.04E-5 ID:SGTC_2983|Compound:9022671|FD-Score:-5.22|P-value:5.01E-7 ID:SGTC_2985|Compound:9022375|FD-Score:5.84|P-value:6.21E-9 ID:SGTC_2986|Compound:9022445|FD-Score:-3.49|P-value:6.05E-4 ID:SGTC_3021|Compound:9087658|FD-Score:4.55|P-value:4.12E-6 ID:SGTC_3031|Compound:9088762|FD-Score:5.77|P-value:9.07E-9 ID:SGTC_3072|Compound:9116419|FD-Score:4.01|P-value:4.06E-5 ID:SGTC_3148|Compound:9097893|FD-Score:3.15|P-value:9.11E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.13|P-value:9.74E-4 ID:SGTC_3301|Compound:9125354|FD-Score:3.55|P-value:2.33E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.13|P-value:9.66E-4

Top fitness defect scores for YPL226W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_770 0389-1121 6.51 67.2 µM 1.23E-10 RPP1 & pyrimidine depletion 3 3.84E-11
2 SGTC_383 2324-0395 6.50 7.4 µM 1.28E-10 azole & statin 14 4.01E-11
3 SGTC_2688 kanamycin b 6.17 96.7 µM 9.59E-10 calcium & mitochondrial duress 149 3.49E-10
4 SGTC_2985 9022375 5.84 71.4 µM 6.21E-9 RPP1 & pyrimidine depletion 6 2.58E-9
5 SGTC_2917 7979103 5.84 53.8 µM 6.43E-9 4 2.68E-9
6 SGTC_3031 9088762 5.77 49.5 µM 9.07E-9 2 3.87E-9
7 SGTC_932 2857-0803 5.68 154.0 µM 1.50E-8 8 6.65E-9
8 SGTC_2211 7117706 5.58 200.0 µM 2.61E-8 2 1.20E-8
9 SGTC_167 3672-0051 5.40 66.2 µM 6.67E-8 17 3.27E-8
10 SGTC_1246 0422-0085 5.27 105.0 µM 1.36E-7 8 7.00E-8
11 SGTC_602 3130-1533 4.87 38.1 µM 9.28E-7 3 5.44E-7
12 SGTC_2466 5983409 4.65 37.1 µM 2.67E-6 14 1.68E-6
13 SGTC_929 2805-0021 4.65 398.0 µM 2.68E-6 6 1.68E-6
14 SGTC_2071 5230951 4.62 39.9 µM 3.07E-6 TSC3-RPN4 11 1.95E-6
15 SGTC_2630 antimycin a 4.58 100.0 µM 3.58E-6 mitochondrial processes 23 2.29E-6
16 SGTC_998 3996-0085 4.56 177.0 µM 3.90E-6 10 2.51E-6
17 SGTC_1319 1306-0155 4.55 43.7 µM 4.08E-6 13 2.63E-6
18 SGTC_3021 9087658 4.55 49.5 µM 4.12E-6 4 2.66E-6
19 SGTC_576 1073-0113 4.50 22.7 µM 5.21E-6 redox potentiating 49 3.42E-6
20 SGTC_2183 6420625 4.44 130.5 µM 6.75E-6 mitochondrial processes 37 4.51E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.67E-10 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.107 5.40E-10 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.104 1.29E-9 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.104 1.32E-9 YLR024C UBR2 hom Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex
0.102 3.48E-9 YLR192C HCR1 hom Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA
0.093 6.14E-8 YDR525W_d API2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology
0.092 8.57E-8 YBR163W EXO5 hom Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2
0.091 1.40E-7 YDR443C SSN2 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation
0.091 1.49E-7 YBR287W_p YBR287W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
0.090 1.75E-7 YHR203C RPS4B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication
0.089 2.70E-7 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.088 2.99E-7 YBR048W RPS11B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication
0.088 3.55E-7 YIL110W HPM1 hom AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance
0.087 5.09E-7 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.084 9.86E-7 YDR241W_d BUD26_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay