YPL229W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YPL229W has a paralog, YMR181C, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL229W / YPL229W

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-3.49|P-value:2.44E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:4.08|P-value:2.34E-5 ID:SGTC_192|Compound:3455-0609|FD-Score:3.90|P-value:4.87E-5 ID:SGTC_323|Compound:4013-0906|FD-Score:4.55|P-value:2.70E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:3.11|P-value:9.46E-4 ID:SGTC_443|Compound:clozapine|FD-Score:5.15|P-value:1.34E-7 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.23|P-value:6.36E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:5.01|P-value:2.76E-7 ID:SGTC_547|Compound:1120-0019|FD-Score:3.47|P-value:2.61E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:5.33|P-value:5.13E-8 ID:SGTC_653|Compound:0203-0016|FD-Score:3.56|P-value:1.89E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.57|P-value:1.80E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.16|P-value:8.01E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.69|P-value:1.12E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.52|P-value:2.16E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.50|P-value:3.47E-6 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.40|P-value:3.36E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.86|P-value:5.81E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.37|P-value:3.84E-4 ID:SGTC_1610|Compound:st001799|FD-Score:3.55|P-value:1.96E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.95|P-value:4.04E-5 ID:SGTC_1638|Compound:st008370|FD-Score:3.28|P-value:5.32E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:4.98|P-value:3.25E-7 ID:SGTC_1737|Compound:st035557|FD-Score:4.42|P-value:5.10E-6 ID:SGTC_1759|Compound:st043059|FD-Score:3.42|P-value:3.21E-4 ID:SGTC_1862|Compound:st057513|FD-Score:5.06|P-value:2.17E-7 ID:SGTC_1866|Compound:st057638|FD-Score:5.74|P-value:4.86E-9 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.65|P-value:1.35E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.37|P-value:3.78E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.26|P-value:5.73E-4 ID:SGTC_2274|Compound:7947094|FD-Score:3.43|P-value:3.05E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.28|P-value:5.29E-4 ID:SGTC_2380|Compound:9035439|FD-Score:4.12|P-value:1.95E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.77|P-value:8.44E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:6.73|P-value:8.53E-12 ID:SGTC_2466|Compound:5983409|FD-Score:3.43|P-value:3.02E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.44|P-value:2.95E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.40|P-value:3.40E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.64|P-value:1.39E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.35|P-value:4.03E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.17|P-value:7.63E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.25|P-value:5.78E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.34|P-value:4.19E-4 ID:SGTC_3128|Compound:9127691|FD-Score:-3.23|P-value:6.14E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.58|P-value:1.75E-4 ID:SGTC_3281|Compound:9140613|FD-Score:4.10|P-value:2.07E-5 ID:SGTC_3282|Compound:9108498|FD-Score:3.22|P-value:6.50E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.86|P-value:5.70E-5 ID:SGTC_3336|Compound:9143619|FD-Score:4.58|P-value:2.37E-6 ID:SGTC_3342|Compound:9147791|FD-Score:3.21|P-value:6.64E-4 ID:SGTC_3344|Compound:9148862|FD-Score:3.14|P-value:8.42E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.48|P-value:2.52E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.21|P-value:6.68E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.49|P-value:2.44E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:4.08|P-value:2.34E-5 ID:SGTC_192|Compound:3455-0609|FD-Score:3.90|P-value:4.87E-5 ID:SGTC_323|Compound:4013-0906|FD-Score:4.55|P-value:2.70E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:3.11|P-value:9.46E-4 ID:SGTC_443|Compound:clozapine|FD-Score:5.15|P-value:1.34E-7 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.23|P-value:6.36E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:5.01|P-value:2.76E-7 ID:SGTC_547|Compound:1120-0019|FD-Score:3.47|P-value:2.61E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:5.33|P-value:5.13E-8 ID:SGTC_653|Compound:0203-0016|FD-Score:3.56|P-value:1.89E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.57|P-value:1.80E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.16|P-value:8.01E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.69|P-value:1.12E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:3.52|P-value:2.16E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.50|P-value:3.47E-6 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.40|P-value:3.36E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.86|P-value:5.81E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.37|P-value:3.84E-4 ID:SGTC_1610|Compound:st001799|FD-Score:3.55|P-value:1.96E-4 ID:SGTC_1613|Compound:st002381|FD-Score:3.95|P-value:4.04E-5 ID:SGTC_1638|Compound:st008370|FD-Score:3.28|P-value:5.32E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:4.98|P-value:3.25E-7 ID:SGTC_1737|Compound:st035557|FD-Score:4.42|P-value:5.10E-6 ID:SGTC_1759|Compound:st043059|FD-Score:3.42|P-value:3.21E-4 ID:SGTC_1862|Compound:st057513|FD-Score:5.06|P-value:2.17E-7 ID:SGTC_1866|Compound:st057638|FD-Score:5.74|P-value:4.86E-9 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.65|P-value:1.35E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.37|P-value:3.78E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.26|P-value:5.73E-4 ID:SGTC_2274|Compound:7947094|FD-Score:3.43|P-value:3.05E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.28|P-value:5.29E-4 ID:SGTC_2380|Compound:9035439|FD-Score:4.12|P-value:1.95E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.77|P-value:8.44E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:6.73|P-value:8.53E-12 ID:SGTC_2466|Compound:5983409|FD-Score:3.43|P-value:3.02E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.44|P-value:2.95E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.40|P-value:3.40E-4 ID:SGTC_2570|Compound:licareol|FD-Score:3.64|P-value:1.39E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-3.35|P-value:4.03E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.17|P-value:7.63E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.25|P-value:5.78E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.34|P-value:4.19E-4 ID:SGTC_3128|Compound:9127691|FD-Score:-3.23|P-value:6.14E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.58|P-value:1.75E-4 ID:SGTC_3281|Compound:9140613|FD-Score:4.10|P-value:2.07E-5 ID:SGTC_3282|Compound:9108498|FD-Score:3.22|P-value:6.50E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.86|P-value:5.70E-5 ID:SGTC_3336|Compound:9143619|FD-Score:4.58|P-value:2.37E-6 ID:SGTC_3342|Compound:9147791|FD-Score:3.21|P-value:6.64E-4 ID:SGTC_3344|Compound:9148862|FD-Score:3.14|P-value:8.42E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.48|P-value:2.52E-4 ID:SGTC_3352|Compound:9151559|FD-Score:3.21|P-value:6.68E-4

Top fitness defect scores for YPL229W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2420 aureobasidin a 6.73 50.0 nM 8.53E-12 10 8.24E-12
2 SGTC_1866 st057638 5.74 64.0 µM 4.86E-9 2 4.73E-9
3 SGTC_621 3584-0052 5.33 32.1 µM 5.13E-8 8 5.00E-8
4 SGTC_443 clozapine 5.15 122.0 µM 1.34E-7 NEO1-PIK1 3 1.31E-7
5 SGTC_1862 st057513 5.06 3.8 µM 2.17E-7 1 2.12E-7
6 SGTC_527 4476-4215 5.01 268.0 µM 2.76E-7 PDR1 16 2.70E-7
7 SGTC_1681 tripelennamine 4.98 100.0 µM 3.25E-7 9 3.18E-7
8 SGTC_3336 9143619 4.58 71.4 µM 2.37E-6 8 2.32E-6
9 SGTC_323 4013-0906 4.55 34.3 µM 2.70E-6 ERG2 7 2.64E-6
10 SGTC_1203 3992-3522 4.50 103.0 µM 3.47E-6 16 3.41E-6
11 SGTC_1737 st035557 4.42 69.7 µM 5.10E-6 10 5.01E-6
12 SGTC_2380 9035439 4.12 200.0 µM 1.95E-5 endomembrane recycling 15 1.91E-5
13 SGTC_3281 9140613 4.10 49.5 µM 2.07E-5 RPP1 & pyrimidine depletion 16 2.04E-5
14 SGTC_92 0063-0024 4.08 660.9 µM 2.34E-5 10 2.30E-5
15 SGTC_1613 st002381 3.95 52.1 µM 4.04E-5 22 3.97E-5
16 SGTC_192 3455-0609 3.90 60.9 µM 4.87E-5 13 4.80E-5
17 SGTC_3291 9121177 3.86 71.4 µM 5.70E-5 15 5.62E-5
18 SGTC_1493 4348-0038 3.86 111.0 µM 5.81E-5 RSC complex & mRNA processing 31 5.72E-5
19 SGTC_2410 aloe-emodin-8-o-glycoside 3.77 46.3 µM 8.44E-5 mitochondrial processes 36 8.32E-5
20 SGTC_1094 duloxetine 3.69 25.4 µM 1.12E-4 RPP1 & pyrimidine depletion 21 1.11E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 2.62E-16 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.111 1.31E-10 YLR103C CDC45 het DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes
0.091 1.22E-7 YOR099W KTR1 hom Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.091 1.49E-7 YKL105C SEG2 hom Eisosome component and paralog of Seg1p; likely plays only minor role in eisosome assembly; shown to interact with Seg1p; similar to A. gossypii SEG gene which is important for stabilizing eisosomes
0.090 1.99E-7 YER046W SPO73 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
0.089 2.69E-7 YBL072C RPS8A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication
0.087 5.18E-7 YLR340W RPP0 het Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10
0.085 9.24E-7 YBR294W SUL1 hom High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
0.083 1.60E-6 YJR058C APS2 hom Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
0.079 4.18E-6 YGR052W_p FMP48_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.075 1.28E-5 YNR038W DBP6 het Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family
0.071 3.83E-5 YIL036W CST6 hom Basic leucine zipper (bZIP) transcription factor, in ATF/CREB family; mediates transcriptional activation of NCE103 (encoding carbonic anhydrase) in response to low CO2 levels such as in the ambient air; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; CST6 has a paralog, ACA1, that arose from the whole genome duplication
0.070 4.91E-5 YDR419W RAD30 hom DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV
0.066 1.18E-4 YJL118W YJL118W hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein
0.066 1.25E-4 YOR298W MUM3 hom Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases