YPL232W / SSO1

Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL232W / SSO1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.45|P-value:3.77E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.35|P-value:5.28E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.37|P-value:4.68E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.21|P-value:8.55E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.79|P-value:1.04E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:-3.87|P-value:7.45E-5 ID:SGTC_389|Compound:tpck|FD-Score:5.48|P-value:4.21E-8 ID:SGTC_884|Compound:0851-0618|FD-Score:3.29|P-value:6.60E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.23|P-value:7.99E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:-3.59|P-value:2.11E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:3.42|P-value:4.20E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:3.41|P-value:4.36E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.84|P-value:1.10E-6 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.72|P-value:1.38E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:-3.29|P-value:6.13E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:-3.25|P-value:7.15E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.38|P-value:4.79E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:4.17|P-value:2.27E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.19|P-value:8.75E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.29|P-value:6.58E-4 ID:SGTC_1703|Compound:st026983|FD-Score:4.55|P-value:4.38E-6 ID:SGTC_1720|Compound:st037298|FD-Score:-3.40|P-value:4.28E-4 ID:SGTC_1721|Compound:st082152|FD-Score:6.99|P-value:3.92E-12 ID:SGTC_1722|Compound:st034304|FD-Score:-3.68|P-value:1.52E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.24|P-value:7.74E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-3.85|P-value:7.87E-5 ID:SGTC_2097|Compound:5376186|FD-Score:4.54|P-value:4.53E-6 ID:SGTC_2106|Compound:5357045|FD-Score:3.29|P-value:6.54E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.46|P-value:3.53E-4 ID:SGTC_2156|Compound:5649887|FD-Score:4.33|P-value:1.16E-5 ID:SGTC_2269|Compound:7935389|FD-Score:3.43|P-value:3.94E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.50|P-value:3.17E-4 ID:SGTC_2318|Compound:6029776|FD-Score:5.16|P-value:2.29E-7 ID:SGTC_2320|Compound:7373003|FD-Score:4.30|P-value:1.30E-5 ID:SGTC_2326|Compound:6164455|FD-Score:-4.61|P-value:3.13E-6 ID:SGTC_2340|Compound:7987427|FD-Score:4.33|P-value:1.16E-5 ID:SGTC_2379|Compound:9035213|FD-Score:4.70|P-value:2.12E-6 ID:SGTC_2484|Compound:5809818|FD-Score:-3.26|P-value:6.83E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.68|P-value:1.53E-4 ID:SGTC_2523|Compound:spermine|FD-Score:3.37|P-value:4.98E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.40|P-value:8.27E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:19.10|P-value:2.67E-78 ID:SGTC_2671|Compound:danthron|FD-Score:3.60|P-value:2.12E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:5.01|P-value:4.85E-7 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.41|P-value:4.23E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.46|P-value:3.59E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.19|P-value:9.19E-4 ID:SGTC_2932|Compound:9016711|FD-Score:4.07|P-value:3.51E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-3.56|P-value:2.41E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.26|P-value:7.15E-4 ID:SGTC_3336|Compound:9143619|FD-Score:3.55|P-value:2.56E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.45|P-value:3.77E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.35|P-value:5.28E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.37|P-value:4.68E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.21|P-value:8.55E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.79|P-value:1.04E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:-3.87|P-value:7.45E-5 ID:SGTC_389|Compound:tpck|FD-Score:5.48|P-value:4.21E-8 ID:SGTC_884|Compound:0851-0618|FD-Score:3.29|P-value:6.60E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.23|P-value:7.99E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:-3.59|P-value:2.11E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:3.42|P-value:4.20E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:3.41|P-value:4.36E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.84|P-value:1.10E-6 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.72|P-value:1.38E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:-3.29|P-value:6.13E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:-3.25|P-value:7.15E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.38|P-value:4.79E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:4.17|P-value:2.27E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:-3.19|P-value:8.75E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.29|P-value:6.58E-4 ID:SGTC_1703|Compound:st026983|FD-Score:4.55|P-value:4.38E-6 ID:SGTC_1720|Compound:st037298|FD-Score:-3.40|P-value:4.28E-4 ID:SGTC_1721|Compound:st082152|FD-Score:6.99|P-value:3.92E-12 ID:SGTC_1722|Compound:st034304|FD-Score:-3.68|P-value:1.52E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.24|P-value:7.74E-4 ID:SGTC_1919|Compound:st067113|FD-Score:-3.85|P-value:7.87E-5 ID:SGTC_2097|Compound:5376186|FD-Score:4.54|P-value:4.53E-6 ID:SGTC_2106|Compound:5357045|FD-Score:3.29|P-value:6.54E-4 ID:SGTC_2137|Compound:5261020|FD-Score:3.46|P-value:3.53E-4 ID:SGTC_2156|Compound:5649887|FD-Score:4.33|P-value:1.16E-5 ID:SGTC_2269|Compound:7935389|FD-Score:3.43|P-value:3.94E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.50|P-value:3.17E-4 ID:SGTC_2318|Compound:6029776|FD-Score:5.16|P-value:2.29E-7 ID:SGTC_2320|Compound:7373003|FD-Score:4.30|P-value:1.30E-5 ID:SGTC_2326|Compound:6164455|FD-Score:-4.61|P-value:3.13E-6 ID:SGTC_2340|Compound:7987427|FD-Score:4.33|P-value:1.16E-5 ID:SGTC_2379|Compound:9035213|FD-Score:4.70|P-value:2.12E-6 ID:SGTC_2484|Compound:5809818|FD-Score:-3.26|P-value:6.83E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.68|P-value:1.53E-4 ID:SGTC_2523|Compound:spermine|FD-Score:3.37|P-value:4.98E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.40|P-value:8.27E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:19.10|P-value:2.67E-78 ID:SGTC_2671|Compound:danthron|FD-Score:3.60|P-value:2.12E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:5.01|P-value:4.85E-7 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.41|P-value:4.23E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.46|P-value:3.59E-4 ID:SGTC_2809|Compound:7964133|FD-Score:3.19|P-value:9.19E-4 ID:SGTC_2932|Compound:9016711|FD-Score:4.07|P-value:3.51E-5 ID:SGTC_3211|Compound:9128781|FD-Score:-3.56|P-value:2.41E-4 ID:SGTC_3235|Compound:9132602|FD-Score:3.26|P-value:7.15E-4 ID:SGTC_3336|Compound:9143619|FD-Score:3.55|P-value:2.56E-4

Top fitness defect scores for YPL232W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 19.10 100.0 µM 2.67E-78 redox potentiating 3 1.37E-81
2 SGTC_1721 st082152 6.99 9.3 µM 3.92E-12 60S ribosome export 4 1.36E-12
3 SGTC_389 tpck 5.48 16.7 µM 4.21E-8 13 2.16E-8
4 SGTC_2318 6029776 5.16 164.0 µM 2.29E-7 10 1.26E-7
5 SGTC_2743 auranofin 5.01 4.3 µM 4.85E-7 RPP1 & pyrimidine depletion 16 2.76E-7
6 SGTC_1135 dihydrocapsaicin 4.84 536.7 nM 1.10E-6 15 6.48E-7
7 SGTC_2379 9035213 4.70 200.0 µM 2.12E-6 6 1.28E-6
8 SGTC_1703 st026983 4.55 48.3 µM 4.38E-6 3 2.74E-6
9 SGTC_2097 5376186 4.54 200.0 µM 4.53E-6 10 2.84E-6
10 SGTC_2566 crystal violet carbinol 4.40 226.0 nM 8.27E-6 30 5.31E-6
11 SGTC_2340 7987427 4.33 183.4 µM 1.16E-5 22 7.52E-6
12 SGTC_2156 5649887 4.33 115.0 µM 1.16E-5 RPP1 & pyrimidine depletion 6 7.57E-6
13 SGTC_2320 7373003 4.30 200.0 µM 1.30E-5 20 8.49E-6
14 SGTC_1356 1502-0781 4.17 85.8 µM 2.27E-5 fatty acid desaturase (OLE1) 12 1.52E-5
15 SGTC_2932 9016711 4.07 44.5 µM 3.51E-5 45 2.39E-5
16 SGTC_290 2043-6722 3.79 48.1 µM 1.04E-4 14 7.43E-5
17 SGTC_1166 k206-0078 3.72 225.0 µM 1.38E-4 24 9.95E-5
18 SGTC_2671 danthron 3.60 100.0 µM 2.12E-4 DNA damage response 54 1.56E-4
19 SGTC_3336 9143619 3.55 71.4 µM 2.56E-4 27 1.90E-4
20 SGTC_2302 7771753 3.50 200.0 µM 3.17E-4 58 2.37E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.370 1.07E-109 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.365 2.58E-106 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.337 4.15E-90 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.330 4.96E-86 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.309 5.08E-75 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.298 8.87E-70 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.294 8.76E-68 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.293 2.23E-67 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.286 2.42E-64 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.276 9.58E-60 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.269 9.46E-57 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.267 8.94E-56 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.241 1.11E-45 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.236 1.03E-43 YCR033W SNT1 hom Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance
0.232 3.56E-42 YJR091C JSN1 hom Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl