YPL235W / RVB2

ATP-dependent DNA helicase, also known as reptin; member of the AAA+ and RuvB protein families, similar to Rvb1p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL235W / RVB2

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:5.76|P-value:1.93E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:-4.55|P-value:7.53E-5 ID:SGTC_94|Compound:0334-0113|FD-Score:4.58|P-value:1.30E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:4.91|P-value:4.44E-5 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.95|P-value:8.44E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:4.62|P-value:1.12E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.42|P-value:2.14E-4 ID:SGTC_466|Compound:geldanamycin|FD-Score:-5.12|P-value:1.07E-5 ID:SGTC_490|Compound:phenamil|FD-Score:-4.58|P-value:6.82E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.83|P-value:6.88E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-3.75|P-value:8.65E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:4.71|P-value:8.60E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:8.27|P-value:1.39E-11 ID:SGTC_806|Compound:3966-4455|FD-Score:-6.34|P-value:7.77E-8 ID:SGTC_823|Compound:0417-1665|FD-Score:4.44|P-value:2.01E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:10.90|P-value:5.17E-19 ID:SGTC_885|Compound:0865-0106|FD-Score:-5.42|P-value:3.50E-6 ID:SGTC_891|Compound:0929-0073|FD-Score:5.54|P-value:4.65E-6 ID:SGTC_892|Compound:0929-0076|FD-Score:-3.78|P-value:7.85E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:6.09|P-value:5.14E-7 ID:SGTC_942|Compound:3253-1115|FD-Score:9.06|P-value:1.40E-13 ID:SGTC_944|Compound:3370-0224|FD-Score:3.92|P-value:9.18E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:7.46|P-value:9.57E-10 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.06|P-value:6.24E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:8.03|P-value:4.91E-11 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.73|P-value:4.24E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:6.85|P-value:1.82E-8 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.94|P-value:8.55E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:4.23|P-value:3.75E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:4.13|P-value:4.98E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:-4.22|P-value:2.15E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:9.30|P-value:3.11E-14 ID:SGTC_1450|Compound:4112-4260|FD-Score:4.31|P-value:2.98E-4 ID:SGTC_1643|Compound:st009866|FD-Score:-4.10|P-value:3.09E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-3.95|P-value:4.80E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.79|P-value:1.76E-6 ID:SGTC_1961|Compound:st076550|FD-Score:4.46|P-value:1.86E-4 ID:SGTC_1990|Compound:st072050|FD-Score:3.92|P-value:9.11E-4 ID:SGTC_2120|Compound:5538279|FD-Score:4.28|P-value:3.24E-4 ID:SGTC_2265|Compound:7929201|FD-Score:3.99|P-value:7.60E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-4.07|P-value:3.45E-4 ID:SGTC_2304|Compound:7443016|FD-Score:4.20|P-value:4.11E-4 ID:SGTC_2361|Compound:9034121|FD-Score:4.56|P-value:1.35E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:4.77|P-value:6.93E-5 ID:SGTC_2601|Compound:securinine|FD-Score:4.12|P-value:5.27E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-5.31|P-value:5.26E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.45|P-value:1.04E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.20|P-value:2.32E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.42|P-value:2.14E-4 ID:SGTC_2701|Compound:st077767|FD-Score:-6.38|P-value:6.62E-8 ID:SGTC_2712|Compound:st079126|FD-Score:4.69|P-value:8.99E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.96|P-value:1.86E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.41|P-value:2.21E-4 ID:SGTC_2794|Compound:7785382|FD-Score:-4.31|P-value:1.66E-4 ID:SGTC_2864|Compound:9034755|FD-Score:5.10|P-value:2.30E-5 ID:SGTC_2964|Compound:9083345|FD-Score:4.42|P-value:2.10E-4 ID:SGTC_2997|Compound:9067075|FD-Score:-4.12|P-value:2.96E-4 ID:SGTC_3065|Compound:9113888|FD-Score:-3.95|P-value:4.87E-4 ID:SGTC_3068|Compound:9116768|FD-Score:-6.45|P-value:4.81E-8 ID:SGTC_3071|Compound:9117417|FD-Score:7.29|P-value:2.26E-9 ID:SGTC_3073|Compound:9114972|FD-Score:4.52|P-value:1.55E-4 ID:SGTC_3078|Compound:9116413|FD-Score:6.72|P-value:3.31E-8 ID:SGTC_3203|Compound:9113543|FD-Score:4.44|P-value:2.00E-4 ID:SGTC_3235|Compound:9132602|FD-Score:4.25|P-value:3.51E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:5.76|P-value:1.93E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:-4.55|P-value:7.53E-5 ID:SGTC_94|Compound:0334-0113|FD-Score:4.58|P-value:1.30E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:4.91|P-value:4.44E-5 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.95|P-value:8.44E-4 ID:SGTC_316|Compound:k060-0003|FD-Score:4.62|P-value:1.12E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.42|P-value:2.14E-4 ID:SGTC_466|Compound:geldanamycin|FD-Score:-5.12|P-value:1.07E-5 ID:SGTC_490|Compound:phenamil|FD-Score:-4.58|P-value:6.82E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.83|P-value:6.88E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-3.75|P-value:8.65E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:4.71|P-value:8.60E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:8.27|P-value:1.39E-11 ID:SGTC_806|Compound:3966-4455|FD-Score:-6.34|P-value:7.77E-8 ID:SGTC_823|Compound:0417-1665|FD-Score:4.44|P-value:2.01E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:10.90|P-value:5.17E-19 ID:SGTC_885|Compound:0865-0106|FD-Score:-5.42|P-value:3.50E-6 ID:SGTC_891|Compound:0929-0073|FD-Score:5.54|P-value:4.65E-6 ID:SGTC_892|Compound:0929-0076|FD-Score:-3.78|P-value:7.85E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:6.09|P-value:5.14E-7 ID:SGTC_942|Compound:3253-1115|FD-Score:9.06|P-value:1.40E-13 ID:SGTC_944|Compound:3370-0224|FD-Score:3.92|P-value:9.18E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:7.46|P-value:9.57E-10 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.06|P-value:6.24E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:8.03|P-value:4.91E-11 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.73|P-value:4.24E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:6.85|P-value:1.82E-8 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.94|P-value:8.55E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:4.23|P-value:3.75E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:4.13|P-value:4.98E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:-4.22|P-value:2.15E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:9.30|P-value:3.11E-14 ID:SGTC_1450|Compound:4112-4260|FD-Score:4.31|P-value:2.98E-4 ID:SGTC_1643|Compound:st009866|FD-Score:-4.10|P-value:3.09E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-3.95|P-value:4.80E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.79|P-value:1.76E-6 ID:SGTC_1961|Compound:st076550|FD-Score:4.46|P-value:1.86E-4 ID:SGTC_1990|Compound:st072050|FD-Score:3.92|P-value:9.11E-4 ID:SGTC_2120|Compound:5538279|FD-Score:4.28|P-value:3.24E-4 ID:SGTC_2265|Compound:7929201|FD-Score:3.99|P-value:7.60E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-4.07|P-value:3.45E-4 ID:SGTC_2304|Compound:7443016|FD-Score:4.20|P-value:4.11E-4 ID:SGTC_2361|Compound:9034121|FD-Score:4.56|P-value:1.35E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:4.77|P-value:6.93E-5 ID:SGTC_2601|Compound:securinine|FD-Score:4.12|P-value:5.27E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-5.31|P-value:5.26E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:-4.45|P-value:1.04E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.20|P-value:2.32E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.42|P-value:2.14E-4 ID:SGTC_2701|Compound:st077767|FD-Score:-6.38|P-value:6.62E-8 ID:SGTC_2712|Compound:st079126|FD-Score:4.69|P-value:8.99E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.96|P-value:1.86E-5 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.41|P-value:2.21E-4 ID:SGTC_2794|Compound:7785382|FD-Score:-4.31|P-value:1.66E-4 ID:SGTC_2864|Compound:9034755|FD-Score:5.10|P-value:2.30E-5 ID:SGTC_2964|Compound:9083345|FD-Score:4.42|P-value:2.10E-4 ID:SGTC_2997|Compound:9067075|FD-Score:-4.12|P-value:2.96E-4 ID:SGTC_3065|Compound:9113888|FD-Score:-3.95|P-value:4.87E-4 ID:SGTC_3068|Compound:9116768|FD-Score:-6.45|P-value:4.81E-8 ID:SGTC_3071|Compound:9117417|FD-Score:7.29|P-value:2.26E-9 ID:SGTC_3073|Compound:9114972|FD-Score:4.52|P-value:1.55E-4 ID:SGTC_3078|Compound:9116413|FD-Score:6.72|P-value:3.31E-8 ID:SGTC_3203|Compound:9113543|FD-Score:4.44|P-value:2.00E-4 ID:SGTC_3235|Compound:9132602|FD-Score:4.25|P-value:3.51E-4

Top fitness defect scores for YPL235W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_832 4083-0019 10.90 164.0 µM 5.17E-19 translation 1 4.05E-28 2.96
2 SGTC_1390 3413-2614 9.30 145.0 µM 3.11E-14 fatty acid desaturase (OLE1) 1 6.85E-21 3.69
3 SGTC_942 3253-1115 9.06 227.0 µM 1.40E-13 1 6.65E-20 2.31
4 SGTC_800 3448-7362 8.27 155.0 µM 1.39E-11 translation 9 6.94E-17 0.10
5 SGTC_1034 k072-0165 8.03 12.7 µM 4.91E-11 Golgi 1 4.69E-16 1.92
6 SGTC_945 3381-0768 7.46 11.3 µM 9.57E-10 endomembrane recycling 2 4.18E-14 0.77
7 SGTC_3071 9117417 7.29 49.5 µM 2.26E-9 fatty acid desaturase (OLE1) 2 1.53E-13 0.08
8 SGTC_1136 pergolide 6.85 1.1 µM 1.82E-8 2 3.59E-12 0.70
9 SGTC_3078 9116413 6.72 49.5 µM 3.31E-8 unfolded protein response 1 8.85E-12 2.02
10 SGTC_939 1165-0479 6.09 45.3 µM 5.14E-7 1 5.59E-10 0.92
11 SGTC_1844 rapamycin 5.79 4.0 nM 1.76E-6 24 3.59E-9 0.03
12 SGTC_49 0717-0965 5.76 32.1 µM 1.93E-6 60S ribosome export 3 4.12E-9 0.67
13 SGTC_891 0929-0073 5.54 133.0 µM 4.65E-6 1 1.55E-8 1.73
14 SGTC_2864 9034755 5.10 47.6 µM 2.30E-5 2 1.73E-7 0.56
15 SGTC_258 haloperidol 4.91 50.8 µM 4.44E-5 fatty acid desaturase (OLE1) 9 4.66E-7 0.09
16 SGTC_2557 derrustone 4.77 83.8 µM 6.93E-5 2 9.11E-7 0.07
17 SGTC_679 0422-0091 4.71 41.4 µM 8.60E-5 Golgi 6 1.26E-6 0.05
18 SGTC_2712 st079126 4.69 47.7 µM 8.99E-5 1 1.35E-6 0.43
19 SGTC_316 k060-0003 4.62 58.6 µM 1.12E-4 2 1.89E-6 0.23
20 SGTC_94 0334-0113 4.58 514.8 µM 1.30E-4 3 2.36E-6 0.76

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.167 2.78E-22 YKL180W RPL17A het Ribosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.161 6.69E-21 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.158 4.61E-20 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly
0.151 1.73E-18 YOL040C RPS15 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
0.149 4.21E-18 YLR076C_d YLR076C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10
0.146 1.87E-17 YLR058C SHM2 hom Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis
0.146 2.28E-17 YPL093W NOG1 het Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins
0.144 5.96E-17 YOL120C RPL18A het Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
0.143 9.10E-17 YLR009W RLP24 het Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp
0.142 1.54E-16 YOR206W NOC2 het Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors
0.133 1.18E-14 YDR280W RRP45 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
0.131 2.56E-14 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.131 2.94E-14 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.129 6.71E-14 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.129 8.69E-14 YJR007W SUI2 het Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress