YPL237W / SUI3

Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL237W / SUI3

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:3.90|P-value:6.44E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.54|P-value:8.97E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:5.21|P-value:8.51E-6 ID:SGTC_132|Compound:0417-1715|FD-Score:6.06|P-value:2.91E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:7.74|P-value:8.62E-11 ID:SGTC_163|Compound:1327-0036|FD-Score:8.02|P-value:1.85E-11 ID:SGTC_221|Compound:trifluoperazine|FD-Score:9.30|P-value:8.34E-15 ID:SGTC_253|Compound:dyclonine|FD-Score:4.03|P-value:4.43E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:7.26|P-value:1.04E-9 ID:SGTC_284|Compound:0988-0104|FD-Score:-4.56|P-value:8.23E-5 ID:SGTC_302|Compound:1094-0063|FD-Score:6.66|P-value:1.94E-8 ID:SGTC_309|Compound:k408-0051|FD-Score:5.06|P-value:1.51E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.95|P-value:5.46E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-5.58|P-value:2.00E-6 ID:SGTC_371|Compound:0195-0006|FD-Score:3.88|P-value:6.95E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:4.16|P-value:3.02E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-4.97|P-value:1.98E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:4.22|P-value:2.52E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:5.54|P-value:2.42E-6 ID:SGTC_667|Compound:1498-1044|FD-Score:4.70|P-value:5.34E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:4.08|P-value:3.89E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:4.35|P-value:1.67E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:4.00|P-value:4.79E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:4.54|P-value:9.07E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:8.17|P-value:7.98E-12 ID:SGTC_830|Compound:4076-0286|FD-Score:4.66|P-value:6.14E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.01|P-value:4.78E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:6.92|P-value:5.68E-9 ID:SGTC_966|Compound:1300-0360|FD-Score:-4.84|P-value:3.12E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:-4.27|P-value:2.05E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.79|P-value:8.85E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:4.43|P-value:1.30E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:4.15|P-value:3.10E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.88|P-value:6.96E-4 ID:SGTC_1766|Compound:st045414|FD-Score:5.44|P-value:3.56E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.34|P-value:1.65E-4 ID:SGTC_1952|Compound:st077036|FD-Score:-4.72|P-value:4.77E-5 ID:SGTC_1955|Compound:wogonin|FD-Score:3.88|P-value:6.85E-4 ID:SGTC_2023|Compound:5144124|FD-Score:8.53|P-value:9.49E-13 ID:SGTC_2063|Compound:5246145|FD-Score:5.63|P-value:1.73E-6 ID:SGTC_2066|Compound:5222451|FD-Score:-5.22|P-value:7.96E-6 ID:SGTC_2089|Compound:5281248|FD-Score:3.98|P-value:5.20E-4 ID:SGTC_2100|Compound:5377183|FD-Score:-3.90|P-value:6.25E-4 ID:SGTC_2200|Compound:6600604|FD-Score:4.03|P-value:4.39E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.78|P-value:9.12E-4 ID:SGTC_2358|Compound:9037157|FD-Score:6.12|P-value:2.18E-7 ID:SGTC_2437|Compound:5741531|FD-Score:-4.34|P-value:1.64E-4 ID:SGTC_2444|Compound:5485484|FD-Score:-4.57|P-value:7.92E-5 ID:SGTC_2445|Compound:5742597|FD-Score:-4.11|P-value:3.42E-4 ID:SGTC_2511|Compound:berberine|FD-Score:-3.79|P-value:8.66E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.91|P-value:6.02E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.71|P-value:5.00E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:9.60|P-value:1.13E-15 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.85|P-value:7.54E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:9.05|P-value:4.10E-14 ID:SGTC_2671|Compound:danthron|FD-Score:5.76|P-value:1.03E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:9.29|P-value:8.61E-15 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.19|P-value:2.68E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-5.15|P-value:1.03E-5 ID:SGTC_2780|Compound:5215298|FD-Score:3.86|P-value:7.22E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.92|P-value:6.05E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.49|P-value:1.04E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.79|P-value:8.85E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-3.98|P-value:5.01E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.90|P-value:6.44E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.54|P-value:8.97E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:5.21|P-value:8.51E-6 ID:SGTC_132|Compound:0417-1715|FD-Score:6.06|P-value:2.91E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:7.74|P-value:8.62E-11 ID:SGTC_163|Compound:1327-0036|FD-Score:8.02|P-value:1.85E-11 ID:SGTC_221|Compound:trifluoperazine|FD-Score:9.30|P-value:8.34E-15 ID:SGTC_253|Compound:dyclonine|FD-Score:4.03|P-value:4.43E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:7.26|P-value:1.04E-9 ID:SGTC_284|Compound:0988-0104|FD-Score:-4.56|P-value:8.23E-5 ID:SGTC_302|Compound:1094-0063|FD-Score:6.66|P-value:1.94E-8 ID:SGTC_309|Compound:k408-0051|FD-Score:5.06|P-value:1.51E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.95|P-value:5.46E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:-5.58|P-value:2.00E-6 ID:SGTC_371|Compound:0195-0006|FD-Score:3.88|P-value:6.95E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:4.16|P-value:3.02E-4 ID:SGTC_393|Compound:acivicin|FD-Score:-4.97|P-value:1.98E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:4.22|P-value:2.52E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:5.54|P-value:2.42E-6 ID:SGTC_667|Compound:1498-1044|FD-Score:4.70|P-value:5.34E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:4.08|P-value:3.89E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:4.35|P-value:1.67E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:4.00|P-value:4.79E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:4.54|P-value:9.07E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:8.17|P-value:7.98E-12 ID:SGTC_830|Compound:4076-0286|FD-Score:4.66|P-value:6.14E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.01|P-value:4.78E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:6.92|P-value:5.68E-9 ID:SGTC_966|Compound:1300-0360|FD-Score:-4.84|P-value:3.12E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:-4.27|P-value:2.05E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.79|P-value:8.85E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:4.43|P-value:1.30E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:4.15|P-value:3.10E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.88|P-value:6.96E-4 ID:SGTC_1766|Compound:st045414|FD-Score:5.44|P-value:3.56E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.34|P-value:1.65E-4 ID:SGTC_1952|Compound:st077036|FD-Score:-4.72|P-value:4.77E-5 ID:SGTC_1955|Compound:wogonin|FD-Score:3.88|P-value:6.85E-4 ID:SGTC_2023|Compound:5144124|FD-Score:8.53|P-value:9.49E-13 ID:SGTC_2063|Compound:5246145|FD-Score:5.63|P-value:1.73E-6 ID:SGTC_2066|Compound:5222451|FD-Score:-5.22|P-value:7.96E-6 ID:SGTC_2089|Compound:5281248|FD-Score:3.98|P-value:5.20E-4 ID:SGTC_2100|Compound:5377183|FD-Score:-3.90|P-value:6.25E-4 ID:SGTC_2200|Compound:6600604|FD-Score:4.03|P-value:4.39E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.78|P-value:9.12E-4 ID:SGTC_2358|Compound:9037157|FD-Score:6.12|P-value:2.18E-7 ID:SGTC_2437|Compound:5741531|FD-Score:-4.34|P-value:1.64E-4 ID:SGTC_2444|Compound:5485484|FD-Score:-4.57|P-value:7.92E-5 ID:SGTC_2445|Compound:5742597|FD-Score:-4.11|P-value:3.42E-4 ID:SGTC_2511|Compound:berberine|FD-Score:-3.79|P-value:8.66E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.91|P-value:6.02E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.71|P-value:5.00E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:9.60|P-value:1.13E-15 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.85|P-value:7.54E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:9.05|P-value:4.10E-14 ID:SGTC_2671|Compound:danthron|FD-Score:5.76|P-value:1.03E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:9.29|P-value:8.61E-15 ID:SGTC_2739|Compound:tacrine|FD-Score:-4.19|P-value:2.68E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:-5.15|P-value:1.03E-5 ID:SGTC_2780|Compound:5215298|FD-Score:3.86|P-value:7.22E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.92|P-value:6.05E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.49|P-value:1.04E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.79|P-value:8.85E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-3.98|P-value:5.01E-4

Top fitness defect scores for YPL237W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2651 1327-0036 9.60 5.0 µM 1.13E-15 17 3.87E-22 0.63
2 SGTC_221 trifluoperazine 9.30 10.3 µM 8.34E-15 NEO1-PIK1 6 7.12E-21 0.02
3 SGTC_2679 rapamycin 9.29 1.0 nM 8.61E-15 11 7.47E-21 0.23
4 SGTC_2658 polymyxin b sulfate 9.05 77.0 µM 4.10E-14 NEO1 3 7.28E-20 0.38
5 SGTC_2023 5144124 8.53 124.0 µM 9.49E-13 1 7.14E-18 2.39
6 SGTC_800 3448-7362 8.17 155.0 µM 7.98E-12 translation 10 1.59E-16 0.37
7 SGTC_163 1327-0036 8.02 7.5 µM 1.85E-11 21 5.42E-16 0.24
8 SGTC_134 0269-0018 7.74 6.9 µM 8.62E-11 6 5.11E-15 1.27
9 SGTC_274 sirtinol 7.26 40.1 µM 1.04E-9 3 1.93E-13 0.53
10 SGTC_894 0960-0238 6.92 55.9 µM 5.68E-9 3 2.27E-12 0.17
11 SGTC_302 1094-0063 6.66 18.9 µM 1.94E-8 2 1.36E-11 0.45
12 SGTC_2358 9037157 6.12 4.0 µM 2.18E-7 3 4.56E-10 0.02
13 SGTC_132 0417-1715 6.06 25.8 µM 2.91E-7 RPP1 & pyrimidine depletion 2 6.95E-10 0.34
14 SGTC_2671 danthron 5.76 100.0 µM 1.03E-6 DNA damage response 8 4.32E-9 0.20
15 SGTC_2063 5246145 5.63 200.0 µM 1.73E-6 3 9.19E-9 0.94
16 SGTC_582 0987-0078 5.54 156.0 µM 2.42E-6 calcium & mitochondrial duress 5 1.50E-8 0.77
17 SGTC_1766 st045414 5.44 44.8 µM 3.56E-6 RPP1 & pyrimidine depletion 8 2.62E-8 1.08
18 SGTC_115 0527-0192 5.21 112.0 µM 8.51E-6 7 9.26E-8 0.07
19 SGTC_309 k408-0051 5.06 1.5 µM 1.51E-5 15 2.13E-7 0.02
20 SGTC_667 1498-1044 4.70 59.0 µM 5.34E-5 RPP1 & pyrimidine depletion 6 1.32E-6 0.47

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.453 1.38E-169 YPL238C_d YPL238C_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W
0.390 4.76E-122 YER025W GCD11 het Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met
0.325 2.91E-83 YJR007W SUI2 het Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress
0.201 6.47E-32 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.198 4.89E-31 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.192 3.05E-29 YDR429C TIF35 het eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation
0.184 7.33E-27 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.182 2.21E-26 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.174 3.69E-24 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.174 3.72E-24 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.171 2.36E-23 YDL150W RPC53 het RNA polymerase III subunit C53
0.164 1.15E-21 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.163 2.66E-21 YLR044C PDC1 hom Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism
0.161 6.58E-21 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.161 8.29E-21 YOR274W MOD5 hom Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis