YPL238C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL238C / YPL238C

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:4.18|P-value:6.79E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:5.35|P-value:2.09E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:10.10|P-value:6.66E-15 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.34|P-value:4.97E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:5.26|P-value:2.81E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.61|P-value:8.56E-6 ID:SGTC_274|Compound:sirtinol|FD-Score:6.72|P-value:1.34E-7 ID:SGTC_346|Compound:4513-0042|FD-Score:-5.54|P-value:1.28E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:-6.92|P-value:7.05E-8 ID:SGTC_356|Compound:1634-0012|FD-Score:4.54|P-value:2.48E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:5.54|P-value:1.09E-5 ID:SGTC_393|Compound:acivicin|FD-Score:-5.58|P-value:1.10E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.88|P-value:9.12E-5 ID:SGTC_490|Compound:phenamil|FD-Score:-4.68|P-value:1.88E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:5.47|P-value:1.38E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:4.03|P-value:9.90E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-5.25|P-value:3.32E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:4.54|P-value:2.50E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.42|P-value:3.56E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:6.24|P-value:9.06E-7 ID:SGTC_785|Compound:1270-0111|FD-Score:6.13|P-value:1.37E-6 ID:SGTC_795|Compound:0685-0265|FD-Score:4.15|P-value:7.34E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:10.80|P-value:6.00E-17 ID:SGTC_832|Compound:4083-0019|FD-Score:5.57|P-value:1.00E-5 ID:SGTC_838|Compound:0109-0203|FD-Score:7.31|P-value:1.12E-8 ID:SGTC_849|Compound:0386-0493|FD-Score:4.46|P-value:3.16E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:-5.49|P-value:1.52E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:7.84|P-value:9.85E-10 ID:SGTC_874|Compound:0599-0792|FD-Score:-4.26|P-value:6.05E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:5.98|P-value:2.35E-6 ID:SGTC_937|Compound:3122-0005|FD-Score:4.73|P-value:1.47E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:4.29|P-value:4.98E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.04|P-value:9.78E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.98|P-value:6.79E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.56|P-value:2.35E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:5.14|P-value:4.11E-5 ID:SGTC_1399|Compound:3562-5772|FD-Score:8.54|P-value:3.21E-11 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.96|P-value:8.24E-5 ID:SGTC_1628|Compound:st004252|FD-Score:5.60|P-value:8.94E-6 ID:SGTC_1635|Compound:st007035|FD-Score:-4.60|P-value:2.41E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-4.23|P-value:6.51E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.16|P-value:7.13E-4 ID:SGTC_1773|Compound:st048542|FD-Score:7.88|P-value:8.38E-10 ID:SGTC_1775|Compound:st081588|FD-Score:-5.51|P-value:1.42E-5 ID:SGTC_1778|Compound:st046819|FD-Score:-5.51|P-value:1.41E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.08|P-value:9.73E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-4.59|P-value:2.48E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-4.25|P-value:6.29E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-4.39|P-value:4.30E-4 ID:SGTC_1940|Compound:st075990|FD-Score:7.04|P-value:3.53E-8 ID:SGTC_1949|Compound:st076024|FD-Score:4.24|P-value:5.83E-4 ID:SGTC_1989|Compound:st071868|FD-Score:6.58|P-value:2.34E-7 ID:SGTC_2023|Compound:5144124|FD-Score:4.27|P-value:5.38E-4 ID:SGTC_2057|Compound:5236571|FD-Score:4.18|P-value:6.82E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-5.27|P-value:3.11E-5 ID:SGTC_2067|Compound:5224629|FD-Score:4.05|P-value:9.46E-4 ID:SGTC_2110|Compound:5483698|FD-Score:4.12|P-value:7.90E-4 ID:SGTC_2126|Compound:5251174|FD-Score:7.33|P-value:1.02E-8 ID:SGTC_2128|Compound:5255449|FD-Score:4.32|P-value:4.66E-4 ID:SGTC_2156|Compound:5649887|FD-Score:4.74|P-value:1.41E-4 ID:SGTC_2293|Compound:7624732|FD-Score:4.91|P-value:8.37E-5 ID:SGTC_2358|Compound:9037157|FD-Score:4.93|P-value:7.86E-5 ID:SGTC_2399|Compound:5884133|FD-Score:4.21|P-value:6.22E-4 ID:SGTC_2437|Compound:5741531|FD-Score:-4.14|P-value:8.37E-4 ID:SGTC_2466|Compound:5983409|FD-Score:4.70|P-value:1.57E-4 ID:SGTC_2483|Compound:5729050|FD-Score:4.06|P-value:9.19E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:8.85|P-value:6.63E-12 ID:SGTC_2629|Compound:bisabolol|FD-Score:4.54|P-value:2.53E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.17|P-value:7.81E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.73|P-value:5.73E-6 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.07|P-value:9.05E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-8.69|P-value:1.89E-11 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.27|P-value:5.92E-4 ID:SGTC_2801|Compound:7907800|FD-Score:4.25|P-value:5.64E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.79|P-value:1.20E-4 ID:SGTC_2880|Compound:9042983|FD-Score:4.32|P-value:4.58E-4 ID:SGTC_2892|Compound:9047358|FD-Score:-4.24|P-value:6.41E-4 ID:SGTC_2993|Compound:9054257|FD-Score:5.10|P-value:4.62E-5 ID:SGTC_3002|Compound:9075603|FD-Score:4.27|P-value:5.26E-4 ID:SGTC_3029|Compound:9088683|FD-Score:-4.27|P-value:5.91E-4 ID:SGTC_3033|Compound:9090887|FD-Score:5.26|P-value:2.83E-5 ID:SGTC_3111|Compound:9122088|FD-Score:4.72|P-value:1.50E-4 ID:SGTC_3232|Compound:9132874|FD-Score:4.12|P-value:7.97E-4 ID:SGTC_3282|Compound:9108498|FD-Score:6.61|P-value:2.07E-7 ID:SGTC_3290|Compound:9121031|FD-Score:4.51|P-value:2.70E-4 ID:SGTC_3323|Compound:9138564|FD-Score:4.06|P-value:9.23E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.18|P-value:6.79E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:5.35|P-value:2.09E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:10.10|P-value:6.66E-15 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.34|P-value:4.97E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:5.26|P-value:2.81E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.61|P-value:8.56E-6 ID:SGTC_274|Compound:sirtinol|FD-Score:6.72|P-value:1.34E-7 ID:SGTC_346|Compound:4513-0042|FD-Score:-5.54|P-value:1.28E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:-6.92|P-value:7.05E-8 ID:SGTC_356|Compound:1634-0012|FD-Score:4.54|P-value:2.48E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:5.54|P-value:1.09E-5 ID:SGTC_393|Compound:acivicin|FD-Score:-5.58|P-value:1.10E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.88|P-value:9.12E-5 ID:SGTC_490|Compound:phenamil|FD-Score:-4.68|P-value:1.88E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:5.47|P-value:1.38E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:4.03|P-value:9.90E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-5.25|P-value:3.32E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:4.54|P-value:2.50E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:4.42|P-value:3.56E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:6.24|P-value:9.06E-7 ID:SGTC_785|Compound:1270-0111|FD-Score:6.13|P-value:1.37E-6 ID:SGTC_795|Compound:0685-0265|FD-Score:4.15|P-value:7.34E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:10.80|P-value:6.00E-17 ID:SGTC_832|Compound:4083-0019|FD-Score:5.57|P-value:1.00E-5 ID:SGTC_838|Compound:0109-0203|FD-Score:7.31|P-value:1.12E-8 ID:SGTC_849|Compound:0386-0493|FD-Score:4.46|P-value:3.16E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:-5.49|P-value:1.52E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:7.84|P-value:9.85E-10 ID:SGTC_874|Compound:0599-0792|FD-Score:-4.26|P-value:6.05E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:5.98|P-value:2.35E-6 ID:SGTC_937|Compound:3122-0005|FD-Score:4.73|P-value:1.47E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:4.29|P-value:4.98E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.04|P-value:9.78E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.98|P-value:6.79E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:4.56|P-value:2.35E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:5.14|P-value:4.11E-5 ID:SGTC_1399|Compound:3562-5772|FD-Score:8.54|P-value:3.21E-11 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.96|P-value:8.24E-5 ID:SGTC_1628|Compound:st004252|FD-Score:5.60|P-value:8.94E-6 ID:SGTC_1635|Compound:st007035|FD-Score:-4.60|P-value:2.41E-4 ID:SGTC_1715|Compound:st032160|FD-Score:-4.23|P-value:6.51E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.16|P-value:7.13E-4 ID:SGTC_1773|Compound:st048542|FD-Score:7.88|P-value:8.38E-10 ID:SGTC_1775|Compound:st081588|FD-Score:-5.51|P-value:1.42E-5 ID:SGTC_1778|Compound:st046819|FD-Score:-5.51|P-value:1.41E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.08|P-value:9.73E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-4.59|P-value:2.48E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-4.25|P-value:6.29E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-4.39|P-value:4.30E-4 ID:SGTC_1940|Compound:st075990|FD-Score:7.04|P-value:3.53E-8 ID:SGTC_1949|Compound:st076024|FD-Score:4.24|P-value:5.83E-4 ID:SGTC_1989|Compound:st071868|FD-Score:6.58|P-value:2.34E-7 ID:SGTC_2023|Compound:5144124|FD-Score:4.27|P-value:5.38E-4 ID:SGTC_2057|Compound:5236571|FD-Score:4.18|P-value:6.82E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-5.27|P-value:3.11E-5 ID:SGTC_2067|Compound:5224629|FD-Score:4.05|P-value:9.46E-4 ID:SGTC_2110|Compound:5483698|FD-Score:4.12|P-value:7.90E-4 ID:SGTC_2126|Compound:5251174|FD-Score:7.33|P-value:1.02E-8 ID:SGTC_2128|Compound:5255449|FD-Score:4.32|P-value:4.66E-4 ID:SGTC_2156|Compound:5649887|FD-Score:4.74|P-value:1.41E-4 ID:SGTC_2293|Compound:7624732|FD-Score:4.91|P-value:8.37E-5 ID:SGTC_2358|Compound:9037157|FD-Score:4.93|P-value:7.86E-5 ID:SGTC_2399|Compound:5884133|FD-Score:4.21|P-value:6.22E-4 ID:SGTC_2437|Compound:5741531|FD-Score:-4.14|P-value:8.37E-4 ID:SGTC_2466|Compound:5983409|FD-Score:4.70|P-value:1.57E-4 ID:SGTC_2483|Compound:5729050|FD-Score:4.06|P-value:9.19E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:8.85|P-value:6.63E-12 ID:SGTC_2629|Compound:bisabolol|FD-Score:4.54|P-value:2.53E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.17|P-value:7.81E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.73|P-value:5.73E-6 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.07|P-value:9.05E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-8.69|P-value:1.89E-11 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.27|P-value:5.92E-4 ID:SGTC_2801|Compound:7907800|FD-Score:4.25|P-value:5.64E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.79|P-value:1.20E-4 ID:SGTC_2880|Compound:9042983|FD-Score:4.32|P-value:4.58E-4 ID:SGTC_2892|Compound:9047358|FD-Score:-4.24|P-value:6.41E-4 ID:SGTC_2993|Compound:9054257|FD-Score:5.10|P-value:4.62E-5 ID:SGTC_3002|Compound:9075603|FD-Score:4.27|P-value:5.26E-4 ID:SGTC_3029|Compound:9088683|FD-Score:-4.27|P-value:5.91E-4 ID:SGTC_3033|Compound:9090887|FD-Score:5.26|P-value:2.83E-5 ID:SGTC_3111|Compound:9122088|FD-Score:4.72|P-value:1.50E-4 ID:SGTC_3232|Compound:9132874|FD-Score:4.12|P-value:7.97E-4 ID:SGTC_3282|Compound:9108498|FD-Score:6.61|P-value:2.07E-7 ID:SGTC_3290|Compound:9121031|FD-Score:4.51|P-value:2.70E-4 ID:SGTC_3323|Compound:9138564|FD-Score:4.06|P-value:9.23E-4

Top fitness defect scores for YPL238C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_800 3448-7362 10.80 155.0 µM 6.00E-17 translation 5 1.16E-27 2.06
2 SGTC_163 1327-0036 10.10 7.5 µM 6.66E-15 15 3.55E-24 0.04
3 SGTC_2549 cedrol 8.85 20.9 µM 6.63E-12 1 4.49E-19 2.91
4 SGTC_1399 3562-5772 8.54 25.0 µM 3.21E-11 RPP1 & pyrimidine depletion 6 6.53E-18 4.09
5 SGTC_1773 st048542 7.88 73.6 µM 8.38E-10 5 1.66E-15 0.86
6 SGTC_868 0527-0199 7.84 213.0 µM 9.85E-10 fatty acid desaturase (OLE1) 2 2.18E-15 1.70
7 SGTC_2126 5251174 7.33 33.9 µM 1.02E-8 1 1.15E-13 0.93
8 SGTC_838 0109-0203 7.31 71.4 µM 1.12E-8 1 1.35E-13 3.24
9 SGTC_1940 st075990 7.04 51.1 µM 3.53E-8 60S ribosome export 1 9.40E-13 1.02
10 SGTC_274 sirtinol 6.72 40.1 µM 1.34E-7 5 8.93E-12 0.30
11 SGTC_3282 9108498 6.61 15.5 µM 2.07E-7 5 1.87E-11 0.89
12 SGTC_1989 st071868 6.58 50.2 µM 2.34E-7 2 2.29E-11 1.59
13 SGTC_783 0848-0141 6.24 92.7 µM 9.06E-7 RSC & ERG11 6 2.25E-10 0.51
14 SGTC_785 1270-0111 6.13 65.3 µM 1.37E-6 1 4.50E-10 0.95
15 SGTC_878 0828-0289 5.98 13.7 µM 2.35E-6 11 1.12E-9 0.04
16 SGTC_2651 1327-0036 5.73 5.0 µM 5.73E-6 34 5.02E-9 0.04
17 SGTC_221 trifluoperazine 5.61 10.3 µM 8.56E-6 NEO1-PIK1 19 9.86E-9 0.46
18 SGTC_1628 st004252 5.60 77.7 µM 8.94E-6 2 1.06E-8 0.63
19 SGTC_832 4083-0019 5.57 164.0 µM 1.00E-5 translation 12 1.28E-8 0.28
20 SGTC_392 N-ethylmaleimide 5.54 8.3 µM 1.09E-5 RNA pol III & RNase P/MRP 5 1.47E-8 0.53

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.453 1.38E-169 YPL237W SUI3 het Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding
0.336 2.20E-89 YJR007W SUI2 het Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress
0.328 1.20E-84 YER025W GCD11 het Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met
0.217 6.36E-37 YDR429C TIF35 het eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation
0.192 3.12E-29 YDL150W RPC53 het RNA polymerase III subunit C53
0.182 2.78E-26 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.180 1.00E-25 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.159 1.88E-20 YNL178W RPS3 het Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
0.152 8.40E-19 YOL040C RPS15 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
0.152 8.55E-19 YMR146C TIF34 het eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates rate of ribosomal scanning during translation reinitiation
0.151 1.77E-18 YPR136C_d YPR136C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.146 1.55E-17 YOL120C RPL18A het Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
0.144 6.35E-17 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly
0.143 8.76E-17 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.142 1.34E-16 YOL127W RPL25 het Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23