YPL241C / CIN2

GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL241C / CIN2

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:7.55|P-value:3.16E-14 ID:SGTC_16|Compound:erodoxin|FD-Score:4.55|P-value:3.17E-6 ID:SGTC_21|Compound:0849-0113|FD-Score:6.79|P-value:7.79E-12 ID:SGTC_44|Compound:0929-0055|FD-Score:-5.65|P-value:1.02E-8 ID:SGTC_71|Compound:0417-1750|FD-Score:4.87|P-value:6.70E-7 ID:SGTC_72|Compound:0744-0168|FD-Score:3.34|P-value:4.60E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.59|P-value:1.84E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.89|P-value:5.98E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:3.66|P-value:1.40E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.88|P-value:6.29E-7 ID:SGTC_177|Compound:1327-0068|FD-Score:3.75|P-value:9.75E-5 ID:SGTC_195|Compound:4234-0266|FD-Score:3.90|P-value:5.42E-5 ID:SGTC_210|Compound:3551-0445|FD-Score:15.20|P-value:1.77E-51 ID:SGTC_212|Compound:3807-4682|FD-Score:14.80|P-value:6.09E-49 ID:SGTC_214|Compound:4373-3496|FD-Score:7.61|P-value:2.12E-14 ID:SGTC_229|Compound:benomyl|FD-Score:12.60|P-value:2.51E-36 ID:SGTC_272|Compound:doxorubicin|FD-Score:4.60|P-value:2.43E-6 ID:SGTC_274|Compound:sirtinol|FD-Score:3.52|P-value:2.33E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:4.46|P-value:4.63E-6 ID:SGTC_333|Compound:3486-0131|FD-Score:4.56|P-value:2.99E-6 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.44|P-value:3.25E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.62|P-value:1.60E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.47|P-value:2.86E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:4.01|P-value:3.36E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.97|P-value:4.09E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:6.40|P-value:1.05E-10 ID:SGTC_638|Compound:3970-0837|FD-Score:4.13|P-value:2.08E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:4.35|P-value:7.69E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:3.85|P-value:6.45E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.87|P-value:6.99E-7 ID:SGTC_836|Compound:0330-0104|FD-Score:3.42|P-value:3.38E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.95|P-value:4.38E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:4.85|P-value:7.10E-7 ID:SGTC_871|Compound:0574-0004|FD-Score:3.90|P-value:5.37E-5 ID:SGTC_897|Compound:1000-0139|FD-Score:5.80|P-value:4.15E-9 ID:SGTC_958|Compound:1222-0007|FD-Score:4.00|P-value:3.61E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:7.26|P-value:2.86E-13 ID:SGTC_1157|Compound:4092-0394|FD-Score:5.11|P-value:1.89E-7 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.13|P-value:9.43E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:5.87|P-value:2.71E-9 ID:SGTC_1352|Compound:1496-0991|FD-Score:4.00|P-value:3.48E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.60|P-value:1.74E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.31|P-value:5.08E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:5.75|P-value:5.48E-9 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.83|P-value:7.06E-5 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.22|P-value:6.94E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:4.28|P-value:1.05E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.13|P-value:2.03E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.63|P-value:1.56E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.22|P-value:6.92E-4 ID:SGTC_1643|Compound:st009866|FD-Score:7.59|P-value:2.34E-14 ID:SGTC_1661|Compound:st013063|FD-Score:4.14|P-value:1.97E-5 ID:SGTC_1711|Compound:st032263|FD-Score:3.78|P-value:8.54E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.56|P-value:2.01E-4 ID:SGTC_1762|Compound:st045503|FD-Score:3.66|P-value:1.40E-4 ID:SGTC_1773|Compound:st048542|FD-Score:7.07|P-value:1.08E-12 ID:SGTC_1783|Compound:st039459|FD-Score:3.82|P-value:7.24E-5 ID:SGTC_1784|Compound:st039334|FD-Score:5.14|P-value:1.66E-7 ID:SGTC_1875|Compound:nocodazole|FD-Score:13.60|P-value:1.45E-41 ID:SGTC_1958|Compound:st076513|FD-Score:8.47|P-value:2.06E-17 ID:SGTC_1977|Compound:st070720|FD-Score:3.12|P-value:9.55E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.14|P-value:8.96E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.83|P-value:7.13E-5 ID:SGTC_2077|Compound:5212015|FD-Score:3.89|P-value:5.53E-5 ID:SGTC_2085|Compound:5307070|FD-Score:3.13|P-value:9.44E-4 ID:SGTC_2089|Compound:5281248|FD-Score:4.39|P-value:6.61E-6 ID:SGTC_2090|Compound:5301565|FD-Score:7.24|P-value:3.14E-13 ID:SGTC_2092|Compound:5303694|FD-Score:3.53|P-value:2.27E-4 ID:SGTC_2125|Compound:5246583|FD-Score:7.27|P-value:2.54E-13 ID:SGTC_2141|Compound:5621638|FD-Score:4.91|P-value:5.34E-7 ID:SGTC_2174|Compound:5790901|FD-Score:5.77|P-value:4.95E-9 ID:SGTC_2200|Compound:6600604|FD-Score:6.16|P-value:4.69E-10 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.52|P-value:2.35E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-4.17|P-value:1.81E-5 ID:SGTC_2246|Compound:7293507|FD-Score:12.40|P-value:6.84E-35 ID:SGTC_2255|Compound:7941087|FD-Score:6.49|P-value:5.61E-11 ID:SGTC_2319|Compound:6033012|FD-Score:4.82|P-value:8.59E-7 ID:SGTC_2408|Compound:sulbentine|FD-Score:6.56|P-value:3.57E-11 ID:SGTC_2430|Compound:5571206|FD-Score:9.06|P-value:1.14E-19 ID:SGTC_2461|Compound:5755302|FD-Score:3.46|P-value:2.91E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.82|P-value:7.41E-5 ID:SGTC_2483|Compound:5729050|FD-Score:5.09|P-value:2.12E-7 ID:SGTC_2484|Compound:5809818|FD-Score:3.43|P-value:3.23E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:7.06|P-value:1.18E-12 ID:SGTC_2584|Compound:androsterone|FD-Score:4.05|P-value:2.85E-5 ID:SGTC_2601|Compound:securinine|FD-Score:3.69|P-value:1.26E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.79|P-value:8.25E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.63|P-value:1.55E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-3.39|P-value:3.85E-4 ID:SGTC_2878|Compound:9043973|FD-Score:3.89|P-value:5.56E-5 ID:SGTC_2907|Compound:7721985|FD-Score:-4.66|P-value:1.92E-6 ID:SGTC_2908|Compound:7930301|FD-Score:3.18|P-value:7.89E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.58|P-value:1.90E-4 ID:SGTC_3282|Compound:9108498|FD-Score:5.98|P-value:1.43E-9 ID:SGTC_3294|Compound:9122953|FD-Score:4.70|P-value:1.49E-6 ID:SGTC_3311|Compound:9131146|FD-Score:3.30|P-value:5.21E-4 ID:SGTC_3317|Compound:9138495|FD-Score:4.72|P-value:1.36E-6 ID:SGTC_12|Compound:0849-0099|FD-Score:7.55|P-value:3.16E-14 ID:SGTC_16|Compound:erodoxin|FD-Score:4.55|P-value:3.17E-6 ID:SGTC_21|Compound:0849-0113|FD-Score:6.79|P-value:7.79E-12 ID:SGTC_44|Compound:0929-0055|FD-Score:-5.65|P-value:1.02E-8 ID:SGTC_71|Compound:0417-1750|FD-Score:4.87|P-value:6.70E-7 ID:SGTC_72|Compound:0744-0168|FD-Score:3.34|P-value:4.60E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.59|P-value:1.84E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:4.89|P-value:5.98E-7 ID:SGTC_163|Compound:1327-0036|FD-Score:3.66|P-value:1.40E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.88|P-value:6.29E-7 ID:SGTC_177|Compound:1327-0068|FD-Score:3.75|P-value:9.75E-5 ID:SGTC_195|Compound:4234-0266|FD-Score:3.90|P-value:5.42E-5 ID:SGTC_210|Compound:3551-0445|FD-Score:15.20|P-value:1.77E-51 ID:SGTC_212|Compound:3807-4682|FD-Score:14.80|P-value:6.09E-49 ID:SGTC_214|Compound:4373-3496|FD-Score:7.61|P-value:2.12E-14 ID:SGTC_229|Compound:benomyl|FD-Score:12.60|P-value:2.51E-36 ID:SGTC_272|Compound:doxorubicin|FD-Score:4.60|P-value:2.43E-6 ID:SGTC_274|Compound:sirtinol|FD-Score:3.52|P-value:2.33E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:4.46|P-value:4.63E-6 ID:SGTC_333|Compound:3486-0131|FD-Score:4.56|P-value:2.99E-6 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.44|P-value:3.25E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.62|P-value:1.60E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.47|P-value:2.86E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:4.01|P-value:3.36E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.97|P-value:4.09E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:6.40|P-value:1.05E-10 ID:SGTC_638|Compound:3970-0837|FD-Score:4.13|P-value:2.08E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:4.35|P-value:7.69E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:3.85|P-value:6.45E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-4.87|P-value:6.99E-7 ID:SGTC_836|Compound:0330-0104|FD-Score:3.42|P-value:3.38E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.95|P-value:4.38E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:4.85|P-value:7.10E-7 ID:SGTC_871|Compound:0574-0004|FD-Score:3.90|P-value:5.37E-5 ID:SGTC_897|Compound:1000-0139|FD-Score:5.80|P-value:4.15E-9 ID:SGTC_958|Compound:1222-0007|FD-Score:4.00|P-value:3.61E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:7.26|P-value:2.86E-13 ID:SGTC_1157|Compound:4092-0394|FD-Score:5.11|P-value:1.89E-7 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.13|P-value:9.43E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:5.87|P-value:2.71E-9 ID:SGTC_1352|Compound:1496-0991|FD-Score:4.00|P-value:3.48E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.60|P-value:1.74E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.31|P-value:5.08E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:5.75|P-value:5.48E-9 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.83|P-value:7.06E-5 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.22|P-value:6.94E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:4.28|P-value:1.05E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:4.13|P-value:2.03E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:3.63|P-value:1.56E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.22|P-value:6.92E-4 ID:SGTC_1643|Compound:st009866|FD-Score:7.59|P-value:2.34E-14 ID:SGTC_1661|Compound:st013063|FD-Score:4.14|P-value:1.97E-5 ID:SGTC_1711|Compound:st032263|FD-Score:3.78|P-value:8.54E-5 ID:SGTC_1741|Compound:st038134|FD-Score:3.56|P-value:2.01E-4 ID:SGTC_1762|Compound:st045503|FD-Score:3.66|P-value:1.40E-4 ID:SGTC_1773|Compound:st048542|FD-Score:7.07|P-value:1.08E-12 ID:SGTC_1783|Compound:st039459|FD-Score:3.82|P-value:7.24E-5 ID:SGTC_1784|Compound:st039334|FD-Score:5.14|P-value:1.66E-7 ID:SGTC_1875|Compound:nocodazole|FD-Score:13.60|P-value:1.45E-41 ID:SGTC_1958|Compound:st076513|FD-Score:8.47|P-value:2.06E-17 ID:SGTC_1977|Compound:st070720|FD-Score:3.12|P-value:9.55E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.14|P-value:8.96E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.83|P-value:7.13E-5 ID:SGTC_2077|Compound:5212015|FD-Score:3.89|P-value:5.53E-5 ID:SGTC_2085|Compound:5307070|FD-Score:3.13|P-value:9.44E-4 ID:SGTC_2089|Compound:5281248|FD-Score:4.39|P-value:6.61E-6 ID:SGTC_2090|Compound:5301565|FD-Score:7.24|P-value:3.14E-13 ID:SGTC_2092|Compound:5303694|FD-Score:3.53|P-value:2.27E-4 ID:SGTC_2125|Compound:5246583|FD-Score:7.27|P-value:2.54E-13 ID:SGTC_2141|Compound:5621638|FD-Score:4.91|P-value:5.34E-7 ID:SGTC_2174|Compound:5790901|FD-Score:5.77|P-value:4.95E-9 ID:SGTC_2200|Compound:6600604|FD-Score:6.16|P-value:4.69E-10 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.52|P-value:2.35E-4 ID:SGTC_2245|Compound:6637752|FD-Score:-4.17|P-value:1.81E-5 ID:SGTC_2246|Compound:7293507|FD-Score:12.40|P-value:6.84E-35 ID:SGTC_2255|Compound:7941087|FD-Score:6.49|P-value:5.61E-11 ID:SGTC_2319|Compound:6033012|FD-Score:4.82|P-value:8.59E-7 ID:SGTC_2408|Compound:sulbentine|FD-Score:6.56|P-value:3.57E-11 ID:SGTC_2430|Compound:5571206|FD-Score:9.06|P-value:1.14E-19 ID:SGTC_2461|Compound:5755302|FD-Score:3.46|P-value:2.91E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.82|P-value:7.41E-5 ID:SGTC_2483|Compound:5729050|FD-Score:5.09|P-value:2.12E-7 ID:SGTC_2484|Compound:5809818|FD-Score:3.43|P-value:3.23E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:7.06|P-value:1.18E-12 ID:SGTC_2584|Compound:androsterone|FD-Score:4.05|P-value:2.85E-5 ID:SGTC_2601|Compound:securinine|FD-Score:3.69|P-value:1.26E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.79|P-value:8.25E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.63|P-value:1.55E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-3.39|P-value:3.85E-4 ID:SGTC_2878|Compound:9043973|FD-Score:3.89|P-value:5.56E-5 ID:SGTC_2907|Compound:7721985|FD-Score:-4.66|P-value:1.92E-6 ID:SGTC_2908|Compound:7930301|FD-Score:3.18|P-value:7.89E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.58|P-value:1.90E-4 ID:SGTC_3282|Compound:9108498|FD-Score:5.98|P-value:1.43E-9 ID:SGTC_3294|Compound:9122953|FD-Score:4.70|P-value:1.49E-6 ID:SGTC_3311|Compound:9131146|FD-Score:3.30|P-value:5.21E-4 ID:SGTC_3317|Compound:9138495|FD-Score:4.72|P-value:1.36E-6

Top fitness defect scores for YPL241C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_210 3551-0445 15.20 56.8 µM 1.77E-51 8 3.33E-52
2 SGTC_212 3807-4682 14.80 38.8 µM 6.09E-49 tubulin folding & SWR complex 3 1.25E-49
3 SGTC_1875 nocodazole 13.60 6.0 µM 1.45E-41 tubulin folding & SWR complex 7 3.84E-42
4 SGTC_229 benomyl 12.60 22.9 µM 2.51E-36 tubulin folding & SWR complex 7 7.92E-37
5 SGTC_2246 7293507 12.40 91.6 µM 6.84E-35 2 2.27E-35
6 SGTC_2430 5571206 9.06 200.0 µM 1.14E-19 11 6.30E-20
7 SGTC_1958 st076513 8.47 41.9 µM 2.06E-17 60S ribosome export 3 1.23E-17
8 SGTC_214 4373-3496 7.61 70.0 µM 2.12E-14 6 1.41E-14
9 SGTC_1643 st009866 7.59 20.2 µM 2.34E-14 15 1.56E-14
10 SGTC_12 0849-0099 7.55 9.3 µM 3.16E-14 5 2.10E-14
11 SGTC_2125 5246583 7.27 200.0 µM 2.54E-13 tubulin folding & SWR complex 10 1.74E-13
12 SGTC_1132 3456-3614 7.26 2.5 µM 2.86E-13 tubulin folding & SWR complex 6 1.97E-13
13 SGTC_2090 5301565 7.24 104.5 µM 3.14E-13 TSC3-RPN4 12 2.16E-13
14 SGTC_1773 st048542 7.07 73.6 µM 1.08E-12 10 7.56E-13
15 SGTC_2510 benzyl isothiocyanate 7.06 8.3 µM 1.18E-12 7 8.29E-13
16 SGTC_21 0849-0113 6.79 23.0 µM 7.79E-12 6 5.62E-12
17 SGTC_2408 sulbentine 6.56 18.4 µM 3.57E-11 18 2.63E-11
18 SGTC_2255 7941087 6.49 197.4 µM 5.61E-11 7 4.17E-11
19 SGTC_589 1227-0070 6.40 34.1 µM 1.05E-10 10 7.88E-11
20 SGTC_2200 6600604 6.16 21.9 µM 4.69E-10 tubulin folding & SWR complex 27 3.59E-10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.701 0 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.664 0 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.529 3.68E-241 YML124C TUB3 hom Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication
0.390 2.76E-122 YML041C VPS71 hom Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.390 1.82E-122 YDR485C VPS72 hom Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.386 9.74E-120 YDR334W SWR1 hom Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.377 6.02E-114 YAL011W SWC3 hom Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
0.374 1.32E-111 YLR085C ARP6 hom Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.338 2.67E-90 YAL024C LTE1 hom Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures
0.334 5.41E-88 YBR231C SWC5 hom Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress
0.307 8.86E-74 YNL298W CLA4 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.280 2.50E-61 YJL008C CCT8 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.279 6.95E-61 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.271 1.95E-57 YOR207C RET1 het Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.262 1.65E-53 YNL148C ALF1 hom Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance