YPL242C / IQG1

Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPL242C / IQG1

Click on Significant Values for Screen Details ID:SGTC_138|Compound:0850-0259|FD-Score:4.79|P-value:5.12E-7 ID:SGTC_147|Compound:4466-0538|FD-Score:3.41|P-value:2.53E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:5.43|P-value:1.58E-8 ID:SGTC_481|Compound:bay k-8644|FD-Score:-3.35|P-value:3.45E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.08|P-value:8.18E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.32|P-value:3.47E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:5.09|P-value:1.03E-7 ID:SGTC_709|Compound:3807-1509|FD-Score:18.00|P-value:1.40E-75 ID:SGTC_722|Compound:3534-0461|FD-Score:3.90|P-value:3.42E-5 ID:SGTC_731|Compound:3966-0296|FD-Score:4.61|P-value:1.28E-6 ID:SGTC_753|Compound:1322-0200|FD-Score:-3.76|P-value:7.06E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.25|P-value:4.96E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.34|P-value:3.19E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:4.01|P-value:2.09E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:6.63|P-value:6.96E-12 ID:SGTC_900|Compound:1112-0045|FD-Score:3.41|P-value:2.45E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:4.54|P-value:1.86E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:16.70|P-value:3.42E-65 ID:SGTC_1286|Compound:0929-0070|FD-Score:4.23|P-value:8.10E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.72|P-value:2.83E-9 ID:SGTC_1647|Compound:st011722|FD-Score:-3.17|P-value:6.76E-4 ID:SGTC_1652|Compound:st011932|FD-Score:4.73|P-value:6.89E-7 ID:SGTC_1654|Compound:st012436|FD-Score:-3.13|P-value:7.67E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.81|P-value:5.08E-5 ID:SGTC_1767|Compound:st044992|FD-Score:3.92|P-value:3.19E-5 ID:SGTC_1868|Compound:st057644|FD-Score:3.68|P-value:8.47E-5 ID:SGTC_1942|Compound:st076330|FD-Score:-3.10|P-value:8.44E-4 ID:SGTC_2109|Compound:5483026|FD-Score:3.37|P-value:2.89E-4 ID:SGTC_2186|Compound:6124449|FD-Score:3.65|P-value:9.57E-5 ID:SGTC_2266|Compound:7929956|FD-Score:3.11|P-value:7.45E-4 ID:SGTC_2273|Compound:7815444|FD-Score:-4.60|P-value:1.58E-6 ID:SGTC_2294|Compound:7971431|FD-Score:-3.99|P-value:2.69E-5 ID:SGTC_2303|Compound:7774051|FD-Score:3.62|P-value:1.08E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-3.22|P-value:5.59E-4 ID:SGTC_2319|Compound:6033012|FD-Score:-5.99|P-value:6.15E-10 ID:SGTC_2321|Compound:7390090|FD-Score:4.08|P-value:1.58E-5 ID:SGTC_2327|Compound:6189656|FD-Score:-3.90|P-value:3.97E-5 ID:SGTC_2328|Compound:6201408|FD-Score:-5.35|P-value:2.97E-8 ID:SGTC_2396|Compound:5342950|FD-Score:18.70|P-value:7.86E-81 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.51|P-value:1.70E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.10|P-value:7.61E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.87|P-value:4.46E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:6.64|P-value:6.66E-12 ID:SGTC_2704|Compound:st078022|FD-Score:3.78|P-value:5.80E-5 ID:SGTC_2836|Compound:9010338|FD-Score:3.89|P-value:3.60E-5 ID:SGTC_2858|Compound:9025781|FD-Score:3.57|P-value:1.34E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.34|P-value:3.28E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-7.97|P-value:3.17E-16 ID:SGTC_3009|Compound:9080819|FD-Score:-3.17|P-value:6.60E-4 ID:SGTC_3065|Compound:9113888|FD-Score:-3.28|P-value:4.46E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.55|P-value:1.46E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.18|P-value:5.77E-4 ID:SGTC_3268|Compound:9137683|FD-Score:3.16|P-value:6.25E-4 ID:SGTC_3270|Compound:9137563|FD-Score:-4.67|P-value:1.11E-6 ID:SGTC_3327|Compound:9140648|FD-Score:3.27|P-value:4.18E-4 ID:SGTC_3340|Compound:9146634|FD-Score:5.26|P-value:4.07E-8 ID:SGTC_138|Compound:0850-0259|FD-Score:4.79|P-value:5.12E-7 ID:SGTC_147|Compound:4466-0538|FD-Score:3.41|P-value:2.53E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:5.43|P-value:1.58E-8 ID:SGTC_481|Compound:bay k-8644|FD-Score:-3.35|P-value:3.45E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.08|P-value:8.18E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.32|P-value:3.47E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:5.09|P-value:1.03E-7 ID:SGTC_709|Compound:3807-1509|FD-Score:18.00|P-value:1.40E-75 ID:SGTC_722|Compound:3534-0461|FD-Score:3.90|P-value:3.42E-5 ID:SGTC_731|Compound:3966-0296|FD-Score:4.61|P-value:1.28E-6 ID:SGTC_753|Compound:1322-0200|FD-Score:-3.76|P-value:7.06E-5 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.25|P-value:4.96E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.34|P-value:3.19E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:4.01|P-value:2.09E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:6.63|P-value:6.96E-12 ID:SGTC_900|Compound:1112-0045|FD-Score:3.41|P-value:2.45E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:4.54|P-value:1.86E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:16.70|P-value:3.42E-65 ID:SGTC_1286|Compound:0929-0070|FD-Score:4.23|P-value:8.10E-6 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.72|P-value:2.83E-9 ID:SGTC_1647|Compound:st011722|FD-Score:-3.17|P-value:6.76E-4 ID:SGTC_1652|Compound:st011932|FD-Score:4.73|P-value:6.89E-7 ID:SGTC_1654|Compound:st012436|FD-Score:-3.13|P-value:7.67E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.81|P-value:5.08E-5 ID:SGTC_1767|Compound:st044992|FD-Score:3.92|P-value:3.19E-5 ID:SGTC_1868|Compound:st057644|FD-Score:3.68|P-value:8.47E-5 ID:SGTC_1942|Compound:st076330|FD-Score:-3.10|P-value:8.44E-4 ID:SGTC_2109|Compound:5483026|FD-Score:3.37|P-value:2.89E-4 ID:SGTC_2186|Compound:6124449|FD-Score:3.65|P-value:9.57E-5 ID:SGTC_2266|Compound:7929956|FD-Score:3.11|P-value:7.45E-4 ID:SGTC_2273|Compound:7815444|FD-Score:-4.60|P-value:1.58E-6 ID:SGTC_2294|Compound:7971431|FD-Score:-3.99|P-value:2.69E-5 ID:SGTC_2303|Compound:7774051|FD-Score:3.62|P-value:1.08E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-3.22|P-value:5.59E-4 ID:SGTC_2319|Compound:6033012|FD-Score:-5.99|P-value:6.15E-10 ID:SGTC_2321|Compound:7390090|FD-Score:4.08|P-value:1.58E-5 ID:SGTC_2327|Compound:6189656|FD-Score:-3.90|P-value:3.97E-5 ID:SGTC_2328|Compound:6201408|FD-Score:-5.35|P-value:2.97E-8 ID:SGTC_2396|Compound:5342950|FD-Score:18.70|P-value:7.86E-81 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.51|P-value:1.70E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.10|P-value:7.61E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-3.87|P-value:4.46E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:6.64|P-value:6.66E-12 ID:SGTC_2704|Compound:st078022|FD-Score:3.78|P-value:5.80E-5 ID:SGTC_2836|Compound:9010338|FD-Score:3.89|P-value:3.60E-5 ID:SGTC_2858|Compound:9025781|FD-Score:3.57|P-value:1.34E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.34|P-value:3.28E-4 ID:SGTC_2965|Compound:9082772|FD-Score:-7.97|P-value:3.17E-16 ID:SGTC_3009|Compound:9080819|FD-Score:-3.17|P-value:6.60E-4 ID:SGTC_3065|Compound:9113888|FD-Score:-3.28|P-value:4.46E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.55|P-value:1.46E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.18|P-value:5.77E-4 ID:SGTC_3268|Compound:9137683|FD-Score:3.16|P-value:6.25E-4 ID:SGTC_3270|Compound:9137563|FD-Score:-4.67|P-value:1.11E-6 ID:SGTC_3327|Compound:9140648|FD-Score:3.27|P-value:4.18E-4 ID:SGTC_3340|Compound:9146634|FD-Score:5.26|P-value:4.07E-8

Top fitness defect scores for YPL242C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2396 5342950 18.70 42.8 µM 7.86E-81 RSC complex & mRNA processing 1 3.78E-78 3.60
2 SGTC_709 3807-1509 18.00 243.0 µM 1.40E-75 RSC complex & mRNA processing 2 4.49E-73 5.38
3 SGTC_1133 3473-0247 16.70 50.0 µM 3.42E-65 RSC complex & mRNA processing 2 4.97E-63 3.77
4 SGTC_2573 2',4'-dihydroxychalcone 6.64 15.0 µM 6.66E-12 5 1.58E-11 0.07
5 SGTC_839 0122-0028 6.63 230.0 µM 6.96E-12 RSC complex & mRNA processing 6 1.65E-11 0.05
6 SGTC_1374 2889-5571 5.72 141.0 µM 2.83E-9 RSC complex & mRNA processing 23 5.46E-9 0.07
7 SGTC_157 1348-1695 5.43 65.8 µM 1.58E-8 iron homeostasis 21 2.87E-8 0.15
8 SGTC_3340 9146634 5.26 11.1 µM 4.07E-8 1 7.18E-8 1.35
9 SGTC_673 1082-0474 5.09 110.0 µM 1.03E-7 RSC complex & mRNA processing 34 1.75E-7 0.19
10 SGTC_138 0850-0259 4.79 40.9 µM 5.12E-7 cell wall 43 8.27E-7 0.07
11 SGTC_1652 st011932 4.73 78.0 µM 6.89E-7 RSC complex & mRNA processing 27 1.10E-6 0.06
12 SGTC_731 3966-0296 4.61 387.0 µM 1.28E-6 1 2.01E-6 0.35
13 SGTC_977 1348-1378 4.54 135.0 µM 1.86E-6 4 2.87E-6 0.06
14 SGTC_1286 0929-0070 4.23 131.0 µM 8.10E-6 4 1.19E-5 0.15
15 SGTC_2321 7390090 4.08 138.8 µM 1.58E-5 5 2.28E-5 0.07
16 SGTC_829 1635-0120 4.01 117.0 µM 2.09E-5 DNA damage response 45 2.97E-5 0.08
17 SGTC_1767 st044992 3.92 70.3 µM 3.19E-5 3 4.47E-5 0.30
18 SGTC_722 3534-0461 3.90 190.0 µM 3.42E-5 PDR1 3 4.79E-5 0.46
19 SGTC_2836 9010338 3.89 19.5 µM 3.60E-5 RPP1 & pyrimidine depletion 4 5.03E-5 0.03
20 SGTC_1707 st032323 3.81 6.3 µM 5.08E-5 DNA damage response 32 7.02E-5 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.310 9.91E-76 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.272 7.96E-58 YHR058C MED6 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress
0.269 1.38E-56 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.226 3.10E-40 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.226 3.81E-40 YDR172W SUP35 het Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype
0.225 9.18E-40 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.223 3.38E-39 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.222 1.36E-38 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.214 3.41E-36 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.208 3.08E-34 YIL106W MOB1 het Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
0.204 8.87E-33 YDL117W CYK3 hom SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants
0.200 1.73E-31 YLR424W SPP382 het Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation
0.199 2.69E-31 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.197 8.63E-31 YIL126W STH1 het ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
0.194 7.43E-30 YKL101W HSL1 hom Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p