Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YPL245W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.120 | 2.54E-12 | YEL063C | CAN1 | hom | Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication |
0.111 | 1.15E-10 | YER096W | SHC1 | hom | Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication |
0.108 | 3.04E-10 | YIL113W | SDP1 | hom | Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock |
0.100 | 5.88E-9 | YGR244C | LSC2 | hom | Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate |
0.095 | 3.96E-8 | YMR273C | ZDS1 | hom | Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication |
0.090 | 1.73E-7 | YLR198C_d | YLR198C_d | het | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W |
0.089 | 2.61E-7 | YNL329C | PEX6 | hom | AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol |
0.081 | 2.37E-6 | YLR030W_p | YLR030W_p | hom | Putative protein of unknown function |
0.080 | 3.22E-6 | YAR003W | SWD1 | hom | Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7 |
0.078 | 6.24E-6 | YKR012C_d | YKR012C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2 |
0.078 | 6.33E-6 | YMR060C | SAM37 | hom | Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability |
0.075 | 1.31E-5 | YGR227W | DIE2 | hom | Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1 |
0.075 | 1.51E-5 | YOR106W | VAM3 | hom | Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region |
0.074 | 1.96E-5 | YDL160C-A | MHF2 | hom | Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2 |
0.073 | 2.06E-5 | YNR064C | YNR064C | hom | Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides |