YPL245W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL245W / YPL245W

Click on Significant Values for Screen Details ID:SGTC_140|Compound:0062-0056|FD-Score:3.46|P-value:2.76E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.37|P-value:3.83E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.00|P-value:3.33E-5 ID:SGTC_417|Compound:st075190|FD-Score:4.19|P-value:1.51E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:4.53|P-value:3.23E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:3.26|P-value:5.61E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:4.46|P-value:4.47E-6 ID:SGTC_977|Compound:1348-1378|FD-Score:3.37|P-value:3.90E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.28|P-value:5.20E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:-3.70|P-value:1.54E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.35|P-value:5.61E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:8.82|P-value:1.18E-18 ID:SGTC_1101|Compound:ebselen|FD-Score:4.21|P-value:1.39E-5 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.52|P-value:2.19E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.21|P-value:6.66E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:4.35|P-value:7.58E-6 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.21|P-value:6.75E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:5.14|P-value:1.64E-7 ID:SGTC_1661|Compound:st013063|FD-Score:3.26|P-value:5.61E-4 ID:SGTC_1677|Compound:st019204|FD-Score:-3.23|P-value:8.30E-4 ID:SGTC_1706|Compound:st031321|FD-Score:-3.60|P-value:2.25E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.18|P-value:7.53E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.39|P-value:3.61E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.35|P-value:4.18E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.15|P-value:8.25E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-3.81|P-value:1.00E-4 ID:SGTC_2067|Compound:5224629|FD-Score:-3.43|P-value:4.19E-4 ID:SGTC_2430|Compound:5571206|FD-Score:5.33|P-value:5.78E-8 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.66|P-value:1.74E-6 ID:SGTC_2796|Compound:7949634|FD-Score:3.19|P-value:7.10E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.23|P-value:6.18E-4 ID:SGTC_3016|Compound:9080866|FD-Score:4.87|P-value:6.27E-7 ID:SGTC_3214|Compound:9129694|FD-Score:3.12|P-value:9.20E-4 ID:SGTC_3221|Compound:9128209|FD-Score:-3.91|P-value:6.96E-5 ID:SGTC_140|Compound:0062-0056|FD-Score:3.46|P-value:2.76E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.37|P-value:3.83E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:4.00|P-value:3.33E-5 ID:SGTC_417|Compound:st075190|FD-Score:4.19|P-value:1.51E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:4.53|P-value:3.23E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:3.26|P-value:5.61E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:4.46|P-value:4.47E-6 ID:SGTC_977|Compound:1348-1378|FD-Score:3.37|P-value:3.90E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.28|P-value:5.20E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:-3.70|P-value:1.54E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:-3.35|P-value:5.61E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:8.82|P-value:1.18E-18 ID:SGTC_1101|Compound:ebselen|FD-Score:4.21|P-value:1.39E-5 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.52|P-value:2.19E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.21|P-value:6.66E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:4.35|P-value:7.58E-6 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.21|P-value:6.75E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:5.14|P-value:1.64E-7 ID:SGTC_1661|Compound:st013063|FD-Score:3.26|P-value:5.61E-4 ID:SGTC_1677|Compound:st019204|FD-Score:-3.23|P-value:8.30E-4 ID:SGTC_1706|Compound:st031321|FD-Score:-3.60|P-value:2.25E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.18|P-value:7.53E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.39|P-value:3.61E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.35|P-value:4.18E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.15|P-value:8.25E-4 ID:SGTC_2014|Compound:4013930|FD-Score:-3.81|P-value:1.00E-4 ID:SGTC_2067|Compound:5224629|FD-Score:-3.43|P-value:4.19E-4 ID:SGTC_2430|Compound:5571206|FD-Score:5.33|P-value:5.78E-8 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.66|P-value:1.74E-6 ID:SGTC_2796|Compound:7949634|FD-Score:3.19|P-value:7.10E-4 ID:SGTC_2801|Compound:7907800|FD-Score:3.23|P-value:6.18E-4 ID:SGTC_3016|Compound:9080866|FD-Score:4.87|P-value:6.27E-7 ID:SGTC_3214|Compound:9129694|FD-Score:3.12|P-value:9.20E-4 ID:SGTC_3221|Compound:9128209|FD-Score:-3.91|P-value:6.96E-5

Top fitness defect scores for YPL245W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_1099 5-nonyloxytryptamine 8.82 2.9 µM 1.18E-18 1 5.73E-19
2 SGTC_2430 5571206 5.33 200.0 µM 5.78E-8 31 4.81E-8
3 SGTC_1446 4239-0190 5.14 62.0 µM 1.64E-7 14 1.39E-7
4 SGTC_3016 9080866 4.87 49.5 µM 6.27E-7 12 5.48E-7
5 SGTC_2697 mebhydrolin 4.66 72.4 µM 1.74E-6 NEO1 48 1.55E-6
6 SGTC_736 0958-0254 4.53 92.6 µM 3.23E-6 Golgi 18 2.91E-6
7 SGTC_976 1348-1067 4.46 47.6 µM 4.47E-6 60S ribosome export 17 4.05E-6
8 SGTC_1169 aniline yellow 4.35 25.8 µM 7.58E-6 5 6.94E-6
9 SGTC_1101 ebselen 4.21 5.3 µM 1.39E-5 17 1.29E-5
10 SGTC_417 st075190 4.19 100.0 µM 1.51E-5 5 1.40E-5
11 SGTC_391 gliotoxin 4.00 8.3 µM 3.33E-5 58 3.13E-5
12 SGTC_1138 3761-0006 3.52 1.0 µM 2.19E-4 11 2.13E-4
13 SGTC_140 0062-0056 3.46 502.5 µM 2.76E-4 36 2.69E-4
14 SGTC_1739 st037196 3.39 92.5 µM 3.61E-4 41 3.53E-4
15 SGTC_385 1494-0393 3.37 12.4 µM 3.83E-4 49 3.75E-4
16 SGTC_977 1348-1378 3.37 135.0 µM 3.90E-4 37 3.82E-4
17 SGTC_1836 st055642 3.35 81.0 µM 4.18E-4 40 4.10E-4
18 SGTC_986 1493-0483 3.28 84.0 µM 5.20E-4 32 5.11E-4
19 SGTC_1661 st013063 3.26 9.7 µM 5.61E-4 47 5.52E-4
20 SGTC_750 4073-0104 3.26 132.0 µM 5.61E-4 28 5.52E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 2.54E-12 YEL063C CAN1 hom Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication
0.111 1.15E-10 YER096W SHC1 hom Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication
0.108 3.04E-10 YIL113W SDP1 hom Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
0.100 5.88E-9 YGR244C LSC2 hom Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate
0.095 3.96E-8 YMR273C ZDS1 hom Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication
0.090 1.73E-7 YLR198C_d YLR198C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W
0.089 2.61E-7 YNL329C PEX6 hom AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol
0.081 2.37E-6 YLR030W_p YLR030W_p hom Putative protein of unknown function
0.080 3.22E-6 YAR003W SWD1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7
0.078 6.24E-6 YKR012C_d YKR012C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
0.078 6.33E-6 YMR060C SAM37 hom Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability
0.075 1.31E-5 YGR227W DIE2 hom Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1
0.075 1.51E-5 YOR106W VAM3 hom Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region
0.074 1.96E-5 YDL160C-A MHF2 hom Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2
0.073 2.06E-5 YNR064C YNR064C hom Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides