YPL247C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest

Zygosity: Homozygous strain
fixedexpanded
Profile for YPL247C / YPL247C

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:4.31|P-value:2.37E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:3.35|P-value:7.31E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:5.88|P-value:1.56E-8 ID:SGTC_179|Compound:1273-0063|FD-Score:3.32|P-value:8.23E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.39|P-value:6.42E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:3.59|P-value:3.39E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:6.02|P-value:7.27E-9 ID:SGTC_825|Compound:1988-2224|FD-Score:4.09|P-value:5.40E-5 ID:SGTC_838|Compound:0109-0203|FD-Score:3.38|P-value:6.72E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.72|P-value:2.14E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.39|P-value:6.40E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.45|P-value:5.38E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.48|P-value:4.83E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.71|P-value:4.32E-6 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.35|P-value:7.31E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:4.73|P-value:4.06E-6 ID:SGTC_1368|Compound:1852-0141|FD-Score:6.02|P-value:7.28E-9 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.01|P-value:7.35E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.93|P-value:1.00E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.67|P-value:2.51E-4 ID:SGTC_1866|Compound:st057638|FD-Score:4.53|P-value:9.43E-6 ID:SGTC_1881|Compound:5652484|FD-Score:3.70|P-value:2.27E-4 ID:SGTC_1927|Compound:st060202|FD-Score:4.00|P-value:7.65E-5 ID:SGTC_1934|Compound:st074720|FD-Score:4.15|P-value:4.36E-5 ID:SGTC_2013|Compound:4024628|FD-Score:10.60|P-value:1.91E-23 ID:SGTC_2015|Compound:5119600|FD-Score:-4.46|P-value:2.18E-5 ID:SGTC_2078|Compound:5212016|FD-Score:-3.63|P-value:4.68E-4 ID:SGTC_2116|Compound:5511452|FD-Score:4.94|P-value:1.62E-6 ID:SGTC_2155|Compound:5570423|FD-Score:5.75|P-value:3.11E-8 ID:SGTC_2241|Compound:6772625|FD-Score:3.35|P-value:7.28E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-3.61|P-value:5.00E-4 ID:SGTC_2260|Compound:7964312|FD-Score:-3.52|P-value:6.63E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.29|P-value:8.81E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.56|P-value:3.74E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:8.69|P-value:1.90E-16 ID:SGTC_2459|Compound:5811157|FD-Score:3.76|P-value:1.83E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:5.88|P-value:1.55E-8 ID:SGTC_2643|Compound:anethole|FD-Score:4.67|P-value:5.23E-6 ID:SGTC_2652|Compound:actinonin|FD-Score:3.54|P-value:3.92E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.29|P-value:8.92E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:4.74|P-value:3.91E-6 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.48|P-value:4.84E-4 ID:SGTC_2782|Compound:7736369|FD-Score:4.19|P-value:3.67E-5 ID:SGTC_2817|Compound:7995342|FD-Score:3.86|P-value:1.28E-4 ID:SGTC_2926|Compound:9010726|FD-Score:4.66|P-value:5.40E-6 ID:SGTC_2934|Compound:9036370|FD-Score:-3.73|P-value:3.29E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.39|P-value:6.47E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.50|P-value:4.46E-4 ID:SGTC_3019|Compound:9081971|FD-Score:4.41|P-value:1.56E-5 ID:SGTC_3094|Compound:9117742|FD-Score:3.73|P-value:2.07E-4 ID:SGTC_3115|Compound:9123671|FD-Score:4.31|P-value:2.34E-5 ID:SGTC_3153|Compound:9100258|FD-Score:3.59|P-value:3.29E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.50|P-value:4.49E-4 ID:SGTC_3178|Compound:9107506|FD-Score:-3.98|P-value:1.35E-4 ID:SGTC_3346|Compound:9158254|FD-Score:-3.74|P-value:3.24E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.34|P-value:7.63E-4 ID:SGTC_3355|Compound:9151058|FD-Score:-3.56|P-value:5.88E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:4.31|P-value:2.37E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:3.35|P-value:7.31E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:5.88|P-value:1.56E-8 ID:SGTC_179|Compound:1273-0063|FD-Score:3.32|P-value:8.23E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.39|P-value:6.42E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:3.59|P-value:3.39E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:6.02|P-value:7.27E-9 ID:SGTC_825|Compound:1988-2224|FD-Score:4.09|P-value:5.40E-5 ID:SGTC_838|Compound:0109-0203|FD-Score:3.38|P-value:6.72E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:3.72|P-value:2.14E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.39|P-value:6.40E-4 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.45|P-value:5.38E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.48|P-value:4.83E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.71|P-value:4.32E-6 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.35|P-value:7.31E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:4.73|P-value:4.06E-6 ID:SGTC_1368|Compound:1852-0141|FD-Score:6.02|P-value:7.28E-9 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.01|P-value:7.35E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.93|P-value:1.00E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.67|P-value:2.51E-4 ID:SGTC_1866|Compound:st057638|FD-Score:4.53|P-value:9.43E-6 ID:SGTC_1881|Compound:5652484|FD-Score:3.70|P-value:2.27E-4 ID:SGTC_1927|Compound:st060202|FD-Score:4.00|P-value:7.65E-5 ID:SGTC_1934|Compound:st074720|FD-Score:4.15|P-value:4.36E-5 ID:SGTC_2013|Compound:4024628|FD-Score:10.60|P-value:1.91E-23 ID:SGTC_2015|Compound:5119600|FD-Score:-4.46|P-value:2.18E-5 ID:SGTC_2078|Compound:5212016|FD-Score:-3.63|P-value:4.68E-4 ID:SGTC_2116|Compound:5511452|FD-Score:4.94|P-value:1.62E-6 ID:SGTC_2155|Compound:5570423|FD-Score:5.75|P-value:3.11E-8 ID:SGTC_2241|Compound:6772625|FD-Score:3.35|P-value:7.28E-4 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-3.61|P-value:5.00E-4 ID:SGTC_2260|Compound:7964312|FD-Score:-3.52|P-value:6.63E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.29|P-value:8.81E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.56|P-value:3.74E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:8.69|P-value:1.90E-16 ID:SGTC_2459|Compound:5811157|FD-Score:3.76|P-value:1.83E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:5.88|P-value:1.55E-8 ID:SGTC_2643|Compound:anethole|FD-Score:4.67|P-value:5.23E-6 ID:SGTC_2652|Compound:actinonin|FD-Score:3.54|P-value:3.92E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.29|P-value:8.92E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:4.74|P-value:3.91E-6 ID:SGTC_2680|Compound:butyl paraben|FD-Score:3.48|P-value:4.84E-4 ID:SGTC_2782|Compound:7736369|FD-Score:4.19|P-value:3.67E-5 ID:SGTC_2817|Compound:7995342|FD-Score:3.86|P-value:1.28E-4 ID:SGTC_2926|Compound:9010726|FD-Score:4.66|P-value:5.40E-6 ID:SGTC_2934|Compound:9036370|FD-Score:-3.73|P-value:3.29E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.39|P-value:6.47E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.50|P-value:4.46E-4 ID:SGTC_3019|Compound:9081971|FD-Score:4.41|P-value:1.56E-5 ID:SGTC_3094|Compound:9117742|FD-Score:3.73|P-value:2.07E-4 ID:SGTC_3115|Compound:9123671|FD-Score:4.31|P-value:2.34E-5 ID:SGTC_3153|Compound:9100258|FD-Score:3.59|P-value:3.29E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.50|P-value:4.49E-4 ID:SGTC_3178|Compound:9107506|FD-Score:-3.98|P-value:1.35E-4 ID:SGTC_3346|Compound:9158254|FD-Score:-3.74|P-value:3.24E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.34|P-value:7.63E-4 ID:SGTC_3355|Compound:9151058|FD-Score:-3.56|P-value:5.88E-4

Top fitness defect scores for YPL247C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2013 4024628 10.60 200.0 µM 1.91E-23 2 1.74E-26
2 SGTC_2418 pentamidine 8.69 31.7 µM 1.90E-16 mitochondrial processes 5 1.83E-18
3 SGTC_710 3448-4187 6.02 58.0 µM 7.27E-9 fatty acid desaturase (OLE1) 16 8.47E-10
4 SGTC_1368 1852-0141 6.02 284.0 µM 7.28E-9 ERG2 11 8.47E-10
5 SGTC_2640 pentamidine 5.88 10.4 µM 1.55E-8 mitochondrial processes 8 2.01E-9
6 SGTC_150 3970-0969 5.88 77.2 µM 1.56E-8 22 2.02E-9
7 SGTC_2155 5570423 5.75 76.0 µM 3.11E-8 ergosterol biosynthesis 1 4.43E-9
8 SGTC_2116 5511452 4.94 16.9 µM 1.62E-6 5 3.97E-7
9 SGTC_2654 protoveratrine a 4.74 100.0 µM 3.91E-6 2 1.08E-6
10 SGTC_1364 1653-0028 4.73 37.6 µM 4.06E-6 9 1.13E-6
11 SGTC_1254 0550-0035 4.71 264.0 µM 4.32E-6 8 1.21E-6
12 SGTC_2643 anethole 4.67 100.0 µM 5.23E-6 8 1.50E-6
13 SGTC_2926 9010726 4.66 65.2 µM 5.40E-6 20 1.56E-6
14 SGTC_1866 st057638 4.53 64.0 µM 9.43E-6 8 2.93E-6
15 SGTC_3019 9081971 4.41 49.5 µM 1.56E-5 10 5.19E-6
16 SGTC_3115 9123671 4.31 49.5 µM 2.34E-5 3 8.18E-6
17 SGTC_66 0109-0187 4.31 42.4 µM 2.37E-5 32 8.31E-6
18 SGTC_2782 7736369 4.19 71.4 µM 3.67E-5 33 1.37E-5
19 SGTC_1934 st074720 4.15 32.6 µM 4.36E-5 48 1.66E-5
20 SGTC_825 1988-2224 4.09 89.6 µM 5.40E-5 cell wall signaling 29 2.11E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.187 9.59E-28 YKR018C YKR018C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
0.118 6.04E-12 YDL004W ATP16 het Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
0.114 4.11E-11 YIR032C DAL3 hom Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression
0.110 1.73E-10 YPR079W MRL1 hom Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in response to DNA replication stress
0.109 2.47E-10 YGL068W MNP1 het Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth
0.096 2.60E-8 YJL030W MAD2 hom Component of the spindle-assembly checkpoint complex; delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I
0.094 5.08E-8 YGR149W_p YGR149W_p hom Putative protein of unknown function; predicted to be an integal membrane protein
0.089 2.80E-7 YPL150W_p YPL150W_p hom Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study
0.086 6.45E-7 YHL040C ARN1 hom ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress
0.085 8.20E-7 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.083 1.33E-6 YLR086W SMC4 het Subunit of the condensin complex; reorganizes chromosomes during cell division; forms a complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate
0.083 1.62E-6 YOR102W_d YOR102W_d het Dubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex
0.082 2.03E-6 YCR013C_d YCR013C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant
0.081 2.64E-6 YBL030C PET9 het Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog, AAC3, that arose from the whole genome duplication
0.080 3.82E-6 YGL113W SLD3 het Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress